WASHINGTON -- A review of the available evidence underscores the safety of the federal childhood immunization schedule, says a new report from the Institute of Medicine. Should signals indicate the need for investigation of the schedule, however, the report offers a framework for conducting safety research using existing or new data collection systems. Roughly 90 percent of American children receive most childhood vaccines advised by the federal immunization schedule by the time they enter kindergarten, noted the committee that wrote the report. However, some parents ...

Philadelphia, Pa. (January 16, 2013) – With the rapidly expanding use of brain and spinal cord stimulation therapy (neuromodulation), new "remote presence" technologies may help to meet the demand for experts to perform stimulator programming, reports a study in the January issue of Neurosurgery, official journal of the Congress of Neurological Surgeons. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health. The preliminary study by Dr. Ivar Mendez of Queen Elizabeth II Health Sciences Centre in Halifax, Nova Scotia, Canada, supports ...

PHILADELPHIA -- In the first study to examine discussion of drug side effects on Internet message boards, researchers from the Perelman School of Medicine at the University of Pennsylvania found that breast cancer survivors taking the commonly prescribed adjuvant therapy known as aromatase inhibitors (AIs) often detailed in these forums troublesome symptoms resulting from the drugs, and they were apt to report discontinuing the treatment or switching to a different drug in the same class. The findings are published online this week in the journal Pharmacoepidemiology and ...

Fashionable people may turn up their noses at jute — the cheap fiber used to make burlap, gunny sacks, twine and other common products — but new research is enhancing jute's appeal as an inexpensive, sustainable reinforcement for mortar and concrete. The study appears in ACS' journal Industrial & Engineering Chemistry Research. Subhasish B Majumder and colleagues note that there has been a resurgence of interest in using economical, sustainable natural fibers, rather than steel or synthetic fibers, to reinforce the cement compositions used to make concrete and mortar, ...

Scientists are reporting development of the first practical way to make large amounts of a promising new anti-cancer substance that kills cancer cells differently than existing medicines. Their article on synthesis of the substance, and tests demonstrating its effectiveness in the laboratory, appears in ACS' Journal of Medicinal Chemistry. Isamu Shiina and colleagues explain that the substance, AMF-26, showed promise against certain forms of cancer in laboratory studies, fostering excitement about its potential for development as a new anti-cancer drug. That excitement ...

Philadelphia, Pa. (January 16, 2012) – Efforts to correct false beliefs about health care reform may backfire, depending on individuals' political views and level of knowledge, suggests a study in the February issue of Medical Care. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health. In the study, more politically knowledgeable people with positive views of Sarah Palin were likely to harden their opposition to the Affordable Care Act (ACA) when presented with information debunking Palin's "death panel" claim, according to the study ...

Philadelphia, Pa. (January 16, 2013) – Researchers using sophisticated genetic testing techniques have identified a promising new biomarker for diagnosis of glioma—the most common type of malignant brain tumor, reports the January issue of Neurosurgery, official journal of the Congress of Neurological Surgeons. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health. The biomarker ELTD1 "may serve as an additional biomarker for gliomas in preclinical and clinical diagnosis of gliomas," according to the study by Rheal A. Towner of Oklahoma ...

LOS ANGELES (Jan. 16, 2013) – In a promising finding for epileptic patients suffering from persistent seizures known as status epilepticus, researchers reported today that new medication could help halt these devastating seizures. To do so, it would have to work directly to antagonize NMDA receptors, the predominant molecular device for controlling synaptic activity and memory function in the brain. "Despite the development of new medications to prevent seizures, status epilepticus remains a life-threatening condition that can cause extensive brain damage in the patients ...

RIVERSIDE, Calif. (www.ucr.edu) — An assistant professor at the University of California, Riverside's Bourns College of Engineering is using the teeth of a marine snail found off the coast of California to create less costly and more efficient nanoscale materials to improve solar cells and lithium-ion batteries. The most recent findings by David Kisailus, an assistant professor of chemical and environmental engineering, details how the teeth of chiton grow. The paper was published today (Jan. 16) in the journal Advanced Functional Materials. It was co-authored by several ...

Researchers of the Catalan Institute of Oncology (ICO) at the Bellvitge Biomedical Research Institute (IDIBELL) have developed and validated a new method to diagnose hereditary breast and ovarian cancer syndrome based on mass sequencing of BRCA1 and BRCA2 genes. The model is based on a genetic and bioinformatic analysis which has been proved very effective. The new protocol has been described in an article published in the European Journal of Human Genetics. In recent years, new advances in sequencing techniques have involved the development of new platforms for nucleic ...

Deborah L. Parker remembers the evening of April 4, 1968. In her rural Waverly Virginia home with no indoor plumbing, on the way to the laundromat with her mother, it seemed as if the world stopped. The headline of the evening news: Dr. Martin Luther King Jr. has been assassinated. What happens to the dream? Deborah wondered. She was poor, black, and a good student in a segregated Sussex County. Her mother was a single parent of four and they lived with her maternal grandparents in a shotgun style house on a wooded back road. But her mother was determined and her grandparents ...

SAN DIEGO – Women who have migraines with aura, which are often visual disturbances such as flashing lights, may be more likely to have problems with their heart and blood vessels, and those on newer contraceptives may be at higher risk for blood clots, according to two studies released today that will be presented at the American Academy of Neurology's 65th Annual Meeting in San Diego, March 16 to 23, 2013. The first study showed that migraine with aura is a strong contributor to the development of major cardiovascular events such as heart attack and stroke. The Women's ...

CHICAGO – In a study that included nearly 1.3 million Medicare beneficiaries who were either first-time enrollees or enrollees switching plans, researchers found a positive association between enrollment and publicly reported Medicare Advantage star ratings reflecting plan quality, according to a study appearing in the January 16 issue of JAMA. "To inform enrollment decisions and spur improvement in the Medicare Advantage marketplace, the U.S. Centers for Medicare & Medicaid Services (CMS) provides star ratings reflecting Medicare Advantage plan quality. A combined Part ...

PHILADELPHIA – Brain diseases associated with the misformed protein tau, including Alzheimer's disease and frontotemporal lobar degeneration with tau pathologies, are characterized by neurofibrillary tangles (NFTs) comprised of pathological tau filaments. Tau tangles are also found in progressive supranuclear palsy, cortical basal degeneration and other related tauopathies, including chronic traumatic encephalopathy due to repetitive traumatic brain injuries sustained in sports or on the battle field. By using synthetic fibrils made from pure recombinant protein, Penn ...

The amount of amyloid β (Aβ) in the brains of people with mild cognitive impairment (MCI) is contributing to early memory loss, and increases with severity of symptoms, finds a study in BioMed Central's open access journal Alzheimer's Research & Therapy. The non-invasive study which used 18F-florbetaben to find Aβ plaques in brain scans to also show that in MCI the affect of Aβ on memory loss is independent of other aspects of mental decline. Positron emission tomography (PET) has previously relied on carbon-11 labeling of Aβ, however this ...

Research: Dietary sugars and body weight: a systematic review and meta-analyses of randomised controlled trials and cohort studies Editorial: Science souring on sugar Feature: Sugar and the heart: old ideas revisited Reducing sugar intake has a small but significant effect on body weight in adults, finds a paper published on bmj.com today. Although the effect is relatively small (an average reduction of 0.8 kg), the findings provide some support for international guidelines to cut sugar intake to less than 10% of total energy to help reduce the global obesity epidemic. Excessive ...

Research: Incidence of pulmonary and venous thromboembolism in pregnancies after in vitro fertilisation: cross sectional study In vitro fertilization (IVF) is associated with an increased risk of pulmonary embolism (blockage of the main artery of the lung) and venous thromboembolism (blood clots) during the first trimester of pregnancy, a study published today on bmj.com suggests. IVF has been used since 1978 for the 10% of couples worldwide affected by infertility. Approximately five million individuals have so far been born after IVF. It is well known that the ...

A virtual heart, developed at The University of Manchester, is revealing new information about one of the world's most common heart conditions. Researchers at the School of Physics and Astronomy used cutting edge technology to build an advanced computational model of an anatomically correct sheep's heart. It was made by taking a series of very thin slices of the heart, imaging them in 2D and then using a computer programme to render them into a 3D model. The reconstruction includes details of the complex fibre structure of the tissue, and the segmentation of the upper ...

Silicon wafers destined to become photovoltaic (PV) cells can take a bruising through assembly lines, as they are oxidized, annealed, purified, diffused, etched, and layered to reach their destinies as efficient converters of the sun's rays into useful electricity. All those refinements are too much for 5% to 10% of the costly wafers. They have micro-cracks left over from incomplete wafer preparation, which causes them to break on the conveyers or during cell fabrication. Scientists at the U.S. Department of Energy's National Renewable Energy Laboratory (NREL) have ...

NEWPORT, Ore. – The $15 billion ornamental fish industry faces a global problem with antibiotic resistance, a new study concludes, raising concern that treatments for fish diseases may not work when needed – and creating yet another mechanism for exposing humans to antibiotic-resistant bacteria. The risk to humans is probably minor unless they frequently work with fish or have compromised immune systems, researchers said, although transmission of disease from tropical fish has been shown to occur. More serious is the risk to this industry, which has grown significantly ...

PHILADELPHIA, January 15, 2013 -- Stage 3 Meaningful Use measures need to focus more on measuring improvements in patient health outcomes rather being than a large and growing collection of functional measures, the American College of Physicians (ACP) says in a letter submitted to the Health Information Technology Policy Committee (HITPC). While praising the HITPC and its Meaningful Use Work Group for their diligence and hard work in developing recommendations for the Meaningful Use portion of the EHR Incentive Program, ACP noted that the proposed Stage 3 measures appear ...

HONOLULU — While the iconic Haleakalā silversword plant made a strong recovery from early 20th-century threats, it has now entered a period of substantial climate-related decline. New research published this week warns that global warming may have severe consequences for the silversword in its native habitat. Known for its striking rosette, the silversword grows for 20-90 years before the single reproductive event at the end of its life, at which time it produces a large (up to six feet tall) inflorescence with as many as 600 flower heads. The plant was in jeopardy ...

New Rochelle, NY, January 15, 2013—A novel therapeutic approach called exon skipping involves bypassing a disease-causing mutation in a gene to restore normal gene expression and protein production. Two innovative examples of this strategy used to correct gene defects associated with muscular dystrophy are described in articles in Human Gene Therapy, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The articles are available free on the Human Gene Therapy website. Willem Hoogaars and a team of researchers from France, the Netherlands, Finland, and Germany ...

Researchers at Western University in London, Canada, have identified a new genetic mutation for amyotrophic lateral sclerosis (ALS), opening the door to future targeted therapies. Dr. Michael Strong, a scientist with Western's Robarts Research Institute and Distinguished University Professor in Clinical Neurological Sciences at the Schulich School of Medicine & Dentistry, and colleagues found that mutations within the ARHGEF28 gene are present in ALS. When they looked across both familial and sporadic forms of the disease, they found that virtually all cases of ALS demonstrated ...

CORVALLIS, Ore. – A new study has concluded that sports fans love to root for a hero and against a villain, but if the game is exciting, they'll enjoy it no matter who wins. The research, recently published in the Journal of Media Psychology, examines emotional experiences, outcome satisfaction, and enjoyment of athletic events, particularly ones featuring individual athletes rather than team sports. Lead author Colleen Bee, an assistant professor of marketing at Oregon State University, said the Olympics are a good example of an event where fans often cheer for little-known ...