PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Women accumulate Alzheimer's-related protein faster

2021-03-25
(Press-News.org) Alzheimer's disease seems to progress faster in women than in men. The protein tau accumulates at a higher rate in women, according to research from Lund University in Sweden. The study was recently published in Brain.

Over 30 million people suffer from Alzheimer's disease worldwide, making it the most common form of dementia. Tau and beta-amyloid are two proteins known to aggregate and accumulate in the brain in patients with Alzheimer's.

The first protein to aggregate in Alzheimer's is beta-amyloid. Men and women are equally affected by the first disease stages, and the analysis did not show any differences in the accumulation of beta-amyloid. Memory dysfunction arises later, when tau starts to accumulate. More women than men are affected by memory problems due to Alzheimer's, and it was for tau that the researchers found a higher rate of accumulation in women.

"Tau accumulation rates vary greatly between individuals of the same sex, but in the temporal lobe, which is affected in Alzheimer's disease, we found a 75% higher accumulation rate in women as a group compared to men," explains Ruben Smith, first author of the study.

The accumulation of tau is faster in patients who already have a pathological accumulation of beta-amyloid, and are in the early phase of the disease. The discovery that the accumulation rate of tau is higher in women remained even after adjusting for age and the levels of tau they had at the beginning. Together with data from three similar cohorts in the USA, the project contains 209 women and 210 men.

"The next step would be to examine why this accumulation is faster in women," says Sebastian Palmqvist, the researcher responsible for the cognitive assessment of the patients.

The study did not investigate the reasons for the higher rate of tau accumulation in women.

"Our study strongly indicates that the faster spread of tau makes women more prone to develop dementia because of Alzheimer's pathology compared to men. Future experimental studies will be important to understand the reasons behind this," concludes Professor Oskar Hansson.

INFORMATION:



ELSE PRESS RELEASES FROM THIS DATE:

Massive study reveals few differences between men and women's brains

2021-03-25
How different are men and women's brains? The question has been explored for decades, but a new study led by Rosalind Franklin University neuroscientist END ...

Combination therapy protects against advanced Marburg virus disease

2021-03-25
GALVESTON, Texas - A new study conducted at the Galveston National Laboratory at the The University of Texas Medical Branch at Galveston (UTMB) has shown substantial benefit to combining monoclonal antibodies and the antiviral remdesivir against advanced Marburg virus. The study was published today in Nature Communications. "Marburg is a highly virulent disease in the same family as the virus that causes Ebola. In Africa, patients often arrive to a physician very ill. It was important to test whether a combination of therapies would work better with really sick people, said Tom Geisbert, a professor in the Department of Microbiology & Immunology at UTMB and the principal investigator ...

In certain circumstances, outsourcing poses risks to vendors

2021-03-25
TROY, N.Y. -- Outsourcing routine tasks, like payroll, customer service, and accounting, offers well-known benefits to businesses and contributes to an economy in which entrepreneurial vendors can support industry and expand employment. However, new research from the Lally School of Management at Rensselaer Polytechnic Institute discovered that not all client-vendor relationships are beneficial for the vendors. "It's important to observe and study both sides of a business relationship," said T. Ravichandran, a chaired professor of information systems in Lally and an author of a new study published in Information Systems Frontiers. "For businesses to thrive, they need a vibrant vendor community that will support ...

Ocean's mammals at crucial crossroads

Oceans mammals at crucial crossroads
2021-03-25
The ocean's mammals are at a crucial crossroads - with some at risk of extinction and others showing signs of recovery, researchers say. In a detailed review of the status of the world's 126 marine mammal species - which include whales, dolphins, seals, sea lions, manatees, dugongs, sea otters and polar bears - scientists found that accidental capture by fisheries (bycatch), climate change and pollution are among the key drivers of decline. A quarter of these species are now classified as being at risk of extinction (vulnerable, endangered or critically endangered on the IUCN Red List), with the near-extinct vaquita porpoise and the critically endangered North Atlantic ...

Researchers capture first 3D super-resolution images in living mice

2021-03-25
WASHINGTON -- Researchers have developed a new microscopy technique that can acquire 3D super-resolution images of subcellular structures from about 100 microns deep inside biological tissue, including the brain. By giving scientists a deeper view into the brain, the method could help reveal subtle changes that occur in neurons over time, during learning, or as result of disease. The new approach is an extension of stimulated emission depletion (STED) microscopy, a breakthrough technique that achieves nanoscale resolution by overcoming the traditional diffraction limit of optical microscopes. Stefan Hell won the 2014 Nobel Prize in Chemistry for developing this super-resolution imaging technique. In Optica, The ...

Researchers reveal how lipids and water molecules regulate 5-HT receptors

2021-03-25
Serotonin, or 5-hydroxytryptamine (5-HT), is a kind of neurotransmitter. 5-HT can regulate multifaceted physiological functions such as mood, cognition, learning, memory, and emotions through 5-HT receptors. 5-HT receptors are a type of G protein-coupled receptor and can be divided into 12 subtypes in humans. As drug targets, they play a vital role in the treatment of schizophrenia, depression, and migraine. However, the structural and functional mechanisms of 5-HT receptors have been largely unknown. In a study published in Nature on March 24, Prof. H. Eric XU and Prof. JIANG Yi from the Shanghai Institute of Materia Medica (SIMM) of the Chinese Academy of ...

New biomarkers of malignant melanoma identified

New biomarkers of malignant melanoma identified
2021-03-25
Their study has shown that these malignant melanoma vesicles produced by CSCs have a different molecular composition from that of differentiated tumour cells. These molecules were also found to be detectable in exosomes present in the blood, and they presented differences in patients with malignant melanoma compared to healthy individuals. This makes them potentially suitable as biomarkers for the diagnosis and prognosis of this disease. The results have been published in the prestigious scientific journal Molecular Oncology. Malignant melanoma is one of the most aggressive types of skin cancer and its prevalence has been increasing worldwide in recent years. Among the factors that contribute to the life-threatening nature and ...

New 'bi-molecule' with multiple technological applications discovered

New bi-molecule with multiple technological applications discovered
2021-03-25
Dr. Rosario González-Férez, a researcher at the Department of Atomic, Molecular and Nuclear Physics and the "Carlos I" Institute of Theoretical and Computational Physics of the University of Granada, has published the article "Ultralong-Range Rydberg Bi-molecules" in the prestigious scientific journal Physical Review Letters. The results of the study show a new type of bi-molecule formed from two nitric oxide (NO) molecules, both in their ground state and in the Rydberg electronic state. The work was made possible thanks to the scientific collaboration between the researcher and the Institute for Theoretical Atomic, Molecular ...

SMART develops rapid deterministic lateral displacement assay to assess immune response

SMART develops rapid deterministic lateral displacement assay to assess immune response
2021-03-25
The novel label-free assay uses unconventional L and inverse-L shaped pillars of deterministic lateral displacement (DLD) microfluidic technology to quantify and profile immune states of white blood cells (WBCs) by assessing biophysical properties of size, deformation, distribution, and cell count The assay requires only 20 microlitres (μl) of unprocessed blood and takes just 15 minutes - much faster than existing methods which require up to 15 millilitres (ml) of blood and take at least a few hours to produce results This new technology measures and profiles the often volatile host immune response, resulting in a more accurate assessment of patient pathophysiology Current methods for early diagnosis of infection focus on ...

The imaginary part of quantum mechanics really exists!

The imaginary part of quantum mechanics really exists!
2021-03-25
For almost a century, physicists have been intrigued by the fundamental question: why are complex numbers so important in quantum mechanics, that is, numbers containing a component with the imaginary number i? Usually, it was assumed that they are only a mathematical trick to facilitate the description of phenomena, and only results expressed in real numbers have a physical meaning. However, a Polish-Chinese-Canadian team of researchers has proved that the imaginary part of quantum mechanics can be observed in action in the real world. We need to significantly reconstruct our naive ...

LAST 30 PRESS RELEASES:

Thirty-year mystery of dissonance in the “ringing” of black holes explained

Less intensive works best for agricultural soil

Arctic rivers project receives “national champion” designation from frontiers foundation

Computational biology paves the way for new ALS tests

Study offers new hope for babies born with opioid withdrawal syndrome

UT, Volkswagen Group of America celebrate research partnership

New Medicare program could dramatically improve affordability for cancer drugs – if patients enroll

Are ‘zombie’ skin cells harmful or helpful? The answer may be in their shapes

University of Cincinnati Cancer Center presents research at AACR 2025

Head and neck, breast, lung and survivorship studies headline Dana-Farber research at AACR Annual Meeting 2025

AACR: Researchers share promising results from MD Anderson clinical trials

New research explains why our waistlines expand in middle age

Advancements in muon detection: Taishan Antineutrino Observatory's innovative top veto tracker

Chips off the old block

Microvascular decompression combined with nerve combing for atypical trigeminal neuralgia

Cutting the complexity from digital carpentry

Lung immune cell type “quietly” controls inflammation in COVID-19

Fiscal impact of expanded Medicare coverage for GLP-1 receptor agonists to treat obesity

State and sociodemographic trends in US cigarette smoking with future projections

Young adults drive historic decline in smoking

NFCR congratulates Dr. Robert C. Bast, Jr. on receiving the AACR-Daniel D. Von Hoff Award for Outstanding Contributions to Education and Training in Cancer Research

Chimpanzee stem cells offer new insights into early embryonic development

This injected protein-like polymer helps tissues heal after a heart attack

FlexTech inaugural issue launches, pioneering interdisciplinary innovation in flexible technology

In Down syndrome mice, 40Hz light and sound improve cognition, neurogenesis, connectivity

Methyl eugenol: potential to inhibit oxidative stress, address related diseases, and its toxicological effects

A vascularized multilayer chip reveals shear stress-induced angiogenesis in diverse fluid conditions

AI helps unravel a cause of Alzheimer's disease and identify a therapeutic candidate

Coalition of Autism Scientists critiques US Department of Health and Human Services Autism Research Initiative

Structure dictates effectiveness, safety in nanomedicine

[Press-News.org] Women accumulate Alzheimer's-related protein faster