(Press-News.org) Cardiovascular system can be regarded as a mechanical system centered on the heart. Blood flow in the vascular system, hemodynamics factors within the vasculature contain wall shear stress, circumferential wall tensile stress and hydrostatic pressure. Mechanical forces play an important role in vasculature and circulation, such as rapid regulation of vascular wall elasticity, administration of vascular remodeling, and the formation of arteriosclerotic lesions. Stress stimulation within the physiological range enables cells in dynamic balance to maintain homeostasis of vascular morphology, structure and function. Inversely, abnormal stresses stimulation, such as low shear stress, disturbed shear stress and high tensile strain, can break this balance and lead to vascular remodeling. Traditionally, blood pressure defines as a hydrostatic pressure on vascular wall. As a vertical pressure, hydrostatic pressure can act on all components of the vessel. However, few studies have addressed vascular smooth muscle cell (VSMC) (the most abundant component of the artery) under hydrostatic pressure as well as challenges to their function and the pathogenesis contributions to cardiovascular diseases.
First, researchers constructed a high-hydrostatic-pressure cell-culture system to imitate constant hypertension and applied single cell RNA-sequencing for identification a novel cellular taxonomy of VSMCs under hydrostatic pressure. Under 100-mmHg (analogous to healthy human blood pressure) or 200-mmHg (analogous to hypertension) hydrostatic pressure for 48 h, six distinct VSMC clusters were defined according to differential gene expression and gene ontology enrichment analysis. Especially, two novel VSMC subsets were identified, named the inflammatory subset, with CXCL2, CXCL3 and CCL2 as markers, and the endothelial-function inhibitory subset, with AKR1C2, AKR1C3, SERPINF1 as markers. The inflammatory subset promoted CXCL2&3 and CCL2 chemokine expression and secretion, triggering monocyte migration; the endothelial-function inhibitory subset secreted SERPINF1 and accelerated prostaglandin F2α generation to inhibit angiogenesis. The expression of the two VSMC subsets was greatly increased in arterial media from patients with hypertension and experimental animal models of hypertension.
Collectively, this study identified high hydrostatic pressure directly driving VSMCs into two new subsets, promoting or exacerbating endothelial dysfunction thereby contributing to the pathogenesis of other cardiovascular diseases such as coronary artery disease, stroke, and cardiac ischemic damage. The findings also partly explain why strict BP control (SBP END
Scientists identifies novel vascular smooth muscle subsets under high hydrostatic pressure
2021-02-17
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