(Press-News.org) Bethesda, MD—Patients with advanced kidney disease who are undergoing hemodialysis are known to be highly susceptible to heart attacks and other cardiovascular complications, and now scientists likely know why. New research findings published in the Journal of Leukocyte Biology show that uremic toxins, which are not removed by hemodialysis, increase heart attack risk. The same scientists also have found what can reduce this risk: an oral adsorbent called "AST-120."
"Treatment with AST-120, an oral adsorbent, will not only delay the progression of kidney disease, but may also prevent future heart attack,'" said Masayuki Yoshida, M.D., a researcher involved in the work from the Life Science and Bioethics Research Center at Tokyo Medical and Dental University in Tokyo, Japan.
To make this discovery, scientists used two groups of mice with kidney failure. The first group received AST-120 and the second group did not. When monocytes taken from both sets of mice were subjected to flow cytometry, Mac-1 expression and oxidative stress was reduced in the group with AST-120. For the first time, a study concludes that AST-120 reduces monocyte inflammation in kidney disease, and may reduce cardiovascular diseases including myocardial infarction and stroke in end-stage kidney patients.
"This discovery has the potential to save lives." said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology, "While the precise connection between monocytes in the blood, uremic toxins and cardiovascular disease appears quite promising, however, more studies are needed. Nevertheless, the insights from these AST-120 studies in a model of kidney failure should open the doors to further research and therapies."
###
The Journal of Leukocyte Biology publishes peer-reviewed manuscripts on original investigations focusing on the cellular and molecular biology of leukocytes and on the origins, the developmental biology, biochemistry and functions of granulocytes, lymphocytes, mononuclear phagocytes and other cells involved in host defense and inflammation. The Journal of Leukocyte Biology is published by the Society for Leukocyte Biology.
Details: Shunsuke Ito, Yusuke Higuchi, Yoko Yagi, Fuyuhiko Nishijima, Hideyuki Yamato, Hideto Ishii, Mizuko Osaka, and Masayuki Yoshida. Reduction of Indoxyl Sulfate by AST-120 Attenuates Monocyte Inflammation Related to Chronic Kidney Disease. J Leukoc Biol June 2013 93:837-845; doi:10.1189/jlb.0112023 ; http://www.jleukbio.org/content/93/6/837.abstract
Mystery solved: Why people on dialysis have increased risk of heart attack
New research published in the Journal of Leukocyte Biology suggests that kidney disease often leads to heart attack because uremic toxins are not removed by hemodialysis; scientists identify treatment
2013-05-30
ELSE PRESS RELEASES FROM THIS DATE:
A newly discovered hormone makes ovaries grow
2013-05-30
Bethesda, MD—A newly discovered hormone produced by the eggs of human females may improve the effectiveness of current fertility treatments for women and possibly lead to entirely new treatments altogether. According to new research published in the June 2013 issue of The FASEB Journal, researchers from Stanford and Akira University in Japan identified a new hormone called "R-spondin2" that promotes follicle development and stimulates ovary growth.
"The finding of a new ovarian hormone produced by the oocytes capable of stimulating ovarian follicle growth could lead ...
Immune system to fight brain tumors
2013-05-30
Research at Lund University in Sweden gives hope that one of the most serious types of brain tumour, glioblastoma multiforme, could be fought by the patients' own immune system. The tumours are difficult to remove with surgery because the tumour cells grow into the surrounding healthy brain tissue. A patient with the disease therefore does not usually survive much longer than a year after the discovery of the tumour.
The team has tested different ways of stimulating the immune system, suppressed by the tumour, with a 'vaccine'. The vaccine is based on tumour cells that ...
New discovery permits rapid diagnosis and treatment of sepsis
2013-05-30
Bethesda, MD—Despite numerous advances in treating infections and disease, effective treatments for sepsis remain elusive. A new discovery published in the June 2013 issue of The FASEB Journal not only could help health care providers predict who is more and less likely to develop sepsis, but it also opens the doors to new therapies that actually address the root cause of the problem, rather than just managing the symptoms. This also has the potential to benefit patients suffering from influenza and other viral infections, as well as chronic inflammatory diseases such ...
New gene delivery method: magnetic nanoparticles
2013-05-30
Bethesda, MD—Stent angioplasty saves lives, but there often are side effects and complications related to the procedure, such as arterial restenosis and thrombosis. In the June 2013 issue of The FASEB Journal, however, scientists report that they have discovered a new nanoparticle gene delivery method that may overcome current limitations of gene therapy vectors and prevent complications associated with the stenting procedure. Specifically, this strategy uses stents as a platform for magnetically targeted gene delivery, where genes are moved to cells at arterial injury ...
Omega-3 fatty acids may help heal a broken heart
2013-05-30
Bethesda, MD—Procedures like angioplasty, stenting and bypass surgery may save lives, but they also cause excessive inflammation and scarring, which ultimately can lead to permanent disability and even death. A new research report appearing in The FASEB Journal, shows that naturally derived compounds from polyunsaturated fatty acids (omega-3s) may reduce the inflammation associated with these procedures to help arteries more fully and completely heal.
"Our study suggests that biologically active, naturally occurring compounds derived from omega-3 PUFAs reduce inflammation ...
Twitter a popular source for vaccination information, debate
2013-05-30
Washington, DC, May 30, 2013 – Twitter is a popular source for receiving and sharing new information about vaccines, and also a basically reliable one, according to a study published in the June issue of the American Journal of Infection Control, the official publication of the Association for Professionals in Infection Control and Epidemiology (APIC).
Researchers from the University of Texas at Austin analyzed 9,510 vaccination-related tweets from one week in January, 2012 to determine the most popular and influential messages. A final sample of 2,580 tweets that had ...
Interleukin-22 protects against post-influenza bacterial superinfection
2013-05-30
Researchers from the Pasteur Institute, Lille, France have shown in a mouse model that interleukin-22 protects against bacterial superinfections that can arise following influenza. Their research is published in the June 2013 issue of the Journal of Virology.
Influenza A viral infection can lead to primary pneumonia and, later on, to serious complications including secondary bacterial pneumonia and sepsis. Post-influenza bacterial superinfections that occur during seasonal epidemics and pandemics are of great concern to human health and impose a considerable socio-economic ...
New agent inhibits HCV replication in mouse models -- No resistance seen
2013-05-30
Treatments against hepatitis C virus have only been partially successful. A major problem is that antivirals generate drug resistance. Now Seong-Wook Lee of Dankook University, Yongin, Republic of Korea and his collaborators have developed agents that bind to the business end of a critical protein, disabling it so successfully that no resistance has arisen. The research is published in the June 2013 issue of the Journal of Virology.
The target protein for the new agents is the NS5B replicase protein, which is the central catalytic enzyme in HCV replication. The researchers ...
Gemini Observatory captures Comet ISON hurtling toward uncertain destiny with the Sun
2013-05-30
The time-sequence images, spanning early February through May 2013, show the comet's remarkable activity despite its current great distance from the Sun and Earth. The information gleaned from the series provides vital clues as to the comet's overall behavior and potential to present a spectacular show. However, it's anyone's guess if the comet has the "right stuff" to survive its extremely close brush with the Sun at the end of November and become an early morning spectacle from Earth in early December 2013.
When Gemini obtained this time sequence, the comet ranged between ...
Gender, race, and HIV therapy: Insights from the GRACE study
2013-05-30
New Rochelle, NY, May 30, 2013—Enrollment of women in clinical trials of new anti-HIV drugs is extremely low, representing only about 15% of all treatment-experienced patients. For women of color it is even lower. Why women, and especially women of color, are so poorly represented in HIV drug trials is the focus of an important article in AIDS Patient Care and STDs, a peer-reviewed publication from Mary Ann Liebert, Inc., publishers. The article is available free on the AIDS Patient Care and STDs website at http://www.liebertpub.com/apc.
HIV-infected individuals that ...
LAST 30 PRESS RELEASES:
New method to study catalysts could lead to better batteries
Current Molecular Pharmacology impact factor rises to 2.9, achieving Q2 ranking in the Pharmacology & Pharmacy category in 2024 JCR
More time with loved ones for cancer patients spared radiation treatment
New methods speed diagnosis of rare genetic disease
Genetics of cardiomyopathy risk in cancer survivors differ by age of onset
Autism inpatient collection releases genetic, phenotypic data for more than 1,500 children with autism
Targeting fusion protein’s role in childhood leukemia produces striking results
Clear understanding of social connections propels strivers up the social ladder
New research reveals why acute and chronic pain are so different – and what might make pain last
Stable cooling fostered life, rapid warming brought death: scientists use high-resolution fusuline data reveal evolutionary responses to cooling and warming
New research casts doubt on ancient drying of northern Africa’s climate
Study identifies umbilical cord blood biomarkers of early onset sepsis in preterm newborns
AI development: seeking consistency in logical structures
Want better sleep for your tween? Start with their screens
Cancer burden in neighborhoods with greater racial diversity and environmental burden
Alzheimer disease in breast cancer survivors
New method revolutionizes beta-blocker production process
Mechanism behind life-threatening cancer drug side-effect revealed
Weighted vests might help older adults meet weight loss goals, but solution for corresponding bone loss still elusive
Scientists find new way to predict how bowel cancer drugs will stop working – paving the way for smarter treatments
Breast cancer patients’ microbiome may hold key to avoiding damaging heart side-effects of cancer therapies
Exercise-induced protein revives aging muscles and bones
American College of Cardiology issues guidance on weight management drugs
Understanding the effect of bedding on thermal insulation during sleep
Cosmic signal from the very early universe will help astronomers detect the first stars
With AI, researchers find increasing immune evasion in H5N1
Study finds hidden effects of wildfires on water systems
Airborne fungal spores may help predict COVID-19 & flu surges
Study shows tissues’ pliability depends on watery fluid between cells
Interfacial polymer cross-linking strategy enables ultra-thin polymeric membranes for fast and selective ion transport
[Press-News.org] Mystery solved: Why people on dialysis have increased risk of heart attackNew research published in the Journal of Leukocyte Biology suggests that kidney disease often leads to heart attack because uremic toxins are not removed by hemodialysis; scientists identify treatment