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Nine-gene MPI can provide accurate survival stratification in patients with NSCLC

( A nine-gene molecular prognostic index (MPI) for patients with early-stage non-small cell lung cancer (NSCLC) was able to provide accurate survival stratification and could potentially inform the use of adjuvant therapy in patients struggling with the disease, according to a study published August 18 in the JNCI: Journal of the National Cancer Institute.

Non-small cell lung cancer (NSCLC) accounts for roughly 85% of all lung cancers, additionally; lung cancer is the leading cause of cancer death through out the world. While gene expression profiles have been shown to provide analytical information in a variety of cancers, translating gene expression-based methods into clinical use has been met with great difficulties.

In order to provide an accurate MPI for patients with stage I NSCLC, Andrew J. Gentles, Ph.D., Department of Radiology, Stanford University, and colleagues, looked at gene expression profiles from 1106 nonsquamous NSCLCs for generation and internal validation of a nine-gene MPI and used a quantitative polymerase chain reaction (qPCR) assay to validate an independent cohort of formalin-fixed paraffin-embedded (FFPE) tissues. They then built a prognostic score that combined the molecular MPI with clinical variable data provided by the national Surveillance, Epidemiology, and End Results (SEER.) database.

The researchers found that by incorporating genes expressed in both the tumor and its microenvironment, the MPI was highly robust and can be applied in a clinical setting using qPCR assays on FFPE tissues. "The MPI outperforms other signatures that satisfy key characteristics of clinical applicability (ie, qPCR assays validated on FFPE tissues)," the authors write. "...our study is the first to provide a composite model that incorporates both gene expression and clinical data from a large, population-based database to leverage the independent prognostic content of these two types of data."


Contact Info: Maximilian Diehn, M.D., Ph.D.,


Reports on US geoscience education published by AGI's Center for Geoscience & Society

Alexandria, VA - The American Geosciences Institute's Center for Geoscience and Society is pleased to release two reports concerning geosciences education in the United States. The reports were developed in response to the need for comprehensive monitoring of the U.S. educational system in terms of the instruction of geoscience content and participation in geoscience-related learning experiences. The reports are based on data pertaining to science education collected from all 50 states and the District of Columbia. The "Report on the Status of K-5 Geosciences Education ...

Scientist: Most complete human brain model to date is a 'brain changer'

COLUMBUS, Ohio - Scientists at The Ohio State University have developed a nearly complete human brain in a dish that equals the brain maturity of a five-week-old fetus. The brain organoid, engineered from adult human skin cells, is the most complete human brain model yet developed, said Rene Anand, professor of biological chemistry and pharmacology at Ohio State. The lab-grown brain, about the size of a pencil eraser, has an identifiable structure and contains 99 percent of the genes present in the human fetal brain. Such a system will enable ethical and more rapid ...

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Baltimore, August 18, 2015--Contact precautions are recommended by the Centers for Disease Control and Prevention (CDC) for all patients known to be infected with or carrying multidrug-resistant organisms (MDROs) such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE). Yet, the use of contact precautions--which require a patient to be isolated in a single hospital room and health care providers to wear a gown and gloves when caring for patients--is widely debated in the medical community. To help inform best practices, a ...

Harnessing the butterfly effect

This news release is available in French. The atmosphere is so unstable that a butterfly flapping its wings can, famously, change the course of weather patterns. The celebrated "butterfly effect" also means that the reliability of weather forecasts drops sharply beyond 10 days. Beyond this, there are strong fluctuations in temperature, with increases tending to be followed by decreases, and vice-versa. The same pattern holds true over months, years and decades. "This natural tendency to return to a basic state is an expression of the atmosphere's memory that is so ...

Is nature mostly a tinkerer or an inventor?

CORAL GABLES, Fla. (August 18, 2015) - The Krüppel-like factor and specificity protein (KLF/SP) genes are found across many species, ranging from single cell organisms to humans. This gene family has been conserved during evolution, because it plays a vital role in regulating the expression of other genes. Understanding the evolutionary history of the KLF/SP gene family may shed light on major events in animal evolution and perhaps help discern some of the molecular mechanisms associated with certain human diseases, including many cancers. By closely examining the ...

Following maternal transmission, group B strep mutates to sicken infants

Washington, DC - August 18, 2015 - Group B streptococcus, a mostly benign inhabitant of healthy adults, is one of the world's leading causes of neonatal sepsis and meningitis. A team of French investigators has now shown that such cases might occur when the microbe mutates within the infant following transmission from the mother. The research appeared August 17 in the Journal of Bacteriology, a publication of the American Society for Microbiology. In the study, the investigators compared for the first time samples of group B streptococcus (GBS) from pairs of infected ...

New internet routing method allows users to avoid sending data through undesired countries

Censorship is one of the greatest threats to open communication on the Internet. Information may be censored by a user's country of residence or the information's desired destination. But recent studies show that censorship by countries through which the data travels along its route is also a danger. Now, computer scientists at the University of Maryland have developed a method for providing concrete proof to Internet users that their information did not cross through certain geographic areas. The new system offers advantages over existing systems: it is immediately deployable ...

Pregnant mothers influence fetal growth through genetics rather than maternal height

Transmitted genes, rather than growth limitations caused by actual differences in maternal height, are the key means by which a mother's height influences her baby's birth weight and length, according to a new study published this week in PLOS Medicine. The report from Ge Zhang and Louis Muglia of Cincinnati Children's Hospital Medical Center and the March of Dimes Prematurity Research Center Ohio Collaborative and colleagues does, however, suggest that maternal height can directly mediate duration of gestation. Compared to tall mothers, short mothers tend to deliver ...

Shorter women have shorter pregnancies

WHITE PLAINS, N.Y., Aug. 18, 2015 - Shorter mothers have shorter pregnancies, smaller babies, and higher risk for a preterm birth. New research has found that a mother's height directly influences her risk for preterm birth. Investigators at the March of Dimes Prematurity Research Center Ohio Collaborative looked at 3,485 Nordic women and their babies, and found that maternal height, which is determined by genetic factors, helped shape the fetal environment, influencing the length of pregnancy and frequency of prematurity. In contrast, birth length and birth weight ...

Hot chilli may unlock a new treatment for obesity

University of Adelaide researchers have discovered a high-fat diet may impair important receptors located in the stomach that signal fullness. Published today* in the journal PLOS ONE, researchers from the University's Centre for Nutrition and Gastrointestinal Diseases (based at the South Australian Health and Medical Research Institute) investigated the association between hot chilli pepper receptors (TRPV1) in the stomach and the feeling of fullness, in laboratory studies. "The stomach stretches when it is full, which activates nerves in the stomach to tell the ...


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