Does where older US adults die affect their wellbeing at the end of life?

Pharmacists play an important role in managing medication-based therapies for older community-dwelling patients, according to a study published in the END ...

Prostate cancer is one of the most common cancers among men. Patients are determined to have prostate cancer primarily based on *PSA, a cancer factor in blood. However, as diagnostic accuracy is as low as 30%, a considerable number of patients undergo additional invasive biopsy and thus suffer from resultant side effects, such as bleeding and pains. *Prostate-Specific Antigen (PSA): a prostate-specific antigen (a cancer factor) used as an index for the screening of prostate cancer. The Korea Institute of Science and Technology (KIST) announced that the collaborative research team led by Dr. Kwan Hyi Lee from the Biomaterials Research Center and Professor In Gab Jeong from Asan Medical Center developed a technique ...

Pathogenic bacteria in humans are developing resistance to antibiotics much faster than expected. Now, computational research at Chalmers University of Technology, Sweden, shows that one reason could be significant genetic transfer between bacteria in our ecosystems and to humans. This work has also led to new tools for resistance researchers. According to the World Health Organisation, antibiotic resistance is one of the greatest threats to global health, food safety and development. It already causes over 33,000 deaths a year in Europe alone. Completely ...

Since 1997 (Reno vs. American Civil Liberties Union), the Supreme Court has used the metaphor of the free market of ideas to define the Internet, thus addressing the regulation of the net as a matter of freedom of speech. In law, metaphors have a constitutive value and, once established, affect the debate and the decisions of the Courts for a long time. In the paper 'Judicial Frames and Fundamental Right in Cyberspace', published in the American Journal of Comparative Law, Oreste Pollicino (Bocconi University) and Alessandro Morelli (Università Magna Graecia, Catanzaro) apply to judicial reasoning reflections on metaphors and go so far as to criticize, on the one hand, the US Supreme Court's orientations on (non-)regulation of the Internet and, on the other, to invoke changes ...

In the first systematic large-scale evaluation of the UK National Early Warning Risk Score (NEWS) 2 as a scoring system for predicting severe COVID-19 outcomes in patients, researchers at King's College London have found poor-to-moderate accuracy for identifying patients at risk of being transferred to intensive care units (ICUs) or dying after 14 days of hospitalisation. Accuracy of predictions in short term (three days) showed moderate success. For people who are hospitalised with severe COVID-19, it is vital to quickly identify which patients may deteriorate and require transfer to an intensive care unit (ICU) for organ support or may die. NEWS2 is an ...

Researchers from the University of Cambridge have discovered a fossil of the earliest starfish-like animal, which helps us understand the origins of the nimble-armed creature. The prototype starfish, which has features in common with both sea lilies and modern-day starfish, is a missing link for scientists trying to piece together its early evolutionary history. The exceptionally preserved fossil, named Cantabrigiaster fezouataensis, was discovered in Morroco's Anti-Atlas mountain range. Its intricate design - with feathery arms akin to a lacework - has been frozen in time for roughly 480 million years. The new species is unusual because it doesn't have many of the key features of its contemporary relatives, lacking roughly 60% of ...

Antidepressants are commonly used worldwide to treat pain, however new research from the University of Sydney shows they offer little to no help for people suffering chronic back pain and osteoarthritis and may even cause harm. Back pain and knee osteoarthritis affect millions of people globally and are leading causes of disability. When first-line pain medications such as paracetamol and ibuprofen fail to improve symptoms, many people are prescribed antidepressants for their pain. Most clinical practice guidelines recommend antidepressants for long term (chronic) back pain and hip and knee osteoarthritis, yet evidence supporting their use is uncertain. Published today in the BMJ the ...

Antidepressant drugs are largely ineffective for back and osteoarthritis pain, despite being widely used for these conditions, suggests a review of the evidence published by The BMJ today. The findings, based on moderate certainty evidence, show that for people with back pain the effects were too small to be worthwhile, but for osteoarthritis a small beneficial effect cannot be ruled out. Most clinical practice guidelines recommend antidepressants for long term (chronic) back pain and hip and knee osteoarthritis, yet evidence supporting their use is uncertain. To address this knowledge gap, researchers led by Giovanni Ferreira at the ...

Adding the arthritis drug tocilizumab to standard care for patients in hospital with severe or critical covid-19 is no better than standard care alone in improving clinical outcomes at 15 days, finds a new trial published by The BMJ today. There was an increased number of deaths at 15 days in patients receiving tocilizumab, resulting in the trial being stopped early. Today's results contradict earlier observational studies suggesting a benefit of tocilizumab. However, observational effects are limited by a high risk that they may be due to other unknown (confounding) factors - and some studies have not yet been peer ...

MINNEAPOLIS - A new study has found a brain pressure disorder called idiopathic intracranial hypertension is on the rise, and the increase corresponds with rising obesity rates. The study is published in the January 20, 2021, online issue of Neurology®, the medical journal of the American Academy of Neurology. The study also found that for women, socioeconomic factors like income, education and housing may play a role in their risk. Idiopathic intracranial hypertension is when the pressure in the fluid surrounding the brain rises. It can mimic the symptoms of a ...