Instant Offer is currently being operated in a limited geographical area and will be closely monitored before potentially being rolled out more widely across the UK later in the year. Instant Offer is aimed at consumers who want to sell their car quickly and conveniently, at a fair price. The user enters details about their car and its condition on Autotrader.co.uk to receive an online offer. If they accept the offer, their car is inspected by an approved dealer to ensure it matches the description online, before the final offer is confirmed. Once the sale is agreed, ...

SALT LAKE CITY – Using advanced computer simulations, University of Utah College of Pharmacy researchers have produced moving images of a protein complex that is an important target for anti-cancer drugs. This advancement has significant implications for discovering new therapies that could attack cancer without damaging the DNA of healthy cells, according to an article published July 31, 2012 in the Proceedings of the National Academy of Sciences. The researchers used high-performance computing technology to demonstrate that a protein complex called LSD1/CoREST undergoes ...

The Department of Homeland Security (DHS) Science and Technology Directorate's (S&T) new low-cost device for dismantling dangerous pipe bombs may look like a tinkerer's project, but that's no accident. The Semi Autonomous Pipe Bomb End-cap Remover (SAPBER) is unassuming in appearance, but sophisticated enough to preserve the forensic evidence needed to track down the perpetrator. "From ten paces away, you might mistake the contraption for a pressure washer," says S&T Program Manager Christine Lee. "But step closer and you'll find an ingenious device bristling with ...

The forests of the coastal regions from California to British Columbia are renowned for their unique and ancient animals and plants, such as coast redwoods, tailed frogs, mountain beavers and the legendary Bigfoot (also known as Sasquatch). Whereas Bigfoot is probably just fiction, a huge, newly discovered spider is very real. Trogloraptor (or "cave robber") is named for its cave home and spectacular, elongate claws. It is a spider so evolutionarily special that it represents not only a new genus and species, but also a new family (Trogloraptoridae). Even for the species-rich ...

Insomnia sufferers in England could have greater access to successful treatment, thanks to a training programme developed as part of trials of Cognitive Behaviour Therapy for Insomnia (CBTi), funded by the Economic and Social Research Council (ESRC). In Britain, people report having insomnia more often than any other psychological condition, including anxiety, depression and even pain, according to the Office of National Statistics. Yet the only treatment offered in most doctors' surgeries is a course of sleeping tablets. "It is well known that sleeping pills can be ...

TUCSON, Ariz. (August 17, 2012) -- Mo Ehsani, Professor Emeritus of Civil Engineering at the University of Arizona, has designed a new, lightweight underground pipe he says could transform the pipeline construction industry. Instead of conventional concrete or steel, Ehsani's new pipe consists of a central layer of lightweight plastic honeycomb, similar to that used in the aerospace industry, sandwiched between layers of resin-saturated carbon fiber fabric. In combination, these materials are as strong, or stronger, than conventional steel and concrete pipes, which ...

When uncoupling proteins are active, mitochondria produce heat instead of ATP. This may be useful under certain circumstances, such as when an animal is hibernating. But non-hibernating animals also have them. Particularly poorly understood is the uncoupling protein UCP2. Elena Pohl and colleagues at the University of Veterinary Medicine, Vienna, show that the protein occurs mainly in cells of the immune system. The group's highly provocative findings are published in the online journal PLOS ONE. Mitochondria represent the powerhouses of the eukaryotic cell. They ...

Santa Cruz, California—Scientists have sequenced the genome of one of the iconic Galapagos finches first described by Charles Darwin. The genome of the medium ground finch (Geospiza fortis) is among the first of a planned 100 genomes of vertebrate species to be sequenced and released by an international collaboration between the Genome 10K project and BGI. This finch genome, the first of the BGI-Genome 10K collaboration to be made available through the UCSC Genome Browser, represents both a scientific and a symbolic advancement, according to Duke University associate professor ...

New research, led by University of Warwick physicist Dr Kareem Osman, has provided significant insight into how the solar wind heats up when it should not. The solar wind rushes outwards from the raging inferno that is our Sun, but from then on the wind should only get cooler as it expands beyond our solar system since there are no particle collisions to dissipate energy. However, the solar wind is surprisingly hotter than it should be, which has puzzled scientists for decades. Two new research papers led by Dr Osman may have solved that puzzle. Turbulence pervades ...

Most people are not aware of the fact that 84% of the European crops are partially or entirely dependent on insect pollination. While managed honeybees pollinate certain crops, wild bees, flies and wasps cover a very broad spectrum of plants, and thus are considered the most important pollinators in Europe. The serious decline in the number of managed honeybees and wild bees reported in Europe over the last few decades has the potential to cause yield decreases with threats to the environment and economy of Europe. The future of the pollination services provided by bees ...

A large-scale survey of the mental condition of military personnel before, during and after their posting to Afghanistan has proved thought-provoking. In total, 746 Danish soldiers took part in the survey. The soldiers completed a questionnaire five times in all – before their posting, during their time in Afghanistan and three times after their return to Denmark. Professor Dorthe Berntsen of the Center on Autobiographical Memory Research – CON AMORE, Department of Psychology, Aarhus University, Business and Social Sciences, is responsible for the study, together with ...

Researchers in India have developed a total cholesterol test that uses a digital camera to take a snapshot of the back of the patient's hand rather than a blood sample. The image obtained is cropped and compared with images in a database for known cholesterol levels. Writing in the International Journal of Medical Engineering and Informatics, N.R. Shanker of the Sree Sastha Institute of Engineering and Technology and colleagues describe how they have developed a non-invasive way to test cholesterol levels in patients at increased risk of heart disease. Their approach ...

TORONTO, Aug. 17, 2012--When members of the public participate in research studies, they are often given incentives – such as cash or gift cards for food – as compensation or reimbursement for their time and effort. Not so for Canada's prison population. A new analysis shows that there is inconsistency in how and when incentives are used for research participants under criminal justice supervision. Of the provinces, territories and federal government, only two jurisdictions have written policy around the use of research incentives, according to a national study led by ...

Whether a material conducts electricity without losses is not least a question of the right temperature. In future it may be possible to make a more reliable prediction for high-temperature superconductors. These materials lose their resistance if they are cooled with liquid nitrogen, which is relatively easy to handle. An international team, in which physicists of the Max Planck Institute for Solid State Research in Stuttgart played a crucial role, has now discovered that this form of superconductivity competes with charge density waves, i.e. with a periodically fluctuating ...

VIDEO: A Spanish researcher has proposed human, agricultural and livestock waste, such as urine, as a way to absorb CO2. Click here for more information. The ocean, the ground, rocks and trees act as carbon drains but are far from places where greenhouses gases are concentrated, especially CO2. A Spanish researcher has proposed human, agricultural and livestock waste, such as urine, as a way to absorb this gas. Absorbing the large quantities of carbon dioxide and other greenhouse ...

EAST LANSING, Mich. --- Two new species of owls have been discovered in the Philippines, and a Michigan State University researcher played a key role in confirming their existence. The discovery, which is featured in the current issue of Forktail, the Journal of Asian Ornithology, took years to confirm, but it was well worth the effort, said the paper's lead author Pam Rasmussen, MSU assistant professor of zoology and assistant curator of mammalogy and ornithology at the MSU Museum. "More than 15 years ago, we realized that new subspecies of Ninox hawk-owls existed ...

CAMBRIDGE, MA -- A penny-sized rocket thruster may soon power the smallest satellites in space. The device, designed by Paulo Lozano, an associate professor of aeronautics and astronautics at MIT, bears little resemblance to today's bulky satellite engines, which are laden with valves, pipes and heavy propellant tanks. Instead, Lozano's design is a flat, compact square — much like a computer chip — covered with 500 microscopic tips that, when stimulated with voltage, emit tiny beams of ions. Together, the array of spiky tips creates a small puff of charged particles that ...

Although George Church's next book doesn't hit the shelves until Oct. 2, it has already passed an enviable benchmark: 70 billion copies—roughly triple the sum of the top 100 books of all time. And they fit on your thumbnail. That's because Church, the Robert Winthrop Professor of Genetics at Harvard Medical School and a founding core faculty member of the Wyss Institute for Biomedical Engineering at Harvard University, and his team encoded the book, Regenesis: How Synthetic Biology Will Reinvent Nature and Ourselves, in DNA, which they then read and copied. Biology's ...

NASA's Terra satellite passed over Tropical Storm Gordon as it continues to spin up in the North central Atlantic Ocean, and revealed the storm has become less symmetric, indicating it is being battered by wind shear. When Terra passed over Gordon on August 16, 2012 at 10:25 a.m. EDT (1425 UTC) the Moderate Resolution Imaging Spectroradiometer (MODIS) instrument captured a visible image of the storm. The image showed that the bulk of Gordon's clouds were pushed to the north and northeast as a result of southwesterly wind shear. The MODIS image showed what appeared to ...

Berkeley — Two new studies by scientists at the University of California, Berkeley, provide a clearer picture of why some species move in response to climate change, and where they go. One study, published online Monday, Aug. 6, in the journal Global Change Biology, finds that changes in precipitation have been underappreciated as a factor in driving bird species out of their normal range. In the other study, published today (Wednesday, Aug. 15) in the journal Proceedings of the Royal Society B, researchers found a sharp decrease in range for the Belding's ground squirrel, ...

Highlights Vancomycin was the most commonly prescribed antibiotic in dialysis patients for treating certain bloodstream infections, but cefazolin was 38% better than vancomycin at preventing hospitalizations and deaths from these infections. Cefazolin was also 48% better at preventing sepsis. Hundreds of thousands of Americans develop bloodstream infections every year. Washington, DC (August 16, 2012) — The antibiotic most commonly prescribed to treat bloodstream infections in dialysis patients may not always be the best choice, according to a study appearing ...

Highlights The blood levels of certain abnormal proteins and the antibodies that attack them rise according to the severity of one of the most common diseases of the kidney. The findings may help in the diagnosis and management of the disease, called IgA nephropathy. IgA nephropathy can lead to high blood pressure, swelling and, in some cases, kidney failure. Washington, DC (August 16, 2012) — Increasing blood levels of particular proteins may act as warning signs for patients with one of the most common diseases of the kidney, according to a study appearing ...

Highlights Approximately 1 in 40 men and 1 in 60 women of middle age will develop kidney failure if they live into their 90s. People with reduced kidney function face an even higher risk. Kidney failure is on the rise and currently afflicts 2 million people worldwide. Washington, DC (August 16, 2012) — How likely are middle-aged adults to develop kidney failure during their lifetime? A study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN) provides some insights, which may be used to help set priorities related to kidney ...

SALT LAKE CITY, Aug. 16, 2012 – A University of Utah survey of judges in 19 states found that if a convicted criminal is a psychopath, judges consider it an aggravating factor in sentencing, but if judges also hear biological explanations for the disorder, they reduce the sentence by about a year on average. The new study, published in the Aug. 17, 2012, issue of the journal Science, illustrates the "double-edged sword" faced by judges when they are given a "biomechanical" explanation for a criminal's mental disorder: If a criminal's behavior has a biological basis, ...

What if a key factor ultimately behind a cancer was not a genetic defect but ecological? Ecologists have long known that when some major change disturbs an environment in some way, ecosystem structure is likely to change dramatically. Further, this shift in interconnected species' diversity, abundances, and relationships can in turn have a transforming effect on health of the whole landscape – causing a rich woodland or grassland to become permanently degraded, for example – as the ecosystem becomes unstable and then breaks down the environment. For this reason, it ...