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Ticking of cellular clock promotes seismic changes in the chromatin landscape associated with aging

Ticking of cellular clock promotes seismic changes in the chromatin landscape associated with aging
2010-10-04
LA JOLLA, CA-Like cats, human cells have a finite number of lives-once they divide a certain number of times (thankfully, more than nine) they change shape, slow their pace, and eventually stop dividing, a phenomenon called "cellular senescence". Biologists know that a cellular clock composed of structures at the chromosome end known as telomeres records how many "lives" a cell has expended. Up to now, investigators have not yet defined how the clock's ticking signals the approach of cellular oblivion. In a study published in the Oct. 3, 2010, issue of Nature Structural ...

Earlier, more accurate prediction of embryo survival enabled by Stanford research

2010-10-04
STANFORD, Calif. — Two-thirds of all human embryos fail to develop successfully. Now, in a new study, researchers at the Stanford University School of Medicine have shown that they can predict with 93 percent certainty which fertilized eggs will make it to a critical developmental milestone and which will stall and die. The findings are important to the understanding of the fundamentals of human development at the earliest stages, which have largely remained a mystery despite the attention given to human embryonic stem cell research. Because the parameters measured by ...

Auxogyn licenses noninvasive embryo assessment technology from Stanford University

2010-10-04
MENLO PARK, Calif. – October 4, 2010 – Auxogyn, Inc., a privately held medical technology company focused on women's reproductive health, today announced that it acquired an exclusive license from Stanford University to develop a set of products that may allow medical practitioners in the field of assisted reproduction to significantly improve the effectiveness of in vitro fertilization (IVF) procedures. The technology licensed from Stanford is described in a publication titled 'Non-invasive imaging of human embryos before embryonic genome activation predicts development ...

Can telemedicine improve geriatric depression?

2010-10-04
PROVIDENCE, RI -- Studies have shown a high rate of depression among elderly homebound individuals, and few patients receive adequate treatment, if any. To address this issue, researchers at Rhode Island Hospital and other organizations have developed a telemedicine-based depression care protocol in home health care. The early findings from their pilot study will be presented at the 29th Annual Meeting and Exposition of the National Association for Home Care and Hospice on October 3. Thomas Sheeran, PhD, ME, clinical psychologist in the department of psychiatry at Rhode ...

OHSU research reveals possible method for boosting the immune system to protect infants against HIV

2010-10-04
PORTLAND, Ore. - - Researchers at Oregon Health &Science University may have uncovered a new weapon for combating HIV as it is passed from mother to newborn child. The research, which was led by researchers at OHSU's Oregon National Primate Research Center, will be published in the October 3rd online edition of the journal Nature Medicine. "Mother-to-infant transmission of HIV is a tremendous worldwide problem, especially in several African nations," said Nancy Haigwood, Ph.D., researcher and director of the Oregon National Primate Research Center at OHSU. According ...

Elasticity found to stretch stem cell growth to higher levels

2010-10-04
One of the major challenges in stem cell transplants is how to obtain sufficient numbers of these remarkably rare cells to put into patients. To help overcome this issue, research from the Centenary Institute, Royal Prince Alfred Hospital and the University of Sydney has found a way to increase the number of blood-forming stem cells when growing them outside of the body. By using a unique stretchy surface that allows the cells to pull on it, the researchers found they could generate up to three times more stem cells than using current methods alone. Published today in ...

The secret life of Ireland's smooth-hound sharks

The secret life of Irelands smooth-hound sharks
2010-10-04
They grow to over a meter in length, can weigh up to twelve kilos and each summer they swarm into the shallow waters of the Irish east coast. Despite this, the starry smooth-hound has remained Ireland's least well known shark species. However, thanks to researchers at University College Dublin, whose work is now published in the Journal of Fish Biology, this may be about to change. Dr. Edward Farrell, who recently graduated from UCD School of Biology & Environmental Science, spent the last four years studying these unusual sharks. Under the supervision of Dr. Stefano ...

New study highlights sexual behavior, condom use by US individuals ages 14 to 94

New study highlights sexual behavior, condom use by US individuals ages 14 to 94
2010-10-04
BLOOMINGTON, Ind. -- Findings from the largest nationally representative study of sexual and sexual-health behaviors ever fielded, conducted by Indiana University sexual health researchers, provides an updated and much needed snapshot of contemporary Americans' sexual behaviors, including a description of more than 40 combinations of sexual acts that people perform during sexual events, patterns of condom use by adolescents and adults, and the percentage of Americans participating in same-sex encounters. The National Survey of Sexual Health and Behavior (NSSHB) was conducted ...

Study finds foreclosure crisis had significant racial dimensions

2010-10-04
Princeton, NJ – September 30, 2010 – Although the rise in subprime lending and the ensuing wave of foreclosures was partly a result of market forces that have been well-documented, the foreclosure crisis was also a highly racialized process, according to a study by two Woodrow Wilson School scholars published in the October 2010 issue of the American Sociological Review. Woodrow Wilson School Ph.D. candidate Jacob Rugh and Woodrow Wilson School's Henry G. Bryant Professor of Sociology and Public Affairs, Douglas Massey, assessed segregation and the American foreclosure ...

Food allergies raise risk of asthma attacks

2010-10-04
Food allergies are more common among people with asthma and may contribute to asthma attacks, according to one of the most comprehensive surveys of food allergies ever undertaken. National Jewish Health Associate Professor of Pediatrics Andrew H. Liu and his colleagues also report in the November 2010 Journal of Allergy and Clinical Immunology that food allergies are more prevalent among children, males and non-Hispanic blacks. "Our study suggests that food allergies may be an important factor, and even an under-recognized trigger for severe asthma exacerbations," said ...

Study focuses on mephedrone use in Northern Ireland post-ban

2010-10-04
Researchers at Queen's University Belfast have completed one of the first studies of mephedrone use in Northern Ireland since the drug was outlawed earlier this year. They found that the ban did not deter those mephedrone users surveyed from taking the substance. Interviews with 23 mephedrone users were completed during a two-month period (May and June 2010) following the legislation that made the drug illegal in the UK. Study participants were aged 19 to 51 years, around half of whom (12) were female. 19 of the 23 people who took part in the study were employed, and ...

Children, males and blacks are at increased risk for food allergies

2010-10-04
A new study estimates that 2.5 percent of the United States population, or about 7.6 million Americans, have food allergies. Food allergy rates were found to be higher for children, non-Hispanic blacks, and males, according to the researchers. The odds of male black children having food allergies were 4.4 times higher than others in the general population. The research, which was funded by the National Institutes of Health and appears in the Journal of Allergy and Clinical Immunology, is the first to use a nationally representative sample, as well as specific immunoglobulin ...

Walnuts, walnut oil, improve reaction to stress

Walnuts, walnut oil, improve reaction to stress
2010-10-04
A diet rich in walnuts and walnut oil may prepare the body to deal better with stress, according to a team of Penn State researchers who looked at how these foods, which contain polyunsaturated fats, influence blood pressure at rest and under stress. Previous studies have shown that omega-3 fatty acids -- like the alpha linolenic acid found in walnuts and flax seeds -- can reduce low density lipoproteins (LDL) -- bad cholesterol. These foods may also reduce c-reactive protein and other markers of inflammation. "People who show an exaggerated biological response to stress ...

What mimicking one's language style may mean about the relationship

2010-10-04
People match each other's language styles more during happier periods of their relationship than at other times, according to new research from psychologists at The University of Texas at Austin. "When two people start a conversation, they usually begin talking alike within a matter of seconds," says James Pennebaker, psychology professor and co-author of the study. "This also happens when people read a book or watch a movie. As soon as the credits roll, they find themselves talking like the author or the central characters." This tendency is called language style matching ...

Lack of private health insurance impacted cancer survival

2010-10-03
MIAMI — Lack of private health insurance and its consequent lack of access to care appears to affect mortality among patients with uterine cancer and may partly explain the mortality disparity between African-Americans and other racial groups, according to data presented at the Third AACR Conference on The Science of Cancer Health Disparities. "African-Americans were twice as likely to die within four years compared to white patients after adjusting for age, facility and education level. However, when insurance, treatment and clinical factors were accounted for, this ...

Social support post-cancer lacking among minority women

2010-10-03
MIAMI — Nonwhite women reported receiving less social support than white women after cancer treatment, according to data presented at the Third AACR Conference on The Science of Cancer Health Disparities, held Sept. 30-Oct. 3, 2010. "This is an important finding when designing and promoting social support resources for female cancer survivors to better include cancer survivors of color," said study author Jennifer M. Jabson, M.P.H., Ph.D., a postdoctoral research fellow in the department of community health sciences at Boston University. "This might be useful when interventionists ...

Decreased survival for Puerto Rican women with 'triple-negative' breast cancer subtype

2010-10-03
MIAMI — Puerto Rican women who had breast cancer that lacked estrogen and progesterone receptors and did not overexpress the HER2neu protein (triple-negative) had worse survival than those with other types of invasive breast cancer, according to a study presented at the Third AACR Conference on The Science of Cancer Health Disparities, held Sept. 30 – Oct. 3, 2010. "As the incidence of breast cancer rises in Puerto Rico, following U.S. trends, it is important to understand the association of disease subtypes with survival," said Ana P. Ortiz Martinez, M.P.H., Ph.D., associate ...

Race not root of disparity in lung cancer between whites and blacks

2010-10-03
MIAMI — Race itself was not a prognostic factor of overall survival among black patients with lung cancer, according to data from a retrospective study presented at the Third AACR Conference on The Science of Cancer Health Disparities. "In simple terms, if 100 patients who are Caucasian and 100 patients who are African-American have the same age, stage of cancer, type of lung cancer and are treated the same way, there should not be differences in their survival just because they are of different races," said Rajesh Sehgal, M.D., a medical oncologist at the Edwards Comprehensive ...

Racial differences in breast cancer treatment persist despite similar economics

2010-10-03
MIAMI — African-American women with breast cancer living in Washington, D.C., are more likely to experience delays in treatment regardless of insurance type, socioeconomic status and cancer characteristics such as stage and grade. Heather A. Young, Ph.D., an associate professor of epidemiology at The George Washington University, said these findings underscore the difficulties in measuring the impact of race and socioeconomic status on health outcomes. "There is likely something about race that we are still not capturing, whether it is different patterns of social ...

A painless way to achieve huge energy savings: Stop wasting food

2010-10-03
WASHINGTON, Oct. 2, 2010 — Scientists have identified a way that the United States could immediately save the energy equivalent of about 350 million barrels of oil a year — without spending a penny or putting a ding in the quality of life: Just stop wasting food. Their study, reported in ACS' semi-monthly journal Environmental Science & Technology, found that it takes the equivalent of about 1.4 billion barrels of oil to produce, package, prepare, preserve and distribute a year's worth of food in the United States. Michael Webber and Amanda Cuéllar note that food contains ...

Operation Unified Response: 3 phases of disaster care in Haiti

2010-10-03
SAN FRANCISCO – A pediatric medical response to a major disaster should focus on three consecutive missions: protection of life and limb, continuing care, and finally, humanitarian aid, according to research presented Sunday, Oct. 3, at the American Academy of Pediatrics (AAP) National Conference and Exhibition in San Francisco. In January, within 24 hours of the worst earthquake in more than 200 years, the United States Naval Ship (USNS) Comfort was deployed to Haiti. With a staff of more than 800 physicians, nurses and ancillary staff, the ship was transformed into ...

Loss of nutrients following gastric bypass surgery in adolescent girls

2010-10-03
SAN FRANCISCO – An increasing number of obese adolescents, particularly females, are undergoing gastric bypass surgery. Yet a case study presented Sunday, Oct. 3, at the American Academy of Pediatrics (AAP) National Conference and Exhibition in San Francisco, highlights the possible link between gastric bypass surgery in adolescent girls and an increased risk for neural tube defects, which can lead to varying degrees of disability such as paralysis and mental retardation due to damage to the nervous system, in their future children. Neural tube defects in the brain and ...

Pediatric field hospital in Haiti provides lessons in disaster planning and response

2010-10-03
SAN FRANCISCO – When a devastating earthquake hit Haiti earlier this year, physicians and health care workers were immediately deployed to the capital, Port-au-Prince. A study on the creation and evolution of a pediatric field hospital – from a disaster service facility to a full-fledged children's hospital – during the weeks and months following the disaster, was presented on Sunday, Oct. 3, 2010, at the American Academy of Pediatrics (AAP) National Conference and Exhibition in San Francisco. "Disaster Response in a Pediatric Field Hospital: Lessons Learned in Haiti," ...

Are pre-teen babysitters able to deal with emergencies?

2010-10-03
SAN FRANCISCO – Nearly all (98 percent) of 11- to 13-year-old babysitters know who to contact in the event of an intruder or if a child is sick or injured (96 percent) or poisoned (85 percent), according to research presented Sunday, Oct. 3, at the American Academy of Pediatrics (AAP) National Conference and Exhibition in San Francisco. However, 40 percent of younger babysitters reported that they had left children unattended while babysitting, and 20 percent opened the door to strangers. In the study, "Babysitter Safety Training: Are Children Aged 11-13 Years Prepared ...

Unemployment linked with child maltreatment

2010-10-03
SAN FRANCISCO – The stresses of poverty have long been associated with child abuse and neglect. In a study presented Sunday, Oct. 3, at the American Academy of Pediatrics (AAP) National Conference and Exhibition in San Francisco, researchers directly linked an increased unemployment rate to child maltreatment one year later. Researchers reviewed state-level unemployment statistics from the Bureau of Labor Statistics, and compared them with child maltreatment data from the National Child Abuse and Neglect Data System (NCANDS), during the years 1990 to 2008. Each 1 percent ...
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