21 May 2013, Paris, France: The DESolve bioresorbable coronary scaffold system achieves good efficacy and safety with low rates of late lumen loss and major coronary adverse events at six months, show first results from the pivotal DESolve Nx trial reported at EuroPCR 2013 today. DESolve (Elixir Medical Corporation) is the first bioresorbable PLLA-based polymer scaffold that releases novolimus, a major metabolite of sirolimus. "The degradation time is about one year," explained the lead study author Alexandre Abizaid, Director of Interventional Cardiology at Institute ...

"We spent 15 percent of home energy on gadgets in 2009, and we're buying more gadgets all the time," says Peter Fischer of the U.S. Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab). Fischer lets you know right away that while it's scientific curiosity that inspires his research at the Lab's Advanced Light Source (ALS), he intends it to help solve pressing problems. "What we're working on now could make these gadgets perform hundreds of times better and also be a hundred times more energy efficient," says Fischer, a staff scientist in the Materials ...

UCLA life scientists provide important new details on how climate change will affect interactions between species in research published online May 21 in the Journal of Animal Ecology. This knowledge, they say, is critical to making accurate predictions and informing policymakers of how species are likely to be impacted by rising temperatures. "There is a growing recognition among biologists that climate change is affecting how species interact with one another, and that this is going to have very important consequences for the stability and functioning of ecosystems," ...

Irvine, Calif., May 22, 2013 – Early screening for prostate cancer could become as easy for men as personal pregnancy testing is for women, thanks to UC Irvine research published today in the Journal of the American Chemical Society. After more than a decade of work, UC Irvine chemists have created a way to clearly identify clinically usable markers for prostate cancer in urine, meaning that the disease could be detected far sooner, with greater accuracy and at dramatically lower cost. The same technology could potentially be used for bladder and multiple myeloma cancers, ...

ATS 2013, PHILADELPHIA ─More than 40 percent of patients being treated for COPD at a federally funded clinic did not have the disease, researchers found after evaluating the patients with spirometry, the diagnostic "gold standard" for chronic obstructive pulmonary disease. "While there have been many studies of the under-diagnosis of COPD, there has not been a U.S.-based study that has quantified the problem of over-diagnosis," said Christian Ghattas, MD., MSc, a second-year medical resident at Saint Elizabeth Health Center in Youngstown, Ohio, who will present ...

Researchers at Johns Hopkins have unraveled the molecular foundations of cocaine's effects on the brain, and identified a compound that blocks cravings for the drug in cocaine-addicted mice. The compound, already proven safe for humans, is undergoing further animal testing in preparation for possible clinical trials in cocaine addicts, the researchers say. "It was remarkably serendipitous that when we learned which brain pathway cocaine acts on, we already knew of a compound, CGP3466B, that blocks that specific pathway," says Solomon Snyder, M.D., a professor of neuroscience ...

Toronto, May 22 2013 - Research presented today shows that high-fructose corn syrup can cause behavioural reactions in rats similar to those produced by drugs of abuse such as cocaine. These results, presented by addiction expert Francesco Leri, Associate Professor of Neuroscience and Applied Cognitive Science at the University of Guelph, suggest food addiction could explain, at least partly, the current global obesity epidemic. These results were presented at the 2013 Canadian Neuroscience Meeting, the annual meeting of the Canadian Association for Neuroscience - Association ...

Toronto - May 22 2013: New research shows that craving drugs such as nicotine can be visualized in specific regions of the brain that are implicated in determining the value of actions, in planning actions and in motivation. Dr. Alain Dagher, from McGill University, suggests abnormal interactions between these decision-making brain regions could underlie addiction. These results were presented at the 2013 Canadian Neuroscience Meeting, the annual meeting of the Canadian Association for Neuroscience - Association Canadienne des Neurosciences (CAN-ACN). Neuroeconomics is ...

VIDEO: The video as it appears on JoVE.com. Click here for more information. On May 22, JoVE will publish details of a technique to measure the health of human genetic material in relation to a patient’s age. The method is demonstrated by the laboratory of Dr. Gil Atzmon at New York’s Albert Einstein College of Medicine. Dr. Atzmon hopes that the dissemination of this technique will lead to the development of a “genetic thermometer” to assess a patient’s health in relation to ...

Costs to treat stroke are projected to more than double and the number of people having strokes may increase 20 percent by 2030, according to the American Heart Association/American Stroke Association. In a statement published in Stroke, an American Heart Association journal, the association cites the aging U.S. population as the main reason for the increases and predicts that by 2030: Almost 4 percent of U.S. adults — nearly one in 25 — will have a stroke. This translates into an additional 3.4 million people with stroke in 2030. Costs to treat stroke may increase ...

Scientists have reversed behavioral and brain abnormalities in adult mice that resemble some features of schizophrenia by restoring normal expression to a suspect gene that is over-expressed in humans with the illness. Targeting expression of the gene Neuregulin1, which makes a protein important for brain development, may hold promise for treating at least some patients with the brain disorder, say researchers funded by the National Institutes of Health. Like patients with schizophrenia, adult mice biogenetically-engineered to have higher Neuregulin 1 levels showed reduced ...

A new method of sourcing the origins of artefacts in high definition is set to improve our understanding of the past. Dr Ellery Frahm at the University of Sheffield developed the new technology to better study Mesopotamian obsidian tools unearthed in Syria, where cultural heritage is threatened by the ongoing conflict. The research brings five decades of research full circle and presents a significant advance in the field. While at the University of Sheffield from 1965 – 1972, Professor Lord Colin Renfrew developed a technique that matched stone tools made of obsidian, ...

NEW YORK, May 22, 2013. Plastic additives known as phthalates (pronounced THAL-ates) are odorless, colorless and just about everywhere: They turn up in flooring, plastic cups, beach balls, plastic wrap, intravenous tubing and—according to the Centers for Disease Control and Prevention—the bodies of most Americans. Once perceived as harmless, phthalates have come under increasing scrutiny. A growing collection of evidence suggests dietary exposure to phthalates (which can leech from packaging and mix with food) may cause significant metabolic and hormonal abnormalities, ...

Toronto – If you're a small charity looking for some corporate largesse, pegging your ask to a big morale-boosting event planned for your community may help seal the deal, suggests a new study on corporate giving. The paper found that corporate philanthropy spikes upward during "mega-events" such as the Olympics, the Super Bowl, or even political conventions. The finding goes against previous research that says corporate giving tends to stay stable. "For non-profit managers, it suggests that one potentially reasonable strategy might be to tie some of their efforts in ...

PASADENA, Calif. – May 22, 2013 — The new 13-valent pneumococcal conjugate vaccine (PCV13) appears to be as safe as the previous version used prior to 2010, the 7-valent pneumococcal conjugate vaccine (PCV7), according to a Kaiser Permanente study published today in Vaccine. The U.S. Food and Drug Administration approved PCV13 for use beginning in 2010 after a series of trials. These trials found that PCV13, which protects against a broader range of pneumococcal types than the previously used PCV7, did not increase the risk for any serious adverse events related to the ...

The University of Gothenburg Vaccine Research Institute (GUVAX) announces successful results in a placebo controlled phase I study of an oral, inactivated Escherichia coli diarrhea vaccine. Enterotoxigenic Escherichia coli (ETEC) bacteria are the primary cause of diarrhea in children living in low and middle income countries result in 400 million diarrheal episodes and approximately 300 000 deaths among children per year. ETEC is also the leading cause of illness among international travelers to developing countries. Among the 65 million people travelling from industrialized ...

Two new minute spider species have been discovered from the Sichuan and Chongqing, China. The tiny new spiders are both less than 2 mm in length, with Trogloneta yuensis being as little as 1.01 mm and Mysmena wawuensis measured to be the even tinier 0.75 mm, which classes it among the smallest spiders known. The two species described in the open access journal Zookeys both have a bizarre body shape with disproportionately big spherical posterior body. The family Mysmenidae to which the new species belong is composed of minute eight-eyed spiders. There are a relatively ...

The feared Legionella pneumophila bacteria is responsible for legionellosis, an infectious disease that can lead to pneumonia. In order to infect us, this pathogen has developed a complex method enabling it to camouflage itself and go unnoticed in our cells, thus avoiding these acting against the infectious bacteria. Research led by the Basque biosciences research centre, CIC bioGUNE, in which teams from the National Institute of Health (NIH) of the USA and the National Supercomputation Centre in Barcelona (BSC) have also participated, has described for the first time ...

This news release is available in German. With their SQUIDs, low-temperature specialists of the Physikalisch-Technische Bundesanstalt (PTB) have made it possible for the magnetic moments of atoms of the rare isotope 3He (helium-3) to be measured with extreme sensitivity. With the aid of these sensors, highly sensitive nuclear resonance spectrometers were developed which have now provided deep insights into the state of matter at extremely low temperatures. In concrete terms, the international research group from London, Ithaca (USA), and PTB's Berlin Institute ...

Adventitious changes in cellular DNA can endanger the whole organism, as they may lead to life-threatening illnesses like cancer. Researchers at Ludwig-Maximilians-Universitaet (LMU) in Munich now report how byproducts of respiration cause mispairing of subunits in the double helix. The DNA in our cells controls the form and function of every cell type in our bodies. The instructions for this are encoded in the linear sequence of the four subunits found in DNA, the bases adenine (A), cytosine (C), guanine (G) and thymine (T). Random changes in the sequence can lead to ...

Researchers at North Carolina State University have developed a new technique for creating high-quality semiconductor thin films at the atomic scale – meaning the films are only one atom thick. The technique can be used to create these thin films on a large scale, sufficient to coat wafers that are two inches wide, or larger. "This could be used to scale current semiconductor technologies down to the atomic scale – lasers, light-emitting diodes (LEDs), computer chips, anything," says Dr. Linyou Cao, an assistant professor of materials science and engineering at NC State ...

AUGUSTA, Ga. – Overexpression of a gene associated with schizophrenia causes classic symptoms of the disorder that are reversed when gene expression returns to normal, scientists report. They genetically engineered mice so they could turn up levels of neuregulin-1 to mimic high levels found in some patients then return levels to normal, said Dr. Lin Mei, Director of the Institute of Molecular Medicine and Genetics at the Medical College of Georgia at Georgia Regents University. They found that when elevated, mice were hyperactive, couldn't remember what they had just ...

This news release is available in German. Trace gases and aerosols are major factors influencing the climate. With the help of highly complex installations, such as MIPAS on board of the ENVISAT satellite, researchers try to better understand the processes in the upper atmosphere. Now, Karlsruhe Institute of Technology presents the most comprehensive overview of sulfur dioxide measurements in the journal of Atmospheric Chemistry and Physics (doi:10.5194/acpd-13-12389-2013). "Sulfur compounds up to 30 km altitude may have a cooling effect," Michael Höpfner, the ...

Tropical plants flower at supra-annual irregular intervals. In addition, mass flowering is typical for the tropical forests in Borneo and elsewhere, where hundreds of different plant timber species from the Dipterocarpaceae family flower synchronously. This phenomenon is all the more puzzling because both temperature and day length are relatively constant all year round due to geographical proximity to the equator. Up to now it was supposed that several weeks of drought may trigger mass flowering in Borneo's forests. However, no empirical data and genetic analyses were ...

The scientists report these findings in the current online edition of "The Lancet Neurology". This pan-European study could open up new possibilities of early diagnosis and smooth the way for treatments which tackle diseases before the patient's nervous system is irreparably damaged. "Spinocerebellar ataxias" comprise a group of genetic diseases of the cerebellum and other parts of the brain. Persons affected only have limited control of their muscles. They also suffer from balance disorders and impaired speech. The symptoms originate from mutations in the patient's ...