(Press-News.org) In far too many cases over the years, scientists have discovered promising new cancer treatments, only to report later that the tumor cells found ways to become resistant. These disappointing results have made overcoming drug resistance a major goal in cancer research.
Now, experts at Cincinnati Children's report success at averting drug resistance in a subtype of brain tumors called glioblastomas. Importantly, the research indicates that the approach may also work in other cancers, such as melanoma, that exhibit a similar pathway of drug resistance.
The method involves inhibiting a protein called SCD and reducing the expression of the transcription factor FOSB (which regulates SCD), so that the tumor cells cannot acquire resistance to the SCD inhibitor. Results were published online Feb. 10, 2021, in the journal END
Brain tumor study reveals surprising gene deletion and method to overcome drug resistance
Inhibiting the enzyme SCD and blocking the function of the transcription factor FOSB, blunts acquired resistance and extends survival in mouse models of glioblastoma; these findings may also apply to others cancers such as melanoma, say experts
2021-02-10
[Attachments] See images for this press release:
ELSE PRESS RELEASES FROM THIS DATE:
Reductions in CFC-11 emissions put ozone recovery back on track
2021-02-10
A potent ozone-depleting chemical whose emissions unexpectedly spiked in recent years has quickly dropped back to much lower levels, putting the recovery of the stratospheric ozone layer back on track, according to a new study by scientists at MIT, the University of Bristol, and other institutions in South Korea, the U.S., Japan, Australia, and Switzerland.
The chemical in question is CFC-11, a chlorofluorocarbon that was once commonly used for refrigeration, insulation, and other purposes. When emitted to the atmosphere, CFC-11 can loft into the stratosphere, where the sun's ultraviolet radiation breaks the chemical down to release chlorine -- a noxious chemical that then eats ...
Creating more sustainable fragrances with biotech
2021-02-10
In the face of a changing climate and crop diseases, manufacturers of products containing natural flavors and fragrances are pivoting to a new way to source ingredients. Companies have been partnering with biotechnology firms to manufacture scents and flavors using fermented microbes, which experts say are more sustainable. A new story in Chemical & Engineering News (C&EN), the weekly newsmagazine of the American Chemical Society, details how the industry is brewing up new fragrances.
Although the availability of natural fragrances and flavors like citrus and vanilla is dwindling, the demand for them has increased, writes Senior Business Editor Melody Bomgardner. In recent years, flavor and fragrance companies have been working with the biotech industry to shore ...
Mobile game that uses implicit learning improved children's short-term food choices
2021-02-10
Rates of overweight and obesity in children are rising around the world, with serious long-term consequences for health and health care costs. In prior research, video and mobile games have helped children eat healthier and exercise more. A new study examined how Indian 10- and 11-year-olds' food choices were affected by playing a pediatric dietary mobile game that uses implicit learning--educating players without making them aware of the lessons through innovations in neurocognitive training and immersive technology. The study found that the game significantly improved children's food choices immediately after play.
The study was conducted by researchers at Carnegie Mellon University (CMU), Hofstra University, Johns Hopkins University Center for Communication Programs (CCP), ...
Google Scholar renders documents not in English invisible
2021-02-10
The visibility of scientific articles and conference papers is conditional upon being easily found in academic search engines, especially Google Scholar. To enhance this visibility, search engine optimization (SEO) has been applied in recent years to academic search engines in order to optimize documents and, thereby, ensure they are better ranked in search pages (i.e., academic search engine optimization or ASEO).
Recent research, published in Future Internet, has found out whether the language of the document is a factor involved in the sorting algorithm of search results on Google Scholar. The study authors are Cristòfol Rovira, Lluís Codina and ...
The role of nanobacteria in the organic matter cycle in freshwater systems
2021-02-10
Because of their small size, some microorganisms can come through the pores of bacterial filters. Such filtrable microorganisms are difficult to grow in lab conditions and therefore remain understudied. Scientists believe that filtrable microorganisms are widely spread in the biosphere and participate in many biogeochemical processes, such as the restoration of sulfur in deep-see regions. They also play an important role in the production and use of dissolved organic matter. This term refers to a group of compounds (such as amino acids, organic acids and monomeric sugars) that are easily utilizable sources of nutrients in freshwater systems.
These compounds occur in pristine lotic systems at very low concentrations mainly from primary producers ...
How the 3-D structure of eye-lens proteins is formed
2021-02-10
FRANKFURT. The lens of the human eye gets its transparency and refractive power from the fact that certain proteins are densely packed in its cells. These are mainly crystallines. If this dense packing cannot be maintained, for example due to hereditary changes in the crystallines, the result is lens opacities, known as cataracts, which are the most common cause of vision loss worldwide.
In order for crystallins to be packed tightly in lens fibre cells, they must be folded stably and correctly. Protein folding already begins during the biosynthesis of proteins in the ribosomes, which are large protein complexes. Ribosomes ...
Tests reveal cybersecurity vulnerabilities of common seismological equipment
2021-02-10
Seismic monitoring devices linked to the internet are vulnerable to cyberattacks that could disrupt data collection and processing, say researchers who have probed the devices for weak points.
Common security issues such as non-encrypted data, insecure protocols, and poor user authentication mechanisms are among the biggest culprits that leave seismological networks open to security breaches, Michael Samios of the National Observatory of Athens and colleagues write in a new study published in Seismological Research Letters.
Modern seismic stations are now implemented as an Internet-of-Things (IoT) station, with physical devices that connect and exchange data with other devices and systems over the Internet. In their test attacks ...
A language learning system that pays attention -- more efficiently than ever before
2021-02-10
Human language can be inefficient. Some words are vital. Others, expendable.
Reread the first sentence of this story. Just two words, "language" and "inefficient," convey almost the entire meaning of the sentence. The importance of key words underlies a popular new tool for natural language processing (NLP) by computers: the attention mechanism. When coded into a broader NLP algorithm, the attention mechanism homes in on key words rather than treating every word with equal importance. That yields better results in NLP tasks like detecting positive or negative sentiment or predicting which words should come next in a sentence.
The attention mechanism's ...
Temple-Led Team: COVID containment measures in Philly associated with rise in gun violence
2021-02-10
(Philadelphia, PA) - While the COVID-19 pandemic brought most of the country to a standstill in March 2020, Philadelphia trauma surgeons noticed an alarming trend in the incidence of firearm violence. Instead of decreasing with containment measures, firearm-injured patients were presenting at even higher rates to Temple University Hospital and other trauma centers around the city.
A team led by Jessica H. Beard, MD, MPH, FACS, Assistant Professor of Surgery and Director of Trauma Research at the Lewis Katz School of Medicine at Temple University (LKSOM), sought to determine the magnitude of Philadelphia's increase in firearm violence during the COVID-19 pandemic. They also aimed to understand potential causes ...
Definitely not the flu: risk of death from COVID-19 3.5 times higher than from flu
2021-02-10
A new study published in CMAJ (Canadian Medical Association Journal) found that the risk of death from COVID-19 was 3.5 times higher than from influenza.
"We can now say definitively that COVID-19 is much more severe than seasonal influenza," says Dr. Amol Verma, St. Michael's Hospital, Unity Health Toronto, and the University of Toronto. "Patients admitted to hospital in Ontario with COVID-19 had a 3.5 times greater risk of death, 1.5 times greater use of the ICU, and 1.5 times longer hospital stays than patients admitted with influenza."
These ...
LAST 30 PRESS RELEASES:
Sexual health symptoms may correlate with poor adherence to adjuvant endocrine therapy in Black women with breast cancer
Black patients with triple-negative breast cancer may be less likely to receive immunotherapy than white patients
Affordable care act may increase access to colon cancer care for underserved groups
UK study shows there is less stigma against LGBTQ people than you might think, but people with mental health problems continue to experience higher levels of stigma
Bringing lost proteins back home
Better than blood tests? Nanoparticle potential found for assessing kidneys
Texas A&M and partner USAging awarded 2024 Immunization Neighborhood Champion Award
UTEP establishes collaboration with DoD, NSA to help enhance U.S. semiconductor workforce
Study finds family members are most common perpetrators of infant and child homicides in the U.S.
Researchers secure funds to create a digital mental health tool for Spanish-speaking Latino families
UAB startup Endomimetics receives $2.8 million Small Business Innovation Research grant
Scientists turn to human skeletons to explore origins of horseback riding
UCF receives prestigious Keck Foundation Award to advance spintronics technology
Cleveland Clinic study shows bariatric surgery outperforms GLP-1 diabetes drugs for kidney protection
Study reveals large ocean heat storage efficiency during the last deglaciation
Fever drives enhanced activity, mitochondrial damage in immune cells
A two-dose schedule could make HIV vaccines more effective
Wastewater monitoring can detect foodborne illness, researchers find
Kowalski, Salonvaara receive ASHRAE Distinguished Service Awards
SkAI launched to further explore universe
SLU researchers identify sex-based differences in immune responses against tumors
Evolved in the lab, found in nature: uncovering hidden pH sensing abilities
Unlocking the potential of patient-derived organoids for personalized sarcoma treatment
New drug molecule could lead to new treatments for Parkinson’s disease in younger patients
Deforestation in the Amazon is driven more by domestic demand than by the export market
Demand-side actions could help construction sector deliver on net-zero targets
Research team discovers molecular mechanism for a bacterial infection
What role does a tailwind play in cycling’s ‘Everesting’?
Projections of extreme temperature–related deaths in the US
Wearable device–based intervention for promoting patient physical activity after lung cancer surgery
[Press-News.org] Brain tumor study reveals surprising gene deletion and method to overcome drug resistanceInhibiting the enzyme SCD and blocking the function of the transcription factor FOSB, blunts acquired resistance and extends survival in mouse models of glioblastoma; these findings may also apply to others cancers such as melanoma, say experts