Treatment with a novel agent that inhibits the activity of SIRT2, an enzyme that regulates many important cellular functions, reduced neurological damage, slowed the loss of motor function and extended survival in two animal models of Huntington's disease. The study led by Massachusetts General Hospital (MGH) researchers will appear in the Dec. 27 issue of Cell Reports and is receiving advance online release. "I believe that the drug efficacy demonstrated in two distinct genetic HD mouse models is quite unique and highly encouraging," says Aleksey Kazantsev, PhD, of ...

Researchers have defined the gene responsible for a rare developmental disorder in children. The team showed that rare variation in a gene involved in brain development causes the disorder. This is the first time that this gene, UBE3B, has been linked to a disease. By using a combination of research in mice and sequencing the DNA of four patients with the disorder, the team showed that disruption of this gene causes symptoms including brain abnormalities and reduced growth, highlighting the power of mouse models for understanding the biology behind rare diseases. "Ubiquitination, ...

Economists and professionals praise the merits of competition, as it leads to lower prices and improvements in quality. But in the automobile smog-testing industry, competition can lead to corruption and even public health problems, according to research by USC Marshall School of Business Assistant Professor of Management Victor Bennett. Bennett, along with colleagues Lamar Pierce of Washington University's Olin School of Business, Jason Snyder at the UCLA Anderson School of Management and Michael W. Toffel of Harvard Business School, found that the structure of the smog-testing ...

PASADENA, Calif., Nov. 29, 2012 – Immunizing older adults with the tetanus-diphtheria-acellular-pertussis vaccine (Tdap) to prevent pertussis (more commonly referred to as whooping cough) was found to be as safe as immunizing them with the tetanus and diphtheria (Td) vaccine, according to a study by Kaiser Permanente published in the journal Clinical Infectious Diseases. Researchers examined the electronic health records of nearly 120,000 people ages 65 and older at seven U.S. health systems between Jan. 1, 2006 and Dec. 31, 2010. The study looked at a number of medical ...

Actuator saturation is ubiquitous in engineering systems. Anti-windup approach to dealing with actuator saturation has been receiving considerable attention from both the industry and the academic community during the past decades. Professor Zongli Lin and his student Xiongjun Wu developed a new anti-windup design paradigm that is capable of achieving significantly improved performances of the resulting closed-loop system. Their work, entitled "Design of multiple anti-windup loops for multiple activations," was published in SCIENCE CHINA Information Sciences, 55(9), 2012. ...

The detection and recognition of an object with small RCS, such as a stealth target, is the most difficult problem to solve for the modern radar system. Professor Hu Cheng and his group at Radar Research Lab, Beijing Institute of Technology set out to tackle this problem. After seven years of innovative research, they have developed a series of methods to detect, track and recognize some targets with small RCS. In particular, they proposed a novel imaging method based on the principle of shadow inverse synthetic aperture radar (SISAR) to extract the target profile accurately ...

The use of technology in the classroom is nothing new, but Topcliffe Primary School in Birmingham is breaking new ground by using technology to help pupils with autism communicate more effectively. The school, which teaches around 30 children with various levels of autism, was one of four schools across UK, which participated in the ECHOES research project, jointly funded by the Economic and Social Research Council (ESRC) and the Engineering and Physical Science Research Council (EPSRC) from universities across the UK to explore how technology can make a difference in ...

Together with the Basque R+D centre's researchers, the group of advisers is made up of researchers from the Spanish Institute of Oceanography (IEO), the French Institute for Exploration of the Sea (IFREMER), the French Institute for Research for Development (IRD),and the Portuguese Institute for Fisheries and Sea Research (IPIMAR).This work comes within the 'European Community's Action Plan on Sharks' which has funding from the European Commission's Directorate-General for Maritime Affairs and Fisheries, and is set to take 15 months. Shark are caught with fishing gear ...

Philadelphia, PA, November 29, 2012 – A potential new therapeutic strategy for treating Fragile X syndrome is detailed in a new report appearing in the current issue of Biological Psychiatry, from researchers led by Dr. Lucia Ciranna at University of Catania in Italy. Fragile X syndrome (FXS), the most common heritable form of autism and intellectual disability, is one of the most exciting areas in brain research at the moment. A decade ago, Dr. Mark Bear and his colleagues discovered that an animal model for FXS was associated with a distinctive alteration in brain ...

The wing of a fruit fly may hold the key to unraveling the genetic and molecular events that transform a normal cell into a cancerous one. The study, conducted on Drosophila melanogaster by scientists at the Institute for Research in Biomedicine (IRB Barcelona) and led by ICREA researcher Marco Milán, has reproduced each of the steps known to take place when a healthy cell turns cancerous. The researchers have thus provided an inexpensive and effective model that will allow the scientific community to scrutinize the genes and molecules involved in each step. Given that ...

EAST LANSING, Mich. — Homicide moves through a city in a process similar to infectious disease, according to a new study that may give police a new tool in tracking and ultimately preventing murders. Using Newark, N.J., as a pilot case, a team of Michigan State University researchers led by April Zeoli successfully applied public health tracking methods to the city's 2,366 homicides between 1982 and 2008. They found the killings were not randomly located but instead followed a pattern, evolving from the city's center and moving southward and westward over time. Like ...

Bethesda, MD—Breakthrough drugs have made it possible for people to live with HIV longer than ever before, but more work must be done to actually cure the disease. One of the challenges researchers face involves fully eradicating the virus when it is latent in the body. A new report appearing in the December 2012 issue of the Journal of Leukocyte Biology suggests that a cancer drug, called JQ1, may be useful in purging latent HIV infection by activating the virus in the presence of potent therapy – essentially a dead end for the virus. "This drug may be useful as adjunctive ...

In order to be effective, a Conservation Unit must have available a list of the species that live within it. They also should have detailed information about the distribution of species among the available habitats. It would be difficult to correctly plan the conservation actions and/or monitoring programs without some minimal knowledge about the species (who are the object of those measures). "This is why our study is so important to the park", said Dr. Miranda from Universidade Federal do Maranhão (CCAA/UFMA), leading author of the article, published in the open access ...

As a result of field work by associate professor James Davis Reimer and two graduate students from the University of the Ryukyus in Okinawa, Japan has found two new species of encrusting anemones, or colonial zoanthids, in unexpected locations. The species belong to the genus Neozoanthus, which was previously known only from a single species in the Indian Ocean. Surprisingly, the new species were found in the Pacific Ocean, in southern Japan and on the Great Barrier Reef, Australia. The study was published in the open access journal ZooKeys. The only previous species ...

This press release is available in German. A group headed by Remco van den Bosch from the Max Planck Institute for Astronomy has discovered a black hole that shakes the foundations of current models of galaxy evolution. This monster has 17 billion solar masses and is thus significantly heavier than the models predict. And even more significantly: the object could be the most massive black hole known to date. Astronomers believe there is a super-massive black hole at the heart of every galaxy. Its mass ranges from several hundred thousand solar masses to a few billion. ...

Giving customers a chance to complain can be a bad idea if customers believe they're to blame for a product's failure, a new study from the Sauder School of Business at UBC shows. "It's commonly assumed that giving customers a chance to voice grievances allows companies to maintain relationships," says Marketing Professor Darren Dahl, who co-authored the recent Journal of Marketing study with PhD student Lea Dunn. "But our research shows that when a person feels implicated in a product's failure – think building Ikea furniture – they're more likely to shift blame to ...

Researchers have pushed the boundaries of High Dynamic Range (HDR) video to match our own eyes' ability to cope with the real world's ever rapidly changing light intensity - such as sun simply going behind clouds. Now researchers at WMG at the University of Warwick, have found a way to compress and stream HDR video directly to monitors and mobile devices, such as an iPad, bringing enormous benefits to industries including gaming and security. Researchers at WMG at the University of Warwick, working in partnership with spinout company goHDR Ltd, have succeeded in achieving ...

WASHINGTON, Nov. 29—Hoping to expand our understanding of auroras and other fleeting atmospheric events, a team of space-weather researchers designed and built NORUSCA II, a new camera with unprecedented capabilities that can simultaneously image multiple spectral bands, in essence different wavelengths or colors, of light. The camera was tested at the Kjell Henriksen Observatory (KHO) in Svalbard, Norway, where it produced the first-ever hyperspectral images of auroras—commonly referred to as "the Northern (or Southern) Lights"—and may already have revealed a previously ...

COLUMBUS, Ohio – Bacteria that cause the tick-borne disease anaplasmosis in humans create their own food supply by hijacking a process in host cells that normally should help kill the pathogenic bugs, scientists have found. This bacterium, Anaplasma phagocytophilum (Ap), secretes a protein that can start this process. The protein binds with another protein produced by white blood cells, and that connection creates compartments that siphon host-cell nutrients to feed the bacteria, enabling their growth inside the white blood cells. The finding defies conventional wisdom ...

Bethesda, MD—As insects evolve to become resistant to insecticides, the need to develop new ways to control pests grows. A team of scientists from Leuven, Belgium have discovered that the sea anemone's venom harbors several toxins that promise to become a new generation of insecticides that are environmentally friendly and avoid resistance by the insects. Since these toxins disable ion channels that mediate pain and inflammation, they could also spur drug development aimed at pain, cardiac disorders, epilepsy and seizure disorders, and immunological diseases such as multiple ...

Prion diseases represent a family of neurodegenerative disorders associated with the loss of brain cells and caused by proteins called prions (derived from 'protein' and 'infection'). The diseases are found in both humans and animals, such as Creutzfeld-Jakob disease and mad cow disease respectively. Although mostly harmless, prions can transform into infectious agents, which accumulate in the brain and destroy the nervous tissue. But how exactly does the accumulation of prions cause destruction of the brain? "Understanding the process by which prions destroy neurons ...

Bethesda, MD—Physicians may now be better at detecting breast cancer than ever before, but much more work remains to ensure accurate diagnosis is possible and especially to assess future risk. That's why researchers from Germany have been working to develop a new test of gene action to predict cancer risk both at first diagnosis and into the future. In a new research report appearing in the December 2012 issue of The FASEB Journal, researchers show that the various genetic switches, which are turned on and off in the regular development of every cell in the body, can be ...

Climate scientists are still grappling with one of the main questions of modern times: how high will global temperatures rise if the atmospheric concentration of carbon dioxide doubles. Many researchers are turning to the past because it holds clues to how nature reacted to climate change before the anthropogenic impact. The divergent results of this research, however, have made it difficult to make precise predictions about the impact of increased carbon dioxide on future warming. An international team of scientists have evaluated previously published estimates and assigned ...

ATHENS, Ohio (Nov. 29, 2012)—Astronomers were puzzled earlier this year when NASA's Hubble Space Telescope spotted an overabundance of dark matter in the heart of the merging galaxy cluster Abell 520. This observation was surprising because dark matter and galaxies should be anchored together, even during a collision between galaxy clusters. Astronomers have abundant evidence that an as-yet-unidentified form of matter is responsible for 90 percent of the gravity within galaxies and clusters of galaxies. Because it is detected via its gravity and not its light, they call ...

ARLINGTON, Va. —The Office of Naval Research (ONR) is looking to the sun for energy in an effort to help Marines do away with diesel-guzzling generators now used in combat outposts, officials announced Nov. 29. The Renewable Sustainable Expeditionary Power (RSEP) program seeks to create a transportable renewable hybrid system that can provide Marines with electricity for a 15-day mission without relying on fuel resupply convoys that often become targets for adversaries. "This program takes on a number of power-related challenges and ultimately will allow the Marine ...