PRESS-NEWS.org - Press Release Distribution
FREE PRESS RELEASES DISTRIBUTION

CNIO experts identify an oncogene regulated by nutrients

CNIO experts identify an oncogene regulated by nutrients
2015-04-13
(Press-News.org) Scientists from the Growth Factors, Nutrients and Cancer Group at the Spanish National Cancer Research Center (CNIO), led by Nabil Djouder, have discovered that the MCRS1 protein, in response to an excess of nutrients, induces an increase in the activity of mTOR (the mammalian/mechanistic Target of Rapamycin); a protein that is altered in human diseases such as cancer and diabetes, processes associated with ageing, as well as in certain cardiovascular and neurodegenerative pathologies. The finding, published in the journal Developmental Cell, opens up new possibilities for the development of drugs that block MCRS1 to treat cancer and diabetes.

Under normal conditions, mTOR regulates essential cellular functions, such as protein synthesis and cell growth and proliferation. However, an overactive stimulation of mTOR in response to nutrients and growth factors --metabolic processes that are crucial in tumor biology-- leads to an increase in cell growth and proliferation.

CORRELATION WITH PROGNOSIS IN COLORECTAL CANCER

CNIO researchers have now discovered how the MCRS1 protein --a protein associated with gene regulation and cell death processes-- is capable of activating mTOR, and thus, stimulate cell proliferation. In this way, in human colorectal cancer samples, a correlation was found between increased MCRS1 activity and tumours with a high proliferation rate, as well as with a worse prognosis of the disease.

"Although in our study we published the results obtained from these colorectal samples, we are also studying the relationship between this protein and diseases of the liver, the primary metabolic organ," explains Djouder.

ONE DISTINCTIVE FEATURE OF CANCER

The incidence of cancer and other related diseases has increased considerably in Western societies; this is partly due to an increased caloric intake and a more sedentary lifestyle. Therefore, unravelling the cellular processes that act in response to an excess of nutrients can contribute to achieve a better understanding of the biology of cancer and, consequently, is key to the fight against this disease.

"We will continue to study this gene using different genetically modified mouse models, where we can study what occurs when there is a gain- or loss-of-function. We are already obtaining interesting results, but further research is necessary."

INFORMATION:

This research has been funded by the Spanish Ministry of Economy and Competitiveness (MINECO; SAF2010 - 18518) and the Spanish Ramón y Cajal Fellowship (MINECO).

Reference article: MCRS1 Binds and Couples Rheb to Amino Acid-Dependent mTORC1 Activation. Mohamad-Ali Fawal, Marta Brandt, Nabil Djouder. Developmental Cell (2015). doi: http://dx.doi.org/10.1016/j.devcel.2015.02.010


[Attachments] See images for this press release:
CNIO experts identify an oncogene regulated by nutrients

ELSE PRESS RELEASES FROM THIS DATE:

New study reveals link between arrival of grandchildren and early retirement of women

2015-04-13
(Washington, D.C.) - According to financial planners, women face unique challenges when preparing to retire. A recent study co-authored by Robin Lumsdaine, Crown Prince of Bahrain Professor of International Finance at American University's Kogod School of Business, reveals retirement-age women who have new grandchildren are 9 percent more likely to retire early than those who do not. The increased probability of early retirement due to the arrival of grandchildren is comparable to the number of women that retire due to worsening health. The decision to retire early has ...

Study: Gene therapy superior to half-matched transplant for 'bubble boy disease'

2015-04-13
(WASHINGTON - April 13, 2015) - New research published online today in Blood, the Journal of the American Society of Hematology (ASH), reports that children with "bubble boy disease" who undergo gene therapy have fewer infections and hospitalizations than those receiving stem cells from a partially matched donor. The research is the first to compare outcomes among children with the rare immune disorder - also known as X-linked severe combined immunodeficiency (SCID-X1) - receiving the two therapeutic approaches. Children with SCID-X1 are born with a genetic defect that ...

Clean up your life with chemistry life hacks (video)

Clean up your life with chemistry life hacks (video)
2015-04-13
WASHINGTON, April 13, 2015 -- Ever run out of your go-to cleaning product, and you've got a mess that you just can't leave alone? Have no fear, chemistry is here. Reactions is back with another round of our Chemistry Life Hacks series, and this week it's all about cleaning. Learn how to make your own glass cleaner, keep red wine from staining your carpet and why spit, yes spit, can also be a great cleaning product. Check out the video here: https://youtu.be/IpG3VClxO3c. INFORMATION:Subscribe to the series at http://bit.ly/ACSReactions, and follow us on Twitter @ACSreactions ...

NYU study identifies teens at risk for hashish use

2015-04-13
The recent increase in popularity of marijuana use coupled with more liberal state-level polices has begun to change the landscape of adolescent marijuana use. More potent forms of marijuana, such as hashish, may present a threat to adolescent health. A wealth of research has been conducted to examine risk factors for teen marijuana use; however, studies rarely differentiate between different forms of marijuana. A new study by researchers affiliated with New York University's Center for Drug Use and HIV Research (CDUHR), was among the first to examine prevalence and correlates ...

Stroke from poor air quality

2015-04-13
Air pollution and smog have health consequences for affected populations ranging from respiratory problems to death. Fine particulate matter especially has become the focus in recent years, because it increases the probability of dying from respiratory or cardiovascular disease. In addition, the risk of stroke is increased, as shown by Barbara Hoffmann and her coauthors in a recent study in Deutsches Ärzteblatt International (Dtsch Arztebl Int 2015; 112: 195-201). In a population of the German Ruhr region, she investigated how often stroke and cardiovascular disease ...

Fragment of continental crust found under south east Iceland

2015-04-13
An international team, including researchers at the University of Liverpool, have shown that south east Iceland is underlain by continental crust. The team found that the accepted theory, that Iceland consists only of very thick oceanic crust, is incorrect. Maps of crustal thickness produced from satellite gravity data, together with geochemical, plate tectonic reconstruction and mantle plume track analysis (an upwelling of abnormally hot rock), were used to show that south east Iceland is underlain by continental crust which extends offshore to the east. Professor ...

Graphics in reverse

2015-04-13
Most recent advances in artificial intelligence -- such as mobile apps that convert speech to text -- are the result of machine learning, in which computers are turned loose on huge data sets to look for patterns. To make machine-learning applications easier to build, computer scientists have begun developing so-called probabilistic programming languages, which let researchers mix and match machine-learning techniques that have worked well in other contexts. In 2013, the U.S. Defense Advanced Research Projects Agency, an incubator of cutting-edge technology, launched ...

Study finds testicular cancer link for muscle-building supplements

2015-04-13
PROVIDENCE, R.I. [Brown University] -- Men who reported taking muscle-building supplements, such as pills and powders with creatine or androstenedione, reported a significantly higher likelihood of having developed testicular cancer than men who did not use such supplements, according to a new study in the British Journal of Cancer. Moreover, said study senior author Tongzhang Zheng, the associated testicular germ cell cancer risk was especially high among men who started using supplements before age 25, those who used multiple supplements and those who used them for ...

New technology provides superior ability to rapidly detect volatile organic compounds

New technology provides superior ability to rapidly detect volatile organic compounds
2015-04-13
Over the past several decades, the progress in micro fabrication technology has revolutionized the world in such fields as computing, signal processing, and automotive manufacturing. Making various types of instruments smaller is another example of how the use of this technology has produced significant advancements. One such instrument is the gas chromatography system used in a number of scientific, medical, and industrial settings to separate and analyze dangerous, volatile organic compounds in gases, liquids, and solids. For the past several years, Masoud Agah, an ...

What's in your wine? New study reveals how production methods affect color and taste of pinot noir

2015-04-13
Amsterdam, April 13, 2015 - The taste and color of your wine depends on the methods used to produce it and the chemicals added during production, says research published in Analytical Chemistry Research. The researchers behind the study say wine bottles should carry information about what the manufacturers add during processing - including sugars and acids. In the study, Dr. Heli Sirén and her colleagues from the University of Helsinki, Finland, analyzed the chemical profiles of eight Pinot Noir wines from different regions - the USA, France, New Zealand and Chile. ...

LAST 30 PRESS RELEASES:

Scientists model 'true prevalence' of COVID-19 throughout pandemic

New breakthrough to help immune systems in the fight against cancer

Through the thin-film glass, researchers spot a new liquid phase

Administering opioids to pregnant mice alters behavior and gene expression in offspring

Brain's 'memory center' needed to recognize image sequences but not single sights

Safety of second dose of mRNA COVID-19 vaccines after first-dose allergic reactions

Changes in disparities in access to care, health after Medicare eligibility

Use of high-risk medications among lonely older adults

65+ and lonely? Don't talk to your doctor about another prescription

Exosome formulation developed to deliver antibodies for choroidal neovascularization therapy

Second COVID-19 mRNA vaccine dose found safe following allergic reactions to first dose

Plant root-associated bacteria preferentially colonize their native host-plant roots

Rare inherited variants in previously unsuspected genes may confer significant risk for autism

International experts call for a unified public health response to NAFLD and NASH epidemic

International collaboration of scientists rewrite the rulebook of flowering plant genetics

Improving air quality reduces dementia risk, multiple studies suggest

Misplaced trust: When trust in science fosters pseudoscience

Two types of blood pressure meds prevent heart events equally, but side effects differ

New statement provides path to include ethnicity, ancestry, race in genomic research

Among effective antihypertensive drugs, less popular choice is slightly safer

Juicy past of favorite Okinawan fruit revealed

Anticipate a resurgence of respiratory viruses in young children

Anxiety, depression, burnout rising as college students prepare to return to campus

Goal-setting and positive parent-child relationships reduce risk of youth vaping

New research identifies cancer types with little survival improvements in adolescents and young adul

Oncotarget: Replication-stress sensitivity in breast cancer cells

Oncotarget: TERT and its binding protein: overexpression of GABPA/B in gliomas

Development of a novel technology to check body temperature with smartphone camera

The mechanics of puncture finally explained

Extreme heat, dry summers main cause of tree death in Colorado's subalpine forests

[Press-News.org] CNIO experts identify an oncogene regulated by nutrients