(Press-News.org) Most obese individuals with kidney failure can prolong their lives by receiving a kidney transplant, although this survival benefit is lower in severely obese individuals. That's the conclusion of a new study published in the American Journal of Transplantation. The findings will hopefully decrease differences in access to transplantation for obese patients.
Obesity is increasing in patients with kidney failure. In some studies, obese kidney failure patients who are on dialysis have a lower risk of dying prematurely than non-obese patients. In contrast, obese kidney transplant recipients have a higher risk of dying prematurely than non-obese recipients. Therefore determining the survival benefit of transplantation in obese transplant recipients is an important issue.
Using data from the United States between 1995 and 2007, John Gill, MD, MS, of the University of British Columbia, in Vancouver, and his colleagues determined the risk of premature death in transplant recipients grouped by body mass index (BMI) compared with transplant candidates with the same BMI who were on the transplant waiting list. The analysis included 208,498 patients, and obesity was defined as a BMI of 30 kg/m2 or higher.
Among the major findings:
Obese patients with a BMI of 30 to 39 kg/m2 derived a similar survival advantage from transplantation as non-obese patients, which equated to more than a 66 percent reduced risk of dying within one year of transplantation.
Obese patients with a BMI of 40 or higher derived a lower survival advantage from transplantation (a 48 percent reduced risk of dying within one year), and a survival advantage was uncertain in Black patients with a BMI of 40 or higher.
Differences in obese compared with non-obese patients were not as profound with transplantations using kidneys from live donors.
The risk of dying early after transplantation was greater in obese compared with non-obese patients.
"Our study shows that obese patients derive a survival advantage from transplantation, and obesity should not exclude patients from consideration of transplantation," said Dr. Gill. "Also, improved early post-transplant care may help reduce the early risk of death in obese patients, and living donor transplantation may be a useful strategy to mitigate the risks of transplantation in obese transplant candidates."
### END
Obese kidney failure patients receive survival benefit from transplantation
2013-07-25
ELSE PRESS RELEASES FROM THIS DATE:
Flow restrictors may reduce young children's accidental ingestion of liquid medications
2013-07-25
Cincinnati, OH -- In the US, child-resistant packaging for most medications has contributed to the prevention of thousands of pediatric deaths. Nevertheless, over 500,000 calls are made to poison control centers each year after accidental ingestion of medications by young children, and the number of emergency department visits for unsupervised medication ingestions is rising. In a new study scheduled for publication in The Journal of Pediatrics, researchers studied whether adding flow restrictors to bottles can limit the amount of liquid medication a child could access ...
Over 90 percent of dementia cases in China are undetected
2013-07-25
An international team of researchers has found that over 90 percent of dementia cases in China go undetected, with a high level of undiagnosed dementia in rural areas. The team of public health experts led by Dr Ruoling Chen at King's College London argues that more mental health education targeting high-risk populations is now needed to improve diagnosis rates, and increase support for sufferers and their families.
Dementia affects 10 million in China and up to 50 million worldwide, of which around 35 million sufferers are undiagnosed. Dementia causes deterioration in ...
Epilepsy in a dish: Stem cell research reveals clues to disease's origins and possible treatment
2013-07-25
ANN ARBOR, Mich. — A new stem cell-based approach to studying epilepsy has yielded a surprising discovery about what causes one form of the disease, and may help in the search for better medicines to treat all kinds of seizure disorders.
The findings, reported by a team of scientists from the University of Michigan Medical School and colleagues, use a technique that could be called "epilepsy in a dish".
By turning skin cells of epilepsy patients into stem cells, and then turning those stem cells into neurons, or brain nerve cells, the team created a miniature testing ...
Trust in leaders, sense of belonging stir people to safeguard common goods, analysis shows
2013-07-25
Every day, people donate to charities, volunteer to clean up city parks, or scale back their driving to curb air pollution. But some take these public goods for granted and ride free on the efforts of others. They watch public television but never make a donation to fund it. Or they run their lawn sprinklers during a drought while their neighbors follow government pleas to limit water consumption.
A new report in Psychological Science in the Public Interest, a journal of the Association for Psychological Science, examines more than 25 years' worth of studies on the use ...
Bee faithful? Plant-pollinator relationships compromised when bee species decline
2013-07-24
Remove even one bumblebee species from an ecosystem and the effect is swift and clear: Pollination is less effective, and plants produce significantly fewer seeds.
This according to research published today in the journal Proceedings of the National Academy of Sciences that focuses on the interactions between bumblebees and larkspur wildflowers in Colorado's Rocky Mountains.
The findings show that reduced competition among pollinators disrupts floral fidelity, or specialization, among the remaining bees in the system, leading to less successful plant reproduction.
"We ...
Face identification accuracy is in the eye (and brain) of the beholder, UCSB researchers say
2013-07-24
(Santa Barbara, Calif.) –– Though humans generally have a tendency to look at a region just below the eyes and above the nose toward the midline when first identifying another person, a small subset of people tend to look further down –– at the tip of the nose, for instance, or at the mouth. However, as UC Santa Barbara researchers Miguel Eckstein and Matthew Peterson recently discovered, "nose lookers" and "mouth lookers" can do just as well as everyone else when it comes to the split-second decision-making that goes into identifying someone. Their findings are in a recent ...
Emergency response could be faster, better, and more confident with 'option awareness' approach
2013-07-24
In a paper on decision making, human factors/ergonomics (HF/E) researchers found that choosing the best available emergency response could be improved by showing decision makers a depiction of the emergency decision space that allows them to compare their options visually. The researchers have developed the theory of option awareness (how people perceive and understand the desirability of available options), which can increase decision-making speed as well as accuracy, and confidence.
In the Journal of Cognitive Engineering and Decision Making article, "Supporting Complex ...
How does the motor relearning program improve neurological function of brain ischemia?
2013-07-24
The motor relearning program can significantly improve various functional disturbance induced by ischemic cerebrovascular diseases. However, its mechanism of action remains poorly understood. According to a study published in the Neural Regeneration Research (Vol. 8, No. 16, 2013), models of ischemic brain injury in the rhesus macaque were induced by electrocoagulation of the M1 segment of the right middle cerebral artery, then the motor relearning program was after model establishment. Glial fibrillary acidic protein and neurofilament protein expression changes could reflect ...
Mechanical tension promotes nerve regeneration of skin pathological scars
2013-07-24
Scars are prone to appear at high tension parts, such as the sternum, shoulder and back, which are serious clinical problems. Surgeons reduce scar formation through Z, W, V-Y flap variation and reducing blade tension, but its specific mechanism are still not very clear. Hu Xiao and colleagues from Shandong Provincial Hospital Affiliated to Shandong University verified that mechanical tension contributed to the formation of a hyperplastic scar in the back skin of rats, in conjunction with increases in both nerve density and nerve growth factor expression in the scar tissue. ...
NPY and leptin receptor in the hypothalamus of rats with chronic immobilization stress
2013-07-24
A recent study entitled "Neuropeptide Y and leptin receptor expression in the hypothalamus of rats with chronic immobilization stress" showed that the body weight and food intake of rats subjected to chronic immobilization stress were significantly decreased; the expression of leptin receptor and the co-localization coeffient in these leptic receptor neurons in the arcuate nucleus of the hypothalamus were both upregulated, while the number of neuropeptide Y neurons was decreased. These findings which were in the Neural Regeneration Research (Vol. 8, No. 18, 2013) indicated ...