Pathologists identify patterns of mutations to help inform design of future trials
2013-03-22
DENVER – Molecular driven therapeutic targets have resulted in a paradigm shift in the treatment of advanced lung adenocarcinoma. However, in early non-small cell lung cancer (NSCLC), surgical resection remains the treatment of choice with adjuvant chemotherapy. In a recent study published in the April 2013 issue of the International Association for the Study of Lung Cancer's (IASLC) Journal of Thoracic Oncology, researchers identified patterns of mutations in early stage node negative lung adenocarcinoma.
They retrospectively reviewed 204 patients with stage IB primary ...
Virginia Tech engineers explain physics of fluids some 100 years after original discovery
2013-03-22
Sunghwan Jung is a fan of the 19th Century born John William Strutt, 3rd, also known as Lord Baron Rayleigh. An English physicist, Rayleigh, along with William Ramsay, discovered the gas argon, an achievement for which he earned the Nobel Prize for Physics in 1904.
But it was Rayleigh's lesser-known discovery of a physical phenomenon in 1878 that was more intriguing to Jung. Some 135 years ago, Rayleigh wrote that two fluid jets or drops do not always merge into one body of liquid, a counter-intuitive topic or phenomena in physics that has since been studied in much detail, ...
Atherosclerosis: Specific microRNAs promote inflammation
2013-03-22
Atherosclerosis, an inflammatory reaction, is at the root of the most common forms of cardiovascular disease. Researchers at Ludwig-Maximilians-Universitaet (LMU) in Munich have now identified a microRNA that plays a prominent role in the process, and offers a promising target for new therapies.
Atherosclerosis – otherwise known as hardening of the arteries – is a prevalent cause of death in modern societies. The condition arises from the build-up of localized fatty deposits called plaques in the arteries. Macrophages, the phagocytic cells of the immune system, migrate ...
Modest changes in military dining facilities promoted healthier eating
2013-03-22
Philadelphia, PA, March 22, 2013 – The prevalence of obesity within the military is currently 13 percent. This rising epidemic, also rampant throughout the general population, could result in military career setbacks, negatively impact operational readiness, and jeopardize Department of Defense operations. To combat the epidemic, a team of researchers chose the military cafeteria as the venue to observe and evaluate eating behavior and the positive impact of modest changes to promote healthy eating and food selection. The results are captured in a new report published by ...
Invasive species: Understanding the threat before it's too late
2013-03-22
Catching rides on cargo ships and fishing boats, many invasive species are now covering our shorelines and compromising the existence of our native marine life.
In a study published in Ecology Letters, Northeastern University Prof. David Kimbro and his team examine what factors allow some invasive species to survive in their new environments and others to fail.
WHY SHOULD WE CARE?
Once invasive species arrive in their new location, they begin multiplying, and in some cases, overpowering the local marine life. This can have a very strong impact on our ecosystems and ...
Certain bacteria suppress production of toxic shock toxin: Probiotic potential looms
2013-03-22
Certain Streptococci increase their production of toxic shock syndrome toxin 1, sometimes to potentially dangerous levels, when aerobic bacteria are present in the vagina. But scientists from the University of Western Ontario have discovered certain strains of lactobacillus bacteria are capable of dampening production of that toxin according to research published in the journal Applied and Environmental Microbiology.
"The risk of potentially fatal toxic shock syndrome appears to be influenced by the types of bacteria present in the vagina," says principal investigator ...
Study shows resources giveaway in Latin America; Outdated model tramples human rights, environment
2013-03-22
Contact: Coimbra Sirica
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52-155-215-38038
Angélica Zambrano
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Burness Communications
Study shows resources giveaway in Latin America; Outdated model tramples human rights, environment
Researcher points to 'colonial mentality' as governments race to attract investors; Cites destruction of forests, rivers, way of life of rural communities in 4 nations
BOGOTÁ, COLOMBIA (21 March 2013)—A new study reveals that governments in Latin America have returned to natural resources extraction to fuel ...
Making axons branch and grow to help nerve regeneration after injury
2013-03-22
PHILADELPHIA (March 22, 2013)— One molecule makes nerve cells grow longer. Another one makes them grow branches. These new experimental manipulations have taken researchers a step closer to understanding how nerve cells are repaired at their farthest reaches after injury. The research was recently published in the Journal of Neuroscience.
"If you injure a peripheral nerve, it will spontaneously regenerate, but it goes very slowly. We're trying to speed that up," said Dr. Jeffery Twiss, a professor and head of the biology department at Drexel University in the College of ...
It all hinges on the bottom line
2013-03-22
This press release is available in French.
Montreal March 22, 2013 – Determining the financial health of a company is no easy task. But new research from Concordia University's John Molson School of Business, recently published in the Journal of Corporate Finance, demonstrates that a company that revises its previous financial statements is more likely to have been poorly governed.
"These restatements can result from a number of factors including accounting errors or omissions or fraud," explains the study's co-author, Lawrence Kryzanowski, professor and Ned Goodman ...
Computer simulations yield clues to how cells interact with surroundings
2013-03-22
Your cells are social butterflies. They constantly interact with their surroundings, taking in cues on when to divide and where to anchor themselves, among other critical tasks.
This networking is driven in part by proteins called integrin, which reside in a cell's outer plasma membrane. Their job is to convert mechanical forces from outside the cell into internal chemical signals that tell the cell what to do. That is, when they work properly. When they misfire, integrins can cause diseases such as atherosclerosis and several types of cancer.
Despite their importance—good ...
Huge and widespread volcanic eruptions triggered the end-Triassic extinction
2013-03-22
CAMBRIDGE, MA -- More than 200 million years ago, a massive extinction decimated 76 percent of marine and terrestrial species, marking the end of the Triassic period and the onset of the Jurassic. This devastating event cleared the way for dinosaurs to dominate Earth for the next 135 million years, taking over ecological niches formerly occupied by other marine and terrestrial species.
It's not entirely clear what caused the end-Triassic extinction, although most scientists agree on a likely scenario: Over a relatively short period of time, massive volcanic eruptions ...
Energy drinks may increase blood pressure, disturb heart rhythm
2013-03-22
Energy drinks may increase blood pressure and disturb your heart's natural rhythm, according to research presented at the American Heart Association's Epidemiology and Prevention/Nutrition, Physical Activity and Metabolism 2013 Scientific Sessions.
Researchers analyzed data from seven previously published observational and interventional studies to determine how consuming energy drinks might impact heart health.
In the first part of the pooled analysis, the researchers examined the QT interval of 93 people who had just consumed one to three cans of energy drinks. They ...
Eating too much salt led to 2.3 million heart-related deaths worldwide in 2010
2013-03-22
Eating too much salt contributed to 2.3 million deaths from heart attacks, strokes and other heart-related diseases throughout the world in 2010, representing 15 percent of all deaths due to these causes, according to research presented at the American Heart Association's Epidemiology and Prevention/Nutrition, Physical Activity and Metabolism 2013 Scientific Sessions.
The researchers analyzed 247 surveys of adult sodium intake, stratified by age, gender, region and country between 1990 and 2010 as part of the 2010 Global Burden of Diseases Study, an international collaborative ...
Most pre-packaged meals, snacks for toddlers contain too much salt
2013-03-22
Nearly 75 percent of commercial pre-packaged meals and savory snacks for toddlers are high in sodium, according to research presented at the American Heart Association's Epidemiology and Prevention/Nutrition, Physical Activity and Metabolism 2013 Scientific Sessions.
In the first study to look at the sodium content in U.S. baby and toddler foods, researchers compared the sodium content per serving of 1,115 products for babies and toddlers using data on major and private label brands compiled by the U.S. Centers for Disease Control (CDC). Baby food was categorized as intended ...
Poor kidney response to hormone may increase risks for kidney disease patients
2013-03-22
Highlights
Suboptimal kidney response to the hormone FGF-23 may put chronic kidney disease patients at increased risk of premature death and cardiovascular events.
Resistance to the hormonal actions of FGF-23 in the kidney may identify novel aspects of kidney dysfunction.
60 million people globally have chronic kidney disease.
Washington, DC (March 21, 2013) — The kidneys' response to a particular hormone may affect kidney disease patients' heart health and longevity, according to a study appearing in an upcoming issue of the Journal of the American Society ...
Healthy lifestyle linked with longer survival among kidney disease patients
2013-03-22
Highlights
Among individuals with chronic kidney disease, adherence to a healthy lifestyle was associated with a greater likelihood of surviving over a 13-year period.
The greatest survival benefits were related to nonsmoking.
60 million people globally have chronic kidney disease.
Washington, DC (March 21, 2013) — Certain lifestyle factors—such as not smoking, getting regular physical activity, and avoiding a low body weight—may help prolong the lives of individuals with chronic kidney disease (CKD), according to a study appearing in an upcoming issue of the ...
Education for kidney failure patients may improve chances living donor transplantation
2013-03-22
Highlights
In an analysis of 695 patients with kidney failure, Blacks had received less transplant education, were less knowledgeable about transplantation, and were less willing to pursue deceased or living donor transplantation than Whites.
Patients who began a transplant evaluation process with a greater knowledge of transplantation and greater motivation to receive living donor transplants were ultimately more successful at receiving a living donor transplant.
In 2010, a total of 28,662 kidney transplants took place in the U.S. Of those, only 6,809 were from ...
Technique could help designers predict how legged robots will move on granular surfaces
2013-03-22
VIDEO:
Using a combination of theory and experiment, Georgia Tech researchers have developed a new approach for understanding and predicting how small legged robots -- and potentially also animals -- move...
Click here for more information.
Using a combination of theory and experiment, researchers have developed a new approach for understanding and predicting how small legged robots – and potentially also animals – move on and interact with complex granular materials such ...
Stem cells use signal orientation to guide division, Stanford study shows
2013-03-22
STANFORD, Calif. — Cells in the body need to be acutely aware of their surroundings. A signal from one direction may cause a cell to react in a very different way than if it had come from another direction. Unfortunately for researchers, such vital directional cues are lost when cells are removed from their natural environment to grow in an artificial broth of nutrients and growth factors.
Now, researchers at the Stanford University School of Medicine and the Howard Hughes Medical Institute have devised a way to mimic in the laboratory the spatially oriented signaling ...
Study: Serious mental illness no barrier to weight loss success
2013-03-22
Through a program that teaches simple nutrition messages and involves both counseling and regular exercise classes, people with serious mental illness can make healthy behavioral changes and achieve significant weight loss, according to new Johns Hopkins research.
These weight loss amounts were similar to those in other successful programs studied with subjects in the general population — studies that specifically excluded people with serious mental illnesses, the researchers say.
Results of the new research, believed to be the first large study of its kind to involve ...
ASU Biodesign Institute scientists develop innovative twists to DNA nanotechnology
2013-03-22
VIDEO:
This is an 11-by-11 gridiron structure (11 vertical helices by 11 horizontal helices) with 21 base pairs (bp) between junctions in both directions uses 5301 of 7249 nucleotides
of the M13...
Click here for more information.
In a new discovery that represents a major step in solving a critical design challenge, Arizona State University Professor Hao Yan has led a research team to produce a wide variety of 2-D and 3-D structures that push the boundaries of the burgeoning ...
Road traffic pollution as serious as passive smoke in the development of childhood asthma
2013-03-22
New research conducted in 10 European cities has estimated that 14% of chronic childhood asthma is due to exposure to traffic pollution near busy roads.
The results are comparable to the burden associated with passive smoking: the World Health Organization estimates that between 4% and 18% of asthma cases in children are linked to passive smoking.
The findings, published online today (22 March 2013) ahead of print in the European Respiratory Journal, come as the European Commission has declared 2013 the 'Year of Air', which highlights the importance of clean air for ...
Acting out dreams linked to development of dementia, Mayo Clinic study finds
2013-03-22
SAN DIEGO — The strongest predictor of whether a man is developing dementia with Lewy bodies — the second most common form of dementia in the elderly — is whether he acts out his dreams while sleeping, Mayo Clinic researchers have discovered. Patients are five times more likely to have dementia with Lewy bodies if they experience a condition known as rapid eye movement (REM) sleep behavior disorder than if they have one of the risk factors now used to make a diagnosis, such as fluctuating cognition or hallucinations, the study found.
The findings were being presented ...
Megavolcanoes tied to pre-dinosaur mass extinction
2013-03-22
Scientists examining evidence across the world from New Jersey to North Africa say they have linked the abrupt disappearance of half of earth's species 200 million years ago to a precisely dated set of gigantic volcanic eruptions. The eruptions may have caused climate changes so sudden that many creatures were unable to adapt—possibly on a pace similar to that of human-influenced climate warming today. The extinction opened the way for dinosaurs to evolve and dominate the planet for the next 135 million years, before they, too, were wiped out in a later planetary cataclysm
...
'Evolutionary glitch' possible cause of childhood ear infections
2013-03-22
Researchers at King's College London have uncovered how the human ear is formed, giving clues as to why children are susceptible to infections such as glue ear. The work was funded by the UK Medical Research Council and published today in the journal Science.
It is estimated that one in five children around the age of two will be affected by glue ear, a build-up of fluid in the middle ear chamber. This part of the ear contains three tiny bones that carry sound vibrations from the eardrum to the inner ear. When fluid builds up in the chamber, this prevents the three ...
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