(Press-News.org) Baltimore, MD—Proper tissue function and regeneration is supported by stem cells, which reside in so-called niches. New work from Carnegie's Yixian Zheng and Haiyang Chen identifies an important component for regulating stem cell niches, with impacts on tissue building and function. The results could have implications for disease research. It is published by Cell Stem Cell.
Lamins are proteins that the major structural component of the material that lines the inside of a cell's nucleus. Lamins have diverse functions, including suppressing gene expression. It has been difficult to understand how mutations in lamins cause diseases in specific tissues and organs, such as skeletal muscles, heart muscle, and fat.
A group of human diseases called laminopathies, which include premature aging, are caused by defects in proteins called lamins. Zheng and her team, which included Xin Chen of Johns Hopkins University, decided to examine whether lamins would link stem cell niche function to healthy tissue building and maintenance.
To understand the tissue-specific effects of lamin mutations, the team focused on fruit fly testis, one of the best-studied stem cell niche systems. In the fruit fly testis, biochemical cross-signaling between the different types of cells that make up the niche environment ensures proper maintenance and differentiation of the testis system's stem cells.
Using an advanced array of techniques available in fruit fly studies, the team demonstrated that lamins were a necessary component of supporting niche organization, which in turn regulates proper proliferation and differentiation of germline stem cells in fruit fly testis.
"These results could have implications for the role of lamins in other types of stem cell niches," Zheng said. "These findings could contribute to the study of diseases caused by lamina-based tissue degeneration. For example, different lamin mutations could disrupt the organization of different niches in the body, which then leads to degeneration in tissues."
INFORMATION:
This work was supported by the NIH.
The Carnegie Institution for Science is a private, nonprofit organization headquartered in Washington, D.C., with six research departments throughout the U.S. Since its founding in 1902, the Carnegie Institution has been a pioneering force in basic scientific research. Carnegie scientists are leaders in plant biology, developmental biology, astronomy, materials science, global ecology, and Earth and planetary science.
END
VIDEO:
Watch the changing dust density and the growth of structure in this simulated debris disk, which extends about 100 times farther from its star than Earth's orbit around the sun....
Click here for more information.
Many young stars known to host planets also possess disks containing dust and icy grains, particles produced by collisions among asteroids and comets also orbiting the star. These debris disks often show sharply defined rings or spiral patterns, features ...
A natural tissue graft can spur regeneration of cartilage and improve symptoms in patients who have cartilage damage in their knee, according to a study by researchers from Hospital for Special Surgery. The new research, the first case-series evaluation of De Novo NT Natural Tissue Graft, will be presented at the annual meeting of the American Orthopaedic Society for Sports Medicine (AOSSM), to be held July 11-14, in Chicago.
"The results at this time are encouraging," said lead author of the study Scott Rodeo, M.D., orthopedic surgeon and co-chief of the sports medicine ...
MANHATTAN, Kan. -- Inflammation. The word typically has a negative connotation. Arthritis … infection … numerous maladies come to mind.
But a Kansas State University researcher found that inflammation that occurs naturally in dairy cows the first few days after giving birth may play a surprisingly beneficial role in the complex process of going from late pregnancy to lactation.
"We know that during the first several days after giving birth and going into the lactating phase, dairy cows naturally experience some degree of inflammation," said Barry Bradford, associate ...
LEMONT, Ill. – Doctors have a new way of thinking about how to treat heart and skeletal muscle diseases. Body builders have a new way of thinking about how they maximize their power. Both owe their new insight to high-energy X-rays, a moth and cloud computing.
The understanding of how muscles get their power has been greatly expanded with new results published online July 10 in the Royal Society journal Proceedings of the Royal Society B. The Royal Society is the U.K.'s national academy of sciences.
The basics of how a muscle generates power remain the same: Filaments ...
Scientists have created a virtual model of the brain that daydreams like humans do.
Researchers created the computer model based on the dynamics of brain cells and the many connections those cells make with their neighbors and with cells in other brain regions. They hope the model will help them understand why certain portions of the brain work together when a person daydreams or is mentally idle. This, in turn, may one day help doctors better diagnose and treat brain injuries.
"We can give our model lesions like those we see in stroke or brain cancer, disabling groups ...
TEMPE, Ariz. -- A new way to look at cancer -- by tracing its deep evolutionary roots to the dawn of multicellularity more than a billion years ago -- has been proposed by Paul Davies of Arizona State University's Beyond Center for Fundamental Concepts in Science in collaboration with Charles Lineweaver of the Australian National University. If their theory is correct, it promises to transform the approach to cancer therapy, and to link the origin of cancer to the origin of life and the developmental processes of embryos.
Davies and Lineweaver are both theoretical physicists ...
Electroencephalography is a test to measure the electrical activity of the brain generated by scalp surface after being picked up by metal electrodes and conductive media. Proper classification of electroencephalography data is the main task in electroencephalography based brain computer interface. Brain-computer interface is a communication system that connects the brain with computer (or other devices) but is not dependent on the normal output of the brain (i.e., peripheral nerve and muscle). Such interface transforms neural activities into signals to establish a new ...
CHICAGO, IL – Programs to improve movement patterns may help prevent stress fractures in athletes and military personnel, say researchers presenting their work today at the American Orthopaedic Society for Sports Medicine's Annual Meeting in Chicago, IL.
"Several potentially modifiable muscular and biomechanical factors may be playing a part in the increased rates of stress fractures in athletes and military personnel," said Kenneth L. Cameron, PhD, MPH, ATC, lead author and Director of Orthopaedic Research at Keller Army Hospital, West Point, NY. "It's possible that ...
Arthroscopic bankart repair surgery is a cost-effective approach for patients suffering their first shoulder dislocation, according to research presented today at the American Orthopaedic Society for Sports Medicine's (AOSSM) Annual Meeting in Chicago, IL.
"We based our conclusions on a Markov model, which takes into account how surgery affects the patient's recovery in relation to the actual costs of medical treatment," commented Ryan P. Donegan, MD, MS, from Dartmouth-Hitchcock Medical Center in Lebanon, NH. "For surgery to be cost-effective in this model, expenses ...
CHICAGO, IL – Corticosteroid injections may speed-up the return time for National Football League (NFL) players suffering high ankle sprains, according to research presented today at the American Orthopaedic Society for Sports Medicine's Annual Meeting in Chicago, IL. Players treated with these injections typically returned 40% faster or approximately 10 days earlier than those not receiving the same treatment.
"After examining players with stable high ankle sprains over an eight-year period, we discovered those treated with corticosteroid injections returned to play ...
