DURHAM, N.C. – A three-dimensional image of one of the proteins that serves as an on-off switch as it binds to receptors on the surface of a cell suggests there may be a sort of main power switch that could be tripped. These surface receptors are responsible for helping cells discern light, set the heart racing, or detect pain. The finding, published online April 21, 2013, in the journal Nature by a research collaboration involving this year's Nobel laureates in chemistry, could help in the development of more effective drugs to switch on or off the cell receptors that ...

Scientists at the Walter and Eliza Hall Institute and their collaborators have tailor-made a new chemical compound that blocks a protein that has been linked to poor responses to treatment in cancer patients. The development of the compound, called WEHI-539, is an important step towards the design of a potential new anti-cancer agent. WEHI-539 has been designed to bind and block the function of a protein called BCL-XL that normally prevents cells from dying. The death and elimination of abnormal cells in the body is an important safeguard against cancer development. But ...

Number of cigarettes smoked a day and the number of years a person has smoked both increase the risk of rheumatoid arthritis (RA), finds research in BioMed Central's open access journal Arthritis Research & Therapy. The risk decreases after giving up smoking but, compared to people who have never smoked, this risk is still elevated 15 years after giving up. Researchers from the Karolinska Institutet and Karolinska University Hospital analysed data from the Swedish Mammography Cohort, which included 34,000 women aged between 54 and 89, 219 of which had RA. Results of ...

Researchers have newly associated nine genetic regions with a rare autoimmune disease of the liver known as primary sclerosing cholangitis (PSC). This brings the total number of genetic regions associated with the disease to 16. Approximately 70 per cent of people who suffer from PSC also suffer from IBD. The team showed that only half of the newly associated genetic regions were shared with inflammatory bowel disease (IBD). For the first time, this definitively proves that PSC, although genetically related to IBD, is a distinct disease. PSC is a chronic, progressive ...

April 21, 2013, New York, NY and San Diego Calif. – Ludwig researchers Arshad Desai and Christopher Campbell, a post-doctoral fellow in his laboratory, were conducting an experiment to parse the molecular details of cell division about three years ago, when they engineered a mutant yeast cell as a control that, in theory, had no chance of surviving. Apparently unaware of this, the mutant thrived. Intrigued, Campbell and Desai began exploring how it had defied its predicted fate. As detailed in the current issue of Nature, what they discovered has overturned the prevailing ...

A new analysis has found that the loss or amplification of particular DNA regions contributes to the development of prostate cancer, and that patients with two of these DNA changes have a high likelihood of dying from the disease. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the study provides valuable information on the genetics of prostate cancer and offers insights into which patients should be treated aggressively. Cells can become cancerous when they lose or amplify pieces of DNA containing important genes. Using a method ...

It is widely accepted that medical insurance helps older adults with chronic health problems to receive better care. But what about young adults between the ages of 18 and 25, a demographic that also tends to have the lowest levels of health insurance coverage? In what may be the first study to measure health care utilization patterns among young adults with chronic health problems—in this case asthma—a team of researchers at Harvard Medical School found that losing health insurance was a significant predictor of deteriorating patterns of health management. Other social ...

New research published as an abstract in The FASEB Journal and presented at Experimental Biology 2013 (EB 2013) on Monday, April 22 ties mushrooms to positive health outcomes in the area of weight management. A one-year, randomized clinical trial conducted by researchers at the Weight Management Center at Johns Hopkins Bloomberg School of Public Health and funded by the Mushroom Council found that substituting white button mushrooms for red meat can be a useful strategy for enhancing and maintaining weight loss.1 Participants included obese adults (73 adults; 88% women; ...

Anyone who has spent time in the tropics knows that the diversity of species found there is astounding and the abundance and diversity of ants, in particular, is unparalleled. Scientists have grappled for centuries to understand why the tropics are home to more species of all kinds than the cooler temperate latitudes on both sides of the equator. Several hypotheses have been proposed to explain the higher species numbers in the tropics, but these hypotheses have never been tested for the ants, which are one of the most ecologically and numerically dominant groups of animals ...

Researchers from ETH Zurich, the Paul Scherrer Institute (PSI) and the Politec-nico di Milano have jointly developed a manufacturing technique to render the semiconductor germanium laser-compatible through high tensile strain. In their article recently published in "Nature Photonics", they reveal how they can gen-erate the necessary tensile strain efficiently. The scientists demonstrate how to use their method to effectively alter the optical properties of germanium, which is naturally unsuitable for lasing: "With a strain of three per cent, the material emits around twenty-five ...

But an accompanying series of editorials points out some important limitations of the two studies—which can't completely overcome previous concerns about the safety of using nitrous oxide (N2O) as a surgical anesthetic. Is Nitrous Oxide Safe for Surgical Anesthesia? Nitrous oxide is the world's oldest general anesthetic, but there's a long history of debate regarding its appropriate role in modern surgical anesthesia. Although nitrous oxide provides effective sedation and pain control, it has known disadvantages and side effects. A previous study, called "ENIGMA-I," ...

Josh Hill, an experienced business-to-business marketer announced availability of the Marketing Rockstar's Guide to Marketo, an independent project aimed at marketers who are new to the marketing automation tool Marketo. Josh started the project to keep track of the many ways Marketo can be used as well as best practice setup techniques. Having gone through previous Marketo implementations with Salesforce.com, Josh believed there was a gap between Marketo documentation and marketers' technical skills. "I work at the nexus of technology, marketing, and sales to ...

Charles & Chubs Pet Furnishings aims to raise funding to manufacture their line of pet products through crowd-funding website, Kickstarter. The primary goal at this time is to get their line of pet beds manufactured out of high-grade plastic with a design that allows the beds to fold nearly flat for storage. Charles & Chubs Pet Furnishings is a startup company with a vision of creating unique pet furniture that not only allow your pet to sleep in style but also make for a decorative piece in your home. "I wanted to create a pet bed that was more than ...

Andre and Marina Soumiatin have officially put the relationship experts on notice: They have created an interactive, "Wiki-style" project in which people's feedback, commentary and questions directly affect the outcome of a book entitled "Timeless Love Pyramid- 5 Essential Steps to Keep Your Passion". This book teaches how to keep passion in a marriage for a life time. People are sharing their love stories and expressing their feelings on what they want to read. People are raving about their experiences: "I just read your first chapter on ...

Several new Stark law initiatives have recently gone into effect, yet the application of those provisions is unclear to many healthcare professionals and patients. "A common misunderstanding is that Stark law applies across the board to all patients, but it does not," says Dr. Carol Mahon, chief compliance officer of Minimally Invasive SpineCARE and CEO of Medical Business Institute. "Stark law only applies to government-funded entities - like Medicare and Medicaid. "There are safe harbors or exceptions to the law that could affect a lot of people ...

Many small online retailers understand the difficulty of building a brand and marketing. With limited budgets and fees eating in sales, store owners on sites like Etsy, eBay, and Amazon are seeking new and creative ways to attract customers. Picsity (www.picsity.com) is a new social shopping site that focuses on building a community of products lovers, while doubling as a cost-free showroom for merchants. Co-founder and CEO Kevin Chow stresses that his company can be a healthy complement to any retailer's marketing strategy. Unlike a traditional e-commerce site, there ...

greeNEWit, a Maryland company that provides energy and water saving upgrades to homeowners and businesses to reduce energy-related expenses, lower utility bills and reduce their carbon footprint, will participate in the Takoma Park Earth Day Festival Sunday, April 21, 2013 from 10 a.m. to 4 p.m. at Grant Avenue at Carroll Avenue in Takoma Park, Maryland. greeNEWit will attend this inaugural event as a vendor, joining more than 35 other green organizations and companies. Takoma Park Earth Day will provide consumers with an opportunity to speak to energy efficiency experts ...

Floor-to-ceiling murals depict streetscapes of the 1950s Jersey Shore in the 10-car garage of "Bayside Villa," an exceptional property being offered for sale at 5030 Gulf of Mexico Drive on Longboat Key. Painted by local artist Lori George, the murals portray the Jersey Shore city of Keansburg, New Jersey, hometown of the late Tony Pompliano, an auto enthusiast who commissioned the delightful works of art. "The murals were taken from old photos, books and Tony's memory," said his widow Irene, who has listed the home with Realtor Leslie Sharp of RoseBay ...

Recording artist Jessi Malay has released her new single, "Bougie," which is now available via digital retailers. The song, produced by Deep Waters, is making head way on Dance radio stations and garnering airplay by world class DJs in nightclubs across the US and world. Jessi Malay is currently part of the Macy's iHeart Radio Rising Star Contest; Vote for Jessi Malay at the following link; http://macys.iheart.com/macys/entries/profile/29.html Official Contest Rules: http://macys.iheart.com/macys/rules.pdf Jessi Malay has launched a new era in her music ...

Area Elementary Students Play with West Michigan Symphony in Unique Performance - Thanks to Carnegie Hall's Link Up Program Muskegon, Michigan, April 19, 2013 - Students who have spent the year studying music using Carnegie Hall's Link Up program through a partnership with the West Michigan Symphony will demonstrate their new music abilities at a special concert on Tuesday, May 7. More than 4,000 third-fifth graders from 50 elementary schools across West Michigan will be both audience and performers in three concerts at the Frauenthal Center in downtown Muskegon. ...

Today author Kerry Watson of OSCmanuals.com released a free "Cheatsheet" for OpenCart administrators showing all of the menus dropped down on one full-color page. This helps any user of any skill level to find what they want, quickly and easily. The new free guide is current to OpenCart 1.5.5.1, but is useful for any version of the OpenCart program. WHO SHOULD DOWNLOAD THE FREE OPENCART 1.5.5.1 ADMIN MENU GUIDE? The free OpenCart Admin Menu Cheatsheet is perfect for non-technical users, such as OpenCart administrators who had their sites installed by ...

Anyone interested in pursuing a career in medicine is welcome to attend a free information session in Toronto, Canada for the Saba University School of Medicine. The information session will take place starting at 1:00pm on April 27th, 2013 at the Thomson Room at the Hyatt Regency Toronto, located at 370 King Street West, Toronto, Canada. The Saba School of Medicine Information Session is open to all prospective medical students and their families. Participants are asked to pre-register online at http://bit.ly/sabainfo At the information session you will receive a ...

While we have enjoyed being Columbus's premier "boot camp" for the past several years, the time has come to change our name to reflect what we truly are—a fitness training program designed to help you become the best YOU that you can be! You aren't a "camper"—you're an athlete! At Improvement Warrior Fitness, you don't come to "work out" or to "exercise." You come to get results, to train, to improve, to reach your goals. Our team of coaches is well-qualified and standing at the ready to help you do so! Improvement Warrior Fitness ...

New Online Dating Survey Shows 52% of Women are Comfortable Dating Men 30+ Years Older than Them According to a recent survey conducted by SugarDaddyForMe.com, famous men like Al Pacino, Michael Douglas and Hugh Heffner are not the only older men that younger women would be comfortable dating. The world's largest sugar daddy online dating website , SugarDaddyForMe.com, has published surprising statistics reflecting the current attitudes regarding age gaps between men and women. The recent online survey was completed by over 4 thousand active sugar baby members on ...

Managing your online reputation has become an integral part of running a business in today's Internet age. Business Breakthroughs International (BBI), a Tony Robbins and Chet Holmes company, recently expanded its Internet marketing division to include online reputation management services. Many companies have experienced firsthand how a poorly handled interaction with a customer can quickly go viral and spiral out of control. The longevity of the search results means that that content can remain highly visible long after the original incident. This means that businesses ...