Auto Trader offers in excess of 60,000 cars priced GBP14,000 and above, more than double the number offered by any of its main online rivals - 36,280 are used cars, 20,880 are nearly new cars less than 12 months old and 3,510 are new cars. Of the total, more than two thirds are offered by franchised dealers, the remainder being offered by used car supermarkets, independent dealers and private motorists. Nathan Coe, Group Director, Auto Trader said: "With more than double the number of cars costing GBP14,000 and above than any of our main online rivals, and with ...

Capital Credit Union and ScotWest Credit Union have been disturbed to discover some of the worst cases of mis-selling of Scottish Trust Deeds, Sequestration Agreements and other unsuitable plans are rogue insolvency practitioners. The use of insolvency agreements has greatly increased in recent years, and the once stringent rules for bankruptcy awards have been relaxed to make it available to a wider range of individuals. Combined with more widespread promotion of bankruptcy as an acceptable debt management solution, the result has been an increasing number of awards ...

Food is a natural part of life for all organisms on earth. While people eat food every day, they may not understand how their food choices can impact their physical and mental health. Over time, the wrong food choices can cause weight gain, heart disease, an increased risk of cancer, depression, anxiety and a wide variety of other health issues. The following guide explores the intricate link between food choices and mental health. The average human being consumes 2,000 calories every day. This amounts to over 700,000 calories every year. While it's possible to get ...

Backlinks - that's a term you have probably heard often when looking into Internet marketing. What does it mean, though? How important ARE backlinks? And, of course, the all-important question: how do you get more of them? Here's the lowdown: Backlinks are one factor that Google's algorithm looks at when deciding on a website's search rank. The reason? The more backlinks a site has, the more Google is likely to think that site contains quality content that deserves to be shared - and therefore, deserves a high rank. It makes sense: good news spreads fast, and ...

Election turnout among young people of color, including African Americans, Latinos and Native Americans, may drop by nearly 700,000 voters in states with new photo ID laws, a decline potentially impacting presidential contests in the battleground states of Florida and Pennsylvania, according to a report released today by the Black Youth Project. Completed by Jon C. Rogowski, PhD, an assistant professor of political science in Arts & Sciences at Washington University in St. Louis, and Cathy Cohen, a University of Chicago political science professor, the report found that ...

New York, NY (September 13, 2012) — Scientists generally think that reduced insulin production by the pancreas, a hallmark of type 2 diabetes, is due to the death of the organ's beta cells. However, a new study by Columbia University Medical Center (CUMC) researchers shows that beta cells do not die but instead revert to a more fundamental, undifferentiated cell type. The findings suggest that strategies to prevent beta cells from de-differentiating, or to coax them to re-differentiate, might improve glucose balance in patients with type 2 diabetes. The study, conducted ...

Lung cancer is a leading cause of death worldwide and is associated with very low survival rates. Two new genome-sequencing studies have uncovered novel genes involved in the deadly disease, as well as striking differences in mutations found in patients with and without a history of smoking. The findings, published September 13th by Cell Press in the journal Cell, could pave the way for personalized therapies that boost survival rates. "These efforts should spur more studies to fully understand the genomic landscape of lung cancer—more specifically, those who have no ...

CINCINNATI – New research reveals that fruit flies and mammals may share a surprising evolutionary link in how they control body temperature through circadian rhythm, unlocking new ways to study the insects as models of human development and disease. The study posted online Sept. 13 by Current Biology reports that similar to people, Drosophila fruit flies – a common research tool in life sciences – have a genetically driven internal clock. This circadian clock prompts the insects to seek out warmer or cooler external temperatures according to the time of the day. Cold-blooded ...

In a study at the University of California, San Diego and VA San Diego Healthcare, researchers were able to regenerate "an astonishing degree" of axonal growth at the site of severe spinal cord injury in rats. Their research revealed that early stage neurons have the ability to survive and extend axons to form new, functional neuronal relays across an injury site in the adult central nervous system (CNS). The study also proved that at least some types of adult CNS axons can overcome a normally inhibitory growth environment to grow over long distances. Importantly, ...

BOSTON – Invariant natural killer T-cells (iNKT) are a unique subset of immune cells that are known to influence inflammatory responses. Now, a scientific team led by researchers at Beth Israel Deaconess Medical Center (BIDMC) has found that iNKT cells play a protective role in guarding against obesity and the metabolic syndrome, a major consequence of obesity. Their discovery, published on-line today in the journal Immunity, also finds that although iNKT cells are lost when humans become obese, they can be restored through weight loss, and further suggests that therapies ...

VIDEO: The video shows beating heart muscle cells, or cardiomyoctes, at day 10 of differentiation. Click here for more information. SAN FRANCISCO, CA—September 13, 2012— Scientists at the Gladstone Institutes have revealed the precise order and timing of hundreds of genetic "switches" required to construct a fully functional heart from embryonic heart cells—providing new clues into the genetic basis for some forms of congenital heart disease. In a study being published ...

BOSTON, MA—Melanoma is the most dangerous type of skin cancer and is the leading cause of death from skin disease. Rates are steadily increasing, and although risk increases with age, melanoma is now frequently seen in young people. But what if we could pinpoint when seemingly innocuous skin pigment cells mutate into melanoma? Researchers at Brigham and Women's Hospital (BWH) have achieved this. Teams led by Yujiang Geno Shi, PhD, from BWH's Department of Medicine, and George F. Murphy, MD, from BWH's Department of Pathology have discovered a new biomarker for the lethal ...

AUDIO: Lung cancer patients with a history of smoking have 10 times more genetic mutations in their tumors than those with the disease who have never smoked, according to a new... Click here for more information. Lung cancer patients with a history of smoking have 10 times more genetic mutations in their tumors than those with the disease who have never smoked, according to a new study from Washington University School of Medicine in St. Louis. "None of us were surprised that ...

TEMPE, Ariz. – If you think this summer was hot, it's nothing compared to the summer of 1913, when the hottest temperature ever recorded was a searing 134 F in Death Valley, Calif. But while that reading was made 99 years ago, it is only being recognized today by the World Meteorological Organization (WMO) as the most extreme temperature ever recorded. That's because an international team of meteorologists recently finished an in-depth investigation of what had been the world-record temperature extreme of 58 C (136.4 F), recorded on Sept. 13, 1922 in El Azizia, Libya. ...

CAMBRIDGE, Mass. (September 13, 2012) – Several years ago, biologists discovered that regular body cells can be reprogrammed into pluripotent stem cells — cells with the ability to become any other type of cell. Such cells hold great promise for treating many human diseases. These induced pluripotent stem cells (iPSCs) are usually created by genetically modifying cells to overexpress four genes that make them revert to an immature, embryonic state. However, the procedure works in only a small percentage of cells. Now, new genetic markers identified by researchers at ...

University of Rochester Medical Center scientists discovered new genetic evidence linking cholesterol and cancer, raising the possibility that cholesterol medications could be useful in the future for cancer prevention or to augment existing cancer treatment. The data, published in the online journal Cell Reports, support several recent population-based studies that suggest individuals who take cholesterol-lowering drugs may have a reduced risk of cancer, and, conversely that individuals with the highest levels of cholesterol seem to have an elevated risk of cancer. The ...

New research could clarify how inflammatory bowel diseases (IBD), conditions that include ulcerative colitis and Crohn's disease, are triggered and develop. Scientists at Emory University School of Medicine have shown how the immune system can compensate for a "leaky gut" and prevent disease in mice that are susceptible to intestinal inflammation. These findings could explain why some individuals who are susceptible to developing IBD do or do not get the disease. The results will be published online Sept. 13 in the journal Immunity. "Our results suggest that when ...

Patients admitted to hospital with obstructed heart arteries were three times more likely to experience complications when they were in hospital if they felt they were not in control of their condition, according to research published in the October issue of the Journal of Advanced Nursing. However, persistent anxiety on its own appeared to have little effect on whether patients experienced complications or not. Researchers looked at 171 patients admitted to hospitals in the USA, Australia and New Zealand with acute coronary syndrome (ACS), following them for two years. ...

It isn't only birds that move south as autumn approaches. Some insects also live their lives on the same principle. A new study of migratory insects has just been published that shows that a considerably higher number of insects survive and migrate back south in the autumn than was previously believed. "These results are really exciting, because we have managed to show that it really is profitable for insects to migrate north at the start of the summer", says Lars Pettersson, a Reader at the Department of Biology, Lund University, Sweden. The findings help to fundamentally ...

Amsterdam, September 12, 2012 - Elsevier, a world-leading provider of scientific, technical and medical information products and services, announced today the publication of a position statement by the European Menopause and Andropause Society (EMAS) in the journal Maturitas. The society published a clinical guide on low-dose vaginal estrogens for postmenopausal vaginal atrophy also including a summary of recommendations. Vaginal atrophy is common after menopause and adversely affects quality of life in one out of every two women. This guide provides the evidence for ...

Philadelphia, PA, September 13, 2012 – Ghrelin is a hormone released by the lining of the stomach that promotes feeding behavior. Decreasing ghrelin levels could potentially help combat obesity -- in fact, a vaccine that lowers ghrelin levels in order to reduce appetite is being studied as a treatment for obesity. However, many people eat as a way to relieve stress. If low ghrelin levels increase stress, its effectiveness as a treatment for obesity may be reduced. In the current issue of Biological Psychiatry, researchers led by Dr. Zane Andrews of Monash University in ...

Inhibitory neurotransmitters dampen the activity of neurons. This regulatory effect forms the basis for the action of many anesthetics. For example, propofol, a common anesthetic, interacts with receptors on neural cell membranes that normally bind the inhibitory neurotransmitter gamma-amino butyric acid (GABA). Binding of GABA opens protein channels through which negatively charged chloride ions stream into the cell. By raising the resting electrical potential across the membrane, this makes the cell less likely to fire in response to an incoming stimulus. Propofol magnifies ...

An international team of scientists headed from the University of Santiago de Compostela ensures that reading the labels on food products is linked to obesity prevention, especially in women. According to the study which used data from the USA, female consumers who consult food labels weigh nearly 4 kilograms less. Along with the Universities of Tennessee, Arkansas (USA) and the Norwegian Institute for Agricultural Finance Research, the University of Santiago de Compostela has participated in a study on the relationship between reading the food label and obesity. The ...

WHAT: Several large clinical trials have demonstrated that a daily oral dose of one or two antiretroviral drugs used to treat HIV infection can prevent infection in an approach known as pre-exposure prophylaxis, or PrEP. The level of protection, however, depends on taking the drugs regularly. For instance, the landmark iPrEx study (http://www.niaid.nih.gov/news/newsreleases/2010/Pages/iPrEx.aspx) found that overall, men who have sex with men who received a daily dose of tenofovir plus emtricitabine (Truvada) had a 44 percent lower risk of HIV infection compared with ...

A mysterious form of cell death, coded in proteins and enzymes, led to a discovery by UNC researchers uncovering a prime suspect for new cancer drug development. CIB1 is a protein discovered in the lab of Leslie Parise, PhD , professor and chair of the department of biochemistry at the University of North Carolina at Chapel Hill. The small calcium binding protein is found in all kinds of cells. Cassandra Moran, DO, was a pediatric oncology fellow at UNC prior to accepting a faculty position at Duke University. She is interested in neuroblastoma, a deadly form of ...