UC San Francisco researchers have found a way to knock down cancers caused by a tumor-driving protein called “myc,” paving the way for patients with myc-driven cancers to enroll in clinical trials for experimental treatments. Myc acts somewhat like a master switch within cells to foster uncontrolled growth. Until now, it has been impossible to target with drugs. The discovery of an unexpected biochemical link within tumor cells should lead to clinical trials for experimental drug treatments that indirectly target myc and that already are being evaluated in human ...

Uruguay has it. So does Latvia, and Senegal. In fact, more than half of the world's countries have some degree of a guaranteed, specific right to public health and medical care for their citizens written into their national constitutions. The United States is one of 86 countries whose constitutions do not guarantee their citizens any kind of health protection. That's the finding of a new study from the UCLA Fielding School of Public Health that examined the level and scope of constitutional protection of specific rights to public health and medical care, as well as ...

In a bit of cosmic irony, planets orbiting cooler stars may be more likely to remain ice-free than planets around hotter stars. This is due to the interaction of a star's light with ice and snow on the planet's surface. Stars emit different types of light. Hotter stars emit high-energy visible and ultraviolet light, and cooler stars give off infrared and near-infrared light, which has a much lower energy. It seems logical that the warmth of terrestrial or rocky planets should depend on the amount of light they get from their stars, all other things being equal. But new ...

If you could hit the reset button on evolution and start over, would essentially the same species appear? Yes, according to a study of Caribbean lizards by researchers at the University of California, Davis, Harvard University and the University of Massachusetts. The work is published July 19 in the journal Science. The predictability of evolution over timescales of millions of years has long been debated by biologists, said Luke Mahler, a postdoctoral fellow at UC Davis and first author on the paper. For example, the late Stephen Jay Gould predicted that if you "rewound ...

Controversy exists over what some mental health experts call "hypersexuality," or sexual "addiction." Namely, is it a mental disorder at all, or something else? It failed to make the cut in the recently updated Diagnostic and Statistical Manual of Mental Disorders, or DSM-5, considered the bible for diagnosing mental disorders. Yet sex addiction has been blamed for ruining relationships, lives and careers. Now, for the first time, UCLA researchers have measured how the brain behaves in so-called hypersexual people who have problems regulating their viewing of sexual ...

One of the most crucial problems affecting the world today is the scarcity of potable water. In a bid to make clean water available at low cost, Mr Ramakrishna Mallampati, a PhD candidate at the National University of Singapore (NUS), experimented with water treatment techniques using materials that are easily available, and came up with novel ways to purify water using the peels of apples and tomatoes. This is the first time that the peels of the two fruits have been used to remove different types of pollutants in water. The studies were conducted under the guidance ...

A new study reports that subdiaphragmatic vagotomy reduces intake of sweet-tasting solutions in rats, and eliminate the hedonic perception produced by sucrose and saccharin in rats. Previous studies have shown that taste information and digestion information in animals during diet intake interact with each other in the central nervous system. So, how does subdiaphragmatic vagotomy influence the intake of sweet-tasting solution in rats? According to a study published in the Neural Regeneration Research (Vol. 8, No. 17, 2013), rats in the sham-surgery group drank more saccharin ...

Maternal alcohol consumption during pregnancy has detrimental effects on fetal central nervous system development. Maternal alcohol consumption prior to and during pregnancy significantly affects cognitive functions in offspring, which may be related to changes in cyclin-dependent kinase 5 because it is associated with modulation of synaptic plasticity and impaired learning and memory. Prof. Ruiling Zhang and team from Xinxiang Medical University explored the correlation between cyclin-dependent kinase 5 expression in the hippocampus and neurological impairments following ...

Recent studies have found that anesthesia drugs have neurotoxicity on the developing neurons, causing learning and memory disorders and behavioral abnormalities. Ketamine is commonly used in pediatric anesthesia. A clinical retrospective study found that children below 3 years old who receive a long time surgery, or because of surgery require ketamine repeatedly will exhibit the performance of school-age learning and memory disorders and behavioral abnormalities. Research group speculates that these abnormalities may be related to the potential neurotoxicity of ketamine. ...

EVANSTON, Ill. --- A new low-cost, high-resolution tool is primed to revolutionize how nanotechnology is produced from the desktop, according to a new study by Northwestern University researchers. Currently, most nanofabrication is done in multibillion-dollar centralized facilities called foundries. This is similar to printing documents in centralized printing shops. Consider, however, how the desktop printer revolutionized the transfer of information by allowing individuals to inexpensively print documents as needed. This paradigm shift is why there has been community-wide ...

The supply of dissolved iron to oceans around continental shelves has been found to be more variable by region than previously believed – with implications for future climate prediction. Iron is key to the removal of carbon dioxide from the Earth's atmosphere as it promotes the growth of microscopic marine plants (phytoplankton), which mop up the greenhouse gas and lock it away in the ocean. A new study, led by researchers based at the National Oceanography Centre Southampton, has found that the amount of dissolved iron released into the ocean from continental ...

An anti-cancer drug has been proven to be equally as effective in treating the most common cause of blindness in older adults as a more expensive drug specifically formulated for this purpose. The results of a two-year trial, led by Queen's scientist Professor Usha Chakravarthy, and published in The Lancet today (Friday 19 July), show that two drug treatments Lucentis and Avastin are equally effective in treating neovascular or wet age-related macular degeneration (wet AMD). Wet AMD is a common cause of sight loss in older people with at least 23,000 older people diagnosed ...

Babies have an innate biological need to be attached to caregivers, usually their parents. But what happens when babies spend a night or more per week away from a primary caregiver, as increasingly happens in cases where the parents share custody, but do not live together? In a new national study, University of Virginia researchers found that infants who spent at least one night per week away from their mothers had more insecure attachments to the mother compared to babies who had fewer overnights or saw their fathers only during the day. The finding is reported in the ...

Just over a century ago, Harvey Cushing published an account of a young woman who showed unusual symptoms because her glands were making excessive amounts of something. Subsequent research has shown that the thing in question is a set of hormones known as glucocorticoids that are produced by the adrenal glands, so "Cushing's disease" is now more commonly known as hyperadrenocorticism, at least by those who can pronounce it. The condition is particularly common in dogs, particularly as the animals grow older. Most cases result from a tumor in the pituitary gland but some ...

This news release is available in German. To write this little piece of text, the brain sends commands to arms and fingers to tap on the keyboard. Neuronal cells with their cable-like extensions, such as axons, transfer this information as electrical pulses that trigger muscles to move. The axonal signal speed can be to up to 100m/s in myelinated axons along the spinal cord. For a long time, scientists assumed that axonal signal conduction is by and large digital: either there is a signal, "1", or there is no signal, "0". Strong propagation speed variations Now, ...

Depth cameras and other motion-tracking devices allow people to use natural gestures to play computer games, yet the experience remains unnatural because they can't feel what their eyes can see. Disney Research, Pittsburgh, has developed a solution, however, that could enhance not only games, but a variety of virtual experiences. Called AIREAL, the new technology uses controlled puffs of compressed air – something akin to smoke rings – to create the impression of a ball bouncing off a hand, of an arm tingling from the flutter of a butterfly's wings, or of the rippling ...

Investigators at Disney Research, Zürich have developed a method for using hundreds of photographic images to build 3D computer models of complex, real-life scenes that meet the increasing demands of today's movie, TV and game producers for high-resolution imagery. Building 3D models from multiple 2D images captured from a variety of viewing positions is nothing new, but doing so for highly detailed or cluttered environments at high resolution has proved difficult because of the large amounts of data involved. The Disney Research, Zürich team, however, developed an algorithm ...

This news release is available in German. For a car to accelerate there has to be friction between the tire and the surface of the road. The amount of friction generated depends on numerous factors, including the minute intermolecular forces acting between the two surfaces in contact – so-called van der Waals forces. The importance of these intermolecular interactions in generating friction has long been known, but has now been demonstrated experimentally for the first time by a research team led by Physics Professor Karin Jacobs from Saarland University and Professor ...

During heat waves -- when ozone production rises -- plants' ozone absorption is curtailed, leaving more pollution in the air, and costing an estimated 460 lives in the UK in the hot summer of 2006. Vegetation plays a crucial role in reducing air pollution, but new research by the Stockholm Environment Institute (SEI) at the University of York shows that they may not protect us when we need it most: during extreme heat, when ozone formation from traffic fumes, industrial processes and other sources is at its worst. The reason, explained lead author Dr Lisa Emberson, is ...

Researchers at the University of Warwick have recovered tuberculosis (TB) genomes from the lung tissue of a 215-year old mummy using a technique known as metagenomics. The team, led by Professor Mark Pallen, Professor of Microbial Genomics at Warwick Medical School, working with Helen Donoghue at University College London and collaborators in Birmingham and Budapest, sought to use the technique to identify TB DNA in a historical specimen. The term 'metagenomics' is used to describe the open-ended sequencing of DNA from samples without the need for culture or target-specific ...

HEIDELBERG, 19 July 2013 – Scientists have identified higher levels of a receptor protein found on the surface of human breast tumour cells that may serve as a new drug target for the treatment of breast cancer. The results, which are published today in EMBO Molecular Medicine, show that elevated levels of the protein Ret, which is short for "Rearranged during transfection", are associated with a lower likelihood of survival for breast cancer patients in the years following surgery to remove tumours and cancerous tissue. "Our findings suggest that Ret kinase might be an ...

Boston—If you were working on something at your computer and a gorilla floated across your computer screen, would you notice it? You would like to think yes, however, research shows that people often miss such events when engaged in a difficult task. This is a phenomenon known as inattentional blindness (IB). In a new study from Brigham and Women's Hospital (BWH) in Boston, researchers have found that even expert searchers, operating in their domain of expertise, are vulnerable to inattentional blindness. This study published this week Psychological Science. "When engaged ...

TORONTO, ON, July 19, 2013 — Kidney patients who take calcium supplements to lower their phosphorous levels may be at a 22 per cent higher risk of death than those who take other non-calcium based treatments, according to a new study by Women's College Hospital's Dr. Sophie Jamal. The study, published today in the Lancet, calls into question the long-time practice of prescribing calcium to lower phosphate levels in patients with chronic kidney disease. The researchers suggest some of the calcium is absorbed into the blood stream and may expedite hardening of the arteries, ...

Achieving a desired motion in an animated physical character, whether it be a small toy or a full-sized figure, demands highly specialized engineering skills. But research teams at Disney Research have created a pair of software packages that can open the design process to people with a broader spectrum of skills and provide more creative choices. One set of software tools can take a drawing of an articulated character and produce a type of animation that pre-dates video and film – gear-driven mechanical characters, such as a dancing clock, a galloping horse or a Sisyphean ...

Providing a "second screen" experience for audiences at movie theaters, stadiums and other public venues need not require a special wireless infrastructure. Instead, a system developed by Disney Research, Zürich, uses the venue's regular sound system to transmit text, games or other information to smartphones using only an audio signal. The smartphones carried by many audience members provide not only a means for viewing content that supplements a movie or sporting event, but comprise an ad hoc microphone network that helps transmit the content among all of the participants ...