INDIANAPOLIS – A School of Science at Indiana University-Purdue University Indianapolis biophysicist has developed a new method to identify communication pathways connecting distant regions within proteins. With this tool, Andrew J. Rader, Ph.D., assistant professor of physics, has identified a mechanism for cooperative behavior within an entire molecule, a finding that suggests that in the future it may be possible to design drugs that target anywhere along the length of a molecule's communication pathway rather than only in a single location as they do today. The discovery ...

CORVALLIS, Ore. – Genetic research is showing that healthy steelhead runs in Pacific Northwest streams can depend heavily on the productivity of their stay-at-home counterparts, rainbow trout. Steelhead and rainbow trout look different, grow differently, and one heads off to sea while the other never leaves home. But the life histories and reproductive health of wild trout and steelhead are tightly linked and interdependent, more so than has been appreciated, a new Oregon State University study concludes. The research could raise new challenges for fishery managers ...

Numerous nanomaterials are currently at the focus of public attention. In particular silver nanoparticles are being investigated in detail, both by scientists as well as by the regulatory authorities. The assumption behind this interest is that they are dealing with a completely new substance. However, Empa researchers Bernd Nowack and Harald Krug, together with Murray Heights of the company HeiQ have shown in a paper recently published in the journal Environmental Science & Technology that nanosilver is by no means the discovery of the 21st century. Silver particles with ...

Offering the morning after pill free over the counter has not reduced the number of teenage pregnancies and may be associated with a rise in sexually-transmitted diseases (STIs), according to a report by experts at The University of Nottingham. Professors David Paton and Sourafel Girma used local health authority data to study the impact that the introduction of Government-backed schemes to offer emergency birth control at pharmacies and without prescription have had on conception rates and the diagnosis of STIs among under-18s. Their findings show that, on average, ...

Geneva, 31 January 2011. CERN today announced that the LHC will run through to the end of 2012 with a short technical stop at the end of 2011. The beam energy for 2011 will be 3.5 TeV. This decision, taken by CERN management following the annual planning workshop held in Chamonix last week and a report delivered today by the laboratory's machine advisory committee, gives the LHC's experiments a good chance of finding new physics in the next two years, before the LHC goes into a long shutdown to prepare for higher energy running starting 2014. "If LHC continues to improve ...

Chestnut Hill, Mass. (1/31/2011) – Red Bull's red and gold logo can "give you wings" – for better or worse – even if consumers don't know it, according to a new study by two Boston College professors, who found the brand's edgy marketing efforts have sold a heavy dose of attitude to consumers. Researchers put subjects at the controls of a car racing video game, supplying each with functionally identical racecars, but each car decorated with a different brand logo and color scheme. Players put in control of the Red Bull car displayed the characteristics often attributed ...

The more we learn about biology, the closer we get to being able to treat disease – and the more complicated our understanding of disease itself becomes. A new research finding showing a strong relationship between complex microbial ecologies in human intestines and the common but serious medical condition known as fatty liver illustrates this paradox. From past genomic studies, we have learned that a mind-boggling multitude of different kinds of benign bacteria inhabit our intestines and that these populations can vary almost infinitely from one human being to the ...

Boston, MA—Scientists have found that free radicals (unstable molecules that cause the death of cells as the body ages) may also cause the damage in the eyes of patients with Fuchs Endothelial Corneal Dystrophy (FECD), a hereditary disease that is one of the most common reasons for corneal transplants worldwide. The finding, published in the November 2010 American Journal of Pathology, holds promise for early and preventative treatments for this disease, which impacts nearly four percent of the population over age 60. "Our discovery is significant, because it gives ...

Berkeley – In a demonstration of "reverse-ecology," biologists at the University of California, Berkeley, have shown that one can determine an organism's adaptive traits by looking first at its genome and checking for variations across a population. The study, to be published the week of Jan. 31 in the journal Proceedings of the National Academy of Sciences, offers a powerful new tool in evolutionary genetics research, one that could be used to help monitor the effects of climate change and habitat destruction. The researchers scanned the genes of 48 different strains ...

The scientists have now carried out the first full run of experiments that smash protons together at almost the speed of light. When these sub-atomic particles collide at the heart of the CMS detector, the resultant energies and densities are similar to those that were present in the first instants of the Universe, immediately after the Big Bang some 13.7 billion years ago. The unique conditions created by these collisions can lead to the production of new particles that would have existed in those early instants and have since disappeared. The researchers say they are ...

New Haven, Conn.—A team of Yale University scientists has synthesized for the first time a chemical compound called lomaiviticin aglycon, leading to the development of a new class of molecules that appear to target and destroy cancer stem cells. Chemists worldwide have been interested in lomaiviticin's potential anticancer properties since its discovery in 2001. But so far, they have been unable to obtain significant quantities of the compound, which is produced by a rare marine bacterium that cannot be easily coaxed into creating the molecule. For the past decade, different ...

Researchers at National Jewish Health have discovered a signaling pathway that is crucial to the devastating effects of acute lung injury (ALI). The data, obtained from cells, animals and ALI patients, suggest several potential therapeutic targets. Experimental blockade of one of the targets significantly reduced flooding of the lungs that is the hallmark of ALI. "Acute lung injury is a devastating disease, with 40 percent mortality and no beneficial therapies," said first author James Finigan, MD, Assistant Professor of Medicine at National Jewish Health. "Our study ...

It takes songbirds and baseball pitchers thousands of repetitions – a choreography of many muscle movements -- to develop an irresistible trill or a killer slider. Now, scientists have discovered that the male Bengalese finch uses a simple mental computation and an uncanny memory to create its near-perfect mate-catching melody -- a finding that could have implications for rehabilitating people with neuromuscular diseases and injuries. Young male Bengalese finches practice their boisterous mating song hundreds of times a day, comparing their melody to the songs of their ...

Researchers have found that a novel form of personalized therapy that genetically engineers a patient's own anti-tumor immune cells to fight tumors could treat metastatic melanoma and metastatic synovial cell sarcoma, representing a potentially new therapeutic approach against these and other cancers. The technique, called adoptive immunotherapy, works with the body's immune system to fight cancer. Immune cells, called T lymphocytes, are removed, modified, expanded in large numbers, and given back to the patient. In this case, the process entailed genetically engineering ...

Researchers are leveraging Ohio Supercomputer Center resources to develop computer-assisted diagnosis tools that will provide pathologists grading Follicular Lymphoma samples with quicker, more consistently accurate diagnoses. "The advent of digital whole-slide scanners in recent years has spurred a revolution in imaging technology for histopathology," according to Metin N. Gurcan, Ph.D., an associate professor of Biomedical Informatics at The Ohio State University Medical Center. "The large multi-gigapixel images produced by these scanners contain a wealth of information ...

Drug- and explosives-sniffing dog/handler teams' performance is affected by human handlers' beliefs, possibly in response to subtle, unintentional handler cues, a study by researchers at UC Davis has found. The study, published in the January issue of the journal Animal Cognition, found that detection-dog/handler teams erroneously "alerted," or identified a scent, when there was no scent present more than 200 times — particularly when the handler believed that there was scent present. "It isn't just about how sensitive a dog's nose is or how well-trained a dog is. There ...

Tropical Storm Anthony made landfall in Queensland, Australia this past weekend, and now the residents are watching a larger, more powerful cyclone headed their way. NASA's Terra satellite captured a visible image of the large Tropical Cyclone Yasi late yesterday as it makes its way west through the Coral Sea toward Queensland. The Moderate Resolution Imaging Spectroradiometer (MODIS) instrument that flies aboard NASA's Terra satellite captured an image of Cyclone Yasi on Jan. 30 at 23:20 UTC (6:20 p.m. EST/09:20 a.m., Monday, January 31 in Australia/Brisbane local time). ...

NASA's Time History of Events and Macroscale Interaction during Substorms (THEMIS) spacecraft combined with computer models have helped track the origin of the energetic particles in Earth's magnetic atmosphere that appear during a kind of space weather called a substorm. Understanding the source of such particles and how they are shuttled through Earth's atmosphere is crucial to better understanding the Sun's complex space weather system and thus protect satellites or even humans in space. The results show that these speedy electrons gain extra energy from changing magnetic ...

(Santa Barbara, Calif.) –– Inspired by the popular confidence trick known as "shell game," researchers at UC Santa Barbara have demonstrated the ability to hide and shuffle "quantum-mechanical peas" –– microwave single photons –– under and between three microwave resonators, or "quantized shells." In a paper published in the Jan. 30 issue of the journal Nature Physics, UCSB researchers show the first demonstration of the coherent control of a multi-resonator architecture. This topic has been a holy grail among physicists studying photons at the quantum-mechanical level ...

Children from poorer families do worse in school, are less likely to graduate from high school, and are less likely to go to college. A new study published in Psychological Science, a journal of the Association for Psychological Science, finds that these differences appear surprisingly early: by the age of 2. It's not a genetic difference. Instead, something about the poorer children's environment is keeping them from realizing their genetic potentials. Past research has found that a gap between poor children and children from wealthier families opens up early in life, ...

ANN ARBOR, Mich.--Brain scans showing neural reactions to pro-health messages can predict if you'll keep that resolution to quit smoking more accurately than you yourself can. That's according to a new study forthcoming in Health Psychology, a peer-reviewed journal. "We targeted smokers who were already taking action to quit," says Emily Falk, the lead author of the study and director of the Communication Neuroscience Laboratory at the U-M Institute for Social Research (ISR) and Department of Communication Studies. "And we found that neural activity can predict behavior ...

EAST LANSING, Mich. — Biopsies in the future may be painless and noninvasive, thanks to smart laser technology being developed at Michigan State University. To test for skin cancer, patients today must endure doctors cutting away a sliver of skin, sending the biopsy to a lab and anxiously awaiting the results. Using laser microscopes that deploy rapid, ultra-short pulses to identify molecules, doctors may soon have the tools to painlessly scan a patient's troublesome mole and review the results on the spot, said Marcos Dantus. The results touting this new molecule-selective ...

WASHINGTON — Five days before intense monsoonal deluges unleashed vast floods across Pakistan last July, computer models at a European weather-forecasting center were giving clear indications that the downpours were imminent. Now, a new scientific study that retrospectively examines the raw data from these computer models, has confirmed that, if the information had been processed, forecasters could have predicted extremely accurate rainfall totals 8-10 days beforehand. The study also finds that the floods themselves could have been predicted if this data, which originated ...

PITTSBURGH—University of Pittsburgh researchers have grown arteries that exhibit the elasticity of natural blood vessels at the highest levels reported, a development that could overcome a major barrier to creating living-tissue replacements for damaged arteries, the team reports in the Proceedings of the National Academy of Sciences. The team used smooth muscle cells from adult baboons to produce the first arteries grown outside the body that contain a substantial amount of the pliant protein elastin, which allows vessels to expand and retract in response to blood flow. ...

WEST LAFAYETTE, Ind. - A Purdue University scientist has found genetic evidence of how some plants adapt to live in unfavorable conditions, a finding he believes could one day be used to help food crops survive in new or changing environments. David Salt, a professor of horticulture, noticed several years ago that a variant of the research plant Arabidopsis thaliana that could tolerate higher levels of sodium had come from coastal areas. To test the observation, Salt grew more than 300 Arabidopsis thaliana plants from seeds gathered across Europe. The plants were grown ...