Osteoarthritis is a leading cause of disability, characterized by the destruction of cartilage tissue in joints, but there is a lack of effective therapies because the underlying molecular causes have been unclear. A study published by Cell Press February 13th in the journal Cell reveals that osteoarthritis-related tissue damage is caused by a molecular pathway that is involved in regulating and responding to zinc levels inside of cartilage cells. A protein called ZIP8 transports zinc inside these cells, setting off a cascade of molecular events that result in the destruction ...

Scientists are using powerful analytical and imaging tools to study artworks from all ages, delving deep below the surface to reveal the process and materials used by some of the world's greatest artists. Northwestern University chemist Richard P. Van Duyne, in collaboration with conservation scientists at the Art Institute of Chicago, has been using a scientific method he discovered nearly four decades ago to investigate masterpieces by Pierre-Auguste Renoir, Winslow Homer and Mary Cassatt. Van Duyne recently identified the chemical components of paint, now partially ...

For nearly a decade, Northwestern University and the Art Institute of Chicago have been partners in conservation science, unlocking secrets about many of the museum's masterpieces -- by Pierre-Auguste Renoir, Pablo Picasso, Henri Matisse, Winslow Homer, George Seurat, Mary Cassatt and others -- and developing new methods and technologies to investigate art. Last year, a $2.5 million grant from the Andrew W. Mellon Foundation established the Northwestern University/Art Institute of Chicago Center for Scientific Studies in the Arts (NU-ACCESS), a new national model of ...

Researchers at the University of California, San Diego School of Medicine have discovered that a well-known protein has a new function: It acts in a biological circuit to determine whether an immature neural cell remains in a stem-like state or proceeds to become a functional neuron. The findings, published in the February 13 online issue of Cell Reports, more fully illuminate a fundamental but still poorly understood cellular act – and may have significant implications for future development of new therapies for specific neurological disorders, including autism and ...

EVANSTON, Ill. --- Today Americans are looking to their marriages to fulfill different goals than in the past — and although the fulfillment of these goals requires especially large investments of time and energy in the marital relationship, on average Americans are actually making smaller investments in their marital relationship than in the past, according to new research from Northwestern University. Those conflicting realities don't bode well for the majority of marriages, according to Eli Finkel, professor of psychology in the Weinberg College of Arts and sciences ...

Orang-utans come down from the trees and spend more time on the ground than previously realised – but this behaviour may be partly influenced by man, a new study has found. Dr Mark Harrison, based in the Department of Geography at the University of Leicester and Managing Director of the Orang-utan Tropical Peatland Project (OuTrop) has, along with international colleagues, published results of a seven year study of orang-utans in Borneo in the journal Scientific Reports. The research, conducted between June 2006 and March 2013, is based on a large-scale analysis of ...

Cells communicate through proteins embedded in their cell membranes. These proteins have diverse functions and can be compared with antennas, switches and gates. For the well-being of the cell, it has to adjust the composition of its membrane proteins and lipids constantly. New proteins are incorporated, while old proteins get recycled or eliminated. The process by which membrane material gets internalized is called endocytosis. A research team headed by Daniël van Damme and Geert De Jaeger from VIB and Ghent University (Belgium), and Staffan Persson from the Max Planck ...

Communication is vital to any successful relationship. Researchers from the Institute of Food Research and the University of East Anglia have discovered how the beneficial bacteria in our guts communicate with our own cells. This is a key step in understanding how our bodies maintain a close relationship with the population of gut bacteria that plays crucial roles in maintaining our health, fighting infection and digesting our food. A study, published in the journal Cell Reports, shows that the gut bacteria produce an enzyme that modifies signalling in cells lining the ...

Researchers from the Broad Institute and MIT have teamed up with colleagues from the University of Tokyo to form the first high definition picture of the Cas9 complex – a key part of the CRISPR-Cas system used by scientists as a genome-editing tool to silence genes and probe the biology of cells. Their findings, which are reported this week in Cell, are expected to help researchers refine and further engineer the tool to accelerate genomic research and bring the technology closer to use in the treatment of human genetic disease. First discovered in bacteria in 1987, CRISPRs ...

In the first study of its kind, a consortium led by UCLA physicians found that giving stroke patients intravenous magnesium within an hour of symptom onset does not improve stroke outcomes, according to research presented today at the American Stroke Association's International Stroke Conference. However, the eight-year study found that, by working with paramedics in the field, intravenous medications can be given to stroke patients within the "golden hour," the window in which patients have the best chance to survive and avoid debilitating, long-term neurological damage. ...

WORCESTER, MA – Everyday our cells take in nutrients from food and convert them into the building blocks that make life possible. However, it has been challenging to pinpoint exactly how a single nutrient or vitamin changes gene expression and physiology. Scientists at the University of Massachusetts Medical School have developed a novel interspecies model system that allows these questions to be answered. In a study appearing in the journal Cell, UMMS researchers use this new approach to show how bacterially supplied vitamin B12 changes gene expression, development and ...

Software that can fix 90 percent of broken links in the web of data, assuming the resources are still on the site's server, has been developed by researchers in Iran. The details are reported this month in the International Journal Web Engineering and Technology. Everyone knows the frustration of following a link to an interesting web site only to discover the target page is no longer there and to be presented with an error page. However, more frustrating and with wider implications for science, healthcare, industry and other areas is when machines communicate and expect ...

Metabolic risk factors cluster similarly in children and adults, according to a study carried out at the University of Eastern Finland. Furthermore, in adults, the clustering of these risk factors increases the risk of premature death caused by type 2 diabetes, myocardial infarction and cardiovascular diseases. The results indicate that lifestyle interventions aiming at the prevention of type 2 diabetes and cardiovascular diseases should be invested in already in childhood. The results of the study were recently published in Diabetologia. Metabolic syndrome ...

Japanese researchers have determined that sarcopenia—a loss of skeletal muscle mass—increases risk of sepsis and mortality risk in patients undergoing live donor liver transplantation. Findings published in Liver Transplantation, a journal of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, suggest that post-transplant sepsis was reduced in candidates with sarcopenia who received early nutritional support with a feeding tube, known as enteral nutrition. While sarcopenia, defined as loss of muscle connected ...

WHO: Chris Field, professor of interdisciplinary environmental studies at Stanford University and co-chair of the U.N. Intergovernmental Panel on Climate Change (IPCC) Fifth Assessment Working Group II. WHAT: The world is staring down the barrel of climate change that is faster than at any time in the last 65 million years, says climate expert Chris Field. He will speak on the topic. WHEN: Friday, Feb. 14, 1:30 to 4:30 p.m. CST. WHERE: American Association for the Advancement of Science (AAAS) Annual Meeting, Hyatt Regency, Grand Ballroom B, ...

New research quantifying the risk of admission to hospital for self-harm has identified a raised risk of self-harm among groups of patients with certain physical illnesses. While it is known that psychiatric illnesses are associated with a greatly elevated risk of self-harm, a moderately elevated risk was seen with common physical illnesses such as diabetes, epilepsy and asthma. The research, published today by the Journal of the Royal Society of Medicine, investigated the risk of self-harm comparing people with different psychiatric and physical disorders in England. Other ...

A group of researchers at the Institute for Research in Immunology and Cancer (IRIC) of Université de Montréal discovered a promising new approach to treating leukemia by disarming a gene that is responsible for tumor progression. That gene, known as Brg1 is a key regulator of leukemia stem cells that are the root cause of the disease, resistance to treatment and relapse. Julie Lessard, principal investigator and her colleagues at IRIC have spent the past four years studying that gene in collaboration with another research group at Stanford University in California. The ...

Many psychiatric disorders are accompanied by memory deficits. Basel scientists have now identified a network of genes that controls fundamental properties of neurons and is important for human brain activity, memory and the development of schizophrenia. Their results have been published in the online edition of the US journal Neuron. The ability to hold transitory information - e.g. memorizing a telephone number - is a fundamental function of the human brain. This so-called working memory enables us to understand the world that surrounds us. To keep the working ...

Female Asian longhorned beetles lure males to their locations by laying down sex-specific pheromone trails on tree surfaces, according to an international team of researchers. The finding could lead to the development of a tool to manage this invasive pest that affects about 25 tree species in the United States. "Tens of thousands of hardwood trees, mostly maples, have been cut down and destroyed in New York, Ohio and Massachusetts because of the Asian longhorned beetle," said Kelli Hoover, professor of entomology, Penn State. "We discovered a pheromone produced by females ...

CLEVELAND, Ohio (Thursday, February 13, 2014)—A woman can beat middle-aged spread, her disease risks, and her hot flashes with the help of her healthcare provider. And even a short term program can spell success for women and fit into a busy provider's practice, shows a demonstration obesity-fighting and health risk reduction program detailed in an article just published online in Menopause, the journal of The North American Menopause Society (NAMS). Making lifestyle changes can take a lot of work. Programs that have successfully helped women lose weight and reduce their ...

An international team of scientists under the leadership of the University of Bonn disproves a dogma: To date, immunologists have assumed that the macrophages functioning as "scavenger cells" can be classified into two different forms. In an extensive search, the researchers have now discovered that these immune cells turn into far more different manifestations. These findings also give rise to completely new therapeutic approaches for many widespread diseases. The results are now being published in the renowned journal Immunity. In the body, macrophages go on patrol ...

Looking for a good book? Stay away from the award-winning section of the bookstore or library. New research from Amanda Sharkey of the University of Chicago Booth School of Business finds that a book read after winning a prestigious award will likely be judged more negatively than if it's read in its pre-award days. In "The Paradox of Publicity: How Awards Can Negatively Affect the Evaluation of Quality," to be published in the March issue of Administrative Science Quarterly, Sharkey and colleague Balázs Kovács of the University of Lugano analyze thousands of reader ...

After offering information about UV light and sun-protective behaviors, the two health-ed videos diverge: one describes the increased skin cancer risk of UV exposure and the other describes effects on appearance including wrinkles and premature aging. Which of these two videos do you think caused teenagers to use more sunscreen six weeks after it was shown? A University of Colorado Cancer Center study shows that while teens who watched both videos learned and retained the same amount of knowledge about UV light and sun-protective behaviors, only the teens who ...

GAINESVILLE, Fla. — Breathing the air outside their homes may be just as toxic to pregnant women — if not more so — as breathing in cigarette smoke, increasing a mom-to-be's risk of developing deadly complications such as preeclampsia, according to findings from a new University of Florida study. UF researchers compared birth data with Environmental Protection Agency estimates of air pollution, finding that heavy exposure to four air pollutants led to a significantly increased risk for developing a high blood pressure disorder during pregnancy. The research was published ...

This news release is available in German. Researchers at the Helmholtz Center Berlin (HZB) have taken a leap forward towards a deeper understanding of an undesired effect in thin film solar cells based on amorphous silicon – one that has puzzled the scientific community for the last 40 years. The researchers were able to demonstrate that tiny voids within the silicon network are partly responsible for reducing solar cell efficiency by some 10 to 15 percent as soon as you start using them. Their work has now been published in Physical Review Letters (DOI: 10.1103/PhysRevLett.112.066403). Amorphous ...