Long-term obesity and biological aging in young adults

JAMA Network Open

2025-07-11

(Press-News.org) About The Study: In this multiple-events case-control study, long-term obesity was associated with the expression of biochemical aging markers in adults ages 28 to 31, consistent with epigenetic alterations, telomere attrition, chronic inflammation, impaired nutrient sensing, mitochondrial stress, and compromised intercellular communication. In young adults, chronic health issues may emerge from accelerated biological aging associated with long-term obesity.

Corresponding Authors: To contact the corresponding authors, email Paulina Correa-Burrows, PhD, (paulina.correa@inta.uchile.cl) and Christian Gonzalez-Billault, PhD, (chrgonza@uchile.cl).

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamanetworkopen.2025.20011)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

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Long-term obesity and biological aging in young adults

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