Nanoparticles enable efficient delivery of antimicrobial peptides

Announcing a new article publication for BIO Integration journal. In this review article the authors Yingxue Deng, Rui Huang, Songyin Huang and Menghua Xiong from South China University of Technology, Guangzhou, Guangdong, P. R. China and Sun Yat-sen University, Guangzhou, Guangdong, P. R. China discuss how nanoparticles enable efficient delivery of antimicrobial peptides for the treatment of deep infections. Antimicrobial peptides (AMPs) are rarely directly used to treat deep infections due to their systemic toxicity and low bioavailability. The authors summarize recent progress that researchers employed nanoparticles based delivery systems to deliver AMPs for the treatment of deep infections.

Nanoparticles-based delivery systems offer a strategy to increase the therapeutic index of AMPs by preventing proteolysis, increasing the accumulation at infection sites, and reducing toxicity. Especially, the development of intelligent nanocarriers can achieve selective activation and active target in the infectious sites, thus improving the therapeutic efficacy against bacterial infection and reducing the toxicity against normal tissues.

INFORMATION:

Article reference: Yingxue Deng, Rui Huang, Songyin Huang and Menghua Xiong, Nanoparticles Enable Efficient Delivery of Antimicrobial Peptides for the Treatment of Deep Infections. BIO Integration, 2021, https://doi.org/10.15212/bioi-2021-0003

BIO Integration is fully open access journal which will allow for the rapid dissemination of multidisciplinary views driving the progress of modern medicine.

As part of its mandate to help bring interesting work and knowledge from around the world to a wider audience, BIOI will actively support authors through open access publishing and through waiving author fees in its first years. Also, publication support for authors whose first language is not English will be offered in areas such as manuscript development, English language editing and artwork assistance.

BIOI is now open for submissions; articles can be submitted online at: https://mc04.manuscriptcentral.com/bioi

Please visit http://www.bio-integration.org to learn more about the journal. Editorial Board: https://bio-integration.org/editorial-board/

Please visit http://www.bio-integration.org to learn more about the journal. Editorial Board: https://bio-integration.org/editorial-board/

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ISSN 2712-0074
eISSN 2712-0082

Keywords: Antimicrobial peptides, deep infections, drug delivery, nanoparticles. END