Genome analysis for sequence variants in SARS-CoV-2 among asymptomatic individuals in long-term care facility

What The Study Did: This Viewpoint discusses potential associations between functional neurological disorder and COVID-19 vaccinations. Authors: David L. Perez, M.D., M.MSc., of  Massachusetts General Hospital and Harvard Medical School in Boston, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamaneurol.2021.1042) Editor's Note: The article includes conflicts of interest disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support. INFORMATION: Media advisory: The full article is linked ...

What The Study Did: Researchers analyzed changes in out-of-pocket health care expenses in the United States during the last two decades. Authors: Amit Jain, M.D., of the Johns Hopkins University School of Medicine in Baltimore, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2021.5499) Editor's Note: The article includes conflicts of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, ...

Researchers at IMBA - Institute of Molecular Biotechnology of the Austrian Academy of Sciences - demonstrate that different viruses can lead to brain malformations through diverse mechanisms by using human brain organoid models. The results are published in the journal Cell Stem Cell. Microcephaly, a term referring to developmental malformations of the fetal brain, can be caused by diverse infections during pregnancy. The infectious agents in question are grouped under the general term of TORCH pathogens, in reference to Toxoplasma gondii, Other, Rubella, Human Cytomegalovirus ...

Electrical batteries are increasingly crucial in a variety of applications, from integration of intermittent energy sources with demand, to unlocking carbon-free power for the transportation sector through electric vehicles (EVs), trains and ships, to a host of advanced electronics and robotic applications. A key challenge however is that batteries degrade quickly with operating conditions. It is currently difficult to estimate battery health without interrupting the operation of the battery or without going through a lengthy procedure of charge-discharge that requires specialised ...

Washington, DC (April 9, 2021) -- The American Society of Nephrology (ASN) and the National Kidney Foundation (NKF) announce the concurrent publication of "Special Article: Reassessing the Inclusion of Race in Diagnosing Kidney Diseases: An Interim Report from the NKF-ASN Task Force" in the Journal of the American Society of Nephrology (JASN) and the American Journal of Kidney Diseases (AJKD). The publication in JASN and AJKD provides an essential review of the many challenges relative to identifying and implementing alternative methods to diagnosing kidney diseases. Last month, ASN and NKF asserted that race modifiers should not be included in equations used to estimate kidney function. ASN and ...

A tiny protein of SARS-CoV-2, the coronavirus that gives rise to COVID-19, may have big implications for future treatments, according to a team of Penn State researchers. Using a novel toolkit of approaches, the scientists uncovered the first full structure of the Nucleocapsid (N) protein and discovered how antibodies from COVID-19 patients interact with that protein. They also determined that the structure appears similar across many coronaviruses, including recent COVID-19 variants -- making it an ideal target for advanced treatments and vaccines. They reported their results in Nanoscale. "We discovered new features about the N protein structure that could have large implications in antibody testing ...

Since 2016, a federal regulation has allowed nurse practitioners and physician assistants to obtain a waiver to prescribe buprenorphine, a medication used to treat opioid use disorder as a medication assisted treatment. But a recent study by Indiana University researchers found the bill, called the Comprehensive Addiction and Recovery Act (CARA), has not greatly increased the amount of nurse practitioners prescribing buprenorphine, especially in states that have further restrictions. The study was published in Medical Care Research and Review. "Nurse practitioners and physician assistants are an important workforce with a capacity to expand treatment access for those with substance use disorders," said Kosali Simon, ...

Michigan State University's Witold Nazarewicz has a simple way to describe the complex work he does at the Facility for Rare Isotope Beams (frib.msu.edu), or FRIB. "I study theoretical nuclear physics," said Nazarewicz, John A. Hannah Distinguished Professor of Physics and chief scientist at FRIB. "Nuclear theorists want to know what makes the nucleus tick." There is a nucleus in every atom. Atoms, in turn, make up matter -- the stuff we interact with every day. But the nucleus is still shrouded in mystery. One of FRIB's goals in creating rare isotopes, or different forms of elements, is to better understand what's going on inside the cores of atoms. In a new paper for END ...

Led by a South African team at the South African Medical Research Council Centre for Health Economics and Decision Science (PRICELESS-SA) in the School of Public Health at the University of the Witwatersrand, Johannesburg (Wits), and the University of the Western Cape, in partnership with the University of North Carolina, USA, the study was published on 8 April in The Lancet Planetary Health. South Africa faces an increasing burden of non-communicable diseases (NCDs) such as diabetes, hypertension, cardiovascular disease and cancers - diseases that can be linked to increased consumption of sugar, particularly ...

A clean energy future propelled by hydrogen fuel depends on figuring out how to reliably and efficiently split water. That's because, even though hydrogen is abundant, it must be derived from another substance that contains it -- and today, that substance is often methane gas. Scientists are seeking ways to isolate this energy-carrying element without using fossil fuels. That would pave the way for hydrogen-fueled cars, for example, that emit only water and warm air at the tailpipe. Water, or H2O, unites hydrogen and oxygen. Hydrogen atoms in the form of molecular hydrogen must be separated out from this compound. That process depends on a key -- but often slow -- step: the oxygen evolution reaction (OER). The OER is what frees up molecular ...