PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Mouse sperm generated in rats

Researchers from the National Institute for Physiological Sciences in Japan successfully grow mouse stem cells into sperm in the body of the rat

Mouse sperm generated in rats
2021-03-02
(Press-News.org) Okazaki, Japan - Making gametes such as sperm and eggs from pluripotent stem cells, primitive cells that can make all the tissues, greatly contributes to efficient reproduction of livestock animals and future assisted reproductive medicine. Researchers pave the way to achieve this goal using a body of xenogenic animals.

The researchers previously developed a method to grow stem cells into an entire organ in the body, so-called blastocyst complementation. The blastocyst is a structure of early embryos. If stem cells are transplanted into the blastocyst obtained from animals that cannot make a certain organ, the stem cells compensate the missing organ in the developing body, and make the entire organ. "We expected this method is also applicable to the efficient production of gametes," explains an author who led the study, Dr. Toshihiro Kobayashi.

A year ago, the researchers created a genetically modified rat that completely lacks sperm and eggs. They hypothesized that the rat can be used as an excellent host to grow exogenous stem cells into gametes.

The researchers firstly transplanted allogenic rat stem cells into blastocyst obtained from rats that are unable to make gametes, and confirmed all the gametes were derived from the stem cells. The generated gametes deliver the genetic information from the stem cells to the next generation, which enables efficient production of genetically modified rats.

Then, researchers tested whether xenogenic mouse stem cells can make mouse gametes in the body of rats. Remarkably, mouse germ cells including sperm and spermatids were observed in the testis of the rats, and the spermatids could fertilize with mouse eggs to produce healthy pups (see figures).

"Making gametes from stem cells even in the xenogenic environment is quite important for the application of this strategy," says another author led the study, Dr. Masumi Hirabayashi. "In the future, we may be able to use the method to preserve endangered species, since their stem cells are available due to iPS cell technology."

INFORMATION:


[Attachments] See images for this press release:
Mouse sperm generated in rats

ELSE PRESS RELEASES FROM THIS DATE:

Gold-phosphorus nanosheets catalyzes nature gas to greener energy selectively

Gold-phosphorus nanosheets catalyzes nature gas to greener energy selectively
2021-03-02
Advances in hydraulic fracturing technology have enabled discovery of large reserves of natural gas which primarily contains methane, which is mainly burned directly and causing global warming potentially. Upgrading methane to greener energy such as methanol through aerobic oxidation is an ideal way to solve the problem and remain 100% atom economy. Yet the difficulties lie in activating methane and preventing methanol from over-oxidation. Methane takes a stable non-polar tetrahedral structure with high dissociation energy of C-H bond, which requires high energy to be activated. ...

Rapid administration of methoxyflurane versus standard care for pain management in the ED

Rapid administration of methoxyflurane versus standard care for pain management in the ED
2021-03-02
Des Plaines, IL - Initial management with inhaled methoxyflurane in the emergency department did not achieve the prespecified substantial reduction in pain, but was associated with clinically significant lower pain scores compared to standard therapy. That is the conclusion of a study titled Rapid Administration of Methoxyflurane to Patients in the Emergency Department (RAMPED) Study: A Randomized Controlled Trial of Methoxyflurane Versus Standard Care that was published recently in the February 2021 issue of Academic Emergency Medicine (AEM), a journal of the Society for Academic Emergency Medicine (SAEM). According to findings of the controlled randomized trial, secondary outcomes included the pain ...

Designing soft materials that mimic biological functions

2021-03-02
Northwestern Engineering researchers have developed a theoretical model to design soft materials that demonstrate autonomous oscillating properties that mimic biological functions. The work could advance the design of responsive materials used to deliver therapeutics as well as for robot-like soft materials that operate autonomously. The design and synthesis of materials with biological functions require a delicate balance between structural form and physiological function. During embryonic development, for instance, flat sheets of embryonic cells morph through a series of folds into intricate three-dimensional structures such as branches, tubes, and furrows. These, in turn, become dynamic, three-dimensional building blocks for organs performing vital functions ...

Parents' school reviews correlated with test scores and demographics, not school effectiveness

2021-03-02
Washington, March 2, 2021--A first-of-its-kind analysis of parents' reviews of U.S. public K-12 schools, posted primarily from 2009 to 2019 on the popular school information site GreatSchools.org, found that most reviews were written by parents at schools in affluent neighborhoods and provided information that correlated strongly with test scores, a measure that closely tracks race and family income. Language associated with school effectiveness, which measures how much students improve in their test scores over time and is less correlated with demographics, was ...

Most older adults haven't gotten screened or tested for hearing loss, poll finds

Most older adults havent gotten screened or tested for hearing loss, poll finds
2021-03-02
Eighty percent of Americans over 50 say their primary care doctor hasn't asked about their hearing in the past two years, and nearly as many - 77% -- haven't had their hearing checked by a professional in that same time, according to a new national poll report. That's despite a growing body of evidence about the importance of hearing to other aspects of life, from dementia and risk of falls to the ability to stay connected to friends and family. Men were more likely than women to say they'd had a recent hearing screening or test, and so were people ages 65 to 80 compared with those in ...

Black NBA players have shorter careers than white players

2021-03-02
COLUMBUS, Ohio - Black players in the NBA have 30% greater odds of leaving the league in any given season than white players who have equivalent performance on the court, a new study finds. The results were driven mostly by bench players, who are the majority of those in the league, but who average less than 20 minutes of action per game. These findings suggest that even in the NBA - a league in which Black players make up 70-75% of those on the court - African Americans face discrimination, said Davon Norris, lead author of the study and a doctoral student in sociology at The Ohio State University. "If there is going to be anywhere in America where you would expect there wouldn't be racial ...

Common bacteria modified to make designer sugar-based drug

Common bacteria modified to make designer sugar-based drug
2021-03-02
TROY, N.Y. -- Envisioning an animal-free drug supply, scientists have -- for the first time -- reprogrammed a common bacterium to make a designer polysaccharide molecule used in pharmaceuticals and nutraceuticals. Published today in Nature Communications, the researchers modified E. coli to produce chondroitin sulfate, a drug best known as a dietary supplement to treat arthritis that is currently sourced from cow trachea. Genetically engineered E. coli is used to make a long list of medicinal proteins, but it took years to coax the bacteria into producing even ...

Meeting the meat needs of the future

Meeting the meat needs of the future
2021-03-02
Tokyo, Japan - Humans are largely omnivores, and meat in various forms has always featured in the diet of most cultures. However, with the increasing population and pressure on the environment, traditional methods of meeting this fundamental food requirement are likely to fall short. Now, researchers at the University of Tokyo report innovative biofabrication of bovine muscle tissue in the laboratory that may help meet escalating future demands for dietary meat. With global urbanization, the economics of animal husbandry are becoming unsustainable. From an environmental viewpoint, the land and water costs of modern mega-scale ...

Secrets of sealed 17th century letters revealed by dental X-ray scanners

2021-03-02
In a world first, an international team of researchers has read an unopened letter from Renaissance Europe - without breaking its seal or damaging it in any way. The research, published in Nature Communications, describes how an X-ray scanner used in dental research and 'virtual unfolding' allowed the interdisciplinary team to read the contents of a securely and intricately folded letter which has remained unopened for 300 years, while preserving its valuable physical evidence. A highly sensitive X-ray microtomography scanner, developed at ...

First ever detailed description of a volcanic eruption from Sierra Negra

2021-03-02
A volcanic eruption in the Galápagos Islands has given scientists a fresh insight into how volcanoes behave and provided vital information that will help to predict future hazards on the islands. Irish scientists, based at Dublin Institute for Advanced Studies (DIAS) and Trinity College Dublin respectively, were members of an international research team from Ireland, United Kingdom, United States, France and Ecuador that made the discovery. The research published today (02.03.21) in Nature Communications reveals the first ever detailed description of a volcanic eruption from Sierra Negra - one ...

LAST 30 PRESS RELEASES:

Thirty-year mystery of dissonance in the “ringing” of black holes explained

Less intensive works best for agricultural soil

Arctic rivers project receives “national champion” designation from frontiers foundation

Computational biology paves the way for new ALS tests

Study offers new hope for babies born with opioid withdrawal syndrome

UT, Volkswagen Group of America celebrate research partnership

New Medicare program could dramatically improve affordability for cancer drugs – if patients enroll

Are ‘zombie’ skin cells harmful or helpful? The answer may be in their shapes

University of Cincinnati Cancer Center presents research at AACR 2025

Head and neck, breast, lung and survivorship studies headline Dana-Farber research at AACR Annual Meeting 2025

AACR: Researchers share promising results from MD Anderson clinical trials

New research explains why our waistlines expand in middle age

Advancements in muon detection: Taishan Antineutrino Observatory's innovative top veto tracker

Chips off the old block

Microvascular decompression combined with nerve combing for atypical trigeminal neuralgia

Cutting the complexity from digital carpentry

Lung immune cell type “quietly” controls inflammation in COVID-19

Fiscal impact of expanded Medicare coverage for GLP-1 receptor agonists to treat obesity

State and sociodemographic trends in US cigarette smoking with future projections

Young adults drive historic decline in smoking

NFCR congratulates Dr. Robert C. Bast, Jr. on receiving the AACR-Daniel D. Von Hoff Award for Outstanding Contributions to Education and Training in Cancer Research

Chimpanzee stem cells offer new insights into early embryonic development

This injected protein-like polymer helps tissues heal after a heart attack

FlexTech inaugural issue launches, pioneering interdisciplinary innovation in flexible technology

In Down syndrome mice, 40Hz light and sound improve cognition, neurogenesis, connectivity

Methyl eugenol: potential to inhibit oxidative stress, address related diseases, and its toxicological effects

A vascularized multilayer chip reveals shear stress-induced angiogenesis in diverse fluid conditions

AI helps unravel a cause of Alzheimer's disease and identify a therapeutic candidate

Coalition of Autism Scientists critiques US Department of Health and Human Services Autism Research Initiative

Structure dictates effectiveness, safety in nanomedicine

[Press-News.org] Mouse sperm generated in rats
Researchers from the National Institute for Physiological Sciences in Japan successfully grow mouse stem cells into sperm in the body of the rat