(Press-News.org) In far too many cases over the years, scientists have discovered promising new cancer treatments, only to report later that the tumor cells found ways to become resistant. These disappointing results have made overcoming drug resistance a major goal in cancer research.
Now, experts at Cincinnati Children's report success at averting drug resistance in a subtype of brain tumors called glioblastomas. Importantly, the research indicates that the approach may also work in other cancers, such as melanoma, that exhibit a similar pathway of drug resistance.
The method involves inhibiting a protein called SCD and reducing the expression of the transcription factor FOSB (which regulates SCD), so that the tumor cells cannot acquire resistance to the SCD inhibitor. Results were published online Feb. 10, 2021, in the journal END
Brain tumor study reveals surprising gene deletion and method to overcome drug resistance
Inhibiting the enzyme SCD and blocking the function of the transcription factor FOSB, blunts acquired resistance and extends survival in mouse models of glioblastoma; these findings may also apply to others cancers such as melanoma, say experts
2021-02-10
[Attachments] See images for this press release:
ELSE PRESS RELEASES FROM THIS DATE:
Reductions in CFC-11 emissions put ozone recovery back on track
2021-02-10
A potent ozone-depleting chemical whose emissions unexpectedly spiked in recent years has quickly dropped back to much lower levels, putting the recovery of the stratospheric ozone layer back on track, according to a new study by scientists at MIT, the University of Bristol, and other institutions in South Korea, the U.S., Japan, Australia, and Switzerland.
The chemical in question is CFC-11, a chlorofluorocarbon that was once commonly used for refrigeration, insulation, and other purposes. When emitted to the atmosphere, CFC-11 can loft into the stratosphere, where the sun's ultraviolet radiation breaks the chemical down to release chlorine -- a noxious chemical that then eats ...
Creating more sustainable fragrances with biotech
2021-02-10
In the face of a changing climate and crop diseases, manufacturers of products containing natural flavors and fragrances are pivoting to a new way to source ingredients. Companies have been partnering with biotechnology firms to manufacture scents and flavors using fermented microbes, which experts say are more sustainable. A new story in Chemical & Engineering News (C&EN), the weekly newsmagazine of the American Chemical Society, details how the industry is brewing up new fragrances.
Although the availability of natural fragrances and flavors like citrus and vanilla is dwindling, the demand for them has increased, writes Senior Business Editor Melody Bomgardner. In recent years, flavor and fragrance companies have been working with the biotech industry to shore ...
Mobile game that uses implicit learning improved children's short-term food choices
2021-02-10
Rates of overweight and obesity in children are rising around the world, with serious long-term consequences for health and health care costs. In prior research, video and mobile games have helped children eat healthier and exercise more. A new study examined how Indian 10- and 11-year-olds' food choices were affected by playing a pediatric dietary mobile game that uses implicit learning--educating players without making them aware of the lessons through innovations in neurocognitive training and immersive technology. The study found that the game significantly improved children's food choices immediately after play.
The study was conducted by researchers at Carnegie Mellon University (CMU), Hofstra University, Johns Hopkins University Center for Communication Programs (CCP), ...
Google Scholar renders documents not in English invisible
2021-02-10
The visibility of scientific articles and conference papers is conditional upon being easily found in academic search engines, especially Google Scholar. To enhance this visibility, search engine optimization (SEO) has been applied in recent years to academic search engines in order to optimize documents and, thereby, ensure they are better ranked in search pages (i.e., academic search engine optimization or ASEO).
Recent research, published in Future Internet, has found out whether the language of the document is a factor involved in the sorting algorithm of search results on Google Scholar. The study authors are Cristòfol Rovira, Lluís Codina and ...
The role of nanobacteria in the organic matter cycle in freshwater systems
2021-02-10
Because of their small size, some microorganisms can come through the pores of bacterial filters. Such filtrable microorganisms are difficult to grow in lab conditions and therefore remain understudied. Scientists believe that filtrable microorganisms are widely spread in the biosphere and participate in many biogeochemical processes, such as the restoration of sulfur in deep-see regions. They also play an important role in the production and use of dissolved organic matter. This term refers to a group of compounds (such as amino acids, organic acids and monomeric sugars) that are easily utilizable sources of nutrients in freshwater systems.
These compounds occur in pristine lotic systems at very low concentrations mainly from primary producers ...
How the 3-D structure of eye-lens proteins is formed
2021-02-10
FRANKFURT. The lens of the human eye gets its transparency and refractive power from the fact that certain proteins are densely packed in its cells. These are mainly crystallines. If this dense packing cannot be maintained, for example due to hereditary changes in the crystallines, the result is lens opacities, known as cataracts, which are the most common cause of vision loss worldwide.
In order for crystallins to be packed tightly in lens fibre cells, they must be folded stably and correctly. Protein folding already begins during the biosynthesis of proteins in the ribosomes, which are large protein complexes. Ribosomes ...
Tests reveal cybersecurity vulnerabilities of common seismological equipment
2021-02-10
Seismic monitoring devices linked to the internet are vulnerable to cyberattacks that could disrupt data collection and processing, say researchers who have probed the devices for weak points.
Common security issues such as non-encrypted data, insecure protocols, and poor user authentication mechanisms are among the biggest culprits that leave seismological networks open to security breaches, Michael Samios of the National Observatory of Athens and colleagues write in a new study published in Seismological Research Letters.
Modern seismic stations are now implemented as an Internet-of-Things (IoT) station, with physical devices that connect and exchange data with other devices and systems over the Internet. In their test attacks ...
A language learning system that pays attention -- more efficiently than ever before
2021-02-10
Human language can be inefficient. Some words are vital. Others, expendable.
Reread the first sentence of this story. Just two words, "language" and "inefficient," convey almost the entire meaning of the sentence. The importance of key words underlies a popular new tool for natural language processing (NLP) by computers: the attention mechanism. When coded into a broader NLP algorithm, the attention mechanism homes in on key words rather than treating every word with equal importance. That yields better results in NLP tasks like detecting positive or negative sentiment or predicting which words should come next in a sentence.
The attention mechanism's ...
Temple-Led Team: COVID containment measures in Philly associated with rise in gun violence
2021-02-10
(Philadelphia, PA) - While the COVID-19 pandemic brought most of the country to a standstill in March 2020, Philadelphia trauma surgeons noticed an alarming trend in the incidence of firearm violence. Instead of decreasing with containment measures, firearm-injured patients were presenting at even higher rates to Temple University Hospital and other trauma centers around the city.
A team led by Jessica H. Beard, MD, MPH, FACS, Assistant Professor of Surgery and Director of Trauma Research at the Lewis Katz School of Medicine at Temple University (LKSOM), sought to determine the magnitude of Philadelphia's increase in firearm violence during the COVID-19 pandemic. They also aimed to understand potential causes ...
Definitely not the flu: risk of death from COVID-19 3.5 times higher than from flu
2021-02-10
A new study published in CMAJ (Canadian Medical Association Journal) found that the risk of death from COVID-19 was 3.5 times higher than from influenza.
"We can now say definitively that COVID-19 is much more severe than seasonal influenza," says Dr. Amol Verma, St. Michael's Hospital, Unity Health Toronto, and the University of Toronto. "Patients admitted to hospital in Ontario with COVID-19 had a 3.5 times greater risk of death, 1.5 times greater use of the ICU, and 1.5 times longer hospital stays than patients admitted with influenza."
These ...
LAST 30 PRESS RELEASES:
Family Heart Foundation appoints Dr. Seth Baum as Chairman of the Board of Directors
New route to ‘quantum spin liquid’ materials discovered for first time
Chang’e-6 basalts offer insights on lunar farside volcanism
Chang’e-6 lunar samples reveal 2.83-billion-year-old basalt with depleted mantle source
Zinc deficiency promotes Acinetobacter lung infection: study
How optogenetics can put the brakes on epilepsy seizures
Children exposed to antiseizure meds during pregnancy face neurodevelopmental risks, Drexel study finds
Adding immunotherapy to neoadjuvant chemoradiation may improve outcomes in esophageal cancer
Scientists transform blood into regenerative materials, paving the way for personalized, blood-based, 3D-printed implants
Maarja Öpik to take up the position of New Phytologist Editor-in-Chief from January 2025
Mountain lions coexist with outdoor recreationists by taking the night shift
Students who use dating apps take more risks with their sexual health
Breakthrough idea for CCU technology commercialization from 'carbon cycle of the earth'
Keck Hospital of USC earns an ‘A’ Hospital Safety Grade from The Leapfrog Group
Depression research pioneer Dr. Philip Gold maps disease's full-body impact
Rapid growth of global wildland-urban interface associated with wildfire risk, study shows
Generation of rat offspring from ovarian oocytes by Cross-species transplantation
Duke-NUS scientists develop novel plug-and-play test to evaluate T cell immunotherapy effectiveness
Compound metalens achieves distortion-free imaging with wide field of view
Age on the molecular level: showing changes through proteins
Label distribution similarity-based noise correction for crowdsourcing
The Lancet: Without immediate action nearly 260 million people in the USA predicted to have overweight or obesity by 2050
Diabetes medication may be effective in helping people drink less alcohol
US over 40s could live extra 5 years if they were all as active as top 25% of population
Limit hospital emissions by using short AI prompts - study
UT Health San Antonio ranks at the top 5% globally among universities for clinical medicine research
Fayetteville police positive about partnership with social workers
Optical biosensor rapidly detects monkeypox virus
New drug targets for Alzheimer’s identified from cerebrospinal fluid
Neuro-oncology experts reveal how to use AI to improve brain cancer diagnosis, monitoring, treatment
[Press-News.org] Brain tumor study reveals surprising gene deletion and method to overcome drug resistanceInhibiting the enzyme SCD and blocking the function of the transcription factor FOSB, blunts acquired resistance and extends survival in mouse models of glioblastoma; these findings may also apply to others cancers such as melanoma, say experts