COLUMBUS, Ohio – A new study by Ohio State University cancer researchers provides a rational for treating breast cancer by combining two kinds of targeted agents, one that inhibits an overactive, cancer-causing pathway in cancer cells and one that reverses changes that silence genes that normally prevent cancer. Both types of agents are currently available and being evaluated individually in clinical trials, the researchers note. The findings, published online in the journal Cancer Research, show that abnormal activation of the PI3K/AKT signaling pathway leads to the ...

The magnitude of climate change during Earth's deep past suggests that future temperatures may eventually rise far more than projected if society continues its pace of emitting greenhouse gases, a new analysis concludes. The study, by National Center for Atmospheric Research (NCAR) scientist Jeffrey Kiehl, will appear as a "Perspectives" article in this week's issue of the journal Science. The work was funded by the National Science Foundation (NSF), NCAR's sponsor. Building on recent research, the study examines the relationship between global temperatures and high ...

Identifying tuberculosis patients in Africa using passive methods is leaving many cases undiagnosed, according to researchers from the Netherlands, Kenya and the United States, who studied case detection methods in HIV-prone western Kenya. Tuberculosis (TB) occurs commonly in men and women with HIV, but in these patients TB can be more difficult to detect. The findings were published online ahead of the print edition of the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine. "Limited information exists on the prevalence of tuberculosis ...

DURHAM, NC and KING COUNTY, WA – An effort in King County, Washington, to add nutrition facts labeling to fast food menus had no effect on consumer behavior in its first year. As part of a comprehensive effort to stem the rise in obesity, the county, which includes Seattle and environs, imposed a mandatory menu labeling regulation on all restaurant chains with 15 or more locations beginning in January, 2009. Restaurants had to disclose calorie information at the point of purchase. Researchers from Duke-National University of Singapore (NUS) Graduate Medical School ...

A simple, automated method of tracking E. coli uses a laser to detect and monitor the microbe in potentially contaminated bodies of water or waterways. The technique described this month in the International Journal of Computational Biology and Drug Design could reduce the incidence of waterborne disease outbreaks. Microbial contamination of water is a worldwide environmental and health problem. Water related diseases are the leading causes of illness and death in the world. The impacts of water quality on public health and economy are highly significant as evidenced ...

Wild red deer on the Isle of Rum, which were featured in the BBC TV series Autumnwatch, are rutting earlier in the year, a study shows. Scientists believe the annual rutting season on the Isle of Rum could be changing because of warming spring and summer temperatures. The study shows that the rutting and calving seasons are now up to two weeks earlier on average compared with 30 years ago. The research was based on a 38-year study of the ecology of red deer on the Isle of Rum and used annual records of breeding success in more than 3,000 individually recognisable ...

The Estero de Domingo Rubio wetland, located near the Marismas del Odiel Natural Area in the Huelva estuary, is regionally, nationally and internationally protected thanks to its ecological value. However, its tributary rivers and the Ría de Huelva estuary pump manmade pollutants into it, which could affect its water quality and ecosystem. Industrial activity, accumulations of dangerous waste, the expansion of farming, and excessive extraction of sand and gravel for the construction industry are the leading threats to the Estero de Domingo Rubio wetland, the tidal system ...

The people in Spain at greatest risk of suffering farming accidents are those aged over 65, followed by people under 16 and people from outside the agricultural sector. These are the results of a study by the Public University of Navarre (UPNA), which shows that most of these deaths are due to people being crushed by tractors. "Aside from recognised farming workers, other employees die in this sector and these deaths are not recorded. Our objective was to compare the real and official data on fatal farming accidents and to classify the most commonly associated risks", ...

Eating blueberries can guard against high blood pressure, according to new research by the University of East Anglia (UEA) and Harvard University. High blood pressure – or hypertension – is one of the major cardiovascular diseases worldwide. It leads to stroke and heart disease and costs more than $300 billion each year. Around a quarter of the adult population is affected globally – including 10 million people in the UK and one in three US adults. Published next month in the American Journal of Clinical Nutrition, the new findings show that bioactive compounds in ...

The unusually cold weather this winter has been caused by a change in the winds. Instead of the typical westerly winds warmed by Atlantic surface ocean currents, cold northerly Arctic winds are influencing much of Europe. However, scientists have long suspected that far more severe and longer-lasting cold intervals have been caused by changes to the circulation of the warm Atlantic ocean currents themselves. Now new research led by Cardiff University, with scientists in the UK and US, reveals that these ocean circulation changes may have been more dramatic than ...

A woman passing by the window display is captivated and asks her companion "Isn't the leather bag chic?" "Which one do you mean? There are so many of them." The woman points to one of the bags and as if by magic the luxurious purse appears on a display behind the shop window. Then she points to a button and the designer object rotates on the screen. "So that's what it looks like from the back." The woman passing by is impressed. She makes another gesture to zoom the bag towards her letting her to see every detail. This particular shopping experience is courtesy of new ...

PITTSBURGH, Jan. 14 – A gene from the measles virus plays a key role in the development of Paget's disease of bone, according to a team of researchers led by the University of Pittsburgh School of Medicine. Their findings, recently published in Cell Metabolism, confirm a long-held speculation that the childhood infection is an environmental trigger for the disease and reveal how the viral gene contributes to the development of its characteristic bone lesions. "Our earlier work showed that bone cells called osteoclasts in about 70 percent of these patients contain a certain ...

The days are long gone when all you needed to be a truck driver was a heavy goods vehicle license and the ability to read a map. Nowadays it is a skilled occupation which requires lots of qualifications. Modern truck drivers have to operate electronic devices, adapt their routes expertly to the given traffic and loading situation, know how to drive fuel-efficiently, be up to date with statutory regulations and monitor the safety of their load. Then there is all the complex legislation introduced at EU level. What's more, drivers who make trips to other countries also need ...

January 14, 2011 -- Intensive early education programs for low-income children have been shown to yield numerous educational benefits, but few studies have looked more broadly at their impact on health and health behaviors. A new study conducted by researchers at Columbia University's Mailman School of Public Health examines this issue, using data from a the well-known Carolina Abecedarian Project (ABC), a randomized control study that enrolled 111 infants in the 1970s and continued to follow them through age 21. Researchers found that individuals who had received the ...

WASHINGTON—Scientists have taken a major step toward accurately determining the amount of energy that the sun provides to Earth, and how variations in that energy may contribute to climate change. In a new study of laboratory and satellite data, researchers report a lower value of that energy, known as total solar irradiance, than previously measured and demonstrate that the satellite instrument that made the measurement—which has a new optical design and was calibrated in a new way—has significantly improved the accuracy and consistency of such measurements. The new ...

AURORA, Colo. (Jan. 14, 2011) - Acute inflammation of the lung is a poorly recognized human disease that develops in surprising and unexpected ways. The acute lung injury (ALI) or adult respiratory distress syndrome (ARDS) is a vital new concern for soldiers, but it can develop in anyone during a systemic infection, after severe trauma, as a result of bone fracture, following severe burns and in many other ways as well-- the initial cause may have nothing apparent to do with the lung itself. However, an answer to halting lung inflammation may have been discovered, thanks ...

An 18-year study of Kenya's coral reefs by the Wildlife Conservation Society and the University of California at Santa Cruz has found that overfished reef systems have more sea urchins—organisms that in turn eat coral algae that build tropical reef systems. By contrast, reef systems closed to fishing have fewer sea urchins—the result of predatory fish keeping urchins under control—and higher coral growth rates and more structure. The paper appears in the December 2010 issue of the scientific journal Ecology. The authors include Jennifer O'Leary of the University of ...

Building high pressure is expected to make Tropical Storm Vince do a U-turn in the Southern Indian Ocean and take a westward track away from Western Australia. Two instruments on NASA's Aqua satellite looked at Vince's clouds this morning before Vince's forecast U-turn. From its vantage point in space, Aqua passed over Tropical Storm Vince on January 14 at 06:20 UTC (1:20 a.m. EST/2:20 p.m. Australia/Perth time) and the Moderate Resolution Spectroradiometer (MODIS) instrument captured a visible image that showed the bulk of Vince's thunderstorms southwest of the storm's ...

Tropical Storm Vania moved through southeastern New Caledonia on January 14 and NASA's TRMM satellite noticed heavy rainfall occurring. Residents of Norfolk Island are now expected to receive gusty winds and rainfall as Vania continues to move south in the South Pacific Ocean. New Caledonia is located in the southwest Pacific and is made up of a main island called Grande Terre, the Loyalty Islands and several smaller islands. At 0422 UTC (3:22 p.m. Pacific/Noumea local time) on January 14, the Tropical Rainfall Measuring Mission (TRMM) satellite, managed by NASA and ...

The low pressure area known as System 94P on January 13 strengthened into the seventh tropical cyclone of the South Pacific Cyclone season, today becoming Tropical Storm Zelia. NASA's TRMM satellite found heavy rainfall was already occurring in the storm as it was turning away from New Zealand and heading toward New Caledonia. New Caledonia just dealt with Tropical Storm Vince today, and is expecting to feel winds and rains from Tropical Storm Zelia as it passes to the southwest of the island group this weekend. The Tropical Rainfall Measuring Mission (TRMM) satellite, ...

SAN ANTONIO (Jan. 14, 2010) — The kidney is made up of roughly 1 million working units called nephrons. These basic structural units remove waste products from the blood, recycle some substances to be reused and eliminate what is left as urine. The end segment of nephrons, called the distal nephron, helps set blood pressure by controlling the amount of sodium in our blood. Today scientists at The University of Texas Health Science Center San Antonio reported how this essential function of the distal nephron is regulated. They demonstrated that sodium handling by the ...

Rice bred to perform well in the toughest conditions where the poorest farmers grow rice is a step away from reaching farmers thanks to a major project led by the Chinese Academy of Agricultural Sciences and the International Rice Research Institute (IRRI). Green Super Rice is actually a mix of more than 250 different potential rice varieties and hybrids variously adapted to difficult growing conditions such as drought and low inputs, including no pesticide and less fertilizer, and with rapid establishment rates to out-compete weeds, thus reducing the need for herbicides. ...

Multilingual support will help the company better meet the needs of its rapidly growing base of international users and attract new consumers. More languages will be supported in the future releases - Dutch and Polish are planned to be released in few weeks already. Since the first commercial release in March 2010, AweSync has been adopted by more than 6200 users from 69 countries. The utility´s user base continues to grow in non-English-speaking countries. By providing multilingual support, eQuality aims to deliver the product that better meets the language preferences ...

The optimized DRM-X 3.0 enables content providers to protect and manage their digital content and monetize them over the whole world. DRM-X 3.0 focuses on supporting cross platform, mobile and portable devices. It enables growth in profits and new business models. Haihaisoft DRM-X 3.0 - new content protection solution now expands to Mac, and it will support Google Android soon. DRM-X 3.0 New Features: New Security Design Based-on the past 7 years DRM research and development, the new DRM-X 3.0 security designs has greatly improved both system security level and ...

Consider many alternatives for retirement investment planning and learn about retirement investment strategies as a young or middle-aged adult can save all kinds of financial worries later. The soundest approach to investing for retirement is to save slowly but persistently, and invest widely with as much information as possible. Jacobson Group will give your business the tools, resources and services you need to thoroughly evaluate, fund, and administer your business deal. We will help you determine key factors, consequences, deal-breakers and opportunities that stand ...