Researchers from the University of California, San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences, in collaboration with materials scientists, engineers and neurobiologists, have discovered a new mechanism for using light to activate drug-delivering nanoparticles and other targeted therapeutic substances inside the body. This discovery represents a major innovation, said Adah Almutairi, PhD, associate professor and director of the joint UC San Diego-KACST Center of Excellence in Nanomedicine. Up to now, she said, only a handful of strategies using light-triggered ...

VIDEO: This 3-D simulated flyby of Tropical Cyclone Hellen on March 30, showed some powerful storms in Hellen's eye wall were reaching heights of over 13 km/8 miles. Click here for more information. When Tropical Cyclone Hellen was near the "peak of her career" NASA's TRMM satellite picked up on her popularity in terms of tropical rainfall. Hellen was a very heavy rainmaker in her heyday with heavy rain rates. Hellen weakened to a remnant low pressure area by April 1, but has ...

Researchers report that low levels of sodium, known as hyponatremia, prior to transplantation does not increase the risk of death following liver transplant. Full findings are published in Liver Transplantation, a journal of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. Medical evidence shows that low sodium concentration is common in patients with end stage liver disease (ESLD), with roughly half of those with cirrhosis having sodium levels below the normal range of 135-145 mmol/L. Moreover, previous research ...

URBANA, Ill. – A new University of Illinois study finds that obese children are slower than healthy-weight children to recognize when they have made an error and correct it. The research is the first to show that weight status not only affects how quickly children react to stimuli but also impacts the level of activity that occurs in the cerebral cortex during action monitoring. "I like to explain action monitoring this way: when you're typing, you don't have to be looking at your keyboard or your screen to realize that you've made a keystroke error. That's because action ...

The amount of water present in the moon may have been overestimated by scientists studying the mineral apatite, says a team of researchers led by Jeremy Boyce of the UCLA Department of Earth, Planetary and Space Sciences. Boyce and his colleagues created a computer model to accurately predict how apatite would have crystallized from cooling bodies of lunar magma early in the moon's history. Their simulations revealed that the unusually hydrogen-rich apatite crystals observed in many lunar rock samples may not have formed within a water-rich environment, as was originally ...

MADISON, Wis. – The latest results from a 25-year study of diet and aging in monkeys shows a significant reduction in mortality and in age-associated diseases among those with calorie-restricted diets. The study, begun at the University of Wisconsin-Madison in 1989, is one of two ongoing, long-term U.S. efforts to examine the effects of a reduced-calorie diet on nonhuman primates. The study of 76 rhesus monkeys, reported Monday in Nature Communications, was performed at the Wisconsin National Primate Research Center in Madison. When they were 7 to 14 years of age, the ...

WASHINGTON D.C., April 1, 2014 -- As wind farms grow in importance across the globe as sources of clean, renewable energy, one key consideration in their construction is their physical design -- spacing and orienting individual turbines to maximize their efficiency and minimize any "wake effects," where the swooping blades of one reduces the energy in the wind available for the following turbine. Optimally spacing turbines allows them to capture more wind, produce more power and increase revenue for the farm. Knowing this, designers in the industry typically apply simple ...

Why zebras have black and white stripes is a question that has intrigued scientists and spectators for centuries. A research team led by the University of California, Davis, has now examined this riddle systematically. Their answer is published April 1 in the online journal Nature Communications. The scientists found that biting flies, including horseflies and tsetse flies, are the evolutionary driver for zebra's stripes. Experimental work had previously shown that such flies tend to avoid black-and-white striped surfaces, but many other hypotheses for zebra stripes have ...

Montreal, April 1, 2014 – From the Murdochs to the Hiltons, families have long sought to keep their businesses in the bloodline. But new research from Concordia University's John Molson School of Business shows that's not necessarily the best method of management. The recent study, published in the journal Entrepreneurship Theory and Practice, shows that if the family business is part of a traditional industry built on quality and reputation, a family member would make a good CEO. But if it operates in an industry that values innovation, and the firm has to stay on the ...

It's not a hair-brained idea: A new research report appearing in the April 2014 issue of The FASEB Journal explains why people with a rare balding condition called "atrichia with papular lesions" lose their hair, and it identifies a strategy for reversing this hair loss. Specifically the report shows for the first time that the "human hairless gene" imparts an essential role in hair biology by regulating a subset of other hair genes. This newly discovered molecular function likely explains why mutations in the hairless gene contribute to the pathogenesis of atrichia with ...

This news release is available in French. Many studies have focused on the influence of breast-feeding on child health. From analysis of data from the ELANCE cohort, Marie Françoise Rolland-Cachera, former researcher at Inserm and her co-workers in the Nutritional Epidemiology Research Team (EREN) have shown that breast-feeding has a protective effect on the risk of obesity at 20 years of age. Researchers also emphasise that nutritional intake at the age of 2 years are critical in providing this beneficial effect. The results of the study are published in The Journal ...

Economics has a "law of one price," which states that identical goods should, in theory, sell for identical prices — or else markets will even out the differences. Empirical work on the topic, however, has produced little evidence in support of this "law," and many studies showing deviations from it. Now a newly published paper co-authored by two MIT economists, along with a colleague from the University of Chicago, presents evidence of a strong convergence of prices within the Eurozone, the region of European countries sharing a common currency. The divergence of product ...

New Rochelle, NY, April 1, 2014 -- Rare, very small embryonic-like stem cells (VSELs) isolated from human adult tissues could provide a new source for developing regenerative therapies to repair complex tissues damaged by disease or trauma. The ability of these most-primitive, multipotent stem cells to differentiate into bone, neurons, connective tissue, and other cell types, and the proper criteria for identifying and isolating VSELs, are described in two articles in Stem Cells and Development, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The articles ...

In a report published in the April edition of the Journal of Spinal Disorders and Techniques, a Johns Hopkins team says that only 10 percent of orthopaedic surgeons and neurosurgeons follow professional guidelines recommending routine psychological screenings of patients prior to major surgery for severe back and leg pain. The oversight, researchers say, may pose a serious risk to patients' surgical recovery. Previous reports have tied bouts of depression to longer recuperations, delayed returns to work, more postsurgical complications and failures to comply with medication ...

Philadelphia, PA--A computer model is a representation of the functional relationship between one set of parameters, which forms the model input, and a corresponding set of target parameters, which forms the model output. A true model for a particular problem can rarely be defined with certainty. The most we can do to mitigate error is to quantify the uncertainty in the model. In a recent paper published in the SIAM/ASA Journal on Uncertainty Quantification, authors Mark Strong and Jeremy Oakley offer a method to incorporate judgments into a model about structural uncertainty ...

ARLINGTON HEIGHTS, Ill. (April 1, 2014) – Stress doesn't cause allergies, but easing your mind might mean less allergy flare-ups this spring. According to a study published in the April issue of Annals of Allergy, Asthma & Immunology, the scientific journal of the American College of Allergy, Asthma and Immunology, allergy sufferers with persistent stress experience more allergy flares. "Stress can cause several negative effects on the body, including causing more symptoms for allergy sufferers," said allergist Amber Patterson, MD, lead study author and ACAAI member. ...

As the Earth's human population marches toward 9 billion, the need for hardy new varieties of grain crops has never been greater. It won't be enough to yield record harvests under perfect conditions. In an era of climate change, pollution and the global spread of pathogens, these new grains must also be able to handle stress. Now, researchers at Michigan Technological University have identified a set of genes that could be key to the development of the next generation of super rice. A meta-data analysis by biologist Ramakrishna Wusirika and PhD student Rafi Shaik has ...

In particular, the protein that activated hair follicle growth was shown to also inhibit fat production. The world first research confirmed that changes in the hair growth cycle led to fluctuations in the thickness of the underlying fat layer of the skin – essentially meaning that the skin can regulate fat production. The research was led by Professor Fiona Watt at King's College London in collaboration with Professor of Dermatology Rodney Sinclair from the University of Melbourne and Epworth Hospital. Professor Sinclair said these findings could potentially be ...

There are differences in prognosis in cutaneous malignant melanoma depending on cohabitation status and gender, according to a new study published in the scientific periodical Journal of Clinical Oncology. Single men of all ages are more likely to die of their disease. Cutaneous malignant melanoma is the most aggressive form of skin cancer. The disease is one of the fastest growing cancers among Caucasian (white) populations and is an escalating health problem even among young individuals. Swedish researchers from Karolinska Institutet and Linköping University have now, ...

Take the sound "bl": how many words starting with that sound can you think of? Blouse, blue, bland... Now try with "lb": how many can you find? None in English and Italian, and even in other languages such words either don't exist or are extremely rare. Human languages offer several examples of this kind, and this indicates that in forming words we tend to prefer certain sound combinations to others, irrespective of which language we speak. The fact that this occurs across languages has prompted linguists to hypothesize the existence of biological bases of language (inborn ...

More than 1.1 million spouses, parents and friends are caring for the injured and disabled who have served in the U.S. military since Sept. 11, 2001, often doing so without a formal support network and putting their own well-being at risk, according to a new RAND Corporation study. The largest-ever study of military caregivers -- commissioned by the Elizabeth Dole Foundation -- finds that Americans who are taking care of veterans who served after 9/11 are younger than other caregivers, are usually employed outside the home and are more likely to care for someone who has ...

Customers are more likely to frequent restaurants that provide both healthful foods and nutrition information, according to researchers at Penn State and the University of Tennessee. "The Affordable Care Act has mandated that chain restaurants -- those with more than 20 restaurants -- provide nutrition information to customers," said David Cranage, associate professor of hospitality management. "Many restaurants had been fighting this legislation because they thought they would lose customers if the customers knew how unhealthy their food was. In this study, we found ...

Researchers from the National Collection of Yeast Cultures (NCYC) at the Institute of Food Research (IFR) have identified a new globe-trotting yeast species that lives on tree-associated beetles. This new species demonstrates the importance of preserving biodiversity, as yeasts like this may help efforts to develop renewable fuel sources in the future. Preserving biodiversity must go beyond plants and animals and also preserve the microbial life. Threats to habitats, for example through oil exploration, could destroy forever potential solutions to global challenges locked ...

To improve recovery for heart attack patients, hospitals should maintain normal day and night cycles for those patients during the first few days after the attack, say University of Guelph researchers. Their new study shows for the first time that interrupting diurnal rhythms impairs healing immediately after a heart attack, said Prof. Tami Martino of the Department of Biomedical Sciences. Researchers already knew that circadian rhythms, or day-night cycles, can affect timing of a heart attack. This is the first study to show the importance of circadian rhythms during ...

Dogs are individual personalities, possess awareness, and are particularly known for their learning capabilities, or trainability. To learn successfully, they must display a sufficient quantity of attention and concentration. However, the attentiveness of dogs' changes in the course of their lives, as it does in humans. The lead author Lisa Wallis and her colleagues investigated 145 Border Collies aged 6 months to 14 years in the Clever Dog Lab at the Vetmeduni Vienna and determined, for the first time, how attentiveness changes in the entire course of a dog's life using ...