(Press-News.org) Rome, June 11 -- The results of a study presented today at the European League Against Rheumatism Annual Congress (EULAR 2015) show that diclofenac, naproxen and etoricoxib significantly inhibit ovulation in women with mild musculoskeletal pain. Of the women receiving NSAIDs, only 6.3 percent (diclofenac), 25 percent (naproxen) and 27.3 percent (etoricoxib) ovulated, compared with 100 percent of the control group.
These findings suggest that readily available non-steroidal anti-inflammatory drugs (NSAIDs) could have a harmful effect on fertility, and should be used with caution in women wishing to start a family.
'After just ten days of treatment we saw a significant decrease in progesterone, a hormone essential for ovulation, across all treatment groups, as well as functional cysts in one third of patients,' said study investigator Professor Sami Salman, Department of Rheumatology, University of Baghdad, Iraq. 'These findings show that even short-term use of these popular, over-the-counter drugs could have a significant impact on a women's ability to have children. This needs to be better communicated to patients with rheumatic diseases, who may take these drugs on a regular basis with little awareness of the impact.'
NSAIDs are among the most commonly used drugs worldwide, and are taken by more than 30 million people every day. Available without prescription, NSAIDS are largely used for the treatment of pain, inflammation and fever -- all common features of rheumatic conditions.
Thirty nine women of childbearing age who suffer from back pain took part in the study, and received diclofenac (100mg once daily), naproxen (500mg twice daily) and etoricoxib (90mg once daily) or placebo. Treatment was given for 10 days from day 10 of the onset of the menstrual cycle; hormonal analysis (progesterone level) and follicle diameter were conducted via blood sample and ultra sonsography respectively.
At the end of the NSAID treatment period, the dominant follicle remained unruptured in 75 percent, 25 percent and 33 percent of patients receiving diclofenac, naproxen and etoricoxib respectively. Rupturing of the dominant follicle, and subsequent release of an oocyte (unfertilised egg), is essential for ovulation to occur.
'These findings highlight the harmful effects NSAIDs may have on fertility, and could open the door for research into a new emergency contraception with a more favourable safety profile than those currently in use,' concluded Professor Sami Salman.
INFORMATION:
Abstract Number: OP0131
Notes to editors
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About EULAR
The European League Against Rheumatism (EULAR) is an umbrella organisation which represents scientific societies, health professional associations and organisations for people with rheumatic diseases throughout Europe.
EULAR aims to promote, stimulate and support the research, prevention, and treatment of rheumatic diseases and the rehabilitation of those it affects.
With 45 scientific member societies, 35 People with Arthritis and Rheumatism in Europe (PARE) organisations, 19 health professionals associations and 21 corporate members, EULAR highlights the importance of combating rheumatic diseases through both medical means and patient care.
EULAR 2015 is set to be the biggest rheumatology event in Europe with around 14,000 scientists, physicians, allied health professionals and related audiences in attendance from more than 120 countries. Over the course of the congress there will be some 300 oral and just under 2,000 poster abstract presentations, more than 150 sessions, 400 lectures, 40 poster tours and 350 invited speakers.
To find out more about the activities of EULAR, visit: http://www.eular.org
Rome, Italy, 11 June 2015: The results of a study presented today at the European League Against Rheumatism Annual Congress (EULAR 2015) Press Conference showed that a diagnosis of ankylosing spondylitis (AS) can be predicted by low birth weight, having older siblings and hospitalisation for infection between the ages of 5-16 years. These data suggest that these factors play an important role in the pathogenesis of the disease.
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Rome, Italy, 11 June 2015: The results of a study presented today at the European League Against Rheumatism Annual Congress (EULAR 2015) demonstrated the value of a new interactive iPad app that helps young people with Juvenile Idiopathic Arthritis (JIA) describe their pain. Almost all of the children preferred the new digital tool, aptly titled 'This Feeling', to other conventional methods and felt it was an interesting and engaging way to communicate about their experiences of pain.1
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Rome, Italy, 11 June 2015: The results of a study presented today at the European League Against Rheumatism Annual Congress (EULAR 2015) Press Conference showed that people with systemic sclerosis (SSc) have a unique bacterial signature in their colon, when compared with healthy people. These findings suggest that changes in the gut ecology could contribute to the clinical symptoms of SSc, and could be used to diagnose the condition, and in the development of alternative treatments.
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The constant movement of children with attention-deficit/hyperactivity disorder (ADHD) may be distracting -- but the fidgeting also may improve their cognitive performance, a study by researchers with the UC Davis MIND Institute has found.
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The study, "A trial-by-trial analysis reveals ...
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Inbreeding can be a big problem for social species such as banded mongooses because they grow up in social groups consisting mainly of close relatives. This study is the first to suggest that social animals are able to avoid the costs of inbreeding without relying on un-related mating partners from other social groups.
Dr Jennifer Sanderson, ...
Main Findings: Lung cancer patients with comorbid conditions such as chronic obstructive pulmonary disease, diabetes, or congestive heart failure had a higher risk of death than lung cancer patients without comorbid conditions.
Journal in Which the Study was Published: Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research
Author: K.M. Monirul Islam, MD, PhD, an assistant professor in the Department of Epidemiology at the University of Nebraska Medical Center College of Public Health
Background: Lung cancer is the leading ...
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Weekend screen time is linked to poorer teen bone health--but only in boys, reveals research published in the online journal BMJ Open.
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At both time periods, ...
