Creating a safe CAR T-Cell therapy to fight solid tumors in children

Astronomers at the Center for Astrophysics | Harvard & Smithsonian have detected the first Jupiter-like planet without clouds or haze in its observable atmosphere. The END ...

Friends are more than just trusted confidantes, say Michigan State University researchers who have examined the cultural and health benefits of close human relationships in a new study. "Friendships are one of the untapped resources people can draw on to pursue a happier and healthier life. They literally cost nothing and have health and well-being benefits," said William Chopik, an assistant professor of psychology at MSU and the study's senior author. Published in Frontiers of Psychology, the study is the largest of its kind and included 323,200 participants from 99 countries. Prior studies compared only a few specific cultures to one another -- but ...

The year 2021 marks the 100th anniversary of a fundamental discovery that's taught in every biochemistry textbook. In 1921, German physician Otto Warburg observed that cancer cells harvest energy from glucose sugar in a strangely inefficient manner: rather than "burn" it using oxygen, cancer cells do what yeast do -- they ferment it. This oxygen-independent process occurs quickly, but leaves much of the energy in glucose untapped. Various hypotheses to explain the Warburg effect have been proposed over the years, including the idea that cancer cells have defective ...

CHAPEL HILL, N.C. - Many organizations are looking at effective ways to communicate the importance of wearing a mask, especially as highly transmissible new strains of coronavirus threaten to cause a surge in infections. Experts at the University of North Carolina at Chapel Hill suggest positive messages are critical to supporting the effort. Their findings, described in a study published in December in the International Journal of Environmental Research and Public Health, give public health experts, leaders and communicators critical insight to craft messaging that could potentially increase mask usage during the pandemic. "As science evolved during ...

Abnormally hyperactive areas in the brain may help better predict the onset of Alzheimer's disease, according to findings of a research team led by Université de Montreal psychology professor Sylvie Belleville, scientific Director of the Institut universitaire de gériatrie de Montréal research centre. Hyperactivation could be an early biomarker of Alzheimer's disease, the researchers say in their study published today in Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, co-authored by Belleville and Nick Corriveau-Lecavalier, a doctoral student she supervises. Worried about their memory In their research, ...

A new study of Type 2 diabetes (T2D) in Japanese populations has uncovered a previously uncharacterized genetic variant that puts male carriers at greater risk for the disease, as well as the mechanism by which it does so. The impact of the variant was most pronounced in sedentary men; those with the variant had a 65% greater rate of T2D than sedentary men without it. Researchers from the University of Southern California, along with colleagues in Japan, led by Professor Noriyuki Fuku of Juntendo University, found higher rates of harmful belly fat and T2D among Japanese men with a specific mitochondrial gene variant. This variant, in the site of the mitochondrial peptide ...

Researchers from LSTM's Centre for Snakebite Research and Interventions (CSRI) have led an international team investigating the evolutionary origins of a novel defensive trait by snakes - venom spitting - and demonstrated that defensive selection pressures can influence venom composition in snakes in a repeatable manner. In a paper published in the journal Science, the team, which includes authors from the UK, USA, Australia, the Netherlands, Spain, Norway, Brazil and Costa Rica, provide the first example of snake venom evolution being demonstrated to be associated with a role in defence, ...

Scientists have created a highly detailed map of skin, which reveals that cellular processes from development are re-activated in cells from patients with inflammatory skin disease. The researchers from the Wellcome Sanger Institute, Newcastle University and Kings College London, discovered that skin from eczema and psoriasis patients share many of the same molecular pathways as developing skin cells. This offers potential new drug targets for treating these painful skin diseases. Published on 22nd January in Science, the study also provides a completely new understanding of inflammatory disease, opening up new avenues for research on other inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease. Part of the global ...

ITHACA, N.Y. - A streamlined process for awarding green cards to international STEM doctoral students graduating from U.S. universities could benefit American innovation and competitiveness, including leveling the field for startups eager to attract such highly skilled workers, according to a new study by researchers from Cornell University and the University of California, San Diego. The new Biden administration backs policy reform aimed at achieving that end, which was part of bipartisan legislation proposed more than a decade ago. But progress has been stalled by broader concerns about visas ...

LA JOLLA, CA--A big question on people's minds these days: how long does immunity to SARS-CoV-2 last following infection? Now a research team from La Jolla Institute for Immunology (LJI), The University of Liverpool and the University of Southampton has uncovered an interesting clue. Their new study suggests that people with severe COVID-19 cases may be left with more of the protective "memory" T cells needed to fight reinfection. "The data from this study suggest people with severe COVID-19 cases may have stronger long-term immunity," says study co-leader LJI Professor Pandurangan Vijayanand, M.D., Ph.D. The research, published Jan. 21 in Science Immunology, is the first to describe the T cells that fight SARS-CoV-2 in "high resolution" ...