MRI-guided focused ultrasound combined with microbubbles can open the blood-brain barrier (BBB) and allow therapeutic drugs to reach the diseased brain location under the guidance of MRI. It is a promising technique that has been shown safe in patients with various brain diseases, such as Alzheimer's diseases, Parkinson's disease, ALS, and glioblastoma. While MRI has been commonly used for treatment guidance and assessment in preclinical research and clinical studies, until now, researchers did not know the impact of the static magnetic field generated by the MRI scanner on the BBB opening size and ...

Children with a devastating genetic disorder characterized by severe motor disability and developmental delay have experienced sometimes dramatic improvements in a gene therapy trial launched at UCSF Benioff Children's Hospitals. The trial includes seven children aged 4 to 9 born with deficiency of AADC, an enzyme involved in the synthesis of neurotransmitters, particularly dopamine, that leaves them unable to speak, feed themselves or hold up their head. Six of the children were treated at UCSF and one at Ohio State Wexner Medical Center. Children in the study experienced improved motor function, better mood, and longer sleep, and were able to interact more fully with their ...

Historically, shared resources such as forests, fishery stocks, and pasture lands have often been managed with an aim toward averting "tragedies of the commons," which are thought to result from selfish overuse. Writing in BioScience, Drs. Senay Yitbarek (University of North Carolina at Chapel Hill), Karen Bailey (University of Colorado Boulder), Nyeema Harris (Yale University), and colleagues critique this model, arguing that, all too often, such conservation has failed to acknowledge the complex socioecological interactions that undergird the health of resource ...

Learning changes the brain, but when learning Braille different brain regions strengthen their connections at varied rates and time frames. A new study published in JNeurosci highlights the dynamic nature of learning-induced brain plasticity. Learning new skills alters the brain's white matter, the nerve fibers connecting brain regions. When people learn to read tactile Braille, their somatosensory and visual cortices reorganize to accommodate the new demands. Prior studies only examined white matter before and after training, so the exact time course of the changes was not known. Molendowska and Matuszewski et al. used diffusion MRI to measure changes in the white matter strength of sighted adults as they learned Braille over the course of eight months. They took measurements ...

Imagine sitting out in the sun, reading a digital screen as thin as paper, but seeing the same image quality as if you were indoors. Thanks to research from Chalmers University of Technology, Sweden, it could soon be a reality. A new type of reflective screen - sometimes described as 'electronic paper' - offers optimal colour display, while using ambient light to keep energy consumption to a minimum. Traditional digital screens use a backlight to illuminate the text or images displayed upon them. This is fine indoors, but we've all experienced the difficulties of viewing such screens in bright sunshine. Reflective screens, however, attempt to use the ambient light, mimicking the way our eyes respond to natural paper. "For reflective screens to compete with the energy-intensive ...

Smoking among young teens has become an increasingly challenging and costly public healthcare issue. Despite legislation to prevent the marketing of tobacco products to children, tobacco companies have shrewdly adapted their advertising tactics to circumvent the ban and maintain their access to this impressionable--and growing--market share. How they do it is the subject of a recent study led by Dr. Yael Bar-Zeev at Hebrew University of Jerusalem (HU)'s Braun School of Public Health and Community Medicine at HU-Hadassah Medical Center. She also serves as Chair of the Israeli Association for Smoking Cessation and Prevention, and teamed up with colleagues at HU and George Washington University. They published their findings in Nicotine and Tobacco Research. Their study ...

July 12, 2021 - Transitions between healthcare sites - such as from the hospital to home or to a skilled nursing facility - carry known risks to patient safety. Many programs have attempted to improve continuity of care during transitions, but it remains difficult to establish and compare the benefits of these complex interventions. An update on patient-centered approaches to transitional care research and implementation is presented in a supplement to the August issue of Medical Care, sponsored by the Patient-Centered Outcomes Research Institute (PCORI). Medical Care is published in the Lippincott portfolio by Wolters ...

North Carolina State University researchers have developed a new technique that can alter plant metabolism. Tested in tobacco plants, the technique showed that it could reduce harmful chemical compounds, including some that are carcinogenic. The findings could be used to improve the health benefits of crops. "A number of techniques can be used to successfully reduce specific chemical compounds, or alkaloids, in plants such as tobacco, but research has shown that some of these techniques can increase other harmful chemical compounds while reducing the target compound," said De-Yu Xie, professor of plant and microbial biology at NC State and the corresponding author of a paper describing the research. "Our technology ...

Snowmelt - the surface runoff from melting snow - is an essential water resource for communities and ecosystems. But extreme snow melt, which occurs when snow melts too rapidly over a short amount of time, can be destructive and deadly, causing floods, landslides and dam failures. To better understand the processes that drive such rapid melting, researchers set out to map extreme snowmelt events over the last 30 years. Their findings are published in a new paper in the Bulletin of the American Meteorological Society. "When we talk about snowmelt, people want to know the basic numbers, just like the weather, but no one has ever provided anything like that before. It's like if nobody told you the maximum and minimum temperature or record temperature in your city," said study co-author ...

The transportation sector is the largest contributor to greenhouse gas emissions in the United States, and a lot of attention has been devoted to electric passenger vehicles and their potential to help reduce those emissions. But with the rise of online shopping and just-in-time shipping, electric delivery fleets have emerged as another opportunity to reduce the transportation sector's environmental impact. Though EVs represent a small fraction of delivery vehicles today, the number is growing. In 2019, Amazon announced plans to obtain 100,000 electric delivery vehicles. UPS has ordered 10,000 of them and FedEx plans to be fully electric by 2040. Now, a study from University of Michigan ...

New Brunswick, NJ--Children and adolescents with multisystem inflammatory syndrome in children (MIS-C) who are treated initially with intravenous immune globulin (IVIG) and glucocorticoids have reduced risk for serious short-term outcomes, including cardiovascular dysfunction, than those who receive an initial treatment of IVIG alone, a new study finds. MIS-C is a rare but serious--and sometimes fatal--condition associated with COVID-19, in which different body organs or systems become inflamed, including the heart, lungs, kidneys, brain, skin, eyes, or gastrointestinal system. It can occur weeks after having COVID-19 and even if the child or caregivers did not know the child had been infected. The new study, published in the New England Journal of Medicine, analyzed treatment ...

Taken together, the bacteria, viruses, fungi and other microbes that live in our intestines form the gut microbiome, which plays a key role in the health of people and animals. In new research from the University of Minnesota, University of Notre Dame and Duke University, scientists found that genetics nearly always plays a role in the composition of the gut microbiome of wild baboons. "In humans, research has shown that family members share a significant portion of microbes in their gut, but it's hard to answer if our microbiome is shaped more by nature, such as those ...

A team led by researchers at Baylor College of Medicine found that a screening method known as untargeted metabolomics profiling can improve the diagnostic rate for inborn errors of metabolism, a group of rare genetic conditions, by about seven-fold when compared to the traditional metabolic screening approach. The study, published in JAMA Network Open, shows that untargeted metabolomics identifies many more disorders of greater variety as compared to traditional methods, including disorders for which there was not a clinically available biochemical test. The researchers hope that adoption of metabolomics to screen for inborn errors of metabolism will result in a more rapid, more efficient ...

The sharp eyes of an eagle, the extraordinary hearing of an owl - to successfully find food, the eyes and ears of birds have adapted optimally to their living conditions. Until now, the sense of smell has played a rather subordinate role. When meadows are freshly mowed, storks often appear there to search for snails and frogs. Researchers at the Max Planck Institute for Animal Behavior in Radolfzell and the Max Planck Institute for Chemistry in Mainz have now studied the birds' behavior and discovered that the storks are attracted by the smell of the mown grass. Only storks that were downwind and could thus perceive the smell reacted to the mowing. The scientists also sprayed a meadow with a spray of green leaf scents released during mowing. Storks appeared here as well. This ...

Recall a phone number or directions just recited and your brain will be actively communicating across many regions. It is thought that working memory relies on interactions between these regions, but how these brain areas interact and properly represent memory has remained a mystery. At Baylor College of Medicine, Dr. Nuo Li, assistant professor of neuroscience and a McNair Scholar, and his colleagues investigated the nature of the communication between brain regions involved in working memory and found evidence that a modular network organization is critical for ...

The function of a protein can depend on its abundance in a cell. So, when investigating the properties of a new protein, it is essential to make sure that the same amount is produced by every cell. Researchers at Baylor College of Medicine and Rice University have found a new way to do just that through the creation of new genetic circuits called Equalizers. The findings, in the current edition of Nature Communications, show how researchers engineered these genetic circuits to buffer protein output from variations in the number of copies of the gene inside the cell, thereby helping to create consistent protein expression. This property is called "gene dosage compensation." The researchers use an analogy of heating ...

 Pure quantum systems can undergo phase transitions analogous to the classical phase transition between the liquid and gaseous states of water. At the quantum level, however, the particle spins in states that emerge from phase transitions display collective entangled behavior. This unexpected observation offers a new avenue for the production of materials with topological properties that are useful in spintronics applications and quantum computing.  The discovery was made by an international collaboration led by Julio Larrea, a professor at the University of São ...

DURHAM, N.C. -- You know your dog gets your gist when you point and say "go find the ball" and he scampers right to it. This knack for understanding human gestures may seem unremarkable, but it's a complex cognitive ability that is rare in the animal kingdom. Our closest relatives, the chimpanzees, can't do it. And the dogs' closest relative, the wolf, can't either, according to a new Duke University-led study published July 12 in the journal Current Biology. More than 14,000 years of hanging out with us has done a curious thing to the minds of dogs. They have what are known as "theory of mind" abilities, or mental skills allowing them to infer what humans are thinking and feeling in some situations. The study, a comparison of 44 ...

Astronomers have made the rare sighting of two stars spiralling to their doom by spotting the tell-tale signs of a teardrop-shaped star. The tragic shape is caused by a massive nearby white dwarf distorting the star with its intense gravity, which will also be the catalyst for an eventual supernova that will consume both. Found by an international team of astronomers and astrophysicists led by the University of Warwick, it is one of only very small number of star systems that has been discovered that will one day see a white dwarf star reignite its core. New research published by the team today (12 July) in Nature Astronomy confirms that the two stars are ...

Researchers from the Buck Institute and Stanford University have created an inflammatory clock of aging (iAge) which measures inflammatory load and predicts multi-morbidity, frailty, immune health, cardiovascular aging and is also associated with exceptional longevity in centenarians. Utilizing deep learning, a form of AI, in studies of the blood immunome of 1001 people, researchers also identified a modifiable chemokine associated with cardiac aging which can be used for early detection of age-related pathology and provides a target for interventions. Results are published in Nature Aging. "Standard immune metrics which can be used to identify individuals most at risk for developing single or even multiple chronic diseases ...

According to the study, Australia, Indonesia and the USA provide the largest carbon storage potential with their coastal ecosystems. The team also calculated which countries benefit most from the coastal CO2 uptake worldwide. The different ways in which countries are affected by climate change are quantified by using the so-called social costs of carbon. "If we take into account the differences in marginal climate damages that occur in each country, we find that Australia and Indonesia are clearly the largest donors in terms of globally avoided climate damages originating from coastal CO2 uptake, as they themselves derive comparatively little benefit ...

Many exoplanets have opaque atmospheres, obscured by clouds or hazes that make it hard for astronomers to characterize their chemical compositions. A new study shows that haze particles produced under different conditions have a wide range of properties that can determine how clear or hazy a planet's atmosphere is likely to be. Photochemical reactions in the atmospheres of temperate exoplanets lead to the formation of small organic haze particles. Large amounts of these photochemical hazes form in Earth's atmosphere every day, yet our planet has relatively clear skies. The reason has to do with how ...

A diet rich in fermented foods enhances the diversity of gut microbes and decreases molecular signs of inflammation, according to researchers at the Stanford School of Medicine. In a clinical trial, 36 healthy adults were randomly assigned to a 10-week diet that included either fermented or high-fiber foods. The two diets resulted in different effects on the gut microbiome and the immune system. Eating foods such as yogurt, kefir, fermented cottage cheese, kimchi and other fermented vegetables, vegetable brine drinks, and kombucha tea led to an increase in overall microbial diversity, with stronger effects from larger servings. ...

You're as old as your immune system. Investigators at the Stanford University School of Medicine and the Buck Institute for Research on Aging have built an inflammatory-aging clock that's more accurate than the number of candles on your birthday cake in predicting how strong your immune system is, how soon you'll become frail or whether you have unseen cardiovascular problems that could become clinical headaches a few years down the road. In the process, the scientists fingered a bloodborne substance whose abundance may accelerate cardiovascular aging. The story of the clock's creation will be published July 12 in Nature Aging. "Every year, the calendar tells us we're a year older," said David ...

The cave of Satsurblia was inhabited by humans in different periods of the Paleolithic: Up to date a single human individual dated from 15,000 years ago has been sequenced from that site. No other human remains have been discovered in the older layers of the cave. The innovative approach used by the international team led by Prof. Ron Pinhasi and Pere Gelabert with Susanna Sawyer of the University of Vienna in collaboration with Pontus Skoglund and Anders Bergström of the Francis Crick Institute in London permits the identification of DNA in samples of environmental ...