Mayo profile identifies patients most at risk of developing pancreatic cancer
(Press-News.org) JACKSONVILLE, Fla. -- When people find out -- usually from a diagnostic scan looking at something else -- that they have a lesion in their pancreas that could morph into pancreatic cancer, they can panic. They insist on having frequent CT scans and biopsies to monitor the lesion, or they ask for surgery. Physicians also don't know if these abnormalities are dangerous, so the patients end up in surgery having part of their pancreas removed. Often the lesion is nothing to worry about.
But a team of international physicians, led by researchers at Mayo Clinic's campus in Jacksonville, Florida, has developed a profile of the patient who would be most at risk of developing lesions that are most likely to develop into cancer. Their analysis is published online today in the journal Digestive and Liver Diseases.
"The factors we found that increase risk of pancreatic cancer now allow us to separate patients as either low or high risk," says the study's senior author, Michael B. Wallace, M.D., MPH, a gastroenterologist at Mayo Clinic. "High-risk patients can then be scanned and biopsied more frequently or can opt for surgery, but low-risk patients don't need such surveillance. They can be watched much less intensively."
"Pancreatic cancer is difficult to detect early -- most patients are diagnosed at later stages when its 95 percent fatal -- so we're seeking ways to understand who is at risk," Dr. Wallace says. "Our study offers valuable insight into the problem."
The lesions evaluated in this study that can become cancerous are known as intraductal papillary mucinous neoplasms. They are common. "Between 10 and 40 percent of people have them," Dr. Wallace says. "Obviously the vast majority of those folks are not developing pancreatic cancer, which is not that common."
To find ways to identify patients at high risk, Dr. Wallace and his collaborators, which include physicians at hospitals throughout the United States and Europe, examined data on 1,126 patients diagnosed with the lesions in the pancreas.
Of this group, only 84 were found to have invasive pancreatic cancer. Those patients had all or some of the following factors that put them at high risk: a history of smoking and obesity, and two symptoms of the disease -- jaundice (yellowing of the eyes and skin) and steatorrhea (fat droplets in stool indicating that the pancreas was not producing sufficient digestive enzyme).
Additionally, a larger cyst size on an imaging scan, cysts in the main pancreatic duct, and the presence of nodules on the cyst wall were all risk factors. Abdominal pain, which had been considered a risk factor, turned out not to be one in this study -- patients at low-risk may have complained of such pain.
"This study refines the current guidelines for treating of these lesions, which are not very specific," Dr. Wallace says. "Hopefully, we can assure worried patients who have these common lesions that they are not at high risk."
The study was supported by the Joyce E. Baker Foundation for research at Mayo Clinic in Florida.
Co-authors from Mayo Clinic include: Maria Moris, M.D.; Massimo Raimondo, M.D.; Timothy A. Woodward, M.D.; Verna Skinner. Co-authors from San Raffaele Scientific Institute, Milano, Italy include: Paolo G. Arcidiacono, M.D.; Maria C. Petrone, M.D. Claudio De Angelis, M.D. The co-author from Azienda Universitario-Ospedaliera San Giovanni Battista, Torino, Italy is Selene Manfre, M.D. The co-author from the University of Bologna/Hospital of Imola, Imola, Italy is Pietro Fusaroli, M.D.
About Mayo Clinic
Mayo Clinic is a nonprofit organization committed to medical research and education, and providing expert, whole-person care to everyone who needs healing. For more information, visit mayoclinic.com or newsnetwork.mayoclinic.org.
MEDIA CONTACT: Kevin Punsky, Mayo Clinic Public Affairs, 904-953-0746, firstname.lastname@example.org
ELSE PRESS RELEASES FROM THIS DATE:
Scientists from the Growth Factors, Nutrients and Cancer Group at the Spanish National Cancer Research Center (CNIO), led by Nabil Djouder, have discovered that the MCRS1 protein, in response to an excess of nutrients, induces an increase in the activity of mTOR (the mammalian/mechanistic Target of Rapamycin); a protein that is altered in human diseases such as cancer and diabetes, processes associated with ageing, as well as in certain cardiovascular and neurodegenerative pathologies. The finding, published in the journal Developmental Cell, opens up new possibilities ...
(Washington, D.C.) - According to financial planners, women face unique challenges when preparing to retire. A recent study co-authored by Robin Lumsdaine, Crown Prince of Bahrain Professor of International Finance at American University's Kogod School of Business, reveals retirement-age women who have new grandchildren are 9 percent more likely to retire early than those who do not. The increased probability of early retirement due to the arrival of grandchildren is comparable to the number of women that retire due to worsening health. The decision to retire early has ...
(WASHINGTON - April 13, 2015) - New research published online today in Blood, the Journal of the American Society of Hematology (ASH), reports that children with "bubble boy disease" who undergo gene therapy have fewer infections and hospitalizations than those receiving stem cells from a partially matched donor. The research is the first to compare outcomes among children with the rare immune disorder - also known as X-linked severe combined immunodeficiency (SCID-X1) - receiving the two therapeutic approaches.
Children with SCID-X1 are born with a genetic defect that ...
WASHINGTON, April 13, 2015 -- Ever run out of your go-to cleaning product, and you've got a mess that you just can't leave alone? Have no fear, chemistry is here. Reactions is back with another round of our Chemistry Life Hacks series, and this week it's all about cleaning. Learn how to make your own glass cleaner, keep red wine from staining your carpet and why spit, yes spit, can also be a great cleaning product. Check out the video here: https://youtu.be/IpG3VClxO3c.
INFORMATION:Subscribe to the series at http://bit.ly/ACSReactions, and follow us on Twitter @ACSreactions ...
The recent increase in popularity of marijuana use coupled with more liberal state-level polices has begun to change the landscape of adolescent marijuana use. More potent forms of marijuana, such as hashish, may present a threat to adolescent health. A wealth of research has been conducted to examine risk factors for teen marijuana use; however, studies rarely differentiate between different forms of marijuana.
A new study by researchers affiliated with New York University's Center for Drug Use and HIV Research (CDUHR), was among the first to examine prevalence and correlates ...
Air pollution and smog have health consequences for affected populations ranging from respiratory problems to death. Fine particulate matter especially has become the focus in recent years, because it increases the probability of dying from respiratory or cardiovascular disease. In addition, the risk of stroke is increased, as shown by Barbara Hoffmann and her coauthors in a recent study in Deutsches Ärzteblatt International (Dtsch Arztebl Int 2015; 112: 195-201). In a population of the German Ruhr region, she investigated how often stroke and cardiovascular disease ...
An international team, including researchers at the University of Liverpool, have shown that south east Iceland is underlain by continental crust.
The team found that the accepted theory, that Iceland consists only of very thick oceanic crust, is incorrect. Maps of crustal thickness produced from satellite gravity data, together with geochemical, plate tectonic reconstruction and mantle plume track analysis (an upwelling of abnormally hot rock), were used to show that south east Iceland is underlain by continental crust which extends offshore to the east.
Most recent advances in artificial intelligence -- such as mobile apps that convert speech to text -- are the result of machine learning, in which computers are turned loose on huge data sets to look for patterns.
To make machine-learning applications easier to build, computer scientists have begun developing so-called probabilistic programming languages, which let researchers mix and match machine-learning techniques that have worked well in other contexts. In 2013, the U.S. Defense Advanced Research Projects Agency, an incubator of cutting-edge technology, launched ...
PROVIDENCE, R.I. [Brown University] -- Men who reported taking muscle-building supplements, such as pills and powders with creatine or androstenedione, reported a significantly higher likelihood of having developed testicular cancer than men who did not use such supplements, according to a new study in the British Journal of Cancer.
Moreover, said study senior author Tongzhang Zheng, the associated testicular germ cell cancer risk was especially high among men who started using supplements before age 25, those who used multiple supplements and those who used them for ...
Over the past several decades, the progress in micro fabrication technology has revolutionized the world in such fields as computing, signal processing, and automotive manufacturing.
Making various types of instruments smaller is another example of how the use of this technology has produced significant advancements. One such instrument is the gas chromatography system used in a number of scientific, medical, and industrial settings to separate and analyze dangerous, volatile organic compounds in gases, liquids, and solids.
For the past several years, Masoud Agah, an ...
LAST 30 PRESS RELEASES:
[Press-News.org] Mayo profile identifies patients most at risk of developing pancreatic cancer