PRESS-NEWS.org - Press Release Distribution
FREE PRESS RELEASES DISTRIBUTION

Child's autism risk accelerates with mother's age over 30

Child's autism risk accelerates with mother's age over 30
2014-04-22
(Press-News.org) PHILADELPHIA (April 22, 2014) – Older parents are more likely to have a child who develops an autism spectrum disorder (ASD) than are younger parents. A recent study from researchers from the Drexel University School of Public Health in Philadelphia and Karolinska Institute in Sweden provides more insight into how the risk associated with parental age varies between mothers' and fathers' ages, and found that the risk of having a child with both ASD and intellectual disability is larger for older parents. In the study, published in the February 2014 issue of the International Journal of Epidemiology, researchers report that fathers' and mothers advancing ages have different impacts on their child's risk. The rise in ASD risk with parental age was greater for older mothers as compared to older fathers. "The open question at hand really is, what biological mechanisms underlie these age effects?" said Brian K. Lee, PhD, an assistant professor in the Drexel University School of Public Health and research fellow of the A.J. Drexel Autism Institute, and senior author of the study. The observed differences in risk based on mothers' and fathers' ages point to a need to continue investigating underlying mechanisms of ASD that may be influenced by a mother's age, Lee said, even though much recent discussion has focused on fathers' and even grandfathers' ages. The risk of having a child with ASD had a more complicated relationship to age in women than in men – whose risk of fathering a child with ASD increased linearly with age across their lifespan. Among women giving birth before the age of 30, the risk of ASD in the child showed no association with age -- it was simply very low. But for babies born to mothers aged 30 and older, the chance of developing ASD rose rapidly with the mother's age. Lee noted that the non-linear maternal age effect that is relatively stronger than the paternal age effect on ASD risk has been observed in previous studies, but has not received much attention. Multiple mechanisms could be in play to account for the different patterns of risk, including environmental risk factors occurring in women after age 30. Factors such as complications in pregnancy could also underlie the effect of mothers' ages on a child's ASD risk but not a paternal age effect. The linear, steady increase in risk associated with fathers' ages is consistent with the hypothesis of increased genomic alterations over the father's lifespan that can increase risk of ASD, Lee said. In this study, Lee and colleagues analyzed a large population registry sample of 417,303 children born in Sweden between 1984 and 2003, adjusted for numerous possible factors that could vary with parental age and also influence risk, such as family income and each parent's psychiatric history. The study also used a particularly comprehensive case-finding approach, to identify more ASD cases than other studies might, based on all pathways to care in a socialized health system. A goal was to study these parental age effects in more detail by looking at possible differing risks of ASD with and without intellectual disability – one of the most serious comorbid diagnoses with ASD, with a significant impact on functional status in life. This was the first population-based study with an ASD sample large enough to study ASD risk in populations of children with and without intellectual disability. "When considering risk factors, we can't necessarily lump all ASD cases together, even though they fall under a broad umbrella of autism," Lee said. "We need to keep an open mind in case intellectual disability might be a marker of a different underlying mechanism." The finding that ASD with intellectual disability had a stronger association with older parents, compared to ASD without intellectual disability, supports continued investigation of possible different mechanisms. Lee noted that, although age effects are important indicators of risk at the population level that could eventually help researchers identify preventable causes of disability, they aren't very significant for a couple's family planning because the overall risk remains low. "The absolute risk of having a child with ASD is still approximately 1 in 100 in the overall sample, and less than 2 in 100 even for mothers up to age 45."

INFORMATION: END

[Attachments] See images for this press release:
Child's autism risk accelerates with mother's age over 30

ELSE PRESS RELEASES FROM THIS DATE:

Nanomaterial outsmarts ions

Nanomaterial outsmarts ions
2014-04-22
Ions are an essential tool in chip manufacturing, but these electrically charged atoms can also be used to produce nano-sieves with homogeneously distributed pores. A particularly large number of electrons, however, must be removed from the atoms for this purpose. Such highly charged ions either lose a surprisingly large amount of energy or almost no energy at all as they pass through a membrane that measures merely one nanometer in thickness. Researchers from the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) and Vienna University of Technology (TU Wien) report in the scientific ...

Gym culture likened to McDonalds

Gym culture likened to McDonalds
2014-04-22
Visit a typical gym and you will encounter a highly standardised notion of what the human body should look like and how much it should weigh. This strictly controlled body ideal is spread across the world by large actors in the fitness industry. A new study explores how the fitness industry in many ways resembles that of fast food. One of the authors is from the University of Gothenburg. McDonaldisation of the gym culture is the theme of an article published in Sports, Education and Society, where Thomas Johansson, professor at the University of Gothenburg, together ...

Two genes linked to inflammatory bowel disease

2014-04-22
CINCINNATI—Inflammatory Bowel Disease (IBD), a group of chronic inflammatory disorders of the intestine that result in painful and debilitating complications, affects over 1.4 million people in the U.S., and while there are treatments to reduce inflammation for patients, there is no cure. Now, Cincinnati Cancer Center and University of Cincinnati (UC) Cancer Institute researcher Susan Waltz, PhD, and scientists in her lab have done what is believed to be the first direct genetic study to document the important function for the Ron receptor, a cell surface protein often ...

New design for mobile phone masts could cut carbon emissions

2014-04-22
A breakthrough in the design of signal amplifiers for mobile phone masts could deliver a massive 200MW cut in the load on UK power stations, reducing CO2 emissions by around 0.5 million tonnes a year. Funded by the Engineering and Physical Sciences Research Council (EPSRC), the Universities of Bristol and Cardiff have designed an amplifier that works at 50 per cent efficiency compared with the 30 per cent now typically achieved. Currently, a 40W transmitter in a phone mast's base station* requires just over 130W of power to amplify signals and send them wirelessly ...

Speed-reading apps may impair reading comprehension by limiting ability to backtrack

2014-04-22
To address the fact that many of us are on the go and pressed for time, app developers have devised speed-reading software that eliminates the time we supposedly waste by moving our eyes as we read. But don't throw away your books, papers, and e-readers just yet — research suggests that the eye movements we make during reading actually play a critical role in our ability to understand what we've just read. The research is published in Psychological Science, a journal of the Association for Psychological Science. "Our findings show that eye movements are a crucial part ...

UV-radiation data to help ecological research

UV-radiation data to help ecological research
2014-04-22
Many research projects study the effects of temperature and precipitation on the global distribution of plant and animal species. However, an important component of climate research, the UV-B radiation, is often neglected. The landscape ecologists from UFZ in collaboration with their colleagues from the Universities in Olomouc (Czechia), Halle and Lüneburg have processed UV-B data from the U.S. NASA space agency in such a way that they can be used to study the influence of UV-B radiation on organisms. The basic input data were provided by a NASA satellite that regularly, ...

A family of compact schemes with minimized dispersion and controllable dissipation was developed

A family of compact schemes with minimized dispersion and controllable dissipation was developed
2014-04-22
Spectral properties optimization is an important issue for developing schemes to resolve flow fields that are characterized by a wide range of length scales such as turbulent flows and aero acoustic phenomena. The work finished by Dr SUN Zhensheng and his ground provided a novel approach to optimize the dissipation and dispersion properties of a family of tri-diagonal compact schemes. The corresponding paper entitled "A high-resolution, hybrid compact-WENO scheme with minimized dispersion and controllable dissipation" was published in Sci China-Phys Mech Astron, 2014 Vol. ...

'Tween' television programming promotes some stereotypical conceptions of gender roles

Tween television programming promotes some stereotypical conceptions of gender roles
2014-04-22
COLUMBIA, Mo. – The term "tween" denotes a child who is between the ages of 8 and 12 and is used to describe a preadolescent who is "in between" being a child and a teen. This demographic watches more television than any other age group and is considered to be a very lucrative market. Tween television programming consists of two genres: "teen scene" (geared toward girls) and "action-adventure" (geared toward boys). Researchers at the University of Missouri found that these programs could lead tweens to limit their views of their potential roles in society just as they begin ...

How often are unauthorized immigrant workers trafficked and abused?

2014-04-22
Los Angeles, CA (April 22, 2014) Labor trafficking – or recruiting a person for labor through force, fraud, or coercion for involuntary servitude, debt bondage, or even slavery – has been a difficult problem to track among undocumented migrant workers. With unique access to a "hidden population" from one of America's largest Spanish-speaking immigrant destinations, a recent study finds that more than 30% of undocumented migrant laborers in this area are victims of labor trafficking and 55% are victims of other labor abuses. In this study, published in the May issue of ...

New tool helps doctors better predict, prevent deadly respiratory failure

New tool helps doctors better predict, prevent deadly respiratory failure
2014-04-22
A new prediction tool can help doctors better identify patients who are at highest risk for respiratory failure after surgery and therefore prevent the often deadly condition, suggest data from a large multi-center study published in the May issue of Anesthesiology. Affecting nearly 200,000 Americans a year, acute respiratory distress syndrome (ARDS) is a sudden failure of the lungs caused by a number of issues ranging from smoke inhalation to pneumonia or blood infection. High-risk patients can develop ARDS after surgery. ARDS is difficult to treat once it develops and ...

LAST 30 PRESS RELEASES:

Scientists model 'true prevalence' of COVID-19 throughout pandemic

New breakthrough to help immune systems in the fight against cancer

Through the thin-film glass, researchers spot a new liquid phase

Administering opioids to pregnant mice alters behavior and gene expression in offspring

Brain's 'memory center' needed to recognize image sequences but not single sights

Safety of second dose of mRNA COVID-19 vaccines after first-dose allergic reactions

Changes in disparities in access to care, health after Medicare eligibility

Use of high-risk medications among lonely older adults

65+ and lonely? Don't talk to your doctor about another prescription

Exosome formulation developed to deliver antibodies for choroidal neovascularization therapy

Second COVID-19 mRNA vaccine dose found safe following allergic reactions to first dose

Plant root-associated bacteria preferentially colonize their native host-plant roots

Rare inherited variants in previously unsuspected genes may confer significant risk for autism

International experts call for a unified public health response to NAFLD and NASH epidemic

International collaboration of scientists rewrite the rulebook of flowering plant genetics

Improving air quality reduces dementia risk, multiple studies suggest

Misplaced trust: When trust in science fosters pseudoscience

Two types of blood pressure meds prevent heart events equally, but side effects differ

New statement provides path to include ethnicity, ancestry, race in genomic research

Among effective antihypertensive drugs, less popular choice is slightly safer

Juicy past of favorite Okinawan fruit revealed

Anticipate a resurgence of respiratory viruses in young children

Anxiety, depression, burnout rising as college students prepare to return to campus

Goal-setting and positive parent-child relationships reduce risk of youth vaping

New research identifies cancer types with little survival improvements in adolescents and young adul

Oncotarget: Replication-stress sensitivity in breast cancer cells

Oncotarget: TERT and its binding protein: overexpression of GABPA/B in gliomas

Development of a novel technology to check body temperature with smartphone camera

The mechanics of puncture finally explained

Extreme heat, dry summers main cause of tree death in Colorado's subalpine forests

[Press-News.org] Child's autism risk accelerates with mother's age over 30