PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

HIV research yields potential drug target

2021-02-10
(Press-News.org) SAN ANTONIO -- Humans possess a formidable multi-layered defense system that protects us against viral infections. Better understanding of these defenses and the tricks that viruses use to evade them could open novel avenues for treating viral infections and possibly other diseases.

For example, a human protein called SAMHD1 impedes replication of the human immunodeficiency virus (HIV) and other viruses by depleting deoxynucleotides ­­-- building blocks needed for the replication of the viral genome. It has long remained a mystery whether and how this protein is activated in response to infection.

Now researchers from The University of Texas Health Science Center at San Antonio (UT Health San Antonio) have discovered that SAMHD1 recognizes a unique molecular pattern in nucleic acids. This pattern, called "phosphorothioation," may act as a signal for action. It's like a sentinel atop a palace wall who sees an invading horde in the distance and calls the troops to battle stations.

Understanding the mechanism of SAMHD1 activation could be a step forward in the fight against HIV/AIDS.

"If we are able to increase SAMHD1 activity using a specific drug, that could potentially have anti-HIV activity," said Corey H. Yu, PhD, postdoctoral fellow in the END


ELSE PRESS RELEASES FROM THIS DATE:

Sawfish face global extinction unless overfishing is curbed

2021-02-10
Sawfish have disappeared from half of the world's coastal waters and the distinctive shark-like rays face complete extinction due to overfishing, according to END ...

Caution: 1918 influenza provides warning for potential future pandemic reemergence

Caution: 1918 influenza provides warning for potential future pandemic reemergence
2021-02-10
EAST LANSING, Mich. - The 1918 influenza pandemic provides a cautionary tale for what the future may hold for COVID-19, says a Michigan State University researcher. After a decade studying a flu virus that killed approximately 15,000 Michigan residents, Siddharth Chandra, a professor in MSU's James Madison College, saw his research come to life as he watched the spread of the COVID-19 pandemic. "It was so surreal," said Chandra, who has a courtesy appointment in epidemiology and biostatistics. "All of a sudden, I was living my research." Chandra's research is published in the American Journal of Public Health with co-authors Julia Christensen, a graduate of James Madison College; Madhur Chandra, Senior ...

Astronomers confirm orbit of most distant object ever observed in our solar system

Astronomers confirm orbit of most distant object ever observed in our solar system
2021-02-10
A team of astronomers, including associate professor Chad Trujillo of Northern Arizona University's Department of Astronomy and Planetary Science, have confirmed a planetoid that is almost four times farther from the Sun than Pluto, making it the most distant object ever observed in our solar system. The planetoid, which has been nicknamed "Farfarout," was first detected in 2018, and the team has now collected enough observations to pin down its orbit. The Minor Planet Center has now given it the official designation of 2018 AG37. Farfarout's nickname distinguished it from the previous record holder "Farout," found by the same team of astronomers ...

Hidden conflict in the mutually beneficial relationship between legumes and rhizobia

Hidden conflict in the mutually beneficial relationship between legumes and rhizobia
2021-02-10
Orange, Calif. - The mutually beneficial relationship between legumes and rhizobia, the nitrogen-fixing soil bacteria that make their home in legume root nodules and create nutrient-rich fertilizer for them, is one of the most well-known and agronomically important examples of symbiosis. New research from END ...

Computational medicine -- moving from uncertainty to precision

Computational medicine -- moving from uncertainty to precision
2021-02-10
Individual choices in medicine carry a certain amount of uncertainty. An innovative partnership at The University of Texas at Austin takes aim at medicine down to the individual level by applying state-of-the-art computation to medical care. "Medicine in its essence is decision-making under uncertainty, decisions about tests and treatments," said Radek Bukowski, MD, PhD, professor and associate chair of Investigation and Discovery in the Department of Women's Health at Dell Medical School at UT Austin. "The human body and the healthcare system are complex systems made of ...

Study finds U.S. first responders have mixed feelings about COVID-19 vaccine

2021-02-10
Firefighters and emergency medical services workers are at high risk of exposure to COVID-19 while on the job and pose an additional risk of transmitting the virus to others. Although vaccines are a promising public health tool for reducing COVID-19 transmission, little has been known about the perceptions of the COVID-19 vaccine among first responders. To provide insight, a University of Miami Miller School of Medicine-led study queried a national sample of U.S. firefighters and emergency medical services workers through an anonymous online survey. The study results, published online Feb. 1 in the Journal of Occupational ...

Electric cable bacteria breathe oxygen with unheard efficiency

Electric cable bacteria breathe oxygen with unheard efficiency
2021-02-10
Ten years ago, researchers at Aarhus University, Denmark, reported the discovery of centimeter-long cable bacteria, that live by conducting an electric current from one end to the other. Now the researchers document that a few cells operate with extremely high oxygen consumption while the rest of the cells process food and grow without oxygen. An outstanding way of life. We humans need food and oxygen to live. Now, imagine if oxygen was to be found only at the mountain top and food only in the valley. That's how the world looks like for cable bacteria, which live in the bottom of seas and lakes. For them, ...

Brain tumor study reveals surprising gene deletion and method to overcome drug resistance

Brain tumor study reveals surprising gene deletion and method to overcome drug resistance
2021-02-10
In far too many cases over the years, scientists have discovered promising new cancer treatments, only to report later that the tumor cells found ways to become resistant. These disappointing results have made overcoming drug resistance a major goal in cancer research. Now, experts at Cincinnati Children's report success at averting drug resistance in a subtype of brain tumors called glioblastomas. Importantly, the research indicates that the approach may also work in other cancers, such as melanoma, that exhibit a similar pathway of drug resistance. The method involves inhibiting a protein called SCD and reducing the ...

Reductions in CFC-11 emissions put ozone recovery back on track

2021-02-10
A potent ozone-depleting chemical whose emissions unexpectedly spiked in recent years has quickly dropped back to much lower levels, putting the recovery of the stratospheric ozone layer back on track, according to a new study by scientists at MIT, the University of Bristol, and other institutions in South Korea, the U.S., Japan, Australia, and Switzerland. The chemical in question is CFC-11, a chlorofluorocarbon that was once commonly used for refrigeration, insulation, and other purposes. When emitted to the atmosphere, CFC-11 can loft into the stratosphere, where the sun's ultraviolet radiation breaks the chemical down to release chlorine -- a noxious chemical that then eats ...

Creating more sustainable fragrances with biotech

2021-02-10
In the face of a changing climate and crop diseases, manufacturers of products containing natural flavors and fragrances are pivoting to a new way to source ingredients. Companies have been partnering with biotechnology firms to manufacture scents and flavors using fermented microbes, which experts say are more sustainable. A new story in Chemical & Engineering News (C&EN), the weekly newsmagazine of the American Chemical Society, details how the industry is brewing up new fragrances. Although the availability of natural fragrances and flavors like citrus and vanilla is dwindling, the demand for them has increased, writes Senior Business Editor Melody Bomgardner. In recent years, flavor and fragrance companies have been working with the biotech industry to shore ...

LAST 30 PRESS RELEASES:

Pavlov’s dogs were conditioned to go to their treat. Why do some animals learn to interact with the bell instead?

Call for Young Editorial Board members at Current Molecular Pharmacology

MSU team develops scalable climate solutions for agricultural carbon markets

Playing an instrument may protect against cognitive aging

UNM study finds link between Grand Canyon landslide and Meteor Crater impact

Ultra-hot Jupiter’s death spiral could reveal stellar secrets

You only get one brain! The best helmet material for protecting your noggin

Neurodegeneration and stroke after GLP-1RAs in diabetes and obesity

Pediatric COVID-19 hospitalization trends by race and ethnicity, 2020-2023

Research spotlight: New genetic roadmap offers insights into obesity and diabetes

Fred Hutch leads new Vanguard Study for Cancer Screening Research Network

‘Mismatched’ transplants now safe, effective for blood cancer patients, study finds

New research helps narrow down uncertainties in near-term precipitation projections for the Asian Water Tower

AI tool accurately detects tumor location on breast MRI

Researchers use OCT imaging to uncover how the fallopian tube transports embryos

PolyU secures RGC theme-based research scheme funding to develop cost-effective and sustainable Co-GenAI model

Van Andel Institute scientists develop technique for high-resolution single cell epigenetic analysis

The Lundquist Institute wins multi-year NIH grant exceeding $11 million to transform diagnosis and treatment of deadly mucormycosis

Review suggests ending adult boosters for tetanus, diphtheria

ESMT Berlin welcomes Rebecca Schaumberg to faculty

Blocking a little-known protein may offer new hope for devastating lung disease

Medieval medicine was smarter than you think – and weirdly similar to TikTok trends

FAU receives NIH grant to investigate amphetamine addiction

Realizing on-site carbon nanotube photo-thermoelectric imaging

Most of us love memes. But are they a form of comics?

Novel biosensor allows real-time monitoring of sucrose uptake in plants

Korea University researchers reveal revealing how WEE1 drives cancer resistance to immunotherapy

Pusan National University researchers develop breakthrough deep learning model that enhances handheld 3D medical imaging

SLAS Discovery and SLAS Technology demonstrate research impact with 2024 impact factors

Disease-causing bacteria can deal with stink as long as they get a meal

[Press-News.org] HIV research yields potential drug target