(Press-News.org) Contact information: Dr. Anna-Sabine Ernst
presse@iqwig.de
49-022-135-6850
Institute for Quality and Efficiency in Health Care
IQWiG publishes new version of its General Methods
Procedure for report production and section on meta-analyses updated / New sections on early benefit assessment
The German Institute for Quality and Efficiency in Health Care (IQWiG) has completed the first step in the revision of its methods paper and published the version "General Methods 4.1" on the Internet on 28 November 2013. From now on the new document forms the basis for the scientific work of the Institute and its external experts and for collaboration with the commissioning agencies (the Federal Joint Committee and the Federal Ministry of Health).
Instead of preparing, as previously, a full update of the methods paper, the Institute is revising the General Methods 4.0 in several steps. The first changes primarily affect Chapter 3 on benefit assessment and Section 7.3.8 on meta-analyses.
What is new?
The levels of certainty of conclusions for different situations of evidence in benefit assessments – proof, indication and hint – are now described in more detail. For this purpose, in the chapter on benefit assessment IQWiG has split former Section 3.1.4 into two sections, namely the new section "Outcome-related assessment" (now 3.1.4) and the former section "Summarizing assessment" (now 3.1.5). In Section 3.1.4 the Institute has extended criteria describing in which exceptional cases proof of benefit, i.e., the highest level of certainty of conclusions, can also be inferred from only one study. IQWiG follows suggestions from the commenting procedure here.
Section 3.3.3 on the early benefit assessment of new drugs now contains a detailed description of how IQWiG operationalizes the determination of the extent of added benefit. A new appendix contains a comprehensive rationale for the underlying methodological approach.
The use of prediction intervals in meta-analyses with random effects was added to Section 7.3.8 on meta-analyses. Prediction intervals are an important instrument in assessing whether and how clearly effects observed in studies are in the same direction. According to the new Section 3.1.4, this again plays an important role when deriving conclusions on the available evidence.
Transparent procedure
IQWiG published the draft containing the first step of the updates of General Methods 4.0 and the new sections of General Methods 4.1 on 19 April 2013 and invited interested parties to submit comments in a commenting procedure. These comments have been considered in the present Version 4.1.
Together with its methods paper IQWiG has published a "Documentation and evaluation of comments", which contains the full verbatim written comments as well as their evaluation, that is, IQWiG's responses to all the main arguments presented in the comments.
The next step
The draft of the next updates and additions are planned for publication in the first quarter of 2014. This will again be followed by a commenting procedure and the final revision of the corresponding sections of the methods paper, resulting in General Methods 4.2. This document will as usual be published on the Institute's website.
The second step involves, among other things, new sections on the assessment of the potential of non-drug interventions in accordance with the testing regulation (Erprobungsregelung). This type of assessment has been conducted by IQWiG since the Health Care Structure Law (Versorgungsstrukturgesetz, GKV-VStG) became effective in 2013.
###
The English-language version of the General Methods Version 4.1 will be available soon. If you would like to be informed when this document is available, please send an e-mail to info@iqwig.de.
IQWiG publishes new version of its General Methods
Procedure for report production and section on meta-analyses updated / New sections on early benefit assessment
2013-12-02
ELSE PRESS RELEASES FROM THIS DATE:
Detailed image shows how genomes are copied
2013-12-02
Detailed image shows how genomes are copied
For the first time, researchers at Umeå University have succeeded in showing how the DNA polymerase epsilon enzyme builds new genomes. The detailed image produced by these researchers shows how ...
The importance of standardizing drug screening studies
2013-12-02
The importance of standardizing drug screening studies
An IRCM researcher sheds light on inconsistencies between large pharmacogenomic studies
Montréal, December 2, 2013 – A bioinformatics expert at the IRCM, Benjamin Haibe-Kains, recently ...
Nanorobot for transporting drugs in the body
2013-12-02
Nanorobot for transporting drugs in the body
A nanorobot is a popular term for molecules with a unique property that enables them to be programmed to carry out a specific task. In collaboration with colleagues in Italy and the USA, researchers at Aarhus University have ...
New report illustrates persistent global burden of anemia among high-risk populations
2013-12-02
New report illustrates persistent global burden of anemia among high-risk populations
(WASHINGTON, December 2, 2013) – Despite increasing efforts to diagnose and treat anemia worldwide, there remains a surprisingly large global burden of the disease, particularly ...
Researchers unlock a new means of growing intestinal stem cells
2013-12-02
Researchers unlock a new means of growing intestinal stem cells
Studying these cells could lead to new treatments for diseases ranging from gastrointestinal disease to diabetes
CAMBRIDGE, MA -- Researchers at MIT and Brigham and Women's Hospital have shown ...
Mice can inherit learned sensitivity to a smell
2013-12-02
Mice can inherit learned sensitivity to a smell
Trauma can scar people so indelibly that their children are affected. History provides examples of generations traumatized by war and starvation, whose children experience altered physiology.
Now researchers at Yerkes ...
Forget the needle consider the haystack
2013-12-02
Forget the needle consider the haystack
Uncovering hidden structures in massive data collections
Advances in computer storage have created collections of data so huge that researchers often have trouble uncovering critical patterns in connections ...
Living with chronic pain: The daily struggle with a 'new self'
2013-12-02
Living with chronic pain: The daily struggle with a 'new self'
People who suffer with chronic musculoskeletal pain face a daily struggle with their sense of self and find it difficult to prove the legitimacy of their condition.
A new study, funded by the National Institute ...
Oxygen levels increase and decrease the effectiveness of anti-inflammatory therapies
2013-12-02
Oxygen levels increase and decrease the effectiveness of anti-inflammatory therapies
New research published in the Journal of Leukocyte Biology suggests that the effectiveness of anti-inflammatory glucocorticoids may be related to ...
Understanding hearing
2013-12-02
Understanding hearing
Computer models of neuronal sound processing in the brain lead to cochlear implant improvements
This news release is available in German.
Intact hearing is a prerequisite for learning to speak. This is why children ...
LAST 30 PRESS RELEASES:
Even healthy children can be severely affected by RSV
Keto diet linked to reduced depression symptoms in college students
Blood test identifies HPV-associated head and neck cancers up to 10 years before symptoms
Odds of dementia strongly linked to number of co-existing mental health disorders
Large social and economic inequalities persist among UK doctors
Research reveals how microplastics threaten Gulf of Mexico marine life
AI tool developed at Oxford helps astronomers find supernovae in a sky full of noise
Hungry star is eating its cosmic twin at rate never seen before
The Age of Feasting: Late Bronze Age networks developed through massive food festivals, with animals brought from far and wide
Study of breast cell changes in motherhood provides clues to breastfeeding difficulties
Seizure spread marks loss of consciousness
Carlos Collet, MD, Ph.D., joins CRF® as director, cardiovascular imaging, physiology and translational therapeutics
Beyond weight loss: How healthy eating cuts chronic pain
Mayo Clinic physician awarded Dr. Scott C. Goodwin Grant for Adenomyosis
Kennesaw State researcher developing electronic nose to detect foodborne illness
New global database opens the door for better understanding of terrestrial ecosystem productivity
Surviving hostile Venus conditions, finding rare earths and other critical metals
New ways of producing methanol from electricity and biomass
Gemini South aids in discovery of elusive cloud-forming chemical on ancient brown dwarf
UIC researchers awarded $8.3M federal grant to study alcohol use disorder
NCCN Policy Summit explores whether artificial intelligence can transform cancer care safely and fairly
Mitcham receives funding to strengthen food as medicine pathways in southwest Virginia
PCORI awards new patient-centered CER to support informed health care decisions
Global integration of traditional and modern medicine: policy developments, regulatory frameworks, and clinical integration model
How to find a cryptic animal: Recording the elusive beaked whale in the Foz do Amazonas Basin
Long COVID and food insecurity in US adults, 2022-2023
Bariatric surgery and incident development of obesity-related comorbidities
Microbiome instability linked to poor growth in kids
Can a healthy gut microbiome help prevent childhood stunting?
Achieving low resistance and high performance in MTJs using high-entropy oxides
[Press-News.org] IQWiG publishes new version of its General MethodsProcedure for report production and section on meta-analyses updated / New sections on early benefit assessment