Researchers at Lund University in Sweden have discovered a new protein that controls the presence of the Vel blood group antigen on our red blood cells. The discovery makes it possible to use simple DNA testing to find blood donors for patients who lack the Vel antigen and need a blood transfusion. Because there has not previously been any simple way to find these rare donors, there is a global shortage of Vel-negative blood. The largest known accumulation of this type of blood donor is found in the Swedish county of Västerbotten, which exports Vel-negative blood all ...

Johns Hopkins scientists have found out how a gout-linked genetic mutation contributes to the disease: by causing a breakdown in a cellular pump that clears an acidic waste product from the bloodstream. By comparing this protein pump to a related protein involved in cystic fibrosis, the researchers also identified a compound that partially repairs the pump in laboratory tests. The mutation in question, known as Q141K, results from the simple exchange of one amino acid for another, but it prevents the protein ABCG2 from pumping uric acid waste out of the bloodstream and ...

Michael Woods m_woods@acs.org 504-670-4707 (New Orleans Press Center, April 5-10) 202-872-6293 American Chemical Society Communicating the science of the '6X°C egg' -- and much more NEW ORLEANS, April 7, 2013 — Why does the "65-degree egg" and its "6X°C" counterparts continue to entice chefs and diners at chic restaurants, when the science underpinning that supposed recipe for perfection in boiling an egg is flawed? It all boils down to the need for greater society-wide understanding of basic scientific concepts, an expert said here today at the 245th National ...

Michael Woods m_woods@acs.org 504-670-4707 (New Orleans Press Center, April 5-10) 202-872-6293 American Chemical Society Reducing waste of food: A key element in feeding billions more people NEW ORLEANS, April 7, 2013 — Families can be key players in a revolution needed to feed the world, and could save money by helping to cut food losses now occurring from field to fork to trash bin, an expert said here today. He described that often-invisible waste in food — 4 out of every 10 pounds produced in the United States alone — and the challenges of feeding a global ...

Contact: Michael Bernstein m_bernstein@acs.org 504-670-4707 (New Orleans Press Center, April 5-10) 202-872-6042 Michael Woods m_woods@acs.org 504-670-4707 (New Orleans Press Center, April 5-10) 202-872-6293 American Chemical Society Widely used filtering material adds arsenic to beers NEW ORLEANS, April 7, 2013 — The mystery of how arsenic levels in beer sold in Germany could be higher than in the water or other ingredients used to brew the beer has been solved, scientists announced here today at the 245th National Meeting & Exposition of the American Chemical ...

Michael Woods m_woods@acs.org 504-670-4707 (New Orleans Press Center, April 5-10) 202-872-6293 American Chemical Society Do cells in the blood, heart and lungs smell the food we eat? NEW ORLEANS, April 7, 2013 — In a discovery suggesting that odors may have a far more important role in life than previously believed, scientists have found that heart, blood, lung and other cells in the body have the same receptors for sensing odors that exist in the nose. It opens the door to questions about whether the heart, for instance, "smells" that fresh-brewed cup of coffee ...

Michael Woods m_woods@acs.org 504-670-4707 (New Orleans Press Center, April 5-10) 202-872-6293 American Chemical Society Microalgae produce more oil faster for energy, food or products NEW ORLEANS, April 7, 2013 — Scientists today described technology that accelerates microalgae's ability to produce many different types of renewable oils for fuels, chemicals, foods and personal-care products within days using standard industrial fermentation. The presentation was part of the 245th National Meeting & Exposition of the American Chemical Society (ACS), the world's ...

WASHINGTON, DC (April 7, 2013)—Women with HIV acquire cancer-causing forms of the human papillomavirus (HPV) that are not included in the current HPV vaccines Gardasil and Cervarix, according to new research from Fox Chase Cancer Center being presented at the AACR Annual Meeting 2013 on Sunday, April 7. "People with issues in their immune system such as HIV will be at risk of acquiring HPV, as well – and the current vaccine may not fully protect them," says study author Elizabeth Blackman, MPH, research specialist at Fox Chase. Women who had been taking HIV medications ...

WASHINGTON, DC (April 7, 2013)—Colorectal cancer is the second leading cause of cancer-related deaths in the United States. Once colorectal cancer has spread to other parts of the body, only 11 percent of patients will survive five years from the date of their diagnosis. Most colorectal cancers are adenocarcinomas—cancers that begin in cells that make and release mucus and other fluids. Adenocarcinomas begin as benign tumors called adenomas, which become malignant over time. By treating adenomas before they become cancerous, it could be possible to prevent colorectal cancer. Researchers ...

An international research team has identified seven new gene loci linked to obesity. Researchers were also able to show that the genetic mechanisms that cause extreme obesity are similar to those that cause milder forms of overweight and obesity. A total of more than 260,000 people were included in the study of the links between genes and obesity, which will be published in the latest issue of Nature Genetics. The aim of the study was to identify new genes that increase the risk of obesity, but also to compare genetic factors that cause extreme obesity with those that ...

A new study has found that pollution from fine particles in the air – mainly the result of burning coal or volcanic eruptions – can shade corals from sunlight and cool the surrounding water resulting in reduced growth rates. Although coral reefs grow under the sea it seems that they have been responding to changes in the concentration of particulate pollution in the atmosphere, according to a paper published this week in the journal Nature Geoscience by a team of climate scientists and coral ecologists from the UK, Australia and Panama. Corals are colonies of simple ...

ANN ARBOR—Researchers in the Life Sciences Institute at the University of Michigan have challenged a long-held belief that whitening of skeletal muscle in diabetes is harmful. In fact, the white muscle that increases with resistance training, age and diabetes helps keep blood sugar in check, the researchers showed. In addition, the insights from the molecular pathways involved in this phenomenon and identified in the study may point the way to potential drug targets for obesity and metabolic disease. "We wanted to figure out the relationship between muscle types ...

The global burden of dengue infection is more than triple current estimates from the World Health Organization, according to a multinational study published today in the journal 'Nature'. The research has created the first detailed and up-to-date map of dengue distribution worldwide, enabling researchers to estimate the total numbers of people affected by the virus globally, regionally and nationally. The findings will help to guide efforts in vaccine, drug and vector control strategies. The study was led by Professor Simon Hay, a Wellcome Trust Senior Research Fellow ...

A new separation process that depends on an easily-distinguished physical difference in adhesive forces among cells could help expand production of stem cells generated through cell reprogramming. By facilitating new research, the separation process could also lead to improvements in the reprogramming technique itself and help scientists model certain disease processes. The reprogramming technique allows a small percentage of cells – often taken from the skin or blood – to become human induced pluripotent stem cells (hiPSCs) capable of producing a wide range of other ...

In a ground-breaking study, researchers from the RIKEN Brain Science Institute in Japan report a new technique that allows them to visualize the distribution of retinoic acid in a live zebrafish embryo, in real-time. This technique enabled them to observe two concentration gradients going in opposing directions along the head-to-tail axis of the embryo, thus providing long-awaited evidence that retinoic acid is a morphogen. The report, published today in the journal Nature, puts an end to a long-standing debate around the presence of retinoic acid gradients across the ...

Researchers at the University of Calgary's Hotchkiss Brain Institute have discovered that stress circuits in the brain undergo profound learning early in life. Using a number of cutting edge approaches, including optogenetics, Jaideep Bains, PhD, and colleagues have shown stress circuits are capable of self-tuning following a single stress. These findings demonstrate that the brain uses stress experience during early life to prepare and optimize for subsequent challenges. The team was able to show the existence of unique time windows following brief stress challenges ...

Researchers have identified four genes newly associated with severe childhood obesity. They also found an increased burden of rare structural variations in severely obese children. The team found that structural variations can delete sections of DNA that help to maintain protein receptors known to be involved in the regulation of weight. These receptors are promising targets for the development of new drugs against obesity. As one of the major health issues affecting modern societies, obesity has increasingly received public attention. Genes, behavior and environment, ...

Researchers have uncovered the gene at the root of a human blood group that has remained a mystery for the past 60 years. They showed that a genetic deletion on this gene is responsible for the lack of this blood group in some people. With the discovery of the gene behind the Vel blood group, medical scientists can now develop a more reliable DNA test to identify people who lack this group. This will reduce the risk of severe, and sometimes life threatening, destruction of the Vel-positive donor red blood cells in patients with antibodies against Vel. The genetic basis ...

WASHINGTON, D.C. – Elevated levels of bilirubin in the blood get attention in the clinic because they often indicate that something has gone wrong with the liver. Now researchers have found that male smokers with low levels of the yellow-tinged chemical are at higher risk for lung cancer and dying from the disease. A team led by researchers at The University of Texas MD Anderson Cancer Center reported its findings in a late-breaking abstract at the AACR Annual Meeting 2013 in Washington, D.C. "Our study indicates male smokers with low levels of bilirubin are a high-risk ...

EMBARGOED UNTIL 1 P.M. EDT, APRIL 7, 2013, Cleveland: A compound abundant in red meat and added as a supplement to popular energy drinks has been found to promote atherosclerosis – or the hardening or clogging of the arteries – according to Cleveland Clinic research published online this week in the journal Nature Medicine. The study shows that bacteria living in the human digestive tract metabolize the compound carnitine, turning it into trimethylamine-N-oxide (TMAO), a metabolite the researchers previously linked in a 2011 study to the promotion of atherosclerosis ...

WASHINGTON–A novel combination of two drugs has shown anti-cancer activity in patients who had incurable solid tumors and carried a germline mutation in their BRCA genes, Dana-Farber Cancer Institute researchers are reporting at the American Association for Cancer Research annual meeting in Washington, April 6-10. The findings (abstract LB-202) will be released at a press conference on Sunday, April 7, 2 p.m. ET, and later at an oral presentation on Tuesday, April 9, 2 p.m. ET, in Room 153, in the Washington Convention Center. The two oral drugs, sapacitabine and seliciclib, ...

One of the most widely used medications to treat arrhythmias may increase the risk of developing cancer, especially in men and people exposed to high amounts of the drug. That is the conclusion of a new retrospective study published early online in CANCER, a peer-reviewed journal of the American Cancer Society. The study's results indicate that a potential link between amiodarone and cancer warrants further investigation. Amiodarone was approved in 1985 for the treatment of arrhythmias, or irregular heartbeats. Because the drug is fat-soluble and degrades very slowly, ...

Researchers from the UK determined that developmental delays are present in children within six weeks following convulsive status epilepticus (CSE)—a seizure lasting longer than thirty minutes. The study appearing today in Epilepsia, a journal published by Wiley on behalf of the International League Against Epilepsy (ILAE), suggests that neurodevelopmental impairments continue to be present one year after CSE. CSE is one of the most common neurological emergencies in children. These prolonged seizures can occur with or without fevers (febrile). Studies show that CSE ...

BLOOMINGTON, Ind. -- A new study found that higher levels of mercury exposure in young adults increased their risks for type 2 diabetes later in life by 65 percent. The study, led by Indiana University School of Public Health-Bloomington epidemiologist Ka He, is the first to establish the link between mercury and diabetes in humans. The study paints a complicated nutritional picture because the main source of mercury in humans comes from the consumption of fish and shellfish, nearly all of which contain traces of mercury. Fish and shellfish also contain lean protein ...

WINSTON-SALEM, N.C. – April 8, 2013 – Women often point to stress, hormones, alcohol, or even the weather as possible triggers for their migraines. But a new study from Wake Forest Baptist Medical Center found that it is nearly impossible for patients to determine the true cause of their migraine episodes without undergoing formal experiments. The majority of migraine sufferers try to figure out for themselves what causes their headaches based on real world conditions, said lead author Timothy T. Houle, Ph.D, associate professor of anesthesia and neurology at Wake Forest ...