PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Intrathecal bumetanide has analgesic effects through inhibition of NKCC1

Intrathecal bumetanide has analgesic effects through inhibition of NKCC1
2014-07-17
(Press-News.org) Accumulating evidence has demonstrated that the sodium-potassium-chloride co-transporter 1 (NKCC1) and potassium-chloride co-transporter 2 (KCC2) have a role in the modulation of pain transmission at the spinal level through chloride regulation in the pain pathway and by effecting neuronal excitability and pain sensitization. Dr. Yanbing He Zhujiang Hospital, Southern Medical University, China and his team found that intrathecal bumetanide could increase NKCC1 expression and decrease KCC2 expression in spinal cord neurons of rats with incisional pain. The authors presumed that intrathecal bumetanide has analgesic effects on incisional pain through inhibition of NKCC1. This paper was published in Neural Regeneration Research (Vol. 9, No. 10, 2014).

INFORMATION: Article: " Analgesic effect of intrathecal bumetanide is accompanied by changes in spinal sodium-potassium-chloride co-transporter 1 and potassium-chloride co-transporter 2 expression in a rat model of incisional pain," by Yanbing He1, 2, Shiyuan Xu1, Junjie Huang2, Qingjuan Gong2 (1 Department of Anesthesiology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China; 2 Department of Anesthesiology and Pain Medicine, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong Province, China) He YB, Xu SY, Huang JJ, Gong QJ. Analgesic effect of intrathecal bumetanide is accompanied by changes in spinal sodium-potassium-chloride co-transporter 1 and potassium-chloride co-transporter 2 expression in a rat model of incisional pain. Neural Regen Res. 2014;9(10):1055-1062.

Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
http://www.nrronline.org/

[Attachments] See images for this press release:
Intrathecal bumetanide has analgesic effects through inhibition of NKCC1

ELSE PRESS RELEASES FROM THIS DATE:

Attenuated inhibition of neuron membrane excitability contributes to childhood depression

2014-07-17
Accumulating evidence suggests that the nucleus accumbens, which is involved in mechanisms of reward and addiction, plays a role in the pathogenesis of depression and in the action of antidepressants. Dandan Liu and her team, Bio-X Institute, Shanghai Jiao Tong University, China for the first time using electrophysiological method studied the signaling transduction pathway mediated by dopamine D2-like receptor in the medium spiny neurons in the core of the nucleus accumbens in the juvenile Wistar Kyoto rat model of depression. They concluded that impaired inhibition of ...

NYU research on persons w/ HIV/AIDS not taking medication and not engaged in care

2014-07-17
Regular attendance at HIV primary care visits and high adherence to antiretroviral therapy (ART) are vital for people living with HIV/AIDS (PLHA), as these health behaviors lead to lowered rates of morbidity and mortality, increased quality of life, and reducing the risk of HIV transmission to others. However, a large proportion of PLHA in the United States are not sufficiently engaged in care and not taking ART when it is medically necessary. A new study, "HIV-infected individuals who delay, decline, or discontinue antiretroviral therapy: Comparing clinic- and peer-recruited ...

Eradicating fatal sleeping sickness by killing off the tsetse fly

Eradicating fatal sleeping sickness by killing off the tsetse fly
2014-07-17
A Brigham Young University ecologist is playing a role in the effort to curb a deadly disease affecting developing nations across equatorial Africa. Steven L. Peck, a BYU professor of biology, has lent his expertise in understanding insect movement to help shape a UN-sanctioned eradication effort of the tsetse fly—a creature that passes the fatal African sleeping sickness to humans, domestic animals, and wildlife. Using Peck's advanced computer models, crews from the UN's Food and Agriculture Organization will know where to concentrate their efforts to eliminate the ...

Investing in sexual and reproductive health of 10 to 14 year olds yields lifetime benefits

Investing in sexual and reproductive health of 10 to 14 year olds yields lifetime benefits
2014-07-17
WASHINGTON -- Age 10 to 14 years, a time when both girls and boys are constructing their own identities and are typically open to new ideas and influences, provides a unique narrow window of opportunity for parents, teachers, healthcare providers and others to facilitate transition into healthy teenage and adulthood years according to researchers from Georgetown University's Institute for Reproductive Health who note the lack worldwide of programs to help children of this age navigate passage from childhood to adulthood. An estimated 1.2 billion adolescents live in the ...

Women's professional self-identity impacts on childcare balance, but not men's

2014-07-17
A new study finds that the more a woman self-identifies with her profession, the more paid hours she works and the less time she spends with the couple's children, but the more equal the childcare balance is between a couple. However, the more a woman identifies herself with motherhood, the less time the father spends with the children. And while the more a man self-identifies as a parent the more time he spends with children, this had no impact on the amount of time the woman spends on childcare – regardless of her self-identity. The study, from Cambridge University's ...

Duck migration study reveals importance of conserving wetlands, MU researchers find

Duck migration study reveals importance of conserving wetlands, MU researchers find
2014-07-17
COLUMBIA, Mo. – During the 2011 and 2012 migration seasons, University of Missouri researchers monitored mallard ducks with new remote satellite tracking technology, marking the first time ducks have been tracked closely during the entirety of their migration from Canada to the American Midwest and back. The research revealed that mallards use public and private wetland conservation areas extensively as they travel hundreds of miles across the continent. Dylan Kesler, an assistant professor of fisheries and wildlife in the College of Agriculture, Food and Natural Resources ...

National Xenopus resource at the MBL innovates new way to study proteins

National Xenopus resource at the MBL innovates new way to study proteins
2014-07-17
WOODS HOLE, Mass.— Proteomics, the study of large groups of proteins, can enhance our understanding of a wide range of organisms, with applications in medicine and developmental biology. Such analyses traditionally require a complete genome for the organism being studied in order to obtain a reference set of proteins. However, many organisms that hold potential for proteomic analysis do not yet have completely sequenced and well-interpreted genomes because the costs, in terms of both time and money, can be prohibitive. Xenopus laevis, the African clawed frog, is one such ...

Birdsongs automatically decoded by computer scientists

2014-07-17
Birdsongs automatically decoded by computer scientists Scientists from Queen Mary University of London have found a successful way of identifying bird sounds from large audio collections, which could be useful for expert and amateur bird-watchers alike. The analysis used recordings of individual birds and of dawn choruses to identify characteristics of bird sounds. It took advantage of large datasets of sound recordings provided by the British Library Sound Archive, and online sources such as the Dutch archive called Xeno Canto. Publishing in the journal PeerJ, ...

Study shows how effects of starvation can be passed to future generations

Study shows how effects of starvation can be passed to future generations
2014-07-17
NEW YORK, NY — Evidence from human famines and animal studies suggests that starvation can affect the health of descendants of famished individuals. But how such an acquired trait might be transmitted from one generation to the next has not been clear. A new study, involving roundworms, shows that starvation induces specific changes in so-called small RNAs and that these changes are inherited through at least three consecutive generations, apparently without any DNA involvement. The study, conducted by Columbia University Medical Center (CUMC) researchers, offers ...

How does working part-time versus working full-time affect breastfeeding goals?

2014-07-17
Los Angeles, CA -- Breastfeeding is known to provide significant health benefits for both infants and their mothers. However, while many women intend to breastfeed despite returning to work, a new study finds that mothers who plan to breastfeed for at least three months but return to work full-time are less likely to meet their breastfeeding goals. Conversely, there is no association between women who return to work part-time and failure to reach the breastfeeding goal of at least three months. This new study was published today in the Journal of Human Lactation. Studying ...

LAST 30 PRESS RELEASES:

Scientists create ChatGPT-like AI model for neuroscience to build one of the most detailed mouse brain maps to date

AI and omics unlock personalized drugs and RNA therapies for heart disease

2023 ocean heatwave ‘unprecedented but not unexpected’

Johns Hopkins researchers develop AI to predict risk of US car crashes

New drug combination offers hope for men with advanced prostate cancer

New discovery finds gene converts insulin-producing cells into blood-sugar boosters

Powerful and precise multi-color lasers now fit on a single chip

Scientists agree chemicals can affect behavior, but industry workers more reluctant about safety testing

DNA nanospring measures cellular motor power

Elsevier Foundation and RIKEN launch “Envisioning Futures” report: paving the way for gender equity and women’s leadership in Japanese research

Researchers discover enlarged areas of the spinal cord in fish, previously found only in four-limbed vertebrates

Bipolar disorder heterogeneity decoded: transforming global psychiatric treatment approaches

Catching Alport syndrome through universal age-3 urine screening

Instructions help you remember something better than emotions or a good night’s sleep

Solar energy is now the world’s cheapest source of power, a Surrey study finds

Scientists reverse Alzheimer’s in mice using nanoparticles

‘Good’ gut bacteria boosts placenta for healthier pregnancy

USC team demonstrates first optical device based on “optical thermodynamics”

Microplastics found to change gut microbiome in first human-sample study

Artificially sweetened and sugary drinks are both associated with an increased risk of liver disease, study finds

Plastic in the soil, but not as we know it: Biodegradable microplastics rewire carbon storage in farm fields

Yeast proteins reveal the secrets of drought resistance

Psychiatry, primary care, and OB/GYN subspecialties hit hardest by physician attrition

New Canadian study reveals where HIV hides in different parts of the body

Lidocaine poisonings rise despite overall drop in local anesthetic toxicity

Politics follow you on the road

Scientists blaze new path to fighting viral diseases

The mouse eye as a window to spotting systemic disease

AI and the Future of Cancer Research and Cancer Care to headline October 24 gathering of global oncology leaders at the National Press Club: NFCR Global Summit to feature top scientists, entrepreneurs

FDA clears UCLA heart tissue regeneration drug AD-NP1 for clinical trials

[Press-News.org] Intrathecal bumetanide has analgesic effects through inhibition of NKCC1