A new study of the megabladder mouse model suggests that tracking changes in the expression of key genes involved in kidney disease could help physicians predict the severity of urinary tract obstruction in pediatric patients, which could help identify children at the greatest risk of chronic kidney disease and permanent organ damage. The work was led by a team that includes Brian Becknell, MD, PhD, a clinician and assistant professor in the Division of Nephrology at Nationwide Children's Hospital. The research, which tracked the expression of a number of genes related ...

A protein at the center of Parkinson’s disease research now also has been found to play a key role in causing the destruction of bacteria that cause tuberculosis, according to scientists led by UC San Francisco microbiologist and tuberculosis expert Jeffery Cox, PhD. The protein, named Parkin, already is the focus of intense investigation in Parkinson’s disease, in which its malfunction is associated with a loss of nerve cells. Cox and colleagues now report that Parkin also acts on tuberculosis, triggering destruction of the bacteria by immune cells known as macrophages. ...

NEW YORK, September 4, 2013 — Memorial Sloan-Kettering Cancer Center study shows that the use of MRI before or immediately after surgery in women with DCIS was not associated with reduced local recurrence or contralateral breast cancer rates. The findings are being presented on Saturday, September 7, 2013, at the 2013 Breast Cancer Symposium. While no clinical practice guidelines exist for the use of MRI around the time of surgery, some surgeons use the screening tool to obtain a clearer picture of the cancer before surgery is performed or immediately after surgery to ...

In the battle against brain cancer, doctors now have a new weapon -- a new imaging technology that will make brain surgery dramatically more accurate by allowing surgeons to distinguish -- at a microscopic level -- between brain tissue and tumors. Called SRS microscopy -- short for stimulated Raman scattering -- a team of researchers that included Xiaoliang Sunney Xie, the Mallinckrodt Professor of Chemistry and Chemical Biology and Minbiao Ji, a Post-Doctoral Fellow in Chemistry and Chemical Biology, were able to "see" the tiniest areas of tumor cells in brain tissue, ...

Case Western Reserve researchers have identified a genetic factor that blocks the blood vessel inflammation that can lead to heart attacks, strokes and other potentially life-threatening events. The breakthrough involving Kruppel-like factor (KLF) 15 is the latest in a string of discoveries from the laboratory of professor of medicine Mukesh K. Jain that involves a remarkable genetic family. Kruppel-like factors appear to play prominent roles in everything from cardiac health and obesity to metabolism and childhood muscular dystrophy. School of Medicine instructor ...

(Santa Barbara, Calif.) –– The results of research conducted by professors at UC Santa Barbara and colleagues mark the beginning of a new paradigm for our understanding of the history of Earth's great global ice sheets. The research shows that, contrary to the popularly held scientific view, an ice sheet on West Antarctica existed 20 million years earlier than previously thought. The findings indicate that ice sheets first grew on the West Antarctic subcontinent at the start of a global transition from warm greenhouse conditions to a cool icehouse climate 34 million years ...

URBANA, Ill. – Farmers who grow corn and soybeans can take advantage of government price support programs and crop insurance, but similar programs are not available for those who grow biomass crops such as Miscanthus. A University of Illinois study recommends a framework for contracts between growers and biorefineries to help spell out expectations for sustainability practices and designate who will assume the risks and costs associated with these new perennial energy crops. "The current biomass market operates more along the lines of a take-it-or-leave-it contract, ...

Tropical Storm Toraji passed over Kyushu and transitioned into an extra-tropical storm while bringing heavy rainfall over the big island of Japan when NASA's Aqua satellite passed overhead on Sept. 4. The extra-tropical storm is now a cold-core system being carried by a frontal system. The Atmospheric Infrared Sounder or AIRS instrument captured infrared data of Extra-Tropical Storm Toraji as it continued tracking through southern Japan on Sept.4 at 0429 UTC/12:29 a.m. EDT. AIRS showed that the coldest cloud top temperatures and strongest thunderstorms with heaviest rainfall ...

CORVALLIS, Ore. – Researchers in the College of Engineering at Oregon State University have made a significant advance in the function of metal-insulator-metal, or MIM diodes, a technology premised on the assumption that the speed of electrons moving through silicon is simply too slow. For the extraordinary speed envisioned in some future electronics applications, these innovative diodes solve problems that would not be possible with silicon-based materials as a limiting factor. The new diodes consist of a "sandwich" of two metals, with two insulators in between, to ...

DENVER – Lung cancer is the most common cause of cancer death in Ontario. Screening for lung cancer using low-dose computed tomography (LDCT) has been the subject of many research studies since the 1990s. The National Lung Screening Trial compared LDCT with chest radiograph in high-risk populations and found a 20 percent reduction in lung cancer mortality at 6 years with LDCT after an initial scan and two annual rounds of screening. While there are still gaps regarding the use of CT-screening, researchers in Ontario developed evidence-based recommendations for screening ...

DENVER – Radiotherapy with or without chemotherapy is increasingly being used in the curative treatment for un-resected non-small cell lung cancer (NSCLC). But, until now, researchers had not looked at the cost-effectiveness of the treatment. In the October issue of the International Association for the Study of Lung Cancer's journal, the Journal of Thoracic Oncology (JTO), researchers compared the cost-effectiveness of different modified radiotherapy schemes and conventional fractional radiotherapy in the curative treatment of un-resected NSCLC patients. They conclude ...

DENVER – Although numerous randomized clinical trials have demonstrated a benefit of chemotherapy for patients with small-cell lung cancer (SCLC), these trials have predominantly compared different chemotherapy regimens rather than comparing chemotherapy to best supportive care. Some of them included chest radiation or prophylactic cranial irradiation. Moreover, many trials excluded elderly patients. A recent retrospective study looked at the benefit of chemotherapy on survival of elderly patients with SCLC in the community. This is the first large-scale analysis of chemotherapy ...

DENVER – According to the American Cancer Society, an estimated 160,340 lung cancer deaths occurred in the United States in 2012, accounting for 28 percent of all cancer deaths. While survival from lung cancer has improved since the early 1990s, racial differences in lung cancer survival persist such that blacks experience poorer 5-year survival for lung cancer compared to whites. In the October issue of the International Association for the Study of Lung Cancer's journal, the Journal of Thoracic Oncology (JTO), researchers conclude that while proportionally more blacks ...

A study at UCLA's Jonsson Comprehensive Cancer Center has found that head and neck cancer patients receiving radiation as part of their treatment were less likely to need a feeding tube or suffer unwanted side effects such as worsening of diet or narrowing of the throat passage if they performed a set of prescribed swallowing exercises — called a "swallow preservation protocol" — during therapy. The study, conducted from 2007 to 2012, was led by Dr. Marilene Wang, a member of the Jonsson Cancer Center and professor-in-residence in the department of head and neck surgery ...

(Philadelphia, PA) - Many people who survive a heart attack find themselves back in the hospital with a failing heart just years later. And the outcome often is unfavorable, owing to limited treatment options. But scientists at Temple University School of Medicine's Cardiovascular Research Center (CVRC) recently found hope in an unlikely source – stem cells in cortical, or compact, bone. In a new study, they show that when it comes to the regeneration of heart tissue, these novel bone-derived cells do a better job than the heart's own stem cells. According to the study's ...

AMSTERDAM, Sept. 4, 2013 – Abbott announced today promising preliminary results from a study presented at the ESC Congress 2013, suggesting that its high sensitive troponin test may help doctors improve the diagnosis and prognosis of patients presenting with symptoms of a heart attack.1 The test could be particularly beneficial for women, who may have different presenting symptoms and are often under-diagnosed.2 The study, which is being conducted by researchers at the University of Edinburgh, is evaluating Abbott's ARCHITECT STAT High Sensitive Troponin-I (hsTnI) test, ...

SHERIDAN, WY—Throughout the western United States, Canada, and Mexico, Rocky Mountain juniper (Juniperus scopulorum Sarg.) is known for its pleasant fragrance and valuable wood. The juniper's wood—highly valued for its durability, rich color, and pleasant aroma—is popular for use as interior paneling, furniture, and fence posts. For centuries, the leaves and berries of Rocky Mountain juniper, which contain strongly aromatic essential oil, have been used extensively by native people of North America to treat a number of medical conditions. A recent study evaluated several ...

GAINESVILLE, FL—The University of Florida's (UF) Blueberry Breeding Program has been developing successful blueberry cultivars for more than 60 years. The cultivars released from UF are credited with creating a Florida blueberry industry that was valued at $48 million in 2010, and allowing rapid expansion of blueberry production in other subtropical areas of the world. In the past, blueberry flavor selection in the program was based on two standards: subjective ratings from breeders, and a berry's sugar-to-acid ratio. Recently, scientists have determined that the "eating ...

BATON ROUGE – What happens when you tell a lie? Set aside your ethical concerns for a moment—after all, lying is a habit we practice with astonishing dexterity and frequency, whether we realize it or not. What goes on in your brain when you willfully deceive someone? And what happens later, when you attempt to access the memory of your deceit? How you remember a lie may be impacted profoundly by how you lie, according to a new study by LSU Associate Professor Sean Lane and former graduate student Kathleen Vieria. The study, accepted for publication in the Journal of Applied ...

A University of Iowa physiologist has a new technique to measure the stiffness of the aorta, a common risk factor for heart disease. And it can be as simple as measuring the pulse in your finger. The new procedure developed by Gary Pierce, assistant professor in the Department of Health and Human Physiology, works by placing an instrument called a transducer on the finger or over the brachial artery, located inside the arm just beneath the elbow. The readout, combined with a person's age and body mass index, lets physicians know whether the aorta has stiffened. Currently, ...

A team of University of Texas at Arlington biologists working with the U.S. Geological Survey has found that watershed wetlands can serve as a natural source for the improvement of streams polluted by acid rain. The group, led by associate professor of biology Sophia Passy, also contends that recent increases in the level of organic matter in surface waters in regions of North America and Europe – also known as "brownification" – holds benefits for aquatic ecosystems. The research team's work appeared in the September issue of the journal Global Change Biology. The ...

Amid growing competition for freshwater from industry and cities, coupled with a rising world shortage of potash, nitrogen and phosphorus, an international study predicts a rapid increase in the use of treated wastewater for farming and other purposes worldwide. However, research shows that treated wastewater -- comparable in North America alone to the volume of water flowing over Niagara Falls -- is mostly unused and, in many nations, not even quantified. Of 181 countries studied, only 55 have information on three key aspects of wastewater: generation, treatment, ...

WASHINGTON – People who get away with cheating when they believe no one is hurt by their dishonesty are more likely to feel upbeat than remorseful afterward, according to new research published by the American Psychological Association. Although people predict they will feel bad after cheating or being dishonest, many of them don't, reports a study published online in APA's Journal of Personality and Social Psychology. "When people do something wrong specifically to harm someone else, such as apply an electrical shock, the consistent reaction in previous research has ...

Tampa, FL (Sept. 3, 2013) -- A stress-related protein genetically linked to depression, anxiety and other psychiatric disorders contributes to the acceleration of Alzheimer's disease, a new study led by researchers at the University of South Florida has found. The study is published online today in the Journal of Clinical Investigation. When the stress-related protein FKBP51 partners with another protein known as Hsp90, this formidable chaperone protein complex prevents the clearance from the brain of the toxic tau protein associated with Alzheimer's disease. Under ...

USC scientists have discovered a population of neurons in the brains of juvenile songbirds that are necessary for allowing the birds to recognize the vocal sounds they are learning to imitate. These neurons encode a memory of learned vocal sounds and form a crucial (and hitherto only theorized) part of the neural system that allows songbirds to hear, imitate, and learn its species' songs – just as human infants acquire speech sounds. This discovery will allow scientists to uncover the exact neural mechanisms that allow songbirds to hear their own self-produced ...