Malignant melanoma is a highly aggressive and notoriously chemoresistant form of cancer. In this paper, Ohanna et al. reveal that anti-melanoma drugs may, paradoxically, induce a senescence-associated secretory profile ("secretome") that can ultimately promote metastasis and contribute to melanoma relapse. While cellular senescence has been thought of as a natural mechanism to combat uncontrolled cell growth, or cancer, recent studies have shown that some cell types express a secretome during senescence that alters the tumor microenvironment and affects the cell's response ...

If Dad loves good food and you love the idea of giving everyone a day off from cooking the week of Father's Day, bring Dad to The Eatery on Beach Street for "Steak Gone Wild." Chef Don Gifford will be making steak three ways. First, a Swiss style steak stuffed with spinach roulade with sun dried tomatoes. A family favorite, Don's stuffed steak is rolled and cut into pinwheels and served with new potatoes and a fresh vegetable medley. Chef Don's Mediterranean-themed smothered steak is seasoned with fresh tomato, onion and olive oil and served with fresh okra ...

The ALPHA Collaboration, an international team of scientists working at CERN in Geneva, Switzerland, has created and stored a total of 309 antihydrogen atoms, some for up to 1,000 seconds (almost 17 minutes), with an indication of much longer storage time as well. ALPHA announced in November, 2010, that they had succeeded in storing antimatter atoms for the first time ever, having captured 38 atoms of antihydrogen and storing each for a sixth of a second. In the weeks following, ALPHA continued to collect anti-atoms and hold them for longer and longer times. Scientists ...

(Embargoed) CHAPEL HILL, N.C. – Researchers at the University of North Carolina at Chapel Hill School of Medicine have shown in an animal study that transplantation of adult stem cells enriched with a bone-regenerating hormone can help mend bone fractures that are not healing properly. The UNC study team led by Anna Spagnoli, MD, associate professor of pediatrics and biomedical engineering, demonstrated that stem cells manufactured with the regenerative hormone insulin-like growth factor (IGF-I) become bone cells and also help the cells within broken bones repair the ...

PROVIDENCE, R.I. [Brown University] — Any parent knows that newborns still have a lot of neurological work to do to attain fully acute vision. In a wide variety of nascent animals, genes provide them with only a rough wiring plan and then leave it to the developing nervous system to do its own finish work. Two studies by Brown University researchers provide new evidence of a role for exposure to light in the environment as mouse pups and tadpoles organize and refine the circuitry of their vision systems. "Through a combination of light-independent and light-dependent ...

INDIANAPOLIS – Researchers at the Indiana University School of Medicine have discovered a peptide that short circuits a pathway for chronic pain. Unlike current treatments this peptide does not exhibit deleterious side effects such as reduced motor coordination, memory loss, or depression, according to an article in Nature Medicine posted online June 5, 2011. The peptide, CBD3, has been shown in mice to interfere with signals that navigate calcium channels to produce pain. Unlike other substances that block pain signals, CBD3 does not directly inhibit the influx of calcium. ...

Innovative Hockey Recruiting and Hockey Scouting Service gives hockey players focus during off season. As hockey rinks become quiet, as the Stanley Cup Finals enter their last days and the sights and sounds of summer re-appear, hockey season nears its end, or does it? Traditionally, for many aspiring hockey players, the 'off-season' promises to be a busy one as they continue their quest to get noticed at the next level of their playing careers. With three new Player packages, PuckProspect.com, the web's most innovative hockey recruiting and hockey scouting service, ...

Using the only microscope of its kind in Australia, medical scientists have been able for the first time to see the inner workings of T-cells, the front-line troops that alert our immune system to go on the defensive against germs and other invaders in our bloodstream. The discovery overturns prevailing understanding, identifying the exact molecular 'switch' that spurs T-cells into action — a breakthrough that could lead to treatments for a range of conditions from auto-immune diseases to cancer. The findings, by researchers at the University of New South Wales (UNSW), ...

Berkeley — Trapping antihydrogen atoms at the European Organization for Nuclear Research (CERN) has become so routine that physicists are confident that they can soon begin experiments on this rare antimatter equivalent of the hydrogen atom, according to researchers at the University of California, Berkeley. "We've trapped antihydrogen atoms for as long as 1,000 seconds, which is forever" in the world of high-energy particle physics, said Joel Fajans, UC Berkeley professor of physics, faculty scientist at Lawrence Berkeley National Laboratory and a member of the ALPHA ...

New York — June 5, 2011 — Moisture and heat fluctuations from the land surface to the atmosphere form a critical nexus between surface hydrology and atmospheric processes, especially those relevant to rainfall. While current theory has suggested that soil moisture has had a positive impact on precipitation, there have been very few large-scale observations of this. A team of researchers from Columbia Engineering, Geophysical Fluid Dynamics Laboratory, and Rutgers University has now demonstrated that evaporation from the land surface is able to modify summertime rainfall ...

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Science fiction is fast approaching science fact as researchers are progressing rapidly toward "bottling" antimatter. In a paper published online today by the journal Nature Physics, the ALPHA experiment at CERN, including key Canadian contributors, reports that it has succeeded in storing antimatter atoms for over 16 minutes. While carrying around bottled antimatter like in the movie Angels and Demons remains fundamentally far-fetched, storing antimatter for long periods of time opens up new vistas for scientists struggling to understand this elusive substance. ALPHA ...

Hotel El Portal in Sedona wants to celebrate with you while you celebrate with them the eighth anniversary of this luxury inn. Stay one night at regular price and get the next consecutive night free Sunday through Thursday from June 1 through June 15 as you celebrate the anniversary of your choice. Some restrictions apply. Please call for details at 800.313.0017. Yes, the anniversary of your choice. Was it June when you got married, graduated of college, paid off your mortgage, married off your last child, won the lottery, or been awarded your imaginary Pulitzer ...

NEW YORK (June 5, 2011) — Less invasive catheter-based aortic valve replacement and open valve-replacement surgery have a similar one-year survival for patients at high risk for surgery. Results from The PARTNER (Placement of AoRTic traNscathetER valves) Trial — the world's first randomized clinical trial of a transcatheter aortic heart valve — were published today in the New England Journal of Medicine. The findings were also presented on June 5 at the Transcatheter Valve Therapies meeting in Vancouver, Canada, and on April 3 at the American College of Cardiology's 60th ...

More and more common is the situation taxpayers are finding themselves in these days whereby they haven't filed tax returns in years and Uncle Sam comes a'callin'. Sometimes, these taxpayers will try to beat the IRS to it by filing late returns before they receive the dreaded Substitute for Return (SFR) that the government will file on your behalf should you fail to file. Ernest (Frewsberg, NY) came to the Blue Tax offices with the news that he had not filed a return since 2003 and wanted to prepare and file all back returns before the IRS assessed a Substitute for ...

The rate of release of carbon into the atmosphere today is nearly 10 times as fast as during the Paleocene-Eocene Thermal Maximum (PETM), 55.9 million years ago, the best analog we have for current global warming, according to an international team of geologists. Rate matters and this current rapid change may not allow sufficient time for the biological environment to adjust. "We looked at the PETM because it is thought to be the best ancient analog for future climate change caused by fossil fuel burning," said Lee R. Kump, professor of geosciences, Penn State. However, ...

Planetary scientists have long wondered why Mars is only about half the size and one-tenth the mass of Earth. As next-door neighbors in the inner solar system, probably formed about the same time, why isn't Mars more like Earth and Venus in size and mass? A paper published in the journal Nature this week provides the first cohesive explanation and, by doing so, reveals an unexpected twist in the early lives of Jupiter and Saturn as well. Dr. Kevin Walsh, a research scientist at Southwest Research Institute® (SwRI®), led an international team performing simulations of ...

CHICAGO -- ASCO Abstract #CRA9015. Flaxseed provides no benefit in easing hot flashes among breast cancer patients and postmenopausal women, according to a Mayo Clinic and North Central Cancer Treatment Group (NCCTG) study. The randomized, placebo-controlled study was conducted on 188 women between October and December 2009 and found no statistically significant difference in mean hot flash scores between women taking flaxseed and those taking a placebo. Preliminary data published in 2007 by Mayo Clinic investigators suggested consuming 40 grams of crushed flaxseed daily ...

Netbook Navigator (www.NetbookNavigator.com), a leading provider of mobile computing devices, today announced they were selected to be 1 out of 4 OEM partners showcased at the Microsoft booth at the International Society for Technology in Education conference later this month. This marks a major accomplishment for Netbook Navigator, who was one of the first companies to deliver a truly portable Windows 7 slate PC in the North American market. "We are honored and delighted to be chosen for such a prestigious occasion," said Matthew Gross, CEO of Netbook Navigator. ...

COLUMBIA, Mo. – A new University of Missouri study shows that the exposure to the controversial chemical Bisphenol A (BPA) through diet has been underestimated by previous lab tests. In the study, researchers compared BPA concentrations in mice that were given a steady diet supplemented with BPA throughout the day, compared to the more common lab method of single exposure, and found an increased absorption and accumulation of BPA in the blood of mice. This is the first study to examine concentrations of BPA in any animal models after exposure through a regular, daily ...

DUARTE, Calif. -- City of Hope researchers participated in more than 50 studies on improvements to cancer treatment, patient care and clinical trials to be presented at the 2011 Annual Meeting of the American Society of Clinical Oncology (ASCO) in Chicago, running from June 3 through 7. Research highlights include: "Impact of neoadjuvant chemotherapy following chemoradiation on tumor response, adverse events and surgical complications in patients with advanced renal cancer treated with TME."Abstract# 3514 Monday, June 6, 8 a.m. to 12 p.m. McCormick Place E450b Discussion: ...

Cigirex LLC, a world leader in electronic cigarettes, is teaming up with Monster Energy to sponsor the after party of the West Coast Premiere of Operation Belvis Bash. The movie features a well known cast of Hollywood names including Corey Feldman, Daniel Baldwin, Alexander Loy, Mark Metcalf, Frank Stallone, the Iron Sheik and Noelle Locke. "We are delighted to showcase our alternative smoking products to movie fans, actors, and media at this exciting event and after party," said Cigirex President Jason Cardiff. "The entertainment industry has embraced ...

Today, InfoTech rolled out a new design for the Media Management System (MMS), its Web-based solution for direct response campaign management. "This is quite an improvement, not only from an aesthetic standpoint, but also in terms of usability," said Derek Viglianti, InfoTech's EVP of Marketing Systems. "The user interface and reports look sharper, which is something that our clients had expressed an interest in seeing." In addition to its new design, MMS was upgraded with several new features, including new per inquiry functionality. This comes ...

Today Whataburger announced two new additions to its menu, the Pineapple Pie and Pineapple Shake, both available for a limited time only. The new menu items will be available Monday, June 6 at 3 p.m. through Monday, August 22 at all Whataburger locations. "While we are known best for our fresh, made-to-order burgers, our pies and shakes have made a name for themselves as well," said Rich Scheffler, Whataburger Restaurants, LP Group Director of Marketing. "The newest pineapple pie and shake are the perfect tropical combination for summer." Whataburger ...

While the other parts experienced a deficit in tour and travel activities, the capital city has marked a whooping rise. Gaining to this, the London hotels are also currently refurbishing themselves in great numbers to accommodate global needs in the most appropriate manner. Most of these hotels offer the best of services that would surely enable any traveller to witness the true colours of British hospitality. But the major issue of the day is perhaps no other but to secure the services of cheap London hotels. To enable the world wide tourists to enjoy pocket friendly ...