PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

New study on UTIs suggests flagellin is key in stimulating body's natural defenses

2013-03-15
(Press-News.org) Arnhem, 11 March 2013 - A new study by British scientists reveals that motile Escherichia coli isolates demonstrated significant activation of NF-κB signaling suggesting that flagellin plays a key role in up-regulating the host innate defences against urinary tract infections (UTIs).

UTIs are commonly caused by Escherichia coli. The host innate defences function to protect the uro-epithelium from microbial assault via a variety of mechanisms. These include NF-κB signalling pathways activated via cell-surface Toll-like-receptors responding to bacterial pathogen associated molecular patterns (PAMPs). Flagellin, a protein responsible for bacterial motility, is a key activating PAMP.

The study, conducted by a multidisciplinary team of researchers at Newcastle University in the UK, investigated the motility of 24 clinical isolates associated with UTIs and their ability to activate NF-kB. The scientists aimed to examine the relationship between flagellin expression and host response.

"Research into the causes and treatment of urinary tract infection (UTI) is vital at this time as the incidence of UTI and bacteriuria are increasing with an aging population," commented Mr. Ased Ali of Newcastle University's Institute of Cellular Medicine and the study's presenting author.

"There is rapidly growing resistance exhibited by organisms, especially E. coli, to conventional antimicrobials which makes infections potentially more and more difficult to treat," he explained. "This is confounded by the fact that there have been no new classes of antibiotics to treat Gram-negative bacilli like E. coli for more than 40 years. It is amazing that the fluoroquinolones were the last new class of antibiotics to treat Gram-negative bacilli! Our ultimate aim is to develop agents that enhance the immune response and help the body defend itself better as an alternative to conventional antibiotics which work against the pathogen alone."

### END


ELSE PRESS RELEASES FROM THIS DATE:

Japanese P2 study shows potential of combined vaccine and steroid drug in castration-resistant PCa

2013-03-15
Arnhem, 11 March 2013- Multi-peptide vaccination therapy combined with the low-dose steroid drug dexamethasone shows promise in treating chemotherapy-naive castration resistant prostate cancer (CRPC) patients. The study, which won the third prize for best abstract in oncology at the 28th European Association of Urology Congress held in Milan, Italy from 15 to 19 March, showed the promising benefit of this combination therapy in patients who are chemotherapy-naive or those not yet exposed to specific antigens. "Results of our randomized prospective study suggest that ...

MS patients did not benefit from CCSVI intervention

2013-03-15
BUFFALO, N.Y. – The first controlled clinical trial to test the safety and efficacy of interventional endovascular therapy on the symptoms and progression of multiple sclerosis has found that the intervention, sometimes called the "liberation treatment," which has attracted intense interest in the global MS community, does not improve patient outcomes. In a few cases, the treatment made symptoms worse. University at Buffalo researchers will present their results in an "Emerging Science" poster session March 20 at the annual American Academy of Neurology meeting in San ...

Inspired by deep sea sponges: Creating flexible minerals

2013-03-15
Scientists at Johannes Gutenberg University Mainz (JGU) and the Max Planck Institute for Polymer Research (MPI-P) in Germany have created a new synthetic hybrid material with a mineral content of almost 90 percent, yet extremely flexible. They imitated the structural elements found in most sea sponges and recreated the sponge spicules using the natural mineral calcium carbonate and a protein of the sponge. Natural minerals are usually very hard and prickly, as fragile as porcelain. Amazingly, the synthetic spicules are superior to their natural counterparts in terms of ...

Improved detection of frontotemporal degeneration may aid clinical trial efforts

2013-03-15
SAN DIEGO - A series of studies demonstrate improved detection of the second most common form of dementia, providing diagnostic specificity that clears the way for refined clinical trials testing targeted treatments. The new research is being presented by experts from the Perelman School of Medicine at the University of Pennsylvania at the American Academy of Neurology's 65th Annual Meeting in San Diego March 16-23, 2013. Frontotemporal degeneration, the most common dementia in people under 60, can be hereditary or sporadic in nature and caused by one of two different ...

Telestroke program increases access to stroke care by 40 percent

2013-03-15
SAN DIEGO - Telestroke programs substantially improve access to life-saving stroke care, extending coverage to less populated areas in an effort to reduce disparities in stroke care access. A new study by researchers from the Perelman School of Medicine at the University of Pennsylvania, being presented at the American Academy of Neurology's 65th Annual Meeting in San Diego March 16-23, 2013, found that telemedicine programs in Oregon pushed stroke coverage into previously uncovered, less populated areas and expanded coverage by approximately 40 percent. "Telestroke ...

Discovery could yield treatment for cocaine addicts

2013-03-15
EAST LANSING, Mich. --- Scientists have discovered a molecular process in the brain triggered by cocaine use that could provide a target for treatments to prevent or reverse addiction to the drug. Reporting in the Journal of Neuroscience, Michigan State University neuroscientist A.J. Robison and colleagues say cocaine alters the nucleus accumbens, the brain's pleasure center that responds to stimuli such as food, sex and drugs. "Understanding what happens molecularly to this brain region during long-term exposure to drugs might give us insight into how addiction occurs," ...

'Dirty blizzard' in Gulf may account for missing Deepwater Horizon oil

2013-03-15
TALLAHASSEE, Fla. — Oil from the 2010 Deepwater Horizon spill acted as a catalyst for plankton and other surface materials to clump together and fall to the sea floor in a massive sedimentation event that researchers are calling a "dirty blizzard." Jeff Chanton, the John Widmer Winchester Professor of Oceanography in the Department of Earth, Ocean and Atmospheric Science at Florida State University, is one of the members of the Deep-C Consortium who presented the dirty blizzard hypothesis at a recent conference in New Orleans that focused on the effects of the oil spill ...

Tau transmission model opens doors for new Alzheimer's, Parkinson's therapies

2013-03-15
SAN DIEGO – Injecting synthetic tau fibrils into animal models induces Alzheimer's-like tau tangles and imitates the spread of tau pathology, according to research from the Perelman School of Medicine at the University of Pennsylvania being presented at the American Academy of Neurology's 65th Annual Meeting in San Diego March 16-23, 2013. This Alzheimer's research, along with additional Parkinson's research from Penn and beyond, further demonstrates the cell-to-cell transmission of neurodegenerative proteins. John Q. Trojanowski, MD, PhD, co-director of the Center for ...

Kessler Foundation researchers share findings in rehabilitation research at AAN meeting in San Diego

2013-03-15
West Orange, NJ. March 15, 2013. Kessler Foundation scientists and their colleagues will discuss their progress in rehabilitation research at the upcoming 65th Annual American Academy of Neurology Conference at the San Diego Convention Center in San Diego, CA, March 16 – 23. A.M. Barrett, MD, director of Stroke Rehabilitation at Kessler Foundation will present on Pharmacologic Enhancement of Stroke Rehabilitation on Friday March 22, 2013 as part of a Specialty in Focus session on Neurorehabilitation Enhancement Techniques. This session addresses the contribution of brain ...

Study offers new insights on invasive fly threatening US fruit crops

Study offers new insights on invasive fly threatening US fruit crops
2013-03-15
Humans aren't the only species with a sweet tooth. Research from North Carolina State University shows that the invasive spotted-wing vinegar fly (Drosophila suzukii) also prefers sweet, soft fruit – giving us new insight into a species that has spread across the United States over the past four years and threatens to cause hundreds of millions of dollars in damage to U.S. fruit crops. "Because we know that D. suzukii prefers softer, sweeter fruit, we can focus our research efforts into which wild fruits may serve as reservoirs for this species and help identify new crops ...

LAST 30 PRESS RELEASES:

Thirty-year mystery of dissonance in the “ringing” of black holes explained

Less intensive works best for agricultural soil

Arctic rivers project receives “national champion” designation from frontiers foundation

Computational biology paves the way for new ALS tests

Study offers new hope for babies born with opioid withdrawal syndrome

UT, Volkswagen Group of America celebrate research partnership

New Medicare program could dramatically improve affordability for cancer drugs – if patients enroll

Are ‘zombie’ skin cells harmful or helpful? The answer may be in their shapes

University of Cincinnati Cancer Center presents research at AACR 2025

Head and neck, breast, lung and survivorship studies headline Dana-Farber research at AACR Annual Meeting 2025

AACR: Researchers share promising results from MD Anderson clinical trials

New research explains why our waistlines expand in middle age

Advancements in muon detection: Taishan Antineutrino Observatory's innovative top veto tracker

Chips off the old block

Microvascular decompression combined with nerve combing for atypical trigeminal neuralgia

Cutting the complexity from digital carpentry

Lung immune cell type “quietly” controls inflammation in COVID-19

Fiscal impact of expanded Medicare coverage for GLP-1 receptor agonists to treat obesity

State and sociodemographic trends in US cigarette smoking with future projections

Young adults drive historic decline in smoking

NFCR congratulates Dr. Robert C. Bast, Jr. on receiving the AACR-Daniel D. Von Hoff Award for Outstanding Contributions to Education and Training in Cancer Research

Chimpanzee stem cells offer new insights into early embryonic development

This injected protein-like polymer helps tissues heal after a heart attack

FlexTech inaugural issue launches, pioneering interdisciplinary innovation in flexible technology

In Down syndrome mice, 40Hz light and sound improve cognition, neurogenesis, connectivity

Methyl eugenol: potential to inhibit oxidative stress, address related diseases, and its toxicological effects

A vascularized multilayer chip reveals shear stress-induced angiogenesis in diverse fluid conditions

AI helps unravel a cause of Alzheimer's disease and identify a therapeutic candidate

Coalition of Autism Scientists critiques US Department of Health and Human Services Autism Research Initiative

Structure dictates effectiveness, safety in nanomedicine

[Press-News.org] New study on UTIs suggests flagellin is key in stimulating body's natural defenses