Professor of Biochemistry Emad Tajkhorshid and colleagues have discovered that membrane transporters help not just sugars and other specific substrates cross from one side of a cellular membrane to the other—water also comes along for the ride. There are two main ways that molecules can cross a membrane. In passive transport, molecules are able to pass through a membrane protein called a channel (which provides a wide open pathway) to get from the high concentration side to low concentration side of the membrane. This requires no energy as the molecule flows easily down ...

The ductal carcinoma in situ (DCIS) Score quantifies the risk of ipsilateral breast event (IBE) and invasive IBE risk, complements both traditional clinical and pathologic factors, and helps provide a new clinical tool to improve the process of selecting individualized treatment for women with DCIS who meet the criteria, according to a study published May 2 in the Journal of the National Cancer Institute. Most women with newly diagnosed cases of DCIS are eligible for breast conservation surgery, either with radiation treatment or without. The risk of developing IBE after ...

BETHESDA, MD, MAY 2, 2013—Progress in American scientific research and reform in American immigration law must go hand in hand, the American Society for Cell Biology (ASCB) declared today in a position paper that outlines four recommendations for modernizing U.S. immigration policy. "Despite having the best research and educational institutions in the world, existing US immigration laws serve as a significant hurdle for retaining the world's most promising scientists and for diversifying the US biomedical workforce and bioeconomy," the ASCB warned in a preface to its ...

Researchers have discovered the mechanism behind one of the Ebola virus' most dangerous attributes: its ability to disarm the adaptive immune system. University of Texas Medical Branch at Galveston scientists determined that Ebola short-circuits the immune system using proteins that work together to shut down cellular signaling related to interferon. Disruption of this activity, the researchers found, allows Ebola to prevent the full development of dendritic cells that would otherwise trigger an immune response to the virus. "Dendritic cells typically undergo a process ...

A team of researchers led by a Boston University Biomedical Engineer has developed a new joint lubricant that could bring longer lasting relief to millions of osteoarthritis sufferers. The new synthetic polymer supplements synovial fluid, the natural lubricant in joints, and works better than comparable treatments currently available. According to Boston University Professor of Biomedical Engineering Mark W. Grinstaff, the best fluid supplement now available offers temporary symptom relief but provides inadequate lubrication to prevent further degradation of the cartilage ...

For tens of thousands of years, humans ran on bare feet. Then we developed an assortment of specialized shoes, including – particularly since the 1960s – a seemingly limitless variety of running shoes. Despite the perceived advantages of foot protection, some runners in recent years have returned to barefoot running, believing it is a more natural way to run and therefore less injurious to the feet and legs. As a result, several shoe manufacturers have produced specialized "minimalist" shoes to accommodate this, such as the Vibram FiveFingers shoes. Such shoes allow a ...

VIDEO: This video is a TRMM flyby of Tropical Cyclone Zane in May 2013. Click here for more information. NASA's Tropical Rainfall Measuring Mission or TRMM satellite passed over Cyclone Zane as it was approaching Queensland Australia's Cape York Peninsula and measured rainfall rates within the storm. TRMM data showed a disorganized storm with the strongest rain falling northwest of the center. Cyclone Zane, as of 12:00 UTC (10:00 p.m. Australian Eastern Standard Time or ...

MINNEAPOLIS/ST. PAUL (MAY 2, 2013) – New research out of the Lillehei Heart Institute at the University of Minnesota shows that by turning on just a single gene, Mesp1, different cell types including the heart, blood and muscle can be created from stem cells. The study was published today in the journal Cell Stem Cell. "Previous research indicated that this gene was the "master regulator" for development of the heart, and that its activity prevented the differentiation of other cell types," said Michael Kyba, Ph.D., associate professor in the University of Minnesota ...

Boulder, Colo., USA – New Geology papers cover ancient iron oceans; the Antarctic and global climate/carbon-cycle feedbacks; evidence of catastrophic spillover from kilometer-deep bodies of water on Mars; the role of volcanic emissions in ozone depletion; "fingerprinting" San Andreas fault sandstone; a climax in Earth's mountain-building cycle; the last place on land undergoing continental breakup; garnet as a proxy for subduction zone dehydration; and evidence of migrating mammals at the Venta del Moro fossil site, Spain. Highlights are provided below. Geology articles ...

Scientists from the Smithsonian and the University of Rhode Island have found unsuspected linkages between the oxidation state of iron in volcanic rocks and variations in the chemistry of the deep Earth. Not only do the trends run counter to predictions from recent decades of study, they belie a role for carbon circulating in the deep Earth. The team's research was published May 2 in Science Express. Elizabeth Cottrell, lead author and research geologist at the Smithsonian's National Museum of Natural History, and Katherine Kelley at the University of Rhode Island's Graduate ...

A common cancer pathway causing tumor growth is now being targeted by a number of new cancer drugs and shows promising results. A team of researchers at Case Western Reserve University School of Medicine have developed a novel method to disrupt this growth signaling pathway, with findings that suggest a new treatment for breast, colon, melanoma and other cancers. The research team has pinpointed the cancer abnormality to a mutation in a gene called PIK3CA that results in a mutant protein, which may be an early cancer switch. By disrupting the mutated signaling pathway, ...

The tick-borne Lone Star virus has been conclusively identified as part of a family of other tick-borne viruses called bunyaviruses, which often cause fever, respiratory problems and bleeding, according to new research led by scientists at UC San Francisco (UCSF). What made the work especially promising, said principal investigator Charles Chiu, MD, PhD, was the speed at which the virus was definitively identified. The team used a new approach to gene sequencing that enabled them to completely reconstruct the virus' previously unknown genome in less than 24 hours – significantly ...

The impact of fiscal cliff negotiations on Pennsylvania estate plans Article provided by Katherman, Heim & Perry Visit us at http://www.khpyork.com Estate planning is a complex legal process. One reason this area of law is so complex is the fact that laws surrounding it are constantly changing. Just this year, legal, tax and financial professionals were carefully watching how Congress would choose to handle the estate tax during the fiscal cliff negotiations. Congress' decision would impact estate plans throughout the nation. If Congressional leaders had ...

Second marriages can lead to estate planning challenges Article provided by Katherman, Heim & Perry Visit us at http://www.khpyork.com Those who find love a second time around can face a unique set of challenges when designing an estate plan. These issues can be particularly difficult if children are present from the first marriage. Some of these challenges include: -Who receives assets, the second spouse or children from the first marriage? -Who makes decisions if someone becomes incapacitated? -Are there ways to equalize the distribution of assets ...

Powerball winner owes thousands in child support payments Article provided by O'Connor and Ryan, P.C. Visit us at http://www.oconnorandryan.com A resident of New Jersey recently struck gold, winning $338 million in the Powerball lottery. Before lottery winnings are provided, officials often run a check on the winner for outstanding debts. In this case, the winner had a warrant out for delinquent child support payments. Pedro Quezada, a 44 year-old father of five children ranging in ages from 5 to 23, had a warrant issued in New Jersey for owing almost $30,000 ...

New law forces Arizona courts to hold first child custody hearing sooner Article provided by Hector A. Montoya Visit us at http://www.thetucsonlawyer.com/ Arizona recently passed into law a measure that will force family law judges to hold an initial hearing more quickly than is currently the case in some situations. After a parent's initial filing, a family judge must now hold the initial hearing within 60 days in most cases. Exceptions may occur if the filing party waives the 60 day requirement, a separate conference or court hearing has already established temporary ...

Even the giants fall: Bankruptcy can impact any business Article provided by The Lobel Firm, L.L.P. Visit us at http://www.thelobelfirm.com Businesses strive for success, but even some of the largest and most successful have faced financial difficulties. Companies like Macy's and Texaco have had to file for relief through bankruptcy in the past and another large company is now joining this group: Suntech Power. Wuxi Suntech, the main subsidiary of this solar power giant, recently filed for bankruptcy. The massive Chinese company, with a small factory in Arizona, ...

A Heggstad petition can save Californians time and money during probate Article provided by Law Offices of H. Michael Soroy Visit us at http://www.soroy.com Most Californians know that it is important to have a last will and testament and a durable power of attorney. Many also know that creating a trust can save heirs time and money after the death of a family member. The estate planning process can be very confusing and it may be advisable to have a revocable living trust. The main reason for placing one's property into the name of a trust is to avoid probate, ...

Lack of communication may play key role in misdiagnoses Article provided by Richard A. Shallcross & Associates, PLLC Visit us at http://www.shallcrosslaw.com Nobody wants to spend a long time at the doctor's office. Yet the quick in-and-out of a routine doctor's visit may play a role in misdiagnoses, a new study found. The study, published online in the Feb. 25 edition of JAMA Internal Medicine, found that eight in 10 misdiagnoses occurred partially due to problems occurring because of the lack of a communication between a doctor and patient or because of ...

Offshore tax compliance issues affecting more in the US Article provided by Law Office of Williams & Associates, P.C. Visit us at http://www.williamslawassociates.com/ As technology advances allow people to be more mobile and interconnected, in a global economy, many find themselves with assets in more than one country. This can create tax problems if people are not careful. The U.S. federal government has focused great attention on stopping U.S. taxpayers from using offshore accounts as a way to circumvent tax obligations. As a result, many taxpayers are finding ...

The Chester River Association is excited to announce the launch of their new website. The new site focuses on helping members learn about the Chester River and discover ways to protect this vital resource. The re-design features email sign-ups for membership and newsletters, interactive maps with information on the health of the river, and an events calendar for CRA activities. Learn More: http://www.chesterriverassociation.org/ "We are thrilled to launch our new website," said Heather Forsyth, Executive Director at the Chester River Association. "The ...

OSS is proud to offer a pet supply donation box at each of our locations for May and June. We encourage all staff, patients, and anyone in the community to stop by and donate pet food, new or gently used pet supplies, and toys for the Doney Memorial Pet Clinic. The Doney Memorial Pet Clinic is 100% volunteer run and donation funded. This local clinic provides veterinary care to the pets of homeless and other low income qualifying pet families. They also offer a pet food bank and have been offering pet care for over 25 years. Their mission in addition to helping pets ...

Marti Reeder of John L. Scott was named "Best Realtor" in the Kent Reporter's 2013 "Best of Kent" contest. This is the fifth time Reeder has received the award, having previously won in 2008, 2009, 2010 and 2012. Nominees for the honor were selected by Kent Reporter readers in the newspaper's annual contest. In addition to selecting their favorite realtor, readers chose their favorite Kent officials, volunteers, restaurants, shops and other businesses. The 2013 "Best Realtor" award comes on the heels of 2012 awards Reeder received for her ...

Starfish Enterprises Ltd. announce the signature of a marketing contract with The Northern Office Innovative Marketing (TNO). The contract signing took place on April 19, 2013. TNO, an independent sales and marketing consultancy, will assist in the re-launching of Starfish Enterprise's marketing of its unique water purification system. The Chairman and CEO of Starfish, Ian Cummins, stated: "We are delighted to announce our new partnership with John & his team at The Northern Office. We have been looking for a while at ways to improve our web presence and ...

David Schlocker, founder and president of DRS and Associates is proud to announce the addition of Mariakay Chakos as Senior Account Manager. Mariakay will serve a range of lighting and kitchen and bath clients for the boutique sized agency headquartered in Los Angeles, with satellite offices in New York and Boston. She will report directly to David Schlocker. For the past fifteen years, Mariakay has immersed herself in public relations. She previously worked as a Public Relations Consultant at PJs Sleep Company where she helped launch their new Ivy Organics organic mattresses ...