(Press-News.org) The Journal of the Institute of Materia Medica, the Chinese Academy of Medical Sciences and the Chinese Pharmaceutical Association, Acta Pharmaceutica Sinica B (APSB) is a monthly journal, in English, which publishes significant original research articles, rapid communications and high quality reviews of recent advances in all areas of pharmaceutical sciences -- including pharmacology, pharmaceutics, medicinal chemistry, natural products, pharmacognosy, pharmaceutical analysis and pharmacokinetics.
Featured papers in this issue are:
Berberine diminishes cancer cell PD-L1 expression and facilitates antitumor immunity via inhibiting the deubiquitination activity of CSN5 by authors Yang Liu, Xiaojia Liu, Na Zhang, Mingxiao Yin, Jingwen Dong, Qingxuan Zeng, Genxiang Mao, Danqing Song, Lu Liu and Hongbin Deng. Berberine diminishes the expression of programmed cell death ligand-1 and promotes antitumor immunity via inhibiting the deubiquitination activity of COP9 signalosome 5 (CSN5) in non-small cell lung cancer.
Inhibitory effects of baicalein against herpes simplex virus type 1 by authors Zhuo Luo, Xiu-Ping Kuang, Qing-Qing Zhou, Chang-Yu Yan, Wen Li, Hai-Biao Gong, Hiroshi Kurihara, Wei-Xi Li, Yi-Fang Li and Rong-Rong He. Baicalein exerts potent ability against HSV-1 infection and dual mechanisms were disclosed. The authors research indicates that baicalein is highly effective in combating HSV-1 infection. Dual mechanisms were involved in its antivirus effect, namely the inactivation of free viral particles to neutralize the infectivity and the suppression of NF-kB activation, which is distinct from that of acyclovir. Hence, this work offers experimental basis for baicalein as a potential drug in treating HSV-1 infection and related diseases.
Discovery of highly selective and orally available benzimidazole-based phosphodiesterase 10 inhibitors with improved solubility and pharmacokinetic properties for treatment of pulmonary arterial hypertension by authors Yuncong Yang, Sirui Zhang, Qian Zhou, Chen Zhang, Yuqi Gao, Hao Wang, Zhe Li, Deyan Wu, Yinuo Wu, Yi-You Huang, Lei Guo and Hai-Bin Luo. A potent and highly selective PDE10A inhibitor, 14·3HCl (IC50 = 2.8 nmol/L and >3500-fold selectivity) with a remarkable bioavailability of 50% was obtained to verify the feasibility for the anti-PAH treatment. The crystal structure of PDE10A-14 complex illustrated the binding pattern, providing a guideline for rational design of highly selective PDE10A inhibitors.
Other articles published in the issue include:
Reviews
Targeting human MutT homolog 1 (MTH1) for cancer eradication: current progress and perspectives
Yizhen Yin, Fener Chen
Small molecules targeting the innate immune cGAS?STING?TBK1 signaling pathway
Chunyong Ding, Zilan Song, Ancheng Shen, Tingting Chen, Ao Zhang
Original Articles
Targeting castration-resistant prostate cancer with a novel RORg antagonist elaiophylin
Jianwei Zheng, Junfeng Wang, Qian Wang, Hongye Zou, Hong Wang, Zhenhua Zhang, Jianghe Chen, Qianqian Wang, Panxia Wang, Yueshan Zhao, Jing Lu, Xiaolei Zhang, Songtao Xiang, Haibin Wang, Jinping Lei, Hong-Wu Chen, Peiqing Liu, Yonghong Liu, Fanghai Han, Junjian Wang
GSH-responsive SN38 dimer-loaded shape-transformable nanoparticles with iRGD for enhancing chemo-photodynamic therapy
Congcong Lin, Fan Tong, Rui Liu, Rou Xie, Ting Lei, Yuxiu Chen, Zhihang Yang, Huile Gao, Xiangrong Yu
CORM-2-entrapped ultradeformable liposomes ameliorate acute skin inflammation in an ear edema model via effective CO delivery
Gwan-Yeong Lee, Alam Zeb, Eun-Hye Kim, Beomseon Suh, Young-Jun Shin, Donghyun Kim, Kyoung-Won Kim, Yeong-Hwan Choe, Ho-Ik Choi, Cheol-Ho Lee, Omer Salman Qureshi, In-Bo Han, Sun-Young Chang, Ok-Nam Bae, Jin-Ki Kim
Selectively enhancing radiosensitivity of cancer cells via in situ enzyme-instructed peptide self-assembly
Yang Gao, Jie Gao, Ganen Mu, Yumin Zhang, Fan Huang, Wenxue Zhang, Chunhua Ren, Cuihong Yang, Jianfeng Liu
Bone-seeking nanoplatform co-delivering cisplatin and zoledronate for synergistic therapy of breast cancer bone metastasis and bone resorption
Yanjuan Huang, Zhanghong Xiao, Zilin Guan, Zishan Zeng, Yifeng Shen, Xiaoyu Xu, Chunshun Zhao
A homogenous nanoporous pulmonary drug delivery system based on metal-organic frameworks with fine aerosolization performance and good compatibility
Yixian Zhou, Boyi Niu, Biyuan Wu, Sulan Luo, Jintao Fu, Yiting Zhao, Guilan Quan, Xin Pan, Chuanbin Wu
IiWRKY34 positively regulates yield, lignan biosynthesis and stress tolerance in Isatis indigotica
Ying Xiao, Jingxian Feng, Qing Li, Yangyun Zhou, Qitao Bu, Junhui Zhou, Hexin Tan, Yingbo Yang, Lei Zhang, Wansheng Chen
INFORMATION:
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Editorial Board: https://www.journals.elsevier.com/acta-pharmaceutica-sinica-b/editorial-board
APSB is available on ScienceDirect.
Submissions to APSB may be made using Editorial Manager®.
CiteScore: 10.5
Impact Factor: 7.097
5-Year Impact Factor: 7.865
Source Normalized Impact per Paper (SNIP): 2.210
SCImago Journal Rank (SJR): 1.792
ISSN 2211-3835
"The findings provide an increased understanding of how the virus gets through the stomach and intestinal system. Continued research can provide answers to whether this property can also be used to create vaccines that ride 'free rides' and thus be given in edible form instead of as syringes," says Lars-Anders Carlson, researcher at Umeå University.
The virus that the researchers have studied is a so-called enteric adenovirus. It has recently been clarified that enteric adenoviruses are one of the most important factors behind diarrhea among infants, and they are estimated to kill more than 50,000 children under the age of five each year, ...
Researchers from Trinity College Dublin have discovered a key mechanism underlying bacterial skin colonisation in atopic dermatitis, which affects millions around the globe.
Atopic dermatitis (AD, also called commonly eczema) is the most common chronic inflammatory skin disorder in children, affecting 15-20% of people in childhood. During disease flares, patients experience painful inflamed skin lesions accompanied by intense itch and recurrent skin infection.
The bacterium Staphylococcus aureus (S. aureus) thrives on skin affected by AD, increasing inflammation and worsening AD symptoms. Although a small number of therapies are available at present for patients with moderate ...
Leading research at Newcastle University has been used to shape how dentistry can be carried out safely during the Covid-19 pandemic by mitigating the risks of dental aerosols.
It is well known that coronavirus can spread in airborne particles, moving around rooms to infect people, and this has been a major consideration when looking into patient and clinician safety.
Research, published in the Journal of Dentistry, has led the way in helping shape national clinical guidance for the profession to work effectively under extremely challenging circumstances.
The findings have been used by the Dental Schools' Council, Association of Dental Hospitals and the Scottish Dental Clinical Effectiveness ...
Micro-CT scanning and digital reconstructions have been used to compare the skulls of the Tasmanian tiger (thylacine) and wolf across their early development and into adulthood, establishing that not only did the thylacine resemble the wolf as adults, but also as newborns and juveniles.
"Remarkably, the Tasmanian tiger pups were more similar to wolf pups than to other closely related marsupials," Professor Andrew Pask from the University of Melbourne said.
The collaborative study with Flinders University and Museums Victoria complement earlier findings that thylacine and wolf have evolved ...
Artificial intelligence and machine learning are already an integral part of our everyday lives online. For example, search engines such as Google use intelligent ranking algorithms and video streaming services such as Netflix use machine learning to personalize movie recommendations.
As the demands for AI online continue to grow, so does the need to speed up AI performance and find ways to reduce its energy consumption.
Now a University of Washington-led team has come up with a system that could help: an optical computing core prototype that uses phase-change material. This system is fast, energy efficient and capable of accelerating ...
Topological materials are characterised by unique electronic and physical properties that are determined by the underlying topology of their electronic systems. Scientists from the Max Planck Institutes for Microstructure Physics (Halle) and for Chemical Physics of Solids (Dresden) have now discovered that (TaSe4)2I is the first material in which a charge density wave induces a phase transition between the semimetal to insulator state.
An international team of scientists at the Max Planck Institute for Microstructure Physics, Halle (Saale), the Max Planck Institute for Chemical Physics of Solids ...
Delivery of genetic molecules such as mRNA into cells is vital with important applications such as vaccine development. Various agents have been developed for mRNA delivery. However, conventional mRNA nanocarriers mainly focus on their physical interaction with mRNA molecules, or protection / delivery of mRNA, such as adjusting physical properties of nanocarriers to control binding with mRNA or cellular uptake. Moreover, effective mRNA delivery in hard-to-transfect APCs remains a challenge. The hard-to-transfect nature in APCs is partly attributed to the suppressed mRNA translation associated with the intrinsic high intracellular glutathione (GSH) level. Thus, ...
Photorespiration is a highly energy consuming process in plants that leads to the release of previously fixed CO2. Thus, engineering this metabolic process is a key approach for improvement of crop yield and for meeting the challenge of ever-rising CO2 levels in the atmosphere. Researchers led by Tobias Erb from the Max Planck Institute for Terrestrial Microbiology in Marburg, Germany, have now succeeded in engineering the TaCo pathway, a synthetic photorespiratory bypass. This new-to-nature metabolic connection opens up new possibilities of CO2 fixation ...
With the rapid development of smart portable electronics and electric vehicles, the consumption of lithium resource will increase dramatically and the cost of lithium-ion batteries (LIBs) may increase significantly in the future. In addition, the shortage (0.0017 wt% in the earth's crust) and uneven crustal distribution of lithium also limit its further development and application. As potassium (2.7 wt% in the earth's crust) have properties similar to lithium and abundant reserves. Therefore, as an alternative to LIBs, potassium ion batteries (PIBs) have become the focus of research. Potassium (2.92 V vs. ...
Scientists from the Max Planck Institute of Psychiatry, led by Nikolaos Koutsouleris, combined psychiatric assessments with machine-learning models that analyse clinical and biological data. Although psychiatrists make very accurate predictions about positive disease outcomes, they might underestimate the frequency of adverse cases that lead to relapses. The algorithmic pattern recognition helps physicians to better predict the course of disease.
The results of the study show that it is the combination of artificial and human intelligence that optimizes the prediction ...
