Contact Information:

Media Contact

Rajeev Samarage
rajeev.samarage@monash.edu
040-172-4586

Twitter: MonashUni

http://www.monash.edu.au




Kredyty mieszkaniowe Kredyty mieszkaniowe

Sprawdź aktualny ranking najlepszych kredytów mieszkaniowych w Polsce - atrakcyjne kredytowanie nieruchomości.

PRESS-NEWS.org - Press Release Distribution
FREE PRESS RELEASES DISTRIBUTION
RSS - Press News Release
Add Press Release

New embryo image processing technology could assist in IVF implantation success rates

A collaboration between biologists and engineers at Monash University has led to the development of a new non-invasive image processing technique to visualize embryo formation


2015-08-28
(Press-News.org) A collaboration between biologists and engineers at Monash University has led to the development of a new non-invasive image processing technique to visualise embryo formation. Researchers were able to see, for the first time, the movement of all of the cells in living mammalian embryos as they develop under the microscope. This breakthrough has important implications for IVF (in vitro fertilisation) treatments and pre-implantation genetic diagnosis (PGD). In the future, this approach could help with embryo selection before the embryo is implanted back into the uterus to improve IVF success rates.

This latest research, published in Developmental Cell, and titled 'Cortical Tension Allocates the First Inner Cells of the Mammalian Embryo', provides new insights into embryo formation and challenges the prevailing model of cell placement through division. The three joint first authors are: Dr Melanie White, Research Fellow at the Plachta Lab at Australian Regenerative Medicine Institute (ARMI), Dr Yanina Alvarez of University of Buenos Aires and Rajeev Samarage, PhD candidate supervised by Prof Andreas Fouras at the Department of Mechanical and Aerospace Engineering at Monash University.

Mammalian embryos start out as a small group of identical cells. Then at an early stage, some of these cells take up an internal position within the embryo. These internal cells are the ones that will go on to form all of the cells of the body while the remaining outer cells go on to form other tissues such as the placenta.

For many years, researchers theorised that the internal cells adopt their position through a special process of cell division, but due to technological limitations, this had never actually been shown. Using their newly developed imaging methods, the Monash University researchers were able to demonstrate that this model of embryo formation was incorrect.

The researchers then applied cutting-edge laser techniques to the mammalian embryo (previously used in fly and plant embryos or cultured cells only) to determine what forces were acting on the cells to make them move inside the embryo.

Using these new imaging techniques, researchers were able to see how the cells moved and changed shape over time as they were 'pushed' inside to form the internal mass. They showed that there are differences in the tension of the membranes of the cells and these differences are what determine which cells will move inside to form the body. By altering the tension of the cells using lasers or genetic manipulations, researchers could change which cells move inside the embryo.

These findings also offer future potential to make alterations to improve inter-cellular forces and cell formation.

"Our findings offer an attractive possibility where alterations to the inter-cellular forces could increase embryo viability leading to better IVF outcomes. We can think of this as a 'push in the right direction'," Mr Samarage said.

Work is underway to use this new custom image segmentation technology with non-invasive imaging approaches to see how human embryos used in IVF or pre-implantation genetic diagnosis (PGD) first organise their cells.

"If in the future, we can combine our new image processing technique with non-harmful dyes that can label the membranes of human embryos, we may be able to evaluate embryos used in IVF and decide which ones to implant to have the best chance of success," said Dr Melanie White.

INFORMATION:


ELSE PRESS RELEASES FROM THIS DATE:

Neurobiology: Light-activated learning

2015-08-28
A German-French team has developed a light-sensitive switch that regulates a protein implicated in the neurobiology of synaptic plasticity. The agent promises to shed new light on the phenomenology of learning, memory and neurodegeneration. Learning is made possible by the fact that the functional connections between nerve cells in the brain are subject to constant remodeling. As a result of activation-dependent modification of these links ('synaptic plasticity'), circuits that are repeatedly stimulated "learn" to transmit signals ever more efficiently. This process is ...

Lack of folic acid enrichment in Europe causes mortality among fetuses

2015-08-28
This news release is available in German. A new international study shows that 5,000 foetuses in Europe annually are affected by spina bifida and other severe defects on the central nervous system. Seventy per cent of these pregnancies are terminated, while increased mortality and serious diseases affect the children who are born. At least half of the cases can be avoided by adding folic acid to staple foods as is already being done in seventy non-European countries. A lack of folic acid enrichment in Europe is the cause of several thousand cases of foaetal abnormalities ...

The alien within: Fetal cells influence maternal health during pregnancy (and long after)

The alien within: Fetal cells influence maternal health during pregnancy (and long after)
2015-08-28
Parents go to great lengths to ensure the health and well-being of their developing offspring. The favor, however, may not always be returned. Dramatic research has shown that during pregnancy, cells of the fetus often migrate through the placenta, taking up residence in many areas of the mother's body, where their influence may benefit or undermine maternal health. The presence of fetal cells in maternal tissue is known as fetal microchimerism. The term alludes to the chimeras of ancient Greek myth--composite creatures built from different animal parts, like the goat-lion-serpent ...

Future climate models greatly affected by fungi and bacteria

2015-08-28
When a plant dies, its leaves and branches fall to the ground. Decomposition of soil organic matter is then mainly carried out by fungi and bacteria, which convert dead plant materials into carbon dioxide and mineral nutrients. Until now, scientists have thought that high quality organic materials, such as leaves that are rich in soluble sugars, are mainly decomposed by bacteria. Lower quality materials, such as cellulose and lignin that are found in wood, are mainly broken down by fungi. Previous research has also shown that organic material that is broken down by ...

Physics meets biology to defeat aging

2015-08-28
The scientific team of a new biotech company Gero in collaboration with one of the leading academics in the field of aging Prof. Robert J. Shmookler Reis (current world record holder in life extension for model animals - 10 fold for nematodes) has recently brought new insights into biology of aging and age-related diseases, primarily, around the stability and stress resistance of certain gene regulatory networks. The work has just been published as "Stability analysis of a model gene network links aging, stress resistance, and negligible senescence" in Scientific Reports ...

New technique could enable design of hybrid glasses and revolutionize gas storage

2015-08-28
A new method of manufacturing glass could lead to the production of 'designer glasses' with applications in advanced photonics, whilst also facilitating industrial scale carbon capture and storage. An international team of researchers, writing today in the journal Nature Communications, report how they have managed to use a relatively new family of sponge-like porous materials to develop new hybrid glasses. The work revolves around a family of compounds called metal-organic frameworks (MOFs), which are cage-like structures consisting of metal ions, linked by organic bonds. ...

Researchers use brain scans to predict response to antipsychotic medications

2015-08-28
MANHASSET, NY - Investigators at The Feinstein Institute for Medical Research have discovered that brain scans can be used to predict patients' response to antipsychotic drug treatment. The findings are published online in the latest issue of The American Journal of Psychiatry. Psychotic disorders, such as schizophrenia and bipolar disorder, are characterized by delusions, hallucinations, and disorganized thoughts and behavior. They are estimated to occur in up to three percent of the population and are a leading cause for disability worldwide. Psychotic episodes are ...

The Lancet Psychiatry: Goth teens could be more vulnerable to depression and self-harm

2015-08-28
Young people who identify with the goth subculture might be at increased risk of depression and self-harm, according to new research published in The Lancet Psychiatry journal. The findings show that teenagers who identified very strongly with being a goth at age 15 were three times more likely to be clinically depressed and were five times more likely to self-harm at age 18 than young people who did not identify with the goth subculture. "Our study does not show that being a goth causes depression or self-harm, but rather that some young goths are more vulnerable to ...

Pregnant women with hypertension and their siblings face increased risk of heart disease

2015-08-28
Highlights Compared with their sister(s) who had normal blood pressure during pregnancy, women who had hypertension in pregnancy were more likely to develop hypertension later in life. Brothers and sisters of women who had high blood pressure during pregnancy were at increased risk of developing high blood pressure later in life. Brothers, but not sisters, of women who had high blood pressure in pregnancy were also at increased risk of developing heart disease. Hypertension develops in approximately 8% of pregnancies. Washington, DC (August 27, 2015) ...

15 percent of cigarettes sold in NYC have illegal tax stamps, study finds

2015-08-28
Licensed tobacco retailers throughout New York City are selling a substantial number of cigarette packs carrying either counterfeit or out-of-state tax stamps, finds an investigation by NYU public health researchers. These illegal cigarette sales are more pervasive in independent stores, as opposed to chain stores, according to the study published in the BMJ journal Tobacco Control. "Our research found that illegal cigarettes are regularly available over the counter in New York City," said study author Diana Silver, associate professor of public health at NYU's Steinhardt ...

LAST 30 PRESS RELEASES:

How your brain decides blame and punishment -- and how it can be changed

Uniquely human brain region enables punishment decisions

Pinpointing punishment

Chapman University publishes research on attractiveness and mating

E-cigarettes: Special issue from Nicotine & Tobacco Research

Placental problems in early pregnancy associated with 5-fold increased risk of OB & fetal disorders

UT study: Invasive brood parasites a threat to native bird species

Criminals acquire guns through social connections

Restoring ocean health

Report: Cancer remains leading cause of death in US Hispanics

Twin study suggests genetic factors contribute to insomnia in adults

To be fragrant or not: Why do some male hairstreak butterflies lack scent organs?

International team discovers natural defense against HIV

Bolivian biodiversity observatory takes its first steps

Choice of college major influences lifetime earnings more than simply getting a degree

Dominant strain of drug-resistant MRSA decreases in hospitals, but persists in community

Synthetic biology needs robust safety mechanisms before real world application

US defense agencies increase investment in federal synthetic biology research

Robots help to map England's only deep-water Marine Conservation Zone

Mayo researchers identify protein -- may predict who will respond to PD-1 immunotherapy for melanoma

How much water do US fracking operations really use?

New approach to mammograms could improve reliability

The influence of citizen science grows despite some resistance

Unlocking secrets of how fossils form

What happens on the molecular level when smog gets into the lungs?

Using ultrasound to clean medical instruments

Platinum and iron oxide working together get the job done

Tiny silica particles could be used to repair damaged teeth, research shows

A quantum lab for everyone

No way? Charity's logo may influence perception of food in package

[Press-News.org] New embryo image processing technology could assist in IVF implantation success rates
A collaboration between biologists and engineers at Monash University has led to the development of a new non-invasive image processing technique to visualize embryo formation
Press-News.org is a service of DragonFly Company. All Rights Reserved.
Issuers of news releases are solely responsible for the accuracy of their content.