Biological clock disruptions increase breast cancer risk, UGA study finds

(Press-News.org) Athens, Ga. – The disruption of a person's circadian rhythm—their 24-hour biological clock—has been linked to an increased risk of breast cancer, according to new University of Georgia research. The culprit, in this study in particular, is artificial light.

"Exposure to artificial light leads to a significantly higher risk for developing breast cancer," said Chunla He, a biostatistics graduate student in the UGA College of Public Health. "To decrease the use of artificial light, people should avoid working at night and implement earlier bed times."

Her research, published in the International Archives of Occupational and Environmental Health, examined key studies that included risk factors for developing breast cancer.

"A large body of related research about circadian rhythms and breast cancer exists," He said. "However, these studies are inconsistent and have a variety of limitations."

Under the mentorship of Sara Wagner Robb, assistant professor of epidemiology in the College of Public Health, He turned to previous studies to see what the research revealed.

In addition to other relevant exposures, He examined studies on breast cancer and flight attendants, who typically work both day and night shifts. The flight attendants represented a group of workers particularly susceptible to disrupted circadian rhythms, which are heavily influenced by light.

In her analysis, He found that employment as a flight attendant was related to an increased risk of breast cancer.

"People naturally secrete the hormone melatonin, which helps to regulate the circadian rhythm," He said. "When the sleep-wake cycle is disrupted by artificial light, melatonin secretion is adversely affected."

Robb recommends spreading this information to shift workers so they understand the harms in disrupting their circadian rhythms.

"Individuals engaging in this type of work should be aware of these risks and may make efforts to adjust their circadian rhythms," she said. "Although additional studies are certainly needed, scientists are becoming increasingly aware of the health risks associated with night workers and others exposed to circadian-disrupting behaviors."

Robb and He also advise that future research needs to examine social constraints—which may foster disruption of circadian rhythms—on shift workers. Additionally, shift workers should contact their primary care physicians for personalized treatment and options.

"This information tells us the harm in disrupting our natural cycle," He said. "With this new analysis, we must be cautious in our exposure to artificial light."

INFORMATION: The article was co-authored by Sonia Taj Anand, a former graduate student in the College of Public Health; Mark H. Ebell, professor of epidemiology; and John E. Vena, Georgia Cancer Coalition Distinguished Scholar.

The paper, published in the International Archives of Occupational and Environmental Health, is available online at http://link.springer.com/article/10.1007/s00420-014-0986-x and at http://news.uga.edu/documents/Circadian-disrupting-exposures-breast-cancer-risk-metaanalysis.pdf.