It is widely accepted that heart muscle cells in mammals stop replicating shortly after birth, limiting the ability of the heart to repair itself after injury. A study published by Cell Press May 8th in the journal Cell now shows that heart muscle cells in mice undergo a brief proliferative burst prior to adolescence, increasing in number by about 40% to allow the heart to meet the increased circulatory needs of the body during a period of rapid growth. The findings suggest that thyroid hormone therapy could stimulate this process and enhance the heart's ability to regenerate ...

Polar bears adapted to life in cold Arctic climates in part by relying on a high-fat diet mainly consisting of seals and their blubber. In a study published by Cell Press May 8th in the journal Cell, researchers discovered that mutations in genes involved in cardiovascular function allowed polar bears to rapidly evolve the ability to consume a fatty diet without developing high rates of heart disease. Moreover, the study revealed that polar bears diverged from brown bears less than 500,000 years ago—much more recently than estimates based on previous genomic data. "In ...

Determining species diversity makes it possible to estimate the impact of human activity on marine ecosystems accurately. The environmental effects of salmon farming have been assessed, until now, by visually identifying the animals living in the marine sediment samples collected at specific distances from farming sites. A team led by Jan Pawlowski, professor at the Faculty of Science of the University of Geneva (UNIGE), Switzerland, analysed this type of sediment using a technique known as "DNA barcoding" that targets certain micro-organisms. Their research, which has ...

A comparison of the genomes of polar bears and brown bears reveals that the polar bear is a much younger species than previously believed, having diverged from brown bears less than 500,000 years ago. The analysis also uncovered several genes that may be involved in the polar bears' extreme adaptations to life in the high Arctic. The species lives much of its life on sea ice, where it subsists on a blubber-rich diet of primarily marine mammals. The genes pinpointed by the study are related to fatty acid metabolism and cardiovascular function, and may explain the bear's ...

A scientific team led by the Gladstone Institutes and UC San Francisco has discovered that a common form of a gene already associated with long life also improves learning and memory, a finding that could have implications for treating age-related diseases like Alzheimer's. The researchers found that people who carry a single copy of the KL-VS variant of the KLOTHO gene perform better on a wide variety of cognitive tests. When the researchers modeled the effects in mice, they found it strengthened the connections between neurons that make learning possible – what is known ...

PHILADELPHIA - Ancient philosophers looked to alchemy for clues to life everlasting. Today, researchers look to their yeast. These single-celled microbes have long served as model systems for the puzzle that is the aging process, and in this week's issue of Cell Metabolism, they fill in yet another piece. The study, led by researchers at the University of Pennsylvania, identifies a new molecular circuit that controls longevity in yeast and more complex organisms and suggests a therapeutic intervention that could mimic the lifespan-enhancing effect of caloric restriction, ...

A newly identified difference between the brains of women and men with multiple sclerosis (MS) may help explain why so many more women than men get the disease, researchers at Washington University School of Medicine in St. Louis report. In recent years, the diagnosis of MS has increased more rapidly among women, who get the disorder nearly four times more than men. The reasons are unclear, but the new study is the first to associate a sex difference in the brain with MS. The findings appear May 8 in The Journal of Clinical Investigation. Studying mice and people, ...

ANN ARBOR, Mich. — A subset of immune cells directly target colon cancers, rather than the immune system, giving the cells the aggressive properties of cancer stem cells. So finds a new study that is an international collaboration among researchers from the United States, China and Poland. "If you want to control cancer stem cells through new therapies, then you need to understand what controls the cancer stem cells," says senior study author Weiping Zou, M.D., Ph.D., Charles B. de Nancrede Professor of surgery, immunology and biology at the University of Michigan Medical ...

What is the secret to aging more slowly and living longer? Not antioxidants, apparently. Many people believe that free radicals, the sometimes-toxic molecules produced by our bodies as we process oxygen, are the culprit behind aging. Yet a number of studies in recent years have produced evidence that the opposite may be true. Now, researchers at McGill University have taken this finding a step further by showing how free radicals promote longevity in an experimental model organism, the roundworm C. elegans. Surprisingly, the team discovered that free radicals – also ...

May 8, 2014, Shenzhen, China – In a paper published in the May 8 issue of the journal Cell as the cover story, researches from BGI, University of California, University of Copenhagen and other institutes presented the first polar bear genome and their new findings about how polar bear successfully adapted to life in the high Arctic environment, and its demographic history throughout the history of its adaptation. Polar bears are at the top of the food chain, and spend most of their lifetimes on the sea ice largely within the Arctic Circle. They were well known to the ...

Hinxton, 8 May 2014 – Researchers at the European Bioinformatics Institute (EMBL-EBI) and the Wellcome Trust Sanger Institute have discovered that some immune cells turn themselves off by producing a steroid. The findings, published in Cell Reports, have implications for the study of cancers, autoimmune diseases and parasitic infections. If you've ever used a steroid, for example cortisone cream on eczema, you'll have seen first-hand how efficient steroids are at suppressing the immune response. Normally, when your body senses that immune cells have finished their job, ...

May 8, 2014 - If you are sending Mother's Day flowers to your mom this weekend, chances are you opted for guaranteed delivery: the promise that they will arrive by a certain time. Should the flowers not arrive in time, you will likely feel betrayed by the sender for breaking their promise. But if they arrive earlier, you likely will be no happier than if they arrive on time, according to new research. The new work suggests that we place such a high premium on keeping a promise that exceeding it confers little or no additional benefit. Whether we make them with a person ...

ROSEMENT, Ill.─As participation in high-demand sports such as basketball and soccer has increased over the past decade, so has the number of anterior cruciate ligament (ACL) injuries in teens and young adults. In a study appearing today in the Journal of Bone and Joint Surgery (JBJS) (a research summary was presented at the 2014 Annual Meeting of the American Academy of Orthopaedic Surgeons in March), researchers found that universal neuromuscular training for high school and college-age athletes—which focuses on the optimal way to bend, jump, land and pivot the knee—is ...

WASHINGTON - Primary care teams that include both psychologists and physicians would help address known barriers to improved primary health care, including missed diagnoses, a lack of attention to behavioral factors and limited patient access to needed care, according to health care experts writing in a special issue of American Psychologist, the flagship journal of the American Psychological Association. "At the heart of the new primary care team is a partnership between a primary care clinician and a psychologist or other mental health professional. The team works together ...

DURHAM, N.C. -- Ice cream lovers and hot tea drinkers with sensitive teeth could one day have a reason to celebrate a new finding from Duke University researchers. The scientists have found a very small change in a single protein that turns a cold-sensitive receptor into one that senses heat. Understanding sensation and pain at this level could lead to more specific pain relievers that wouldn't affect the central nervous system, likely producing less severe side effects than existing medications, said Jörg Grandl, Ph.D., an assistant professor of neurobiology in Duke's ...

AURORA, Colo. (May 8, 2014) - Results from a study by University of Colorado School of Medicine researchers show that pravastatin, a medicine widely used for treatment of high cholesterol, also slows down the growth of kidney cysts in children and young adults with autosomal dominant polycystic kidney disease (ADPKD). ADPKD is the most common potentially lethal hereditary kidney disease, affecting at least 1 in 1000 people. ADPKD is characterized by progressive kidney enlargement due to cyst growth, which results in loss of kidney function over time. At one time, ADPKD ...

Some Ecuadorian tribes were famous for making mummified shrunken heads from the remains of their conquered foes. Field work in the cloud forests of Ecuador by Professor Scott Shaw, University of Wyoming, Laramie, and colleagues, has resulted in the discovery of 24 new species of Aleiodes wasps that mummify caterpillars. The research by Eduardo Shimbori, Universidade Federal de São Carlos, Brazil, and Scott Shaw, was recently published in the open access journal ZooKeys. Among the 24 new insect species described by Shimbori and Shaw, several were named after famous people ...

The tropical low pressure area known as System 91B has been making a slow northerly crawl while sitting inland in southwestern India, and NASA's Terra satellite captured a visible image of the struggling storm that showed half of it is over the Northern Indian Ocean. NASA's Terra satellite passed over System 91B over southwestern India and the Moderate Resolution Imaging Spectroradiometer (MODIS) instrument captured a visible image on May 8 at 05:40 UTC/1:40 a.m. EDT. The despite having a poorly defined low-level circulation center on infrared imagery, the circulation ...

Tumors shrank or disappeared and disease progression was temporarily halted in 15 children with advanced neuroblastoma enrolled in a safety study of an experimental antibody produced at St. Jude Children's Research Hospital. Four patients are still alive after more than two-and-a-half years and without additional treatment. Findings from the Phase I study were published recently online and will appear in the May 10 edition of the Journal of Clinical Oncology. The results prompted St. Jude to expand clinical trials of the monoclonal antibody hu14.18K322A to include patients ...

WINSTON-SALEM, N.C. – May 8, 2014 – An old idea of retreating lung tumors with radiation is new again, especially with the technological advances seen in radiation oncology over the last decade. The Comprehensive Cancer Center of Wake Forest Baptist Medical Center is one of only a handful of cancer centers that is attempting to give lung cancer patients out of treatment options a chance to keep the cancer at bay. For these patients, hope lies in a second course of treatment – repeat radiation. Two complementary papers published back-to-back recently in the journal Radiotherapy ...

New Rochelle, NY, May 8, 2014—When Massachusetts enacted its own statewide health insurance reform in 2006, low-income women transitioned from receiving free, federally subsidized screening for breast and cervical cancer and cardiovascular disease risk to an insurance-based payment system. The effects on screening rates in this vulnerable population are explored in Journal of Women's Health, a peer-reviewed publication from Mary Ann Liebert, Inc., publishers. The article is available free on the Journal of Women's Health website at http://online.liebertpub.com/doi/full/10.1089/jwh.2013.4612. A ...

Microscopes don't exactly lie, but their limitations affect the truths they can tell. For example, scanning electron microscopes (SEMs) simply can't see materials that don't conduct electricity very well, and their high energies can actually damage some types of samples. In an effort to extract a little more truth from the world of nanomaterials and nanostructures, researchers at the National Institute of Standards and Technology (NIST) have built the first low-energy focused ion beam (FIB) microscope that uses a lithium ion source.* The team's new approach opens up ...

EUGENE, Ore. -- When tracking a moving object, the two halves of the human brain operate much like runners successfully passing a baton during a relay race, says a University of Oregon researcher. In a study online ahead of print in Current Biology, electroencephalogram (EEG) measured brainwaves from healthy young adults revealed how information about an attended object -- one being watched closely -- moves from one brain hemisphere to the other. Such handoffs are necessary because the human visual system is contralateral; objects on the left side of space are processed ...

A newly discovered grasshopper by University of Central Florida scientists now bears the name of Grammy-award winning singer and activist Ana Lila Downs Sanchez. The scientists named the new species discovered on the side of a mountain road near Oaxaca, Mexico, after the Mexican-American singer as a nod to her efforts to preserve indigenous culture and penchant for wearing colorful, local costumes as part of her performances. "It was primarily Paolo's idea to name the grasshopper after the singer" said Derek Woller, one of the authors of the paper referring to colleague ...

A new study, published today in the Journal of Health Psychology, found that patients who gained weight 18 months after taking Orlistat attributed their weight-loss failure either to the side effects which have prevented them from sticking to the medication or felt that the medication simply had not worked. The team from the University of Surrey also found that participants described a series of barriers to weight loss including psychological and physical health issues, relationships and the make-up of their bodies. They also described a number of alternative methods ...