(Press-News.org) ALEXANDRIA, Va. – Co-sponsors of the 2013 Genitourinary Cancers Symposium announced today important research to be presented at this year's meeting, taking place February 14-16 at the Rosen Shingle Creek in Orlando, Florida. Three of the featured studies focus on the prevention, diagnosis and treatment of prostate cancers; another study looks at a new immunotherapy for metastatic kidney cancer.
Thursday, February 14 Presentations
Abstract # 10: Long-term survival of subjects in the prostate cancer prevention trial.
General Poster Session A
Thursday, February 14, 2013, 11:45 AM – 01:15 PM EST
Thursday, February 14, 2013, 05:05 PM – 06:35 PM EST
Rosen, Gatlin Ballroom B
Phyllis J. Goodman, M.S.
SWOG Statistical Center
Seattle, WA
"A randomized trial designed to evaluate finasteride as a chemopreventative agent in prostate cancer has been previously reported (NEJM 349:213-222, 2003) and demonstrated an almost 25% reduction in the risk of being diagnosed with prostate cancer over a 7-year period for those receiving finasteride as opposed to placebo; and an increased risk of higher Gleason grade tumors in those receiving finasteride, although it was unclear whether this latter finding represented a true change in the biology of the tumors in response to finasteride, or an artificial by-product on the way the trial was conducted. If finasteride truly affected the natural history of the cancer, then this should be reflected as a long-term reduction of survival in this group. In this report, with follow-up to 18 years, 7-year administration of finasteride does not decrease overall mortality from prostate cancer despite the diagnosis of higher grade tumors, but significantly reduces the risk of a prostate cancer diagnosis."
– Bruce J. Roth, MD
Member, 2013 Genitourinary Cancers Symposium News Planning Team
American Society of Clinical Oncology (ASCO)
Abstract #32: Validation of the biopsy-based genomic prostate score (GPS) as a predictor of high-grade or extracapsular prostate cancer to improve patient selection for active surveillance (AS).
General Poster Session A
Thursday, February 14, 2013, 11:45 AM – 01:15 PM EST
Thursday, February 14, 2013, 05:05 PM – 06:35 PM EST
Rosen, Gatlin Ballroom B
Matthew R. Cooperberg, MD, MPH
University of California, San Francisco
San Francisco, CA
"PSA based screening for prostate cancer has resulted in the increased diagnosis of many cases of clinically insignificant prostate cancer that will never harm a man in his lifetime. This has popularized the concept of active surveillance where patients are monitored rather than definitively treated for their localized prostate cancer. The development of this genomic prostate score (GPS) provides a unique new tool with more information than is currently routinely available to allow physicians and their patients to choose the prostate cancer active surveillance approach with confidence."
– Leonard G. Gomella, MD, FACS
Member, 2013 Genitourinary Cancers Symposium News Planning Team
Society of Urologic Oncology (SUO)
Abstract #28: The effect of therapeutic anticoagulation on overall survival (OS) in men receiving docetaxel chemotherapy for metastatic castration-resistant prostate cancer (mCRPC).
General Poster Session A
Thursday, February 14, 2013, 11:45 AM – 01:15 PM EST
Thursday, February 14, 2013, 05:05 PM – 06:35 PM EST
Rosen, Gatlin Ballroom B
Caroline F. Pratz, CRNP
Johns Hopkins Sidney Kimmel - Comprehensive Cancer Center
Baltimore, MD
Saturday, February 16 Presentations
Abstract #357: Prolonged survival with personalized immunotherapy (AGS-003) in combination with sunitinib in unfavorable risk metastatic RCC (mRCC)
General Poster Session C
Saturday, February 16, 2013, 06:45 AM – 07:55 AM EST
Saturday, February 16, 2013, 11:50 AM – 01:05 PM EST
Rosen, Gatlin Ballroom B
Asim Amin, MD, PhD
Carolinas Medical Center
Blumental Cancer Center
Charlotte, NC
"Advanced metastatic kidney cancer carries a poor prognosis with newer oral medications and immunotherapy each showing some modest improvements in survival. This study uses a patient's own specific cancer fighting immune cells (AGS-003) in combination with a standard oral medication, sunitinib, known as a targeted therapy that blocks kidney cancer's specific pathways that contribute to cancer growth and survival. This novel combination therapy using patient specific immunotherapy combined with an oral agent showed significant benefits with a doubling of survival in patients with aggressive metastatic kidney cancer. This is very encouraging and will need to be confirmed in a larger number of patients."
– Leonard G. Gomella, MD, FACS
Member, 2013 Genitourinary Cancers Symposium News Planning Team
Society of Urologic Oncology (SUO)
2013 Genitourinary Cancers Symposium News Planning Team
Bruce J. Roth, MD, American Society of Clinical Oncology (ASCO); Mark K. Buyyounouski, MD, American Society for Radiation Oncology (ASTRO); Leonard G. Gomella, MD, FACS, Society of Urologic Oncology (SUO).
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