The ability for substances to pass through the blood-brain barrier is increased after adult stroke, but not after neonatal stroke, according to a new study the UCSF that will be published July 11 in the Journal of Neuroscience. The novel findings may have major implications for drug development and the treatment of neonatal stroke, the researchers said. The blood-brain barrier is selectively permeable and blocks unwanted molecules from entering into the brain. The selectivity is achieved through fine coordination in function of many transporting systems in endothelial ...

Research: Long term alcohol intake and risk of rheumatoid arthritis in women: a population based cohort study Moderate consumption of alcohol is associated with a reduced risk of developing rheumatoid arthritis, suggests a study published on bmj.com today. The results show that women who regularly consume more than three alcoholic drinks a week for at least 10 years have about half the risk of developing rheumatoid arthritis compared with non-drinkers. After adjusting for factors such as age, smoking and dietary habits, women who reported drinking more than three ...

Research: Weight gain in smokers after quitting cigarettes: meta-analysis Editorial: Quitting smoking and gaining weight: the odd couple Giving up smoking is associated with an average weight gain of 4-5 kg after 12 months, most of which occurs within the first three months of quitting, finds a study published on bmj.com today. Although this figure is higher than previously thought, an accompanying editorial argues that the health benefits of quitting far outweigh this modest gain in body weight and should not deter people from quitting. It is well known that ...

Toronto – Not all brand–consumer relationships are created equal. Marketers who realize this will be in a better position to retain customers and improve the perceptions of consumers who are unhappy with a brand's service or product, says a new paper from the University of Toronto. Consumers form connections with brands in ways that mirror social relationships. How consumers evaluate a brand depends heavily on whether the brand adheres to—or violates—the implicit relationship agreement. Pankaj Aggarwal, a marketing professor at the Rotman School of Management and ...

A new study published in the July 11 issue of the Journal of Neuroscience details the development of the first mouse model engineered to carry the most common mutation in Usher syndrome III causative gene (Clarin-1) in North America. Further, the research team from Case Western Reserve University School of Medicine used this new model to understand why mutation in Clarin-1 leads to hearing loss. Usher Syndrome is an incurable genetic disease and it is the most common cause of the dual sensory deficits of deafness and blindness. It affects an estimated 50,000 Americans ...

Ottawa, ON – July 10, 2012 — Monitoring the effectiveness of the HPV vaccine in Canada requires that data from multiple registries and other data sources be combined. Linking registries can be problematic, however, since they are often managed by unrelated organizations. Privacy legislation may also restrict the sharing of data for such linkages. To address these challenges, Dr. Khaled El-Emam and his team at the CHEO Research Institute have developed a secure protocol that allows the linking of individual patient records without revealing personal information, which has ...

People with lower incomes value the institution of marriage just as much as those with higher incomes and have similar romantic standards for marriage, according to a new study published in the Journal of Marriage and Family. The new research suggests that government initiatives to strengthen marriage among low-income populations should move beyond promoting the value of marriage and instead focus on the actual problems that low-income couples face. The study, which analysed results from a survey of 6,012 people, was carried out by Dr Thomas Trail and Dr Benjamin Karney ...

In his thesis, Gul Amin, who recently received his doctorate at the Physical Electronics and Nanotechnology group, Campus Norrköping, shows how it is possible to grow white LEDs directly on paper and also to print them on wallpaper for example - this method has a patent pending. The active components are nanorods of zinc oxide on a thin layer of polydiethylflourene (PFO), a conducting polymer. But the paper has first been coated with a thin, water-repellent, protective and levelling layer of cyclotene, a resin. "This is the first time anyone has been able to build ...

This press release is available in German. Black skin cancer, also known as melanoma, is particularly aggressive and becoming increasingly common in Switzerland. Despite intensive research, however, there is still no treatment. Researchers from the University of Zurich have now discovered a gene that plays a central role in black skin cancer. Suppressing this gene in mice inhibits the development of melanoma and its proliferation – a discovery that could pave the way for new forms of therapy. Until recently, it was assumed that a tumor was composed of many ...

Migratory birds and fish use the Earth's magnetic field to find their way. LMU researchers have now identified cells with internal compass needles for the perception of the field – and can explain why high-tension cables perturb the magnetic orientation. Although many animal species can sense the geomagnetic field and exploit it for spatial orientation, efforts to pinpoint the cells that detect the field and convert the information into nerve impulses have so far failed. "The field penetrates the whole organism, so such cells could be located almost anywhere, making them ...

A new species of monkey flower, created by the union of two foreign plant species, has been discovered on the bank of a stream in Scotland. Genetic changes in this attractive yellow-flowered hybrid have allowed it to overcome infertility and made it a rare example of a brand new species that has originated in the wild in the last 150 years. Thousands of wild species and some crops are thought to have originated in this way, yet only a handful of examples exist where this type of species formation has occurred in recent history. The ancestors of the new plant were brought ...

Scientists at the University Medical Center of Johannes Gutenberg University Mainz in Germany identified a novel strategy to target the oncologically relevant protein-cleaving enzyme Taspase1. Taspase1 levels are not only elevated in cancer cells of patients with head and neck tumors and other solid malignancies but the enzyme is also critical for the development of leukemias. Central to this concept is the approach to inhibit the enzyme's activity by 'gluing together' individual Taspase1 molecules. The results of a study undertaken by Professor Dr. Roland Stauber of the ...

From the air, the twists and turns of rivers can easily be seen. In the body, however, tracing the twists and turns of blood vessels is difficult, but important. Vessel "bendiness" can indicate the presence and progression of cancer. This principle led UNC scientists to a new method of using a high-resolution ultrasound to identify early tumors in preclinical studies. The method, based on vessel bendiness or "tortuosity," potentially offers an inexpensive, non-invasive and fast method to detect cancer that could someday help doctors identify cancers when tumors are ...

CAMBRIDGE, MA -- A clinical trial of an Alzheimer's disease treatment developed at MIT has found that the nutrient cocktail can improve memory in patients with early Alzheimer's. The results confirm and expand the findings of an earlier trial of the nutritional supplement, which is designed to promote new connections between brain cells. Alzheimer's patients gradually lose those connections, known as synapses, leading to memory loss and other cognitive impairments. The supplement mixture, known as Souvenaid, appears to stimulate growth of new synapses, says Richard Wurtman, ...

BOSTON, MA—Researchers at Brigham and Women's Hospital (BWH) are the first to report a new approach that integrates rational drug design with supramolecular nanochemistry in cancer treatment. Supramolecular chemistry is the development of complex chemical systems using molecular building blocks. The researchers utilized such methods to create nanoparticles that significantly enhanced antitumor activity with decreased toxicity in breast and ovarian cancer models. "This work is effectively moving beyond using nanotechnology as drug 'delivery' vehicles to reengineering ...

The 'Civil Space Strategy' setting out the direction for the UK space sector over the next four years has been launched today, Tuesday 10th July, at the Farnborough International Airshow. The Strategy sets out the UK Space Agency's framework supporting the growth of the sector over the next four years. The Civil Space Strategy was formally launched by the Minister for Universities and Science to the international space community, gathered for Space Day at Farnborough. David Willetts discussed the Strategy in his speech to the Space Conference as well as revealing the ...

SAN ANTONIO (July 10, 2012) — Chemical intolerance contributes to the illnesses of 1 in 5 patients but the condition seldom figures in their diagnosis, according to clinical research directed by a UT Medicine San Antonio physician. Clinical tools are available to identify chemical intolerance but health care practitioners may not be using them, lead author David Katerndahl, M.D., M.A., said. The study is in the July 9 issue of Annals of Family Medicine. UT Medicine is the clinical practice of the School of Medicine at The University of Texas Health Science Center San ...

Richmond, Va. (July 9, 2012) – Patients who use an interactive personal health record (IPHR) are almost twice as likely to be up to date with clinical preventive services as those who do not, according to a new study led by Alex Krist, M.D., M.P.H., research member of the Cancer Prevention and Control program at Virginia Commonwealth University Massey Cancer Center. Published today in the journal Annals of Family Medicine, the randomized controlled trial involved eight primary care practices and 4,500 patients. The patients were divided into a control group and an intervention ...

BLOOMINGTON, Ind. -- Elevated levels of atmospheric carbon dioxide accelerate carbon cycling and soil carbon loss in forests, new research led by an Indiana University biologist has found. The new evidence supports an emerging view that although forests remove a substantial amount of carbon dioxide from the atmosphere, much of the carbon is being stored in living woody biomass rather than as dead organic matter in soils. Richard P. Phillips, lead author on the paper and an assistant professor of biology in the IU College of Arts and Sciences, said that after nearly ...

Chevy Chase, MD – The Endocrine Society commissioned Lake Research Partners to conduct a national survey of 424 internal medicine, family practice and OB/GYN physicians about their attitudes and experiences related to treating menopausal symptoms. According to the survey, physicians say the primary barrier to women receiving hormone therapy is patients' fears about the risks and their unwillingness to discuss the option. This new survey follows a study conducted in April 2012 among 810 women ages 45 to 60 on the same topic. Hormone therapy has been under intense scrutiny ...

How does a tumor cell set up a signaling pathway in order to metastasize? Scientists at Technische Universität München's (TUM) Klinikum rechts der Isar and Helmholtz Zentrum München have made a significant discovery in this area by studying colon cancer. They have learned that the tumor cells release certain proteins known as chemokines. In the case of metastatic colon cancer cells, the chemokine concerned is CCL2. The CCL2 chemokine docks on to the cells of the inner blood vessel walls (endothelial cells) and activates the corresponding receptor (CCR2 receptor). This connection ...

ITHACA, N.Y. – No matter how you drill it, using natural gas as an energy source is a smart move in the battle against global climate change and a good transition step on the road toward low-carbon energy from wind, solar and nuclear power. That is the conclusion of a new study by Cornell Professor Lawrence M. Cathles, published in the most recent edition of the peer-reviewed journal Geochemistry, Geophysics and Geosystems. Cathles, a faculty member in Cornell's Department of Earth and Atmospheric Sciences, reviewed the most recent government and industry data on natural ...

Contraceptive use likely prevents more than 272,000 maternal deaths from childbirth each year, according to a new study led by researchers at the Johns Hopkins Bloomberg School of Public Health. Researchers further estimate that satisfying the global unmet need for contraception could reduce maternal deaths an additional 30 percent. Their findings were published July 10 by The Lancet as part of a series of articles on family planning. "Promotion of contraceptive use is an effective primary prevention strategy for reducing maternal mortality in developing countries. Our ...

CHICAGO --- If you hire a caregiver from an agency for an elderly family member, you might assume the person had undergone a thorough criminal background check and drug testing, was experienced and trained for the job. You'd be wrong in many cases, according to new Northwestern Medicine research. A troubling new national study finds many agencies recruit random strangers off Craigslist and place them in the homes of vulnerable elderly people with dementia, don't do national criminal background checks or drug testing, lie about testing the qualifications of caregivers ...

Researchers who studied a large sample of middle- and high-school students in Washington state found that mixed-race adolescents are more similar to their white counterparts than previously believed. Experts have thought that multiracial adolescents, the fastest growing youth group in the United States, use drugs and engage in violence more than their single-race peers. Racial discrimination and greater vulnerability to peer pressure have been blamed for these problems, due to the belief that as mixed-race youngsters struggle to fit in they become more likely to fall ...