Development of a novel dual JAK/Src kinase inhibitor Inhibitors of both JAK and Src kinases represent promising targets for cancer therapeutics because of the central importance of these kinases in tumor cell proliferation and survival. Furthermore, in cancer cells activation ...

Out-of-pocket costs play major role in treatment adherence for cancer patients The cost of insurance co-payments for cutting-edge pharmaceuticals can vary widely from patient to patient. When the patient's share of prescription costs becomes ...

NASA's Fermi makes first gamma-ray study of a gravitational lens

Ear tubes vs. watchful waiting: Tubes do not improve long-term development Watchful waiting or ear tube surgery? It is a decision faced by millions of families of children with recurrent or chronic otitis media with effusion (non-infected ...

Including women on convening committees increases women speakers at scientific meetings Women are currently underrepresented among speakers at scientific meetings, both in absolute terms and relative to their representation among attendees, but a new study suggests ...

'Traffic light' food labels, positioning of healthy items produce lasting choice changes The use of color-coded "traffic light" food labels and changes in the way popular items are displayed appear to have produced a long-term increase in the choice ...

Boost careers of female scientists: Make sure women help choose meeting speakers January 7, 2014 — (BRONX, NY) — More women are choosing science careers, yet women are notoriously underrepresented in senior academic positions—often because they ...

Similar characteristics of brain DTI for healthy adult rhesus monkey and young people Diffusion-tensor imaging can be used to observe the microstructure of brain tissue. Fractional anisotropy reflects the integrity of white matter fibers. Fractional anisotropy of ...

Mannotriose promotes survival of hippocampal neurons The main component of the Chinese herb Rehmannia, mannotriose, can improve learning and memory. Dr. Lina Zhang and colleagues from Shanghai University of Traditional Chinese Medicine in China used 1 × 10 mol/L ...

Gabapentin inhibits central sensitization during migraine Gabapentin is a gamma-aminobutyric acid derivative, and was approved for the treatment of neuropathic pain by the U.S. Food and Drug Administration in 2002. However, little evidence is available on the effects ...

A single-domain antibody that specifically recognizes amyloid-beta 42 oligomers Earlier amyloid-beta assemblies may be one of the most important causes of Alzheimer's disease. Passive immunization of anti-amyloid-beta antibodies can reduce amyloid-beta burden and ...

Intraoperative monitoring of SSEPs is a new measure to avoid iatrogenic spinal cord injury Currently intraoperative monitoring using somatosensory evoked potentials has been widely recognized to prevent iatrogenic spinal cord injury. Previous studies only reported ...

Newly discovered 3-star system could debunk Einstein's theory of General Relativity A newly discovered system of two white dwarf stars and a superdense pulsar--all packed within a space smaller than the Earth's orbit around the sun -- is enabling astronomers to probe ...

Supernova's super dust factory imaged with ALMA Galaxies can be remarkably dusty places and supernovas are thought to be a primary source of that dust, especially in the early Universe. Direct evidence of a supernova's dust-making capabilities, however, has ...

1 'villain' of the housing crisis played only a small role Mortgage defaults still high after predatory lenders forced out COLUMBUS, Ohio -- One of the major factors blamed for the subprime mortgage crisis may have actually played only a minor role in the housing meltdown, ...

Marriage promotion has failed to stem poverty among single moms On 50th anniversary of War on Poverty, expert says new approach needed COLUMBUS, Ohio – As the United States marks the 50th anniversary of the War on Poverty this month, a new report suggests one ...

Researchers find that computer components can be damaged by key manufacturing processes Manufacturers of increasingly minute computer chips, transistors and other products will have to take special note of research findings at the University of Huddersfield. The ...

New discovery of biomarker to improve diagnosis, prognosis and treatment of ESCC Latest study by NUS researchers first to demonstrate that editing of protein-making sequences promotes development of Esophageal Squamous Cell Carcinoma Esophageal Squamous Cell ...

Technology 1 step ahead of war laws Los Angeles, London (January 06, 2013). Today's emerging military technologies—including unmanned aerial vehicles, directed-energy weapons, lethal autonomous robots, and cyber weapons like Stuxnet—raise the prospect of upheavals ...

The loving touch is critical for premature infants Philadelphia, PA, January 6, 2014 – The benefit that premature infants gain from skin-to-skin contact with their mothers is measurable even 10 years after birth, reports a new study in Biological Psychiatry. Physical ...

CWRU researcher finds released inmates need programs to meet basic and mental health needs When inmates with severe mental illness are released from jail, their priority is finding shelter, food, money and clothes. Even needs as basic as soap and a ...

Suicide risk doesn't differ in children taking 2 types of commonly prescribed antidepressants A Vanderbilt University Medical Center study released today shows there is no evidence that the risk of suicide differs with two commonly prescribed ...

Laying money on the line leads to healthier food choices over time People are more likely to choose healthy options at the grocery store if they use the risk of losing their monthly healthy food discount as a motivational tool, according ...

MRSA infection rates drop in Veterans Affairs long-term care facilities Washington, DC, January 6, 2014 – Four years after implementing a national initiative to reduce methicillin-resistant Staphylococcus aureus (MRSA) rates in Veterans Affairs (VA) long-term care facilities, ...

Stimulating brain cells stops binge drinking, animal study finds Results suggest it may be possible to use gene therapy in the brain to treat substance abuse, neurological diseases and mental illnesses BUFFALO, N.Y. – Researchers at the University at Buffalo have ...