PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Inflammation in the mouth and joints in rheumatoid arthritis

2015-03-12
(Press-News.org) Boston, Mass., USA - Today at the 93rd General Session and Exhibition of the International Association for Dental Research, researcher Sheila Arvikar, Massachusetts General Hospital, Boston, USA, will present a study titled "Inflammation in the Mouth and Joints in Rheumatoid Arthritis." The IADR General Session is being held in conjunction with the 44th Annual Meeting of the American Association for Dental Research and the 39th Annual Meeting of the Canadian Association for Dental Research.

Periodontitis shares pathogenic mechanisms with rheumatoid arthritis (RA) and may trigger its onset. In this study, researchers performed joint and dental examinations, determined Porphyromonas gingivalis (P. gingivalis) antibodies, and examined inflammatory microenvironments in early and chronic RA patients.

Twenty-three RA patients, (15 new-onset disease, eight chronic) and 20 age/gender-matched healthy subjects (HS) without periodontitis/RA were enrolled in this study. Serum P. gingivalis IgG antibodies were measured by ELISA. Twenty inflammatory mediators were measured in serum, saliva, gingival crevicular fluid (GCF), and joint fluid by Luminex.

The 23 patients (87% female) received routine dental care, except for one; none currently smoked. Of the 23 RA patients, 10 had gingivitis and nine had periodontitis. RA patients exhibited increased pocket depth, clinical attachment loss, bleeding on probing and GCF volume compared with HS. Six of 23 patients had P. gingivalis antibodies, and all six had periodontitis.

RA patients showed a marked inflammatory profile in all microenvironments, including oral, despite routine dental care. P. gingivalis antibodies can be considered as biomarkers for rheumatologists in identifying those who may benefit from periodontal treatment.

This research is supported by a grant from the American College of Rheumatology, "Within Our Reach, Finding a Cure for Rheumatoid Arthritis," a post-doctoral fellowship from the Arthritis Foundation (CRTA5923) and the National Institutes of Health-National Institute of Dental and Craniofacial Research NIH grants DE018917 and DE020906.

This is a summary of abstract #1702 titled "Inflammation in the Mouth and Joints in Rheumatoid Arthritis," to be presented by Sheila Arvikar on Thursday, March 12, 2015, from 3:30 p.m. - 4:45 p.m. in Hall C of the Hynes Convention Center.

INFORMATION:

About the International Association for Dental Research The International Association for Dental Research (IADR) is a nonprofit organization with nearly 11,000 individual members worldwide, dedicated to: (1) advancing research and increasing knowledge for the improvement of oral health worldwide, (2) supporting and representing the oral health research community, and (3) facilitating the communication and application of research findings. To learn more, visit http://www.iadr.org. The American Association for Dental Research (AADR) is the largest Division of IADR, with nearly 3,400 members in the United States. To learn more, visit http://www.aadr.org.



ELSE PRESS RELEASES FROM THIS DATE:

Largest review of clinical trials to assess risk of patients using Champix

2015-03-12
Findings from the largest review of clinical trials to date to determine whether patients prescribed the smoking cessation drug Varenicline (brand name Champix in the UK) are at an increased risk of neuropsychiatric events are published online in the British Medical Journal [BMJ] today [12 Mar]. The drug, which was first licensed in the UK in 2006, has been shown to be the most clinically effective smoking cessation medicine for reducing nicotine cravings and withdrawal symptoms for short-term abstinence. However, since its introduction there have been concerns over its ...

Reaching '80 percent by 2018' would prevent more than 20,000 colorectal cancer deaths per year

2015-03-12
ATLANTA - March 12, 2015-Increasing colorectal cancer screening rates to 80% by 2018 would prevent an additional 21,000 colorectal cancer deaths per year by 2030, according to a new study. The study is the first to estimate the public health benefits of increasing screening rates to "80% by 2018," a recent initiative from the National Colorectal Cancer Roundtable (NCCRT), a national coalition of public, private, and voluntary organizations, to aim for screening rates of 80% in the United States by 2018. The study is co-authored by American Cancer Society epidemiologist ...

Study bolsters 'turbocharged' protein as a promising tool in hemophilia gene therapy

2015-03-12
Using gene therapy to produce a mutant human protein with unusually high blood-clotting power, scientists have successfully treated dogs with the bleeding disorder hemophilia, without triggering an unwanted immune response. In addition, the "turbocharged" clotting factor protein eliminated pre-existing antibodies that often weaken conventional treatments for people with hemophilia. "Our findings may provide a new approach to gene therapy for hemophilia and perhaps other genetic diseases that have similar complications from inhibiting antibodies," said the study leader, ...

Health law hasn't cut insurers' rate of overhead spending: Study

2015-03-12
Despite claims by the Obama administration that the Affordable Care Act will reduce health insurance companies' spending on overhead, thereby channeling a greater share of consumers' premium dollars into actual patient care, insurers' financial filings show the law had no impact on the percentage of insurer expenditures on such things as administration, marketing and profits. That's the chief finding of a team of researchers, including two prominent physicians on the faculties of the City University of New York's School of Public Health and Harvard Medical School, in ...

Mind reading thanks to metaphors

2015-03-12
Observe whether two people use metaphors in conversation with each other if you want to guess how close they are as friends. Or sharpen your ability to tune into other people's emotional or mental states by observing the metaphors they use. Why is this? Because metaphors can in fact help one to 'mind read,' report Andrea Bowes and Albert Katz of the University of Ontario in Canada in Springer's journal Memory & Cognition. Metaphor is a type of language that forms part of our daily conversations and communication. In this type of language, the literal or usual meaning ...

Social status has impact on overall health of mammals

Social status has impact on overall health of mammals
2015-03-12
EAST LANSING, Mich. - High social status has its privileges -- when it comes to aging -- even in wild animals. In a first-of-its-kind study involving a wild species, Michigan State University researchers have shown that social and ecological factors affect animal health. The results, published in the current issue of Biology Letters, focused on spotted hyenas in Kenya. "High-ranking members in hyena clans reproduce more, they live longer and appear to be in better overall health," said Nora Lewin, MSU doctoral student of zoology and co-lead author. "If you want to see ...

The ACA may reduce ER visits (slightly) but doesn't affect hospitalizations

2015-03-12
WASHINGTON - Two patient groups created by the Affordable Care Act (ACA) - Medicare patients enrolled in federally designated patient-centered medical homes and people under age 26 who are allowed to remain on their parents' health insurance - had slightly fewer emergency department visits than they had before health care reform. However, there was no change in the rate of the most expensive types of emergency visits: those that lead to hospitalization. One study examined the rate of emergency department visits and hospitalizations for Medicare patients treated by ...

Predicting which African storms will intensify into hurricanes

2015-03-12
Hurricanes require moisture, the rotation of the earth, and warm ocean temperatures to grow from a mere atmospheric disturbance into a tropical storm. But where do these storm cells originate, and exactly what makes an atmospheric disturbance amp up full throttle? A new study published in Geophysical Research Letters by Tel Aviv University's Prof. Colin Price and his graduate student Naama Reicher of the Department of Geosciences at TAU's Faculty of Exact Sciences finds most hurricanes over the Atlantic that eventually make landfall in North America actually start as ...

Engineers create chameleon-like artificial 'skin' that shifts color on demand

Engineers create chameleon-like artificial skin that shifts color on demand
2015-03-12
WASHINGTON, March 12, 2015--Borrowing a trick from nature, engineers from the University of California at Berkeley have created an incredibly thin, chameleon-like material that can be made to change color -- on demand -- by simply applying a minute amount of force. This new material-of-many-colors offers intriguing possibilities for an entirely new class of display technologies, color-shifting camouflage, and sensors that can detect otherwise imperceptible defects in buildings, bridges, and aircraft. "This is the first time anybody has made a flexible chameleon-like ...

Secret of how plants regulate their vitamin C production revealed

2015-03-12
A QUT scientist has helped unravel the way in which plants regulate their levels of vitamin C, the vitamin essential for preventing iron deficiency anaemia and conditions such as scurvy. Professor Roger Hellens, working with Dr William Laing from New Zealand's Plant and Food Research, has discovered the mechanism plants use to regulate the levels of Vitamin C in each of their cells in response to the environment. "Understanding these mechanisms may help in plant breeding programmes to produce hardier plant crops and improve human health because iron deficiency anaemia ...

LAST 30 PRESS RELEASES:

Pink skies

Monkeys are world’s best yodellers - new research

Key differences between visual- and memory-led Alzheimer’s discovered

% weight loss targets in obesity management – is this the wrong objective?

An app can change how you see yourself at work

NYC speed cameras take six months to change driver behavior, effects vary by neighborhood, new study reveals

New research shows that propaganda is on the rise in China

Even the richest Americans face shorter lifespans than their European counterparts, study finds

Novel genes linked to rare childhood diarrhea

New computer model reveals how Bronze Age Scandinavians could have crossed the sea

Novel point-of-care technology delivers accurate HIV results in minutes

Researchers reveal key brain differences to explain why Ritalin helps improve focus in some more than others

Study finds nearly five-fold increase in hospitalizations for common cause of stroke

Study reveals how alcohol abuse damages cognition

Medicinal cannabis is linked to long-term benefits in health-related quality of life

Microplastics detected in cat placentas and fetuses during early pregnancy

Ancient amphibians as big as alligators died in mass mortality event in Triassic Wyoming

Scientists uncover the first clear evidence of air sacs in the fossilized bones of alvarezsaurian dinosaurs: the "hollow bones" which help modern day birds to fly

Alcohol makes male flies sexy

TB patients globally often incur "catastrophic costs" of up to $11,329 USD, despite many countries offering free treatment, with predominant drivers of cost being hospitalization and loss of income

Study links teen girls’ screen time to sleep disruptions and depression

Scientists unveil starfish-inspired wearable tech for heart monitoring

Footprints reveal prehistoric Scottish lagoons were stomping grounds for giant Jurassic dinosaurs

AI effectively predicts dementia risk in American Indian/Alaska Native elders

First guideline on newborn screening for cystic fibrosis calls for changes in practice to improve outcomes

Existing international law can help secure peace and security in outer space, study shows

Pinning down the process of West Nile virus transmission

UTA-backed research tackles health challenges across ages

In pancreatic cancer, a race against time

Targeting FGFR2 may prevent or delay some KRAS-mutated pancreatic cancers

[Press-News.org] Inflammation in the mouth and joints in rheumatoid arthritis