CORVALLIS, Ore. – The "empty nest" of past generations, in which the kids are grown up and middle-aged adults have more time to themselves, has been replaced in the United States by a nest that's full – kids who can't leave, can't find a job and aging parents who need more help than ever before. According to a new study by researchers at Oregon State University, what was once a life stage of new freedoms, options and opportunities has largely disappeared. An economic recession and tough job market has made it hard on young adults to start their careers and families. ...

Vanderbilt biochemists have discovered that the process bacteria undergo when they become drug resistant can act as a powerful tool for drug discovery. Their findings – reported this week in the Online Early Edition of the Proceedings of the National Academy of Sciences – should give a major boost to natural products drug discovery – the process of finding new drugs from compounds isolated from living organisms – by substantially increasing the number of novel compounds that scientists can extract from individual microorganisms. Bacteria have traditionally been the ...

PULLMAN, Wash.—Washington State University researchers have lengthened their list of environmental toxicants that can negatively affect as many as three generations of an exposed animal's offspring. Writing in the online journal PLOS ONE, scientists led by molecular biologist Michael Skinner document reproductive disease and obesity in the descendants of rats exposed to the plasticizer bisephenol-A, or BPA, as well DEHP and DBP, plastic compounds known as phthalates. In a separate article in the journal Reproductive Toxicology, they report the first observation of cross-generation ...

Highlights The breast milk of mothers taking the immunosuppressant tacrolimus contains only very low levels of the drug. Women taking tacrolimus who wish to breast-feed after appropriate counseling should not be discouraged from doing so. Increasing numbers of pregnant women are taking tacrolimus after organ transplantation and for other conditions. Washington, DC (January 24, 2013) — Women taking the immunosuppressant tacrolimus can rest assured that breast feeding will not elevate their babies' exposure to the drug, according to a study appearing in an upcoming ...

Highlights Among people without diabetes or kidney disease, 10-year mortality was 7.7%. Among individuals with diabetes but without kidney disease, mortality was 11.5%. Among those with both diabetes and kidney disease, mortality was 31.1%. 26 million people in the US and 340 million people in the world have type 2 diabetes. Washington, DC (January 24, 2013) — One in every 10 Americans has diabetes, and a third or more of those with the condition will develop kidney disease. It may be possible to live a long and healthy life with diabetes, but once kidney disease ...

Northwestern University graduate student Jonathan Barnes had a hunch for creating an exotic new chemical compound, and his idea that the force of love is stronger than hate proved correct. He and his colleagues are the first to permanently interlock two identical tetracationic rings that normally are repelled by each other. Many experts had said it couldn't be done. On the surface, the rings hate each other because each carries four positive charges (making them tetracationic). But Barnes discovered by introducing radicals (unpaired electrons) onto the scene, the researchers ...

NEW YORK (Jan. 24, 2013) -- A team of researchers led by Weill Cornell Medical College is calling into question the published statistics, methods and findings of a highly publicized research study that claimed bedside electroencephalography (EEG) identified evidence of awareness in three patients diagnosed to be in a vegetative state. The new reanalysis study led by Weill Cornell neurologists Drs. Andrew Goldfine, Jonathan Victor, and Nicholas Schiff, published in the Jan. 26 issue of the journal Lancet, reports the statistical results and methodology used by a research ...

Using a satellite X-ray telescope combined with terrestrial radio telescopes the pulsar was found to flip on a roughly half-hour timescale between two extreme states; one dominated by X-ray pulses, the other by a highly-organised pattern of radio pulses. The research was led by Professor Wim Hermsen from The Netherlands Institute for Space Research and the University of Amsterdam and will appear in the journal Science on the 25th January 2013. Researchers from Jodrell Bank Observatory, as well as institutions around the world, used simultaneous observations with the ...

Nearly the entire genetic landscape of the most common form of brain tumor can be explained by abnormalities in just five genes, an international team of researchers led by Yale School of Medicine scientists report online in the Jan. 24 edition of the journal Science. Knowledge of the genomic profile of the tumors and their location in the brain make it possible for the first time to develop personalized medical therapies for meningiomas, which currently are only managed surgically. Meningioma tumors affect about 170,000 patients in the United States. They are usually ...

Claims that most species will go extinct before they can be discovered have been debunked in the latest issue of Science, by researchers from The University of Auckland, Griffith University, and the University of Oxford. The scientists show that the claims are based on two key misconceptions: an over-estimation of how many species may exist on Earth, and the erroneous belief that the number of taxonomists (people who describe and identify species) is declining. "Our findings are potentially good news for the conservation of global biodiversity," says lead author Associate ...

At the heart of computing are tiny crystals that transmit and store digital information's ones and zeroes. Today these are hard and brittle materials. But cheap, flexible, nontoxic organic molecules may play a role in the future of hardware. A team led by the University of Washington in Seattle and the Southeast University in China discovered a molecule that shows promise as an organic alternative to today's silicon-based semiconductors. The findings, published this week in the journal Science, display properties that make it well suited to a wide range of applications ...

Viruses similar to those that cause AIDS in humans were present in non-human primates in Africa at least 5 million years ago and perhaps up to 12 million years ago, according to study published January 24 in the Open Access journal PLOS Pathogens by scientists at Fred Hutchinson Cancer Research Center. Until now, researchers have hypothesized that such viruses originated much more recently. HIV-1, the virus responsible for AIDS, infiltrated the human population in the early 20th century following multiple transmissions of a similar chimpanzee virus known as SIVcpz. Previous ...

For the tiny Daubenton's bat, the attractions of family life seem to vary more with altitude than with the allure of the opposite sex. For more than a decade, a team led by Professor John Altringham from the University of Leeds' School of Biology has studied a population of several hundred bats along a 50-km stretch of the River Wharfe. They monitored roosts in Ilkley and Addingham, upstream in the market town of Grassington and higher still in the villages of Kettlewell and Buckden. The researchers found that all Daubenton's bats in nursery roosts in lowland areas ...

Concerns that many animals are becoming extinct, before scientists even have time to identify them, are greatly overstated according Griffith University researcher, Professor Nigel Stork. Professor Stork has taken part in an international study, the findings of which have been detailed in "Can we name Earth's species before they go extinct?" published in the journal Science. Deputy Head of the Griffith School of Environment, Professor Stork said a number of misconceptions have fuelled these fears, and there is no evidence that extinction rates are as high as some have ...

The diversity of biobanks, collections of human specimens from a variety of sources, raises questions about the best way to manage and govern them, finds a study published in BioMed Central's open access journal Genome Medicine. The research highlights difficulties in standardizing these collections and how to make these samples available for research. Biobanks have been around for decades, storing hundreds of millions of human specimens. But there has been a dramatic increase in the number of biobanks in the last ten years, since the human genome sequencing project. ...

CHAPEL HILL, N.C. – Cells in the immune system called macrophages normally engulf and kill intruding bacteria, holding them inside a membrane-bound bag called a vacuole, where they kill and digest them. Some bacteria thwart this effort by ripping the bag open and then escaping into the macrophage's nutrient-rich cytosol compartment, where they divide and could eventually go on to invade other cells. But research from the University of North Carolina School of Medicine shows that macrophages have a suicide alarm system, a signaling pathway to detect this escape into ...

Out-of-pocket costs resulting from breast cancer care in the year following diagnosis are likely manageable for most women, but some women are at a higher risk of experiencing the financial burden that comes from those costs in Canadian breast cancer patients, according to a study published January 24 in the Journal of the National Cancer Institute. While extensive information about the level of out-of-pocket costs after early breast cancer diagnosis has been unavailable until now, the costs resulting from the disease and the effects the costs have on family financial ...

There is no association between total fruit and vegetable intake and risk of overall breast cancer, but vegetable consumption is associated with a lower risk of estrogen receptor-negative (ER-) breast cancer, according to a study published January 24 in the Journal of the National Cancer Institute. The intake of fruits and vegetables has been hypothesized to lower breast cancer risk, however the existing evidence is inconclusive. There are many subtypes of breast cancer including ER- and ER positive (ER+) tumors and each may have distinct etiologies. Since ER- tumors, ...

The authors say spotting it early could substantially reduce the risk, and this needs to become a cornerstone of safety and effectiveness in antenatal care. Stillbirth rates in the United Kingdom are among the highest in developed countries. They have often been considered unexplained and unavoidable, and their rates have changed little over the last two decades. Recently, doctors have found that many stillborn babies fail to reach their growth potential, prompting a renewed focus on what causes fetal growth restriction. So a team of researchers at the West Midlands ...

New research reveals a potential way for how parents' experiences could be passed to their offspring's genes. The research was published today, 25 January, in the journal Science. Epigenetics is a system that turns our genes on and off. The process works by chemical tags, known as epigenetic marks, attaching to DNA and telling a cell to either use or ignore a particular gene. The most common epigenetic mark is a methyl group. When these groups fasten to DNA through a process called methylation they block the attachment of proteins which normally turn the genes on. ...

BOSTON—Two new mutations that collectively occur in 71 percent of malignant melanoma tumors have been discovered in what scientists call the "dark matter" of the cancer genome, where cancer-related mutations haven't been previously found. Reporting their findings in the Jan. 24 issue of Science Express, the researchers from Dana-Farber Cancer Institute and the Broad Institute said the highly "recurrent" mutations – occurring in the tumors of many people – may be the most common mutations in melanoma cells found to date. The researchers said these cancer-associated ...

(Edmonton) A University of Alberta professor has revealed the workings of a celestial event involving binary stars that results in an explosion so powerful it ranks close to Supernovae in luminosity. Astrophysicists have long debated about what happens when binary stars, two stars that orbit one another, come together in a common envelope. When this dramatic cannibalizing event ends there are two possible outcomes; the two stars merge into a single star or an initial binary transforms in an exotic short-period one. The event is believed to take anywhere from a dozen ...

(MEMPHIS, Tenn. – January 24, 2013) Genome sequencing data once regarded as junk is now being used to gain important clues to help understand disease. The latest example comes from the St. Jude Children's Research Hospital – Washington University Pediatric Cancer Genome Project, where scientists have developed an approach to mine the repetitive segments of DNA at the ends of chromosomes for insights into cancer. These segments, known as telomeres, had previously been ignored in next-generation sequencing efforts. That is because their repetitive nature meant that the ...

ITHACA, N.Y. – With projections of 9.5 billion people by 2050, humanity faces the challenge of feeding modern diets to additional mouths while using the same amounts of water, fertilizer and arable land as today. Cornell University researchers have taken a leap toward meeting those needs by discovering a gene that could lead to new varieties of staple crops with 50 percent higher yields. The gene, called Scarecrow, is the first discovered to control a special leaf structure, known as Kranz anatomy, which leads to more efficient photosynthesis. Plants photosynthesize ...

Have you ever woken up to a sunny forecast only to get soaked on your way to the office? On days like that it's easy to blame the weatherman. But BYU mechanical engineering professor Julie Crockett doesn't get mad at meteorologists. She understands something that very few people know: it's not the weatherman's fault he's wrong so often. According to Crockett, forecasters make mistakes because the models they use for predicting weather can't accurately track highly influential elements called internal waves. Atmospheric internal waves are waves that propagate between ...