Adhering to a Mediterranean-type diet (MedDi) does not appear associated with the time to clinical onset of Huntington disease (phenoconversion), according to a study by Karen Marder, M.D., M.P.H., of Columbia University College of Physicians and Surgeons, New York, N.Y., and colleagues. The Mediterranean diet, a diet high in plant foods (e.g. fruits, nuts, legumes, and cereals) and fish, with olive oil as the primary source of monounsaturated fat (MUSF) and low to moderate intake of wine, as well as low intake of red meat, poultry, and dairy products, is known to be ...

LOS ANGELES — The common refrain about health care is that it's a broken system. A new joint program between the University of California, Los Angeles (UCLA) and the University of Southern California (USC), demonstrates a way to mend the system with a new patient-centered program that is getting raves from patients, as well as the residents and nurses who provide their care. Results from the program are highlighted in a study being released in September. The program, Galaxy Health, debuted at Los Angeles County + USC Medical Center (LAC+USC) in 2012 with a goal of substantially ...

With new insights into the classical game theory match-up known as the "Prisoner's Dilemma," University of Pennsylvania biologists offer a mathematically based explanation for why cooperation and generosity have evolved in nature. Their work builds upon the seminal findings of economist John Nash, who advanced the field of game theory in the 1950s, as well as those of computational biologist William Press and physicist-mathematician Freeman Dyson, who last year identified a new class of strategies for succeeding in the Prisoner's Dilemma. Postdoctoral researcher Alexander ...

Scientists have uncovered strong evidence that soot, or black carbon, sent into the air by a rapidly industrializing Europe, likely caused the abrupt retreat of mountain glaciers in the European Alps. The research, published Sept. 2 in the Proceedings of the National Academy of Sciences, may help resolve a longstanding scientific debate about why the Alps glaciers retreated beginning in the 1860s, decades before global temperatures started rising again. Thomas Painter, a snow and ice scientist at NASA's Jet Propulsion Laboratory in Pasadena, Calif., is lead author of ...

MANHATTAN, KAN. -- A collaborative project involving a Kansas State University ecologist has shown that the Clean Air Act has helped forest systems recover from decades of sulfur pollution and acid rain. The research team -- which included Jesse Nippert, associate professor of biology -- spent four years studying centuries-old eastern red cedar trees, or Juniperus virginiana, in the Central Appalachian Mountains of West Virginia. The region is downwind of the Ohio River Valley coal power plants and experienced high amounts of acidic pollution -- caused by sulfur dioxide ...

Scientists estimate that there is a minimum of 320,000 viruses in mammals awaiting discovery. Collecting evidence of these viruses, or even a majority of them, they say, could provide information critical to early detection and mitigation of disease outbreaks in humans. This undertaking would cost approximately $6.3 billion, or $1.4 billion if limited to 85% of total viral diversity -- a fraction of the economic impact of a major pandemic like SARS. Close to 70% of emerging viral diseases such as HIV/AIDS, West Nile, Ebola, SARS, and influenza, are zoonoses -- infections ...

NEW YORK – September 3, 2013 – EcoHealth Alliance, a nonprofit organization that focuses on local conservation and global health issues, and the Center for Infection and Immunity (CII) at Columbia University's Mailman School of Public Health announced a new strategy to identify the total number of wildlife viruses that could potentially cause emerging disease outbreaks that threaten both public and wildlife health. Combining field investigations with a new statistical approach, scientists estimate that there may exist a minimum of 320,000 viruses awaiting discovery from ...

Researchers from major universities in the U.S. have developed specific tests to identify cancer biomarkers in patients with dermatomyositis—a systemic inflammatory disease associated with increased risk of malignancy. According to study findings published in the American College of Rheumatology (ACR) journal, Arthritis & Rheumatism, the assays detect antibodies against anti-transcriptional intermediary factor-1 (TIF-1γ) and nuclear matrix protein NXP-2. Patients with dermatomyositis experience muscle weakness, skin inflammation, and sometimes inflammation of the ...

Consistently uniform, easily manufactured microcapsules containing a brain cancer drug may simplify treatment and provide more tightly controlled therapy, according to Penn State researchers. "Brain tumors are one of the world's deadliest diseases," said Mohammad Reza Abidian, assistant professor of bioengineering, chemical engineering and materials science and engineering. "Typically doctors resect the tumors, do radiation therapy and then chemotherapy." The majority of chemotherapy is done intravenously, but, because the drugs are very toxic and are not targeted, ...

ARLINGTON HEIGHTS, ILL. -- Asthma is a disease that mostly affects young boys and adult women. And according to a new study, women in their 40s and 50s with asthma are hospitalized more than twice as often as men in the same age group. The 10-year study is published in the September issue of Annals of Allergy, Asthma & Immunology, the scientific journal of the American College of Allergy, Asthma and Immunology (ACAAI). "Until puberty, boys have higher rates of asthma than girls," said Robert Yao-wen Lin, MD, allergist and lead study author. "Then, during the menopausal ...

LOS ANGELES — Teenagers who see friends smoking and drinking alcohol in photographs posted on Facebook and Myspace are more likely to smoke and drink themselves, according to a new study from the University of Southern California (USC). "Our study shows that adolescents can be influenced by their friends' online pictures to smoke or drink alcohol," said Thomas W. Valente, Ph.D., professor of preventive medicine at the Keck School of Medicine of USC and the study's principal investigator. "To our knowledge, this is the first study to apply social network analysis methods ...

Amsterdam, The Netherlands – Tuesday 3 September 2013: Low BMI is a risk factor for CVD in hypertensive patients with diabetes, according to research presented at the ESC Congress today by Dr Takanori Nagahiro from Japan. The findings provide evidence for an obesity paradox in hypertensive patients with glucose intolerance. Dr Nagahiro said: "Obesity is a risk factor for cardiovascular disease (CVD) but several studies have reported that low body mass index (BMI, kg/m2) was associated with worse cardiovascular outcome compared to middle or higher BMI. This strange phenomenon ...

What do lotus flowers, soap bubbles, and aerated chocolate have in common? They may seem innocuous, even pleasant, but each of these items is a trigger for people who report suffering from trypophobia, or the fear of holes. For trypophobes, the sight of clusters of holes in various formations can cause intensely unpleasant visceral reactions. New research from psychological scientists Geoff Cole and Arnold Wilkins of the University of Essex suggests that trypophobia may occur as a result of a specific visual feature also found among various poisonous animals. The findings ...

Chevy Chase, MD—Researchers have developed the first animal model simulating the eye complications associated with the thyroid condition Graves' disease, a breakthrough that could pave the way for better treatments, according to a recent study accepted for publication in The Endocrine Society's journal Endocrinology. Graves' disease is an autoimmune disorder that causes the body to produce antibodies that attack the thyroid gland. The condition causes the thyroid gland to become overactive and produce too much thyroid hormone. If left untreated, it can lead to heart failure ...

CAMBRIDGE, Mass. (September 3, 2013) – Unlike humans, planarian flatworms have the remarkable ability to regrow any missing body part, making them an ideal model with which to study the molecular basis of regeneration. Over the years scientists have learned that planarians mount recovery responses that differ depending on the severity of the injury they suffer. For example, a worm with a cut or a puncture wound reacts at the cellular and molecular levels quite differently from one that loses its head or tail. What has remained unclear, however, is just exactly how these ...

AMSTERDAM, The Netherlands – French participants in the Tour de France between 1947-2012 lived longer than their same-age French counterparts according to the results of a study marking the centenary of the race this year. "In the context of recent concerns regarding performance-enhancing techniques and the potential negative health effects of excessive high-level physical activity, data on the long-term outcomes and causes of death in elite endurance cyclists is of particular interest," said Xavier Jouven, MD, PhD, from the Sudden Death Expertise Center in Paris, France. "Although ...

AMSTERDAM, The Netherlands – An emergency department strategy that uses two biomarkers to triage patients with suspected acute coronary syndrome (ACS) can increase the rate of early, safe hospital discharge, according to results of the Biomarkers in Cardiology 8 (BIC-8) trial. "This biomarker strategy using a state-of-the-art quantitative troponin assay in combination with an ultrasensitive copeptin assay has the potential to change clinical practice with high patient safety," said lead investigator Martin Möckel, MD, PhD, from Charité - Universitätsmedizin Berlin, in ...

AMSTERDAM, The Netherlands – Omecamtiv mecarbil, a cardiac myosin-activator, did not achieve its primary efficacy endpoint in reducing dyspnoea (shortness of breath) in patients with acute heart failure, according to the results of the phase II ATOMIC-AHF (Acute Treatment with Omecamtiv Mecarbil to Increase Contractility in Acute Heart Failure) study. However, a cohort which received the highest dose of the drug showed greater dyspnoea relief compared with placebo, and there were also other favourable dose and concentration-related trends, noted lead investigator John ...

AMSTERDAM, The Netherlands – The blood pressure lowering drug aliskiren did not improve coronary artery disease when given to patients who had prehypertension, results of the Aliskiren Quantitative Atherosclerosis Regression Intravascular Ultrasound Study (AQUARIUS) reveal. The findings, reported at the European Society of Cardiology Congress with simultaneous publication in the Journal of the American Medical Association, offer new insight into the value of lowering blood pressure beyond prehypertensive goals, suggested lead investigator Stephen Nicholls MBBS, PhD, Deputy ...

Use of bioprosthetic heart valves has dramatically increased (from 18% in 1991 to 59% in 2003), mainly in older patients with comorbidities. This is due to the increased risk of bleeding complications associated with lifelong use of anticoagulation for mechanical prostheses. But structural valve deterioration is one the main complications associated with bioprosthetic heart valves. In large registries including more than 300 000 patients undergoing aortic valve replacement the reoperation rate for patients receiving a bioprosthesis was 3.1% at 11-13 years of follow-up ...

Dr Sherif said: "Earlier studies on the impact of gender on outcome after transcatheter aortic valve implantation (TAVI) have had conflicting results. A Canadian study reported in 641 consecutive patients that female sex is associated with a better long-term and short-term survival after TAVI.1 An Italian study of 305 high risk patients found no gender differences in composite safety and efficacy endpoints at 30 days and one year after TAVI."2 The current analysis examined gender differences in outcomes for 1432 consecutive patients from 27 centers who were enrolled in ...

Bicuspid aortic valve (BV) is the most common congenital valvular abnormality, occurring in 1-2% of the general population. Two of the aortic valvular leaflets fuse during development resulting in a valve that is bicuspid instead of the normal tricuspid configuration. BV is associated with increased mechanical stress which predisposes to calcification and development of aortic stenosis which narrows the opening of the aortic valve. Dr Bauer said: "TAVI is used to treat elderly high risk patients with severe aortic stenosis. Despite previous assumptions the frequency of ...

Measures taken in developed countries to reduce noncommunicable diseases – the leading causes of death globally – have improved the life expectancy of women aged 50 years and older over the last 20 to 30 years. But, according to a study that will be published in the Bulletin of the World Health Organization on 2 September, the gap in life expectancy between such women in rich and poor countries is growing. The WHO study, one of a collection of articles in a special issue of the journal devoted to women's health beyond reproduction, found that the leading causes of death ...

Helicobacter pylori is a bacterium that establishes a life-long stomach infection in humans, which in some cases can lead to duodenal ulcers or stomach cancer. New research, presented at this week's Society for General Microbiology Autumn Conference, gives us a clearer understanding of how these bacteria can manipulate the human immune system to survive in the mucosal lining of the stomach. Researchers from the University of Nottingham have shown that H. pylori is able to supress the body's normal production of 'human beta defensin 1' (hβD1), an antimicrobial factor ...

OKLAHOMA CITY, September 1, 2013 — A new finding could lead to novel treatments to reduce bleeding in trauma and severe infections. The research, from Oklahoma Medical Research Foundation scientists Lijun Xia, M.D., Ph.D., Jianxin Fu, M.D., Ph.D., and Brett Herzog, Ph.D., appears in the most recent issue of the journal Nature. One way the immune system keeps a body healthy is through immune surveillance. Lymphocytes, a type of white blood cell, constantly exit the bloodstream and "check in" at the lymph nodes to learn about possible pathogens or abnormal cell growth. ...