An international team of researchers – led by principal investigator Paul S. Mischel, MD, a member of the Ludwig Institute for Cancer Research and professor in the Department of Pathology at the University of California, San Diego School of Medicine – has found that a singular gene mutation helps brain cancer cells to not just survive, but grow tumors rapidly by altering the splicing of genes that control cellular metabolism. The findings are published online in the journal Cell Metabolism. Mischel, who heads the Ludwig Institute's molecular pathology laboratory based ...

Researchers at the University of Georgia, Athens, have identified a strong link between the prevalence and load of certain food-borne pathogens on poultry farms, and later downstream at the processing plant. They report their findings in a manuscript published ahead of print in the journal Applied and Environmental Microbiology. "This study suggests that reducing foodborne pathogen loads on broiler chicken farms would help to reduce pathogen loads at processing, and may ultimately help to reduce the risk of foodborne illness," says Roy Berghaus, an author on the study. ...

A major question in ecology has centered on the role of microbes in regulating ecosystem function. Now, in research published ahead of print in the journal Applied and Environmental Microbiology, Brajesh Singh of the University of Western Sydney, Australia, and collaborators show how changes in the populations of methanotrophic bacteria can have consequences for methane mitigation at ecosystem levels. "Ecological theories developed for macro-ecology can explain the microbial regulation of the methane cycle," says Singh. In the study, as grasslands, bogs, and moors ...

Philadelphia, PA—Recurrent infection is a common feature of persistent viral diseases. It includes episodes of high viral production interspersed by periods of relative quiescence. These quiescent or silent stages are hard to study with experimental models. Mathematical analysis can help fill in the gaps. In a paper titled Conditions for Transient Viremia in Deterministic in-Host Models: Viral Blips Need No Exogenous Trigger, published last month in the SIAM Journal on Applied Mathematics, authors Wenjing Zhang, Lindi M. Wahl, and Pei Yu present a model to study persistent ...

Philadelphia, PA—The first few hours to days following exposure to human immunodeficiency virus (HIV) can be of critical importance in determining if infection occurs in a patient. But the low numbers of viruses and infected cells at this stage makes it very difficult to study these events in humans or animal models. Theoretical mathematical models can help analyze viral dynamics in this early phase, and hence offer insights into therapeutic and prevention strategies, as evidenced by a paper published last month in the SIAM Journal on Applied Mathematics. In a paper ...

The Moderate Resolution Imaging Spectroradiometer (MODIS) on NASA's Aqua satellite detected dozens of fires burning in western Mexico on May 30, 2013. The fires are outlined in red. The location, widespread nature, and number of fires suggest that these fires were deliberately set to manage land. Farmers often use fire to return nutrients to the soil and to clear the ground of unwanted plants. While fire helps enhance crops and grasses for pasture, the fires also produce smoke that degrades air quality. Although the smoke hits hardest right around the area being burned, ...

Food insecurity increases the risk of death among injection drug users living with HIV/AIDS even when they are receiving life-prolonging antiretroviral therapy (ART), according to a new study involving Simon Fraser University. The study, recently published in the peer-reviewed science journal, PLoS One, examines the impact of food insecurity and hunger on survival among injection drug users. Food insecurity is defined by the United Nations' World Food Programme as having insufficient access to adequate quantity and quality of food. Researchers found that drug users who ...

Orange, Calif., May 31, 2013 — Any breast cancer surgeon who regularly performs lumpectomies confronts the question "Did I get it all?" Thirty to 60 percent of the time in the U.S., the answer is "no," requiring the patient to undergo a second surgery to remove the remaining tumor. Surgeons at UC Irvine Medical Center are the first in the country to use a device that reduces by half the need to reoperate and cut out breast cancer cells missed during an initial lumpectomy. The MarginProbe System lets the surgeon immediately assess whether cancer cells remain on the margins ...

NEW YORK — With so much on the line for job seekers in this difficult economic climate, a lot of new hires might be wondering how — or whether at all — to negotiate salary when offered a new position. A recently published study on the art of negotiation by two professors at Columbia Business School could help these new hires — and all negotiators — seal a stronger deal than before. Research conducted by Professors Malia Mason and Daniel Ames and doctoral students Alice Lee and Elizabeth Wiley finds that asking for a specific and precise dollar amount versus a rounded-off ...

VIDEO: NOAA's GOES-14 satellite captured Hurricane Barbara's landfall in southwestern Mexico and movement across land, northward toward the Gulf of Mexico. This 43 second animation of NOAA's GOES-14 satellite observations from... Click here for more information. NOAA's GOES-14 satellite captured Hurricane Barbara's landfall in southwestern Mexico and movement across land, northward toward the Gulf of Mexico. This 43 second animation of NOAA's GOES-14 satellite observations ...

COLUMBUS, Ohio – A virus that infects most Americans but that usually remains dormant in the body might speed the progression of an aggressive form of brain cancer when particular genes are shut off in tumor cells, new research shows. The animal study by researchers at the Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) and at Dana Farber Cancer Institute suggests that cytomegalovirus (CMV) might significantly accelerate the development and progression of glioblastoma, a deadly ...

CHICAGO, IL — Many glioblastoma patients treated with bevacizumab (Avastin®) have significant deterioration in neurocognitive function, symptoms and quality of life. Not only that, the changes often predict treatment outcomes, according to new research from The University of Texas MD Anderson Cancer Center. The findings from the large national multi-center Phase III trial, RTOG 0825, were presented today at the annual meeting of the American Society of Clinical Oncology. Glioblastoma is the most frequent and aggressive type of brain tumor. Despite slight gains, tumors ...

The American Thoracic Society has released new clinical practice guidelines on sleep apnea, sleepiness, and driving risk on non-commercial drivers. The new guidelines, which are an update of a 1994 ATS statement on this topic, appear in the June 1, 2013 American Journal of Respiratory and Critical Care Medicine. "Up to 20 percent of crashes that occur on monotonous roads can be attributed to sleepiness, and the most common medical cause of excessive daytime sleepiness is obstructive sleep apnea (OSA)," said Kingman P. Strohl, MD, program director, sleep medicine, University ...

Madison, Wis. — Genetically engineered immune cells seem to promote healing in mice infected with a neurological disease similar to multiple sclerosis (MS), cleaning up lesions and allowing the mice to regain use of their legs and tails. The new finding, by a team of University of Wisconsin School of Medicine and Public Health researchers, suggests that immune cells could be engineered to create a new type of treatment for people with MS. Currently, there are few good medications for MS, an autoimmune inflammatory disease that affects some 400,000 people in the United ...

In March of this year, Australian-based business, JumpHigher Science (JHS), launched what is predicted as the start of a new generation in high performance training systems, and specifically, vertical jump training systems. It seems as though the days for a "one size fits all" approach to online, goal-specific programs are gone. Now, companies like JumpHigher Science are recognising the need to provide options for their clients to make it easier to train, wherever and whenever. The highlight of the program is a 12-week program that anyone can undertake, regardless ...

Soft4Boost releases a new skinable audio program - Soft4Boost Ringtone Creator. The program offers a multilingual interface that is available in English, French, Russian, Hungarian, German, Spanish, and Italian. Soft4Boost today announced the launch of own Ringtone Creator, a software program which helps users quickly create a new ringtone. Whatever it is: a song, a piece of music, a speech in a movie, or a fun clip, a funny sound, or even a human voice or any audio file, all can be used to create a new and unique ringtone. With Soft4Boost Ringtone Creator, it only ...

Applicants must be able to demonstrate that they are able to financially care for the maintenance of the home. Additional information may be required from the candidate. Deed restrictions will apply. The candidate selected will participate in a ribbon cutting ceremony on June 25, 2013. How To Apply: http://www.bestgeorgiahomesearch.com/DownloadForms http://anothermartinimoment.com/2013/05/31/new-hud-inc-and-chase-bank ... u-qualify/ Submit BOTH your completed application and Letter of Explanation (1,000 words or less only) to Jackie Campbell at Keller Williams ...

MediPurpose, a manufacturer and master distributor of medical products, today published a case study that revealed additional findings from recent clinical evaluations of several MediPlus Advanced Wound Care product categories. In February, MediPurpose published A Case Study of Product Performance From Two Nursing Homes. The study demonstrated that MediPlus wound dressings performed at (or above) the same level as current products being used in nursing homes, and provided evidence of MediPlus' product efficacy. Using results from clinical studies at two South Carolina ...

A lot of lessons can be gleaned from the coverage of actress Angelina Jolie's announcement earlier this month that she underwent a preventive double mastectomy. One lesson women should focus on is that coordinated planning for her breast reconstruction began early on, says Harrisburg plastic surgeon Dr. John P. Stratis. "It's clear when you read Ms. Jolie's article and the blog post written by her doctor that there was early collaboration with the plastic surgeon," Stratis says. "It works out to everyone's advantage when both physicians work together." ...

New research is giving high marks to breast enlargement surgery, which is no surprise to Seattle plastic surgery specialist Dr. Wandra K. Miles. A study published in the May 2013 issue of Plastic and Reconstructive Surgery , the journal of the American Society of Plastic Surgeons (ASPS), evaluated breast augmentation results from patients' perspectives. The study followed one doctor's breast augmentation patients over 5 years, and found that of the 225 patients interviewed, 91.1% reported increased self-esteem after their surgery, and 64.3% reported improved quality ...

Ateam Inc., a leading mobile application developer, is excited to announce that their hit monster battle game Dark Summoner has surpassed the staggering 7 million download milestone! To show their appreciation to the millions of fans who made this achievement possible, Ateam Inc. is holding a 7 Million Download Anniversary Campaign! New Emporium feature added! Special event held to mark the occasion! As a follow up to the recently added Relica feature, a new Emporium system has been added to the game as well. Players collect Jewels through various methods such ...

Concurrency consultant and Microsoft MVP Annur Sumar is presenting in three separate sessions at Microsoft's 2013 TechEd North America conference, taking place next week in New Orleans. Sumar will share lessons learned from the field, including Concurrency's enterprise-scale implementations of Microsoft System Center and Windows Azure solutions. Sumar is a three-time Microsoft Most Valuable Professional. In 2013 he received the "Cluster MVP" Award, which is presented by Microsoft in recognition of deep expertise and knowledge-sharing. Sumar's presentations ...

Dr. Jeffrey Rubino, Hagerstown dentist has recently announced the launch of his practice's Facebook, Twitter and blog. The practice's new presence on these leading social media platforms has enabled the practice to communicate with existing and prospective patients more effectively and efficiently. Patients can now read Dr. Rubino's blog for informal dental information on Hagerstown dental implants or become a "fan" or "friend" of the practice's Facebook and Twitter pages for updates on office happenings. To access and join Dr. Rubino's social network, ...

Dr. Ruth Morgan, Canton dentist, is excited to announce that her practice is offering a mobile version of her comprehensive dental website. The mobile site is optimized for use on smartphone and tablet devices. "More and more people today are accessing the internet with their smartphones or tablets. I believe it is important to have an easy to use mobile site to be able to reach all of these patients. I hope all of our patients will take the time to check out our new mobile site," said Dr. Morgan, Canton, MS dentist. Because of mobile devices' limited ...

Dr. Osmani Diaz, dentist in Pembroke Pines, is providing special services on his website that are designed to make it easy for new patients to learn about and find his practice. "I am glad that our practice is able to provide services for new patients. I believe we offer a great level of service at our practice and any new patients will quickly become regular patients. I look forward to treating any new patients that decide to come in to our practice," said Dr. Diaz, Pembroke Pines dentist. There will soon be downloadable forms on Dr. Diaz's website that ...